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The Infrastructure Innovation for Biological Research Program (Innovation) supports research to design novel or greatly improved research tools and methods that advance contemporary biology in any research area supported by the Directorate for Biological Sciences at NSF. The Innovation Program focuses on research infrastructure that is broadly applicable to researchers in three programmatic areas: Bioinformatics, Instrumentation, and Research Methods. Infrastructure supported by this program is expected to advance biological understanding by improving scientists’ abilities to manipulate, control, analyze, or measure critical aspects of biological systems, which can be essential for addressing important fundamental research questions. Proposals submitted to these programmatic areas can do one of three things to advance or transform research in biology: develop novel infrastructure, significantly redesign existing infrastructure, or adapt existing infrastructure in novel ways. Projects are expected to have a significant application to one or more biological science questions and have the potential to be used by a community of researchers beyond a single research team. Please refer to the descriptions of individual programmatic areas for detailed guidance on what is supported through this solicitation (see links below).
Funding Opportunity Number: 23-578. Assistance Listing: 47.074. Funding Instrument: G. Category: ST. Award Amount: $300K – $800K per award.
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Or search similar grants →According to the current listing, eligibility includes: Eligible applicants: Others (see text field entitled Additional Information on Eligibility for clarification). *Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs): Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of sub-awards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus. *Who May Serve as PI: There are no restrictions or limits. Confirm the full requirements in the official notice before applying.
The current listing shows $300K – $800K per award. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Infrastructure Innovation for Biological Research (Innovation) are due October 30, 2076. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Yes — Infrastructure Innovation for Biological Research (Innovation) is offered by U.S. National Science Foundation and this listing comes from Grants.gov, an official U.S. federal source. Federal applications generally require registrations (for example SAM.gov or an agency submission portal), so allow extra lead time.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
Innovate Cities & Infrastructure (INCI) Programme - Urban Research Grants is sponsored by Swiss State Secretariat for Economic Affairs (SECO). The INCI Programme supports interdisciplinary, practice-oriented research that pairs ETH-Domain researchers with practice partners to develop evidence-based solutions for sustainable urban development, resilient infrastructure, and effective local governance in SECO partner countries (including Ukraine) and selected EU countries. While broadly focused on urban development and infrastructure, proposals related to digital infrastructure and computing for sustainable development could be relevant.
Rural Health Transformation Program (RHTP) - North Carolina Rural Health Innovation Fund is sponsored by U.S. Department of Health and Human Services (HHS) / North Carolina Department of Information Technology (NCDIT). This fund supports North Carolina's rural health providers in modernizing their infrastructure. Eligible projects include expanding telehealth, upgrading electronic health records, strengthening cybersecurity protections for health information, and adopting technology for informed care decisions. It aims to help rural providers leverage innovative technologies for better care.
Trapped-Ion Platform Technologies is sponsored by European Commission — Horizon Europe. Expected Outcome: This action will advance Europe’s leadership in trapped-ion quantum computing by achieving the following key outcomes: Establishment of a full-stack ion-trap quantum computer aiming at more than 1.000 qubits, fully integrated into high-performance computing (HPC) systems, and accessible via the cloud. Demonstration of quantum advantage for selected real-world applications, validated against benchmarks. Strengthened European capabilities to develop modular, interoperable, and scalable quantum computing architectures. Implementation and demonstration of advanced error correction and fault-tolerant quantum computing techniques. Integration of full-stack hardware-software systems with standardised and certified interfaces. Engagement with industry and academia through open access to quantum computing resources and co-design of applications. Scope: The action should support the scale-up of European trapped-ion quantum computing platforms, aiming at technological maturity and usability for industrial and scientific applications. In particular, the action must address at least two major technical roadblocks defined in the Strategic Research and Industry Agenda (SRIA 2030) for trapped-ion quantum computing. These include the limited scalability of ion trap architectures, particularly the need for modular designs and inter-chain coupling, and the integration of photonic components for laser delivery, enabling compact and fault-tolerant systems. The proposal is expected to demonstrate system-level innovation and practical application addressing these and other equally critical challenges. The proposal should also: Develop a full-stack trapped-ion quantum computer with more than 1000 physical qubits, including: Initialisation, manipulation, and readout fully integrated into the cryogenic setup. Reduced system footprint via standardised interfaces and integrated waveguides. Advance scalable error correction and fault-tolerant computing: Develop and benchmark error correction codes suitable for trapped-ion architectures. Demonstrate error mitigation in noisy environments and real-life quantum information tasks. Enable real-life application testing: Select and implement at least two practical use cases (aligned with industrial or scientific challenges). Demonstrate computational advantage over classical simulations where possible or show progress towards it. Develop standards and modular interoperability: Establish interface specifications for both hardware and software layers, enabling integration across vendors and platforms. Align with European efforts on standardisation, benchmarking, and certification. Integrate with classical computing infrastructures: Ensure seamless operation alongside HPC resources, with remote access and hybrid quantum-classical workflows. Provide access and foster ecosystem participation: Support researchers and industry (including SMEs) with open, cloud-based access, comprehensive user documentation, and training resources. Contribute to a sustainable European supply chain: Address key technological components such as lasers, ion traps, control electronics, and packaging solutions, aiming for independent and robust sourcing Technology Readiness Level - Technology readiness level expected from completed projects The rules are described in General Annex B of the Horizon Europe Work Programme 2026-2027. Activities are expected to start at TRL 4 and to achieve TRL 7 by the end of the project Programme areas: Digital, Industry and Space, Global Challenges and European Industrial Competitiveness, Horizon Europe (HORIZON)
On October 28, 2026, NSF sent its revised Guidance on Financial Assistance to OMB after 3,277 public responses. The revision drops four provisions borrowed from OMB's unfinished 2 CFR 200 rewrite: no fixed-price awards, no publication costs, termination for convenience, and indirect costs subject to available funds. The final 30-day comment period runs through about November 27. Here is what changed, what didn't, and what research offices should do before the December 11 funding cliff.
Read articleNSF 26-022, the July 8, 2026 Dear Colleague Letter last updated October 27, says NSF will prohibit its funds from supporting research collaborations with entities on U.S. restricted-party lists in FY2027, on the same timeline as the Guidance on Financial Assistance. Authorized organizational representatives and senior/key personnel will certify compliance at proposal submission. Here is what is covered, what is still undefined, and a 60-day plan for research offices and PIs.
Read articleThe FY2027 Defense University Research Instrumentation Program closes November 6, 2026 at 5:00 PM ET with roughly $28 million, awards from $50,000 to $3 million, and no cost-share requirement. It is down about $6 million from FY2026, it funds equipment and nothing else, and it lands ten days before the NSF MRI deadline. Here is how to split an equipment wishlist across two overlapping windows.
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