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Immunological Responses to SARS-CoV-2 is a grant from the National Institute of Allergy and Infectious Diseases (NIAID) that funds research investigating how the human immune system responds to SARS-CoV-2 infection, including the development of protective immunity, the role of antibodies and T cells, mechanisms of immune evasion, and immune dysregulation associated with severe COVID-19 and Long COVID.
Research supported under this program informs vaccine design, therapeutic development, and public health strategies. Eligible applicants include universities, nonprofit research institutions, and state and local governments conducting relevant immunology and infectious disease research. Funding amounts vary by grant mechanism and study scope.
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Immune Response to COVID-19 | NIAID: National Institute of Allergy and Infectious Diseases Resources for Researchers Division of Intramural Research Labs Research at Vaccine Research Center Intramural Scientist & Clinician Directory Research Rules & Policies Allergy, Immunology & Transplantation Resources for Researchers Antimicrobial (Drug) Resistance Antimicrobial Resistance Threats Information for Researchers Risk Factors & Prevention Research Immune Tolerance Processes Disease-Specific Research Information for Researchers Autoimmune Lymphoproliferative Syndrome (ALPS) Basic & Preclinical Research Information for Researchers Information for Researchers Shiga Toxin-Producing E.
coli (STEC) Researching Ebola in Africa Information for Researchers Information for Researchers Why Food Allergy is a Priority for NIAID Characterizing Food Allergy & Addressing Related Disorders Information for Researchers Diagnosis & Management Guidelines Disease-Specific Research Information for Researchers Genomics & Advanced Technologies Pathogen-Based Initiatives Information for Researchers Information for Researchers Group A Streptococcal Infections Disease-Specific Research Information for Researchers Overview of the Immune System Features of an Immune Response Information for Researchers Information for Researchers Leprosy (Hansen's Disease) How NIAID is Addressing Lyme Disease Information for Researchers Parasite, Mosquito & Human Host Prevention, Treatment & Control Strategies Strategic Partnerships & Research Capacity Information for Researchers Information for Researchers Neglected Tropical Diseases Information for Researchers Translational & Clinical Research Cross-cutting Preparedness Molecular & Genetic Research Primary Immune Deficiency Diseases (PIDDs) Information for Researchers Animal Prion Diseases and Humans Information for Researchers Respiratory Syncytial Virus (RSV) Schistosomiasis (Bilharzia) Research in Endemic Regions Sexually Transmitted Infections (STIs) NIAID's Research Approach Information for Researchers Disease-Specific Research Information for Researchers Information for Researchers Disease-Specific Vaccines Information for Researchers Translational & Clinical Research Information for Researchers Biology, Genetics & Clinical Research NIAID's Approach to Women's Health Research Sex-Specific Health Challenges Facing Women Biennial Report (FY 2019-2020) Information for Researchers Why NIAID Is Researching Zika Virus Information for Researchers Find a Funding Opportunity Opportunities & Announcements NIAID Research Priorities Plan Your Budget & Personnel Additional Application Elements Research with Special Considerations After You Submit an Application Funding Policies and Considerations Understand the Review Process Respond to Pre-Award Requests Negotiation & Initial Award Become a Healthy Volunteer Participant's Guide to Clinical Trials HIV and Emerging Infectious Diseases Laboratory of Infectious Diseases Primary Immune Deficiency Clinic Vaccine Research Center Clinical Studies Fill Out the Volunteer Form Q&A: Vaccine Clinical Studies Vaccine Clinical Studies Safeguards Clinical Trial Publications NIAID-Funded Research News Division of Allergy, Immunology, and Transplantation Division of Microbiology and Infectious Diseases Division of Extramural Activities Division of Clinical Research Division of Intramural Research Dr. Joseph J.
Kinyoun: Father of the NIH Dr. Joseph Kinyoun The Indispensable Forgotten Man Dr. Joseph Kinyoun: Selected Bibliography NIAID 60th Anniversary Timeline Research Training at NIAID Campuses Grant Programs that NIAID Funds AIDS Research Advisory Committee AIDS Vaccine Research Subcommittee Board of Scientific Counselors Members Advisory and Peer Review Committees Autoimmune Diseases Committee Website Policies and Notices External Link Icon and Disclaimers Freedom of Information Act (FOIA) Voluntarily Submitted Information Immune Response to COVID-19 Menu Immune Response to COVID-19 Analysis of Autoantibodies Neutrophil Dysregulation in COVID-19 Immune Response to COVID-19 Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient.
Comprehensive analyses of innate and adaptive immune responses during acute COVID-19 infection and convalescence The research projects will examine the following: Genetic markers of susceptibility to severe COVID-19 infection Composition of T- and B-cell repertoire and mapping of virus-specific T-cell receptor (TCR) sequences Cytokine and chemokine profiling, including interferon (IFN) signature and soluble markers of inflammation Antibody responses to COVID-19 infection Anti-cytokine autoantibodies Levels of plasma gelsolin Humoral immunological signature of the human virome Anti-commensal antibody repertoire Systems biology approach to understand changes in the immune system Intrapatient SARS-CoV-2 genetic variation Role of neutrophil extracellular traps (NETs) This website is designed to inform physicians of the research occurring at NIAID.
If interested in contributing to any or all of these research projects, please reach out to the contact person on the respective project page. As of September 2024, several projects including collaborative studies with external sites are still being pursued, but research activity has greatly diminished with the tailing off of the pandemic.
Researchers in the Human Immunological Diseases Section believe COVID-19 causes mild or no illness in some individuals and not others because of our genetic makeup. The lab will sequence and analyze the genomes of previously healthy patients who experienced severe or fatal COVID-19 infection.
T-Cell and B-Cell Repertoires The Immune Deficiency Genetics Section aims to analyze the dynamic changes that occur within an individual’s T-cell and B-cell repertoires during the transition from acute COVID-19 infection into convalescence. The Translational Autoinflammatory Diseases Section will harness the power of Nanostring and RNA-Seq to measure and characterize the pro-inflammatory cytokine signature of COVID-19.
The Medical Virology Section is interested in performing serologic studies to better understand the epidemiology of COVID-19 in specific cohorts. Analysis of Autoantibodies Researchers in the Immunopathogenesis Section believe that anti-cytokine antibodies that can neutralize antiviral cytokines may contribute to COVID-19 disease progression, as they do in other immune-mediated diseases.
The NIAID Microbiome Program and the Metaorganism Immunity Section propose that immune responses to the gut microbiota may predict which patients get very sick with COVID-19 while others remain asymptomatic.
The Multiscale Systems Biology Section will integrate computational approaches and several cutting-edge high-throughput methods to assess changes in the epigenome, transcriptome, and proteome throughout the course of COVID-19 disease. The Virus Persistence and Dynamics Section will explore the intrapatient diversity of SARS-CoV-2 sequences using high-throughput, long-read, single-molecule sequencing.
Neutrophil Dysregulation in COVID-19 The Systemic Autoimmunity Branch at NIAMS will study in detail the role of neutrophil dysregulation and NETs in the induction of enhanced proinflammatory responses, tissue damage, vasculopathy, and prothrombotic manifestations. We seek hospitals to collaborate in our research project by submitting samples. For sample requirements, see the specific project pages.
See the list of participating hospitals These are original research publications using samples obtained from the NIAID COVID Consortium. Each paper addresses one or more of the scientific questions outlined in the project pages, with the goal of elucidating the immune response to COVID-19. Content last reviewed on September 11, 2024
According to the current listing, eligibility includes: Universities, Nonprofits, State/local governments. Confirm the full requirements in the official notice before applying.
Immunological Responses to SARS-CoV-2 is funded by National Institute of Allergy and Infectious Diseases (NIAID). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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