Improved Fetal Screening using 0.55T MRI

Improved Fetal Screening using 0.55T MRI is sponsored by National Institute of Child Health and Human Development (NICHD). This opportunity supports mission-aligned projects and measurable outcomes.

ISMRM20 Digital Posters Page: Body: Abdominopelvic MRI - Benign ISMRM & SMRT Virtual Conference • 08-14 August 2020 Body: Abdominopelvic MRI - Benign Note: There are no live presentations or sessions associated with these posters.

2478 -2492 Abdominopelvic MRI - Benign - Diffuse Liver: Fat & Contrast 2493 -2506 Abdominopelvic MRI - Benign - Liver Fibrosis & Cirrhosis 2507 -2520 Abdominopelvic MRI - Benign - Pancreas 2521 -2534 Abdominopelvic MRI - Benign - Female Pelvis, Placenta & Fetal 2535 -2549 Abdominopelvic MRI - Benign - Liver: Iron & Bile 2550 -2561 Abdominopelvic MRI - Benign - Diabetes, Nutrition & Metabolism 2562 -2575 Abdominopelvic MRI - Benign - Female Pelvis & Maternal-Fetal Imaging 2576 -2591 Abdominopelvic MRI - Benign - Gastrointestinal & Abdominal 2592 -2605 Abdominopelvic MRI - Benign - Machine Learning & Radiomics in Body MRI 2606 -2620 Abdominopelvic MRI - Benign - Emerging & Advanced MRI Techniques in Body MRI 2621 -2634 Abdominopelvic MRI - Benign - Pancreas & Hepatobiliary 2635 -2649 Abdominopelvic MRI - Benign - Genitourinary Imaging Innovation, Quality Control & Post-Processing Session Topic: Abdominopelvic MRI - Benign Session Sub-Topic: Diffuse Liver: Fat & Contrast Simultaneous T1 and Fat Fraction Quantification using Multi-Echo Radial Look-Locker Imaging Mahesh Bharath Keerthivasan 1 , Xiaodong Zhong 2 , Marcel Dominik Nickel 3 , David Garcia 4 , Maria Altbach 4 , Berthold Kiefer 3 , and Vibhas Deshpande 5 1 Siemens Healthcare USA, Tucson, AZ, United States, 2 Siemens Healthcare USA, Los Angeles, CA, United States, 3 Siemens Healthcare Gmbh, Erlangen, Germany, 4 University of Arizona, Tucson, AZ, United States, 5 Siemens Healthcare USA, Austin, TX, United States Abdominal T1 mapping has been used for the quantification of various pathologies including the characterization of focal liver lesions and liver fibrosis.

The presence of fat and iron in the liver act as confounding factors resulting in T1 estimation errors. In this work, we present a multi-echo inversion-recovery radial Look-Locker technique with FLASH readouts for simultaneous T1w, T2* and PDFF quantification. We also propose two fitting strategies to generate water-only T1 estimates from the acquired data.

Performance of the method is evaluated on phantoms and in vivo results are presented.

Multiparametric MRI evaluation of liposomal prostaglandin E1 intervention on hepatic warm ischemia-reperfusion injury in rabbits Qian Ji 1 , JingYao Li 1 , Jiabing Jiang 1 , Robert Grimm 2 , and Jinxia Zhu 3 1 Tianjin First Central Hospital, Tianjin, China, 2 Siemens Healthcare GmbH, Erlangen, Germany, 3 MR collaboration, Siemens Healthcare Ltd, Beijing, China This study evaluated if multiparametric magnetic resonance imaging (MRI) could identify changes in warm ischemia-reperfusion injury (WIRI) after liposomal prostaglandin E1 (Lipo-PGE1) intervention in rabbit livers.

We measured blood oxygen level–dependent, diffusion tensor, and intravoxel incoherent motion imaging on functional hepatic parameters in rabbits exposed to 1) warm ischemia at different times, 2) Lipo-PGE1 interventions, and 3) sham operations. The parameters were sensitive to perfusion and oxygenation changes during WIRI. Multiparametric MRI successfully identified changes after Lipo-PGE1 intervention.

These results offer new insights to quantitatively evaluate the effect of drugs on hepatic WIRI after liver transplantation and hepatectomy.

Limits of Fat Quantification with Chemical Shift Encoded Magnetic Resonance Imaging in the Presence of Iron Overload Timothy J Colgan 1 , Diego Hernando 1,2 , and Scott B Reeder 1,2,3,4,5 1 Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2 Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 3 Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 4 Medicine, University of Wisconsin - Madison, Madison, WI, United States, 5 Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States Quantitative confounder-corrected chemical shift encoded MRI estimates of proton density fat fraction (PDFF) are corrected for R2* signal decay.

However, at very high levels of iron overload, the observed signal in CSE-MRI decays rapidly (high R2*), complicating the separation of water and fat signals, and therefore the quantification of PDFF. This work characterized the degree of iron overload above which the quantification of PDFF is limited and developed practical clinical and research guidelines for PDFF estimation protocol design for 1. 5T and 3.

0T.

Association between visceral adipose tissue and hepatic steatosis and steatohepatitis in obese patients Ilkay S Idilman 1,2 , Hsien Min Low 3 , Tolga Gidener 1 , Kenneth Philbrick 1 , Taofic Mounajjed 4 , Jiahui Li 1 , Alina Allen 5 , Meng Yin 1 , and Sudhakar K Venkatesh 1 1 Radiology, Mayo Clinic, Rochester, MN, United States, 2 Radiology, Hacetep University, Ankara, Turkey, 3 Radiology, Tan Tock Seng Hospital, Singapore, Singapore, 4 Pathology, Mayo Clinic, Rochester, MN, United States, 5 Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States In this study we measured visceral adipose tissue (VAT), proton density fat fraction (PDFF) of liver, liver volume and correlated with liver biopsy features in obese patients at risk for non-alcoholic fatty liver disease (NAFLD).

VAT shows moderately significant association with PDFF and liver volume. VAT also shows weak but significant correlation with hepatic steatosis, non-alcoholic steatohepatitis (NASH) and fibrosis at histology. Liver volume was significantly larger in patients in hepatic steatosis, NASH and fibrosis.

VAT has moderate accuracy for detection of hepatic steatosis (0. 71), NASH (0. 68), fibrosis (0.

68) and significant fibrosis (0. 73) at histology.

Feasibility of Liver Fat Quantification based on the Threshold Extraction on fast 3D mDIXON images Nan Zhang 1 , Qingwei Song 1 , Renwang Pu 1 , Haonan Zhang 1 , Yu Song 1 , Jiazheng Wang 2 , Liangjie Lin 2 , and Ailian Liu 1 1 The First Affiliated Hospital of Dalian Medical University, Dalian, China, 2 Philips Healthcare, Beijing, China The present study aims to explore feasibility of the threshold extraction method for liver fat quantification on the CS-SENSE 3D mDIXON-Quant images.

Different from the conventional measurement of liver fat contents based on regions of interest that can be limited when the patients are associated with inhomogeneous fat distribution, liver fat quantification based on the 3D threshold-extraction can be more convenient and reliable.

Gd-BOPTA-enhanced MRI predicts the severity of esophageal varices (EV) and portal vein pressure in hepatitis B cirrhosis patients Xinya Zhao 1 , Xianshun Yuan 1 , Mengxiao Liu 2 , Xiang Feng 3 , Xiangtao Lin 1 , and Ximing Wang 1 1 Department of Radiology, Shandong Provincial Hospital, Jinan, China, 2 MR Scientific Marketing, Diagnostic Imaging, Siemens Healthcare Ltd, shanghai, China, 3 MR Scientific Marketing, Diagnostic Imaging, Siemens Healthcare Ltd, Beijing, China The characteristics of liver cirrhosis are usually hepatic dysfunction and portal hypertension.

Portal hypertension further leads to ascites and esophageal varices (EV). To our knowledge, no methods are currently available for the simultaneous evaluation of portal hypertension and EV severity. The results of this study positively illustrate that Gd-BOPTA-enhanced MRI can serve as a novel and efficient tool to simultaneously and accurately evaluate portal hypertension and high-risk EVs.

Relative enhancement ratio (RE) is correlated with estimated HVPG. The formula (-6. 483+15.

612*portal vein width + 2. 251 * RE - 0. 176 * platelet count) could be used for the prediction of high-risk EVs.

Gadolinium-BOPTA Contrast-enhanced MRI in the Hepatobiliary Phase: Evaluating Liver Function based on the visualizing degree of Biliary System Xinya Zhao 1 , Xianshun Yuan 1 , Xiang Feng 2 , Mengxiao Liu 3 , Xiangtao Lin 1 , and Ximing Wang 1 1 Department of Radiology, Shandong Provincial Hospital, Jinan, China, 2 MR Scientific Marketing, Diagnostic Imaging, Siemens Healthcare Ltd, Beijing, China, 3 MR Scientific Marketing, Diagnostic Imaging, Siemens Healthcare Ltd, shanghai, China Gd-BOPTA, as a widely used hepatobiliary-specific MR contrast agent, has advantages in diagnosing focal liver lesions and may be a valuable assessment tool for the estimation of liver function.

The aim of our study was to evaluate liver function according to the degree of biliary system visualization using Gd-BOPTA. Our results suggested that the degree of biliary system visualization using Gd-BOPTA-enhanced MRI may be used as a quantifiable metric to estimate liver function and liver function reserve.

Evaluation of liver function using the hepatocyte fraction based on gadoxetic acid–enhanced MR imaging Mao-Tong LIU 1 , Xue-Qin ZHANG 1 , Jian LU 1 , and Wei-Bo CHEN 2 1 Third Affiliated Hospital of Nantong University & Nantong Third People's Hospital, Nan Tong, China, 2 Philips Healthcare Shanghai, China, Shang Hai, China The purpose of this study was to evaluate the feasibility of using the hepatocyte fraction based on gadoxetic acid–enhanced MRI for the assessment of liver function.

Firstly, T1 mapping imaging was performed before and 20 minutes after Gd-EOB-DTPA administration, The following parameters are then obtained from the images: pre- and postcontrast T1 values of the liver (T1pre and T1post), increase in the T1 relaxation rate (Δ R1), rate of the decrease of the T1 relaxation time (Δ T1), hepatocyte fraction (HeF), and uptake coefficient (K).

Our study showed that hepatocyte fraction is an effective method to evaluate liver function in patients with hepatitis B cirrhosis.

Radiomics Analysis on Gd-EOB-DTPA-Enhanced MRI for Prediction of Liver Function and Hepatic Cirrhosis Xie Yuanliang 1 , Wang Xiang 1 , Li Hui 1 , Liu Xiaoyu 1 , and Sun Jianqing 2 1 Radiology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2 Clinical Science,Philips Healthcare, Shanghai, China This retrospective study explored the value of a radiomics-based model on Gd-EOB-DTPA-Enhanced MRI for predicting liver function and cirrhosis in clinic.

Multi-class radiomics feature extraction was performed on 2D-view whole liver at portal level on HBP MRI obtained 20 min after Gd-EOB-DTPA-enhanced MRI. A prediction model including 15 radiomics features using a machine learning logistic regression classifier showed the mean AUCs on train dataset and test dataset were 0. 91 and 0.

87 for diagnosing Child-Pugh A respectively; 0. 93 and 0. 93 for diagnosing liver cirrhosis, respectively.

A New Possibility of Late Phase Image in Gd-EOB-DTPA-enhanced MRI: Visual Assessment of Hepatic Function and Fibrosis Based on Uptake Rate of EOB Yasuhiro Inokuchi 1 , Masahiro Uematsu 1 , and Tsuneyuki Takashina 1 1 Radiology, Edogawa Hospital, Tokyo, Japan We identified visual assessment value of late phase image to assess abnormal hepatic function and fibrosis.

We retrospectively selected 41 patients who underwent Gd-EOB-DTPA enhanced MRI and classified them into three groups based on visual assessment of late phase images. Kruskal–Willis t-test was used to assess significant differences in the LSR of hepatobiliary phase, FIB-4, APRI, and platelet count. Intra-class correlation coefficient (ICC) was used for intra-reader visual assessment of late phase image.

Significant differences in all parameters were observed in the groups. ICC was 0. 85.

Hepatic function or fibrosis might be assessed by visual assessment of late phase image.

A unified model for hepatobiliary transporter function assessment using Gadoxetate DCE-MRI Sirisha Tadimalla 1,2 and Steven Sourbron 2,3 1 Institute of Medical Physics, University of Sydney, Sydney, Australia, 2 Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, 3 Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom A variety of models for Gadoxetate DCE-MRI in the liver has been proposed, but comparing results of different groups is difficult due to a lack of consistency in the definitions, nomenclature and units.

We perform a rigorous classification of existing models and definitions by defining a general unified Gadoxetate DCE-MRI liver model, and identifying the relationship with existing models. Six distinct models were identified in the literature and a translation table was derived to allow direct comparison of measured quantities. The method provides a rational basis for a new standard in this field.

Quantitative Assessment of Liver Function by Using T1mapping based on Gadoxetic Acid–enhanced MRI Xueqin Zhang 1 , Jian LU 1 , Jifeng JIANG 1 , and Weibo CHEN 2 1 the Third People’s Hospital of Nantong, Nantong, China, 2 Philips Healthcare, Shanghai, China The purpose of this study was to investigate whether liver function as determined by indocyanine green (ICG) clearance can be estimated quantitatively from magnetic resonance T1mapping with Gd-EOB-DTPA.

We used Look-Locker sequences to acquire T1 mapping images pre and post-contrast at 5, 10, 15 and 20 minutes after Gd-EOB-DTPA administration, T1 relaxation times of the liver were measured, reduction rates of T1 relaxation times were calculated, our study showed that Gd-EOB-DTPA-enhanced T1mapping MRI is helpful for the quantitative evaluation of liver function, T1 relaxation time post-contrast at 20 minutes was the independent factor to predict ICG R 15 ＞20%.

Prediction of post-hepatectomy liver function with Dynamic Gadoxetate-Enhanced MRI David Longbotham 1 , Daniel Wilson 2 , Ian Rowe 3 , Dhakshinamoorthy Vijayanand 4 , Magdy Attia 4 , Ashley Guthrie 5 , Mark Gilthorpe 3 , Rajendra Prasad 4 , and Steven Sourbron 6 1 University of Leeds, Leeds, United Kingdom, 2 Department of Medical Physics, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3 Leeds Institute of Data Analytics, University of Leeds, Leeds, United Kingdom, 4 Hepatobiliary and Transplantation Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 5 Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6 Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom The aim of this study was to identify Dynamic Gadoxetate-Enhanced MRI (DGE-MRI) biomarkers that can improve predictions of post-hepatectomy liver function.

29 patients requiring resection for colorectal liver metastases were recruited, with post-operative bilirubin as outcome measure. The results suggest that: (a) functional imaging substantially improves outcome predictions over demographical and biochemical tests; (b) it is critical to separately characterise the future liver remnant; (c) volumetry does not offer any added predictive value.

We conclude that DGE-MRI may improve patient selection for hepatectomy, potentially reducing the risk of post-hepatectomy liver failure while allowing more patients to be operated.

Comparative study of T1ρ and Gd-EOB-DTPA-enhanced T1mapping with extracellular volume fraction in assessment of liver fibrosis in rabbit model Qing Wang 1 , wei xing 1 , Yanan Du 1 , Zuhui Zhu 1 , Yufeng Li 1 , and Jilei Zhang 2 1 Third Affiliated Hospital of Soochow University & First People's Hospital of Changzhou.

, changzhou, China, 2 Clinical Science,Philips Healthcare, shanghai, China This study aimed to compare the diagnostic performance for liver fibrosis staging of T1ρ and Gd-EOB-DTPA-enhanced T1mapping with extracellular volume fraction measurement in CCL4 rabbit model. Result showed that T1ρ performed better diagnostic performance and correlation with LF and fibrosis percentage of postive staining(%) than T1 native .

Diffusion Kurtosis Imaging Quantification of Liver Microscopic Changes in Rats Following Partial Hepatectomy at Different Proportions Caixin Qiu 1 , Shuangshuang Xie 1 , Jinxia Zhu 2 , Chengwen Liu 2 , Robert Grimm 3 , Qing Li 1 , and Wen Shen 1 1 Tianjin First Center Hospital, Tianjin, China, 2 MR Collaboration, Siemens Healthcare Ltd, Beijing, China, 3 Siemens Healthcare GmbH, Erlangen, Germany In this study, we used DKI to quantify the microscopic changes of residual liver in two groups of rats with different proportions of a partial hepatectomy (PH).

All the rats underwent DWI to acquire DKI data at baseline and multiple time points after surgery. The results showed that DKI-derived MD in the 70% PH group were lower than in the 30% PH group at all time points after surgery. MD decreased to a minimum by the fifth day before rising back to baseline.

This suggests that DKI is a practical technique for the timely evaluation of the liver regeneration process.

Session Topic: Abdominopelvic MRI - Benign Session Sub-Topic: Liver Fibrosis & Cirrhosis Effect of spatial resolution on Gradient Echo Magnetic Resonance Elastography at 3T Chris R Bradley 1,2 , Deirdre McGrath 1,2 , Eleanor F Cox 1,2 , and Susan T Francis 1,2 1 Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2 NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom Iron-mediated T 2 * effects are more prominent in MRE data acquired at 3T compared to 1.

5 T, and have been suggested to lead to failure rates of up to 15% for MRE at 3T. MRE based liver stiffness was measured using the QIBA recommendation with a 2D gradient‐recalled‐echo MRE sequence using a 1. 5x4.

5x10 mm 3 acqusition. For comparison, MRE data was also collected at 4. 5mm isotropic spatial resolution.

A larger voxel volume in the MRE acquisition provided higher SNR which in turn resulted in a higher proportion of voxels being fit for stiffness with confidence >0. 95.

Assessing the variation of MR and non-invasive markers in compensated cirrhosis: insights for assessing disease progression Chris R Bradley 1,2 , Eleanor F Cox 1,2 , Naaventhan Palaniyappan 2 , Guruprasad P Aithal 2 , I Neil Guha 2 , and Susan T Francis 1,2 1 Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2 NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom Baseline multi-organ MRI measures of structure and haemodynamics in the liver, spleen, heart and kidneys were collected in healthy volunteers, compensated cirrhosis (CC) and decompensated cirrhosis patients to benchmark the change in measures with disease severity.

In a stable CC cohort, observed annually for 3 years, we show liver T 1 , liver perfusion, superior mesenteric artery flow, spleen perfusion, and renal cortex T 1 (measures that predict negative liver related outcomes) have sufficient resolution to track disease progression. A Fast MR Elastography Sequence with Interleaved Inflow Saturation and Compressed SENSE Hui Wang 1,2,3 , Amol Pednekar 2,3 , Jean A. Tkach 2,3 , Kaley R.

Bridgewater 2 , Andrew T. Trout 2,3 , Jonathan R. Dillman 2,3 , and Charles L.

Dumoulin 2,3 1 Philips, Cincinnati, OH, United States, 2 Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 3 Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States We describe a fast field-echo Magnetic Resonance Elastography pulse sequence to measure liver stiffness in less than half the breath hold time (≈6.

3 sec/slice) of the conventional implementation. Key features include: 1) non-alternating motion encoding gradients to allow a shorter TR while maintaining appropriate gradient waveform polarity synchronization with the applied mechanical motion; 2) interleaved flow saturation pre-pulses to suppress flow; and 3) pseudorandom undersampling k-space with Compressed SENSE reconstruction.

The technique was validated in two gel phantoms differing in stiffness and used to evaluate liver stiffness in five volunteers. A Fast 3D MR Elastography Sequence for Measurement of Liver Stiffness in One Breath Hold Hui Wang 1,2,3 , Amol Pednekar 2,3 , Jean A. Tkach 2,3 , Charles L.

Dumoulin 2,3 , Kaley R. Bridgewater 2 , Andrew T. Trout 2,3 , and Jonathan R.

Dillman 2,3 1 Philips, Cincinnati, OH, United States, 2 Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 3 Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States We describe a 3D fast field echo (FFE) Magnetic Resonance Elastography (MRE) pulse sequence for measurement of liver stiffness in a single breath hold.

The key features of the sequence include: 1) 3D acquisition; 2) mechanical wave magnitude labelling of 1. 5 cycles of motion for each RF excitation; 3) flow saturation pre-pulses to suppress vascular flow; and 4) pseudorandom undersampling of k-space with Compressed SENSE reconstruction. The technique was validated in two gel phantoms with different stiffness and used to measure liver stiffness in five volunteers.

Comparison Of Manual And Automatic Liver MR Elastography Processing For Shear Stiffness Estimation In Children And Young Adults Deep B. Gandhi 1 , Adebayo B. Braimah 1 , Jonathan Dudley 1 , Jean A.

Tkach 1 , Amol Pednekar 1 , Andrew T. Trout 1 , Alexander G. Miethke 2 , Jeremiah A.

Heilman 3 , Bogdan Dzyubak 4 , David S. Lake 4 , and Jonathan R.

Dillman 1 1 Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2 Division of Hepatology, Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3 Resoundant Inc., Rochester, MN, United States, 4 Department of Radiology, Mayo Clinic, Rochester, MN, United States Autoimmune liver diseases lead to fibrosis and is manifested as excessive accumulation of extracellular matrix and collagen that ultimately causes increase in liver stiffness.

MR Elastography (MRE) has proven to be an important tool to clinically diagnose liver fibrosis. In this study we performed MRE at 1. 5T on 65 subjects with autoimmune liver disease.

The data was then manually processed by 2 independent readers and an automated algorithm. Near-perfect correlation and excellent agreement were observed between Reader1 and Reader2 against the automated algorithm (r=0. 987 and r=0.

981, respectively). Readers had excellent inter-reader agreement(ICC=0. 988) and the automated algorithm also demonstrated perfect reproducibility.

Comparison Of GraSE Versus FSE T2 Mapping In The Liver And Correlation With Histologic Fibrosis Stage In Pediatric Autoimmune Liver Disease Deep B. Gandhi 1 , Jonathan Dudley 1 , Ruchi Singh 2 , Jean A. Tkach 1 , Divya Sharma 3 , Amy Taylor 2 , Alexander G.

Miethke 2 , and Jonathan R.

Dillman 1 1 Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2 Division of Hepatology, Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3 Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, United States Autoimmune liver diseases can lead to hepatic fibrosis which, when progressive, can lead to liver failure ultimately requiring transplantation.

In this study 31 patients with autoimmune liver diseases underwent conventional and GraSE T2 mapping at 1. 5T as well as liver biopsy with histologic fibrosis staging. Significant positive correlations between GraSE and conventional liver T2 measurements were observed for the weighted mean of all slices (r=0.

80; p<0. 0001) and for individual slices from all subjects (r=0. 72; p<0.

0001). Conventional T2 measurements were higher, on average, than GraSE T2 measurements. There was no significant correlation observed between liver T2 measurements and histologic fibrosis stage.

Comparison of T1rho and Diffusion Kurtosis Imaging in Evaluation of Hepatic Sinusoidal Obstruction Syndrome in Rats Jian Lyu 1,2 , Guixiang Yang 3,4 , Yingjie Mei 5 , Li Guo 1,2,6 , Yihao Guo 1,2 , Kaixuan Zhao 1 , Xinyuan Zhang 1,2 , Yikai Xu 3,4 , and Yanqiu Feng 1,2 1 School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2 Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, 3 Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, 4 Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, China, 5 Philips Healthcare, Guangzhou, China, 6 Department of MRI, The First People’s Hospital of Foshan (Affiliated Foshan Hospital of Sun Yat-sen University), Foshan, China T1rho represents the spin-lattice relaxation time constant in the rotating frame, which sever as a biomarker for liver function associated with alteration in the macromolecular content of tissues.

Diffusion kurtosis imaging (DKI) was developed to measure non-Gaussian diffusion, which have increasingly been used to characterize microstructural heterogeneity in vivo. Sinusoidal obstruction syndrome (SOS) is a dynamic process with complex histopathological changes in liver.

Our study attempts to investigate the relationship between T1rho and DKI parameters in the light of pathological examinations to help us better understand the contribution of the possible factors to changes in T1rho.

Staging liver fibrosis on multi-parametric MRI in a rabbit model: elastography, susceptibility-weighted imaging and T1ρ imaging Hai-Feng Liu 1 , Li-Qiu Zou 2 , Qing Wang 1 , Yu-Feng Li 1 , Ya-Nan Du 1 , and Wei Xing 1 1 Third Affiliated Hospital of Soochow University, changzhou, China, 2 Sixth Affiliated Hospital of Shenzhen University, shenzhen, China In this prospective experimental study, we evaluated the independent value and diagnostic efficacy of multi-parametric MRI using quantitative measurements of the liver stiffness (LS) on MRE, liver-to-muscle signal intensity ratio (SIR) on SWI, and T1ρ value for staging LF in a rabbit model.

Evaluation of liver fibrosis and cirrhosis on the basis of T1 mapping and the impact of inflammation, age and liver volume as confounding factors Hanns-Christian Breit 1 , David Winkel 2 , and Tobias Heye 2 1 Radiology, University Hospital of Basel, Basel, Switzerland, 2 University Hospital of Basel, Basel, Switzerland Aim of our study was to evaluate confounding factors for the assessment of liver fibrosis.

A total of 200 patients were retrospectively included (67 patients with fibrosis or cirrhosis, 40 patients with acute elevation of laboratory parameters, 93 healthy patients). T1 values were significantly lower in healthy patients without known fibrotic changes than in patients with acute liver disease or known fibrosis or cirrhosis. Therefor T1 mapping seems to be a capable predictor for the detection of liver fibrosis and cirrhosis.

Whole-liver apparent diffusion coefficient histogram analysis for the diagnosis and staging of liver fibrosis Zheng You 1,2 , Lei Jun-qiang 2 , and Xu Yong-sheng 2 1 First Clinical Medical College of LanZhou University, Lanzhou, Gansu, China, 2 Radiology, First Hospital of LanZhou University, Lanzhou, Gansu, China This study aimed to determine whether whole-liver apparent diffusion coefficient (ADC) histogram parameters can contribute to hepatic fibrosis staging.

We evaluated quantitative histogram parameters between different pathological fibrosis stages. And the diagnostic performance of ADC histogram parameters in discriminating stage 1 or greater (≥F1), stage 2 or greater (≥F2), and stage 3 or greater (≥F3) liver fibrosis were compared.

The results showed that many histogram parameters (kurtosis, skewness, entropy, mode, 75 th and 90 th percentiles) had statistical significance among the pathologic liver fibrosis stages (P<0. 05), and kurtosis yielded the highest area under the curve (0. 801).

Comparison of the degree of R1rho dispersion in liver between healthy volunteers and patients with liver disease Minori Onoda 1 , Yu Ueda 2 , Satoshi Kobayashi 1,3,4 , Tosiaki Miyati 3 , Naoki Ohno 3 , Yudai Shogan 1 , Tadanori Takata 1 , Yukihiro Matsuura 1 , and Toshifumi Gabata 4 1 Department of Radiological Technology, Kanazawa University hospital, Kanazawa, Japan, 2 Philips Japan, Tokyo, Japan, 3 Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 4 Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan In this study, we compared the degree of R1rho dispersion in liver of healthy volunteers and patients with liver disease to better understand the behavior of T1rho in liver.

T1rho in normal liver tissue was correlated with the perfusion-independent diffusion coefficient (D) calculated by IVIM analysis, whereas in patients with liver disease, there was no correlation between T1rho and D. Furthermore, there was no significant difference between the R1rho dispersion values in liver between volunteers and patients.

Free-Breathing, Confounder-Corrected T1 Mapping in the Liver with 3D Radial Inversion Recovery MRI Yavuz Muslu 1,2 , Steven Kecskemeti 2,3 , Diego Hernando 1,2,4 , and Scott B.

Reeder 1,2,4,5,6 1 Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2 Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3 Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, 4 Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 5 Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, 6 Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States Quantitative T 1 mapping in the liver is an emerging biomarker of hepatic fibrosis and characterization of liver function.

Existing T 1 mapping methods in abdomen are generally sensitive to tissue fat and B1 inhomogeneities , both of which confound estimates of T 1 . Further, Cartesian methods may suffer from motion related ghosting artifacts. In this work, we propose to combine 3D-radial inversion recovery with chemical shift encoded imaging to jointly estimate T 1 of water, T 1 of fat, proton density fat fraction (PDFF), and B 0 and B 1 inhomogeneities.

The feasibility and performance of the proposed method are evaluated with simulations, and phantom experiments.

Assessment of fibrosis grades in chronic liver disease using liver heterogeneity and nodularity quantification program Tae-Hoon Kim 1 , Ji Eon Kim 1 , Jong-Hyun Ryu 1 , SeungJin Kim 2 , Min-Gi Pak 2 , Chang-Won Jeong 1 , and Kwon-Ha Yoon 1,3 1 Medical Convergence Research Center, Wonkwang University, Iksan, Korea, Republic of, 2 Medical Science, Wonkwang University, Iksan, Korea, Republic of, 3 Radiology, Wonkwang University, Iksan, Korea, Republic of Poster Permission Withheld Liver fibrosis is a hallmark of chronic liver disease (CLD) characterized by the excessive accumulation of extracellular matrix proteins.

To diagnose and grade the liver fibrosis, liver biopsy is the reference standard, however the method has some limitations, including potential pain, sampling variability, and low patient acceptance. Therefore, there have been efforts to develop noninvasive imaging techniques and quantification softwares for diagnosis, staging, and monitoring of liver fibrosis.

This study developed a MRI-suitable quantification program for assessing heterogeneity and nodularity in the liver and compared the difference between fibrosis grades in CLD.

Histogram Analysis of T1 relaxation time in the rotating frame and Apparent Diffusion Coefficient for Diagnosis of Liver Fibrosis Jing Li 1 , Xinming Li 1 , Xianyue Quan 1 , Genwen Hu 2 , Yingjie Mei 3 , Da Shi 1 , Shisi Li 4 , Zhendong Qi 1 , and Xiao Zhang 5 1 Zhujiang Hospital, Southern Medical University, Guangzhou, China, 2 Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen, China, 3 Phlips Healthcare, Guangzhou, China, 4 The Third Affiliated Hospital of Southern Medical University, Guangzhou, China, 5 Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, China To explore the potential of histogram analysis to evaluate the liver fibrosis stages, histogram of T1rho and ADC were acquired from liver fibrosis model built in seventy-five rats by injecting 50% carbon tetrachloride and olive oil.

In this study, we found that the parameters of histogram analysis showed strong correlations with liver fibrosis stages, as well as inflammatory activity，while T1rho is regarded to be better than ADC.

Session Topic: Abdominopelvic MRI - Benign Session Sub-Topic: Pancreas DCE-MRI with a free-breathing compressed sensing VIBE for pancreatic ductal adenocarcinoma: correlation with ECV fraction Yoshihiko Fukukura 1 , Yuichi Kumagae 1 , Hiroaki Nagano 1 , Koji Takumi 1 , Hiroshi Imai 2 , Marcel Dominik Nickel 3 , and Takashi Yoshiura 1 1 Kagoshima University Graduate School of