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Find similar grantsIndia ENIGMA Initiative for Global Aging & Mental Health is sponsored by National Institute on Aging (NIA). This initiative aims to advance research on aging and mental health in India through the ENIGMA consortium, focusing on neuroimaging and genetic studies.
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India ENIGMA Initiative for Global Aging & Mental Health - John John India ENIGMA Initiative for Global Aging & Mental Health Venkatasubramanian, Ganesan University of Southern California, Los Angeles, CA, United States Search grants from University of Southern California Hazardous Material Worker Health and Safety Training (U45), Cooperative Agreement Center for Lupus Research Childhood Lead Poisoning Prevention Programs (CLPPP) An Intervention to Improve End-of-life Sympton Distress An Undergraduate Laboratory Economics Curriculum Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants Cohort Differences in Cognitive Impairment and Alzheimer Disease and Related Dementias: Education Effects and Sex Differences Resistance-gene-guided genome mining for novel antifungal compounds Targeting the Structurally Conserved Portal Protein as a Strategy to Develop a First-In-Class Broad-Spectrum Herpesvirus Antiviral Drug, PORT 1 Genomic Profiling of T-cell Acute Lymphoblastic Leukemia in Children Our revised proposal launches the India ENIGMA Initiative for Global Aging & Mental Health - a globally coordinated study of brain aging and Alzheimer's disease (AD), created response to the NIH FOA: Global Brain and Nervous System Disorders Research Across the Lifespan (R01; PAR-18-834; https://grants.
nih. gov/grants/guide/pa-files/PAR-18-835. html).
Our overall goal is to identify predictive markers in the blood, genome, and epigenome that influence brain aging in India, to better understand prognosis, and to support personalized risk evaluations on each continent. We plan to identify etiological pathways to resilience using the rich biobanking strategy developed by our partners at NIMHANS in India. To do this, we will leverage our global consortium, ENIGMA (http://enigma.
ini. usc. edu), to partner with dementia research pioneers in India, creating new links between international biobanks, and building research capacity.
By 2020, 70% of the world's population over age 60 will live in developing countries, with 14% in India (Mathuranath 2012). Recently, attention has been drawn to a ? diversity?
crisis in brain research, as most brain research is conducted in Caucasian populations from relatively wealthy backgrounds (LeWinn 2017). This lack of ethnic diversity means that: (1) we do not know if predictors of health (and disease) generalize to other ethnic groups, and (2) we fail to collect vital data that could teach us how AD progresses in populations with different genetic and environmental backgrounds.
Our coordinated analyses in US/EU and Indian biobanks will help identify brain aging predictors specific to India and those that are universal. Specifically, we will: Aim 1. Create Lifespan Charts of brain aging Trajectories in India using MRI, DWI and Resting State Functional MRI.
Aim 2. Identify Blood and Epigenetic Markers that Predict Brain Aging and AD in India. Aim 3.
Using a combination of multimodal imaging, blood markers, and clinical data to predict clinical decline in India. We test structural equation models that hypothesize how brain aging depends on lifestyle and psychosocial factors (diet, family support, drug abuse, literacy, sleep, and depression), as well as sex, education, and AD genetic risk.
With novel machine learning methods, will analyze blood markers and plasma proteomic analytes, to define processes that are harmful to brain aging. In Capacity Building Aims, we will leverage ENIGMA's successful strategies to train emerging and established scientists in India to analyze their data with high quality control and precision, with targeted biostatistical and imaging workshops to bolster capacity.
This collaborative India-US initiative will enable future science initiatives, and equip the NIMHANS team with the necessary tools to train new scientists and independently conduct high impact research bridging efforts into numerous international partnerships. We launch the India ENIGMA Initiative for Global Aging & Mental Health - a globally coordinated study of brain aging and Alzheimer's disease (AD).
Our overall goal is to identify predictive markers in the blood, genome, and epigenome, and psychosocial/lifestyle factors that influence brain aging in India, to better understand prognosis, and to support personalized risk evaluations on each continent. We plan to identify etiological pathways to resilience using the rich biobanking strategy developed by our partners at NIMHANS in India.
Agency National Institute of Health (NIH) Institute National Institute on Aging (NIA) Type Research Project (R01) Project # 1R01AG060610-01A1 Study Section Special Emphasis Panel (ZRG1) Program Officer Wagster, Molly V Name University of Southern California India ENIGMA Initiative for Global Aging & Mental Health John, John P. ; Thompson, Paul M.
; Venkatasubramanian, Ganesan / University of Southern California India ENIGMA Initiative for Global Aging & Mental Health John, John P. ; Thompson, Paul M. ; Venkatasubramanian, Ganesan / University of Southern California Be the first to comment on this grant
According to the current listing, eligibility includes: Universities, research institutions, and organizations with expertise in neuroimaging, genetics, and mental health research. Confirm the full requirements in the official notice before applying.
India ENIGMA Initiative for Global Aging & Mental Health is funded by National Institute on Aging (NIA). Verify program details on the funder's official page before applying.
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