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INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) is sponsored by National Heart, Lung, and Blood Institute (NHLBI). This funding opportunity supports phased clinical trials for Down syndrome research. Given the common cardiovascular comorbidities in Down syndrome, research in this area may be relevant.
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Opportunity Listing - INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) Agency: National Institutes of Health Assistance Listings: 93. 310 -- Trans-NIH Research Support 93. 350 -- National Center for Advancing Translational Sciences 93.
837 -- Cardiovascular Diseases Research 93. 846 -- Arthritis, Musculoskeletal and Skin Diseases Research 93. 847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research 93.
395 -- Cancer Treatment Research 93. 839 -- Blood Diseases and Resources Research 93. 865 -- Child Health and Human Development Extramural Research 93.
840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders 93. 838 -- Lung Diseases Research 93. 173 -- Research Related to Deafness and Communication Disorders 93.
233 -- National Center on Sleep Disorders Research Last Updated: May 13, 2026 View version history on Grants. gov The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome.
The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven. The total project period for an application submitted in response to this NOFO may...
not exceed five years. This NOFO provides support for up to two years (R61 phase) for preliminary/developmental/planning studies, followed by possible transition to clinical trial support (R33) of up to three years, although the total duration of the award may not exceed five years. This NOFO requires measurable R61 milestones.
City or township governments Special district governments Public and Indian housing authorities Federally recognized Native American tribal governments Independent school districts Private institutions of higher education Public and state institutions of higher education Nonprofits non-higher education without 501(c)(3) Nonprofits non-higher education with 501(c)(3) Other Native American tribal organizations For-profit organizations other than small businesses Refer to Section III.
Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Grantor contact information DownSyndromeINCLUDE@mail. nih.
gov DownSyndromeINCLUDE@mail. nih. gov DownSyndromeINCLUDE@mail.
nih. gov File name Description Last updated RFA-OD-27-005-Full-Announcement. html RFA-OD-27-005-Full-Announcement.
html May 13, 2026 01:51 PM UTC Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: See official notice. Clinical trial is required. Confirm the full requirements in the official notice before applying.
Applications for INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) are due June 16, 2028. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) is funded by National Heart, Lung, and Blood Institute (NHLBI). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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