Interdisciplinary Aging-Relevant Research in the Social, Affective, and Economic Neurosciences (PAR-11-336)

Interdisciplinary Aging-Relevant Research in the Social, Affective, and Economic Neurosciences (PAR-11-336) is sponsored by National Institute on Aging (NIA). This Funding Opportunity Announcement (FOA) from NIA stimulates interdisciplinary aging-relevant research in the social, affective, and economic neurosciences.

Expired PAR-11-336: Social Neuroscience and Neuroeconomics of Aging (R21) This notice has expired. Check the NIH Guide for active opportunities and notices. of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) of Participating Organizations National Institute on Aging ( NIA ) Funding Opportunity Title Social Neuroscience and Neuroeconomics of R21 Exploratory/Developmental Research Grant Award May 30, 2013 ( NOT-OD-13-074 ) - NIH to Require Use of Updated Electronic Application Forms for Due Dates on or after September 25, 2013.

Forms-C applications are required for due dates on or after September 25, 2013. Funding Opportunity Announcement (FOA) Number PAR-11-337 , R01 Research Project Grant Additional Information on Eligibility .

Catalog of Federal Domestic Assistance (CFDA) Number(s) The National Institute on Aging (NIA) issues this Funding Opportunity Announcement (FOA) with special review to stimulate interdisciplinary aging-relevant research in the social, affective and economic neurosciences.

The NIA invites applications examining social, emotional and economic behaviors of relevance to aging, using approaches that examine mechanisms and processes at both (a) the social, behavioral or psychological (emotional, cognitive, motivational) level, and (b) the neurobiological or genetic level.

Applications are encouraged that have an overriding emphasis on economic, social or emotional processes and associated genetic or neurobiological processes. Applications should demonstrate either relevance for aging or for age differences or age-related changes in these processes.

Aging-relevant applications can address issues of importance to the well-being and health of either mid-life or older adults, and can include data spanning the entire life course.

Open Date (Earliest Submission Date) Letter of Intent Due Date 16, 2012, February 16, 2013, and February 16, 2014 for new applications; March 16, 2012, March 16, 2013 and March 16, 2014 for resubmission applications), by 5:00 PM local time of applicant organization. AIDS Application Due Date(s) May 7, 2012, May 7, 2013 and May 7, 2014 by 5:00 PM local time of applicant organization.

Required Application Instructions It is critical that applicants follow the instructions in 424 (R&R) Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Part 1. Overview Information Part 2. Full Text of the Announcement Section I.

Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Full Text of Announcement Section I. Funding Opportunity Description The National Institute on Aging (NIA) issues this Funding Opportunity Announcement (FOA) with special review to stimulate interdisciplinary aging-relevant research in the social, affective and economic neurosciences.

The NIA invites applications examining social, emotional and economic behaviors of relevance to aging, using approaches that examine mechanisms and processes at both (a) the social, behavioral or psychological (emotional, cognitive, motivational) level, and (b) the neurobiological or genetic level.

Applications are encouraged that have an overriding emphasis on economic, social or emotional processes and associated genetic or neurobiological processes. Applications should demonstrate either relevance for aging or for age differences or age-related changes in these processes.

Aging-relevant applications can address issues of importance to the well-being and health of either mid-life or older adults, and can include data spanning Changes in emotional, cognitive, and physical capacities as people age, in combination with life course changes in motivation and goals, affect economic, social and emotional behaviors in ways that are only beginning to be understood.

Only recently have these issues been explored using approaches that integrate methods from the behavioral, social, genetic and neural sciences. Neuroeconomic and social neuroscience approaches to these topics offer the opportunity for understanding how the neurobiological and genetic processes associated with aging influence or are influenced by life course changes in social, emotional, cognitive, and motivational factors.

Neuroeconomics integrates approaches from psychology, economics, and neuroscience to understand the foundations of economic behavior. Neuroeconomics of aging addresses how age differences or age-related changes in behavioral, psychological and neural processes and mechanisms influence social, financial, and health-related choices affecting the well-being of mid-life and older adults.

Knowledge of such changes can inform the development and refinement of integrative lifespan economic theories of utility, learning, and strategic choice.

Advances in this area have the potential to provide the foundation for development of interventions to promote adaptive decision making Social neuroscience directly addresses relations among genetic factors, neurobiological systems, and aspects of socioemotional behavior and social processes.

Social neuroscience of aging examines the mechanisms and pathways linking socioemotional behaviors and social relationships to the physical health, functionality, and psychological well-being of middle-aged and older adults.

The NIA is interested in research that examines the neurobiological and/or genetic foundations and correlates of socioemotional behaviors and social relationships of particular relevance to middle-aged and older adults.

Life course or life-span developmental research that explores neurobiological and genetic mechanisms or pathways by which socioemotional behaviors and social relationships affect important aging outcomes is strongly The NIA also encourages research projects that propose advances in measurement of economic and social phenotypes.

Research is needed to identify core psychological and behavioral constructs and intermediary neurobiological phenotypes responsible for individual differences in economic and socioemotional behaviors, to enhance the potential for their application to life course genetic studies.

There is an increasing need for measures that are harmonizable (to enable data pooling and cross-study comparisons) and flexible (capable of application across laboratory and field contexts).

Applicants are encouraged to refer to summary reports from the following NIA Exploratory Workshops: Neuroeconomics of Aging Workshop (2006); Decision Making and Aging Work Group (2006); Social Neuroscience of Aging (2007); NIA Workshop on Refining Economic Phenotypes (2007); Using GWAS to Explore Fundamental Questions about Aging in the HRS Sample (2010); NIA Workshop on Economic Phenotypes (2010), located at: http://www. nia. nih.

gov/ResearchInformation/ExtramuralPrograms/BehavioralAndSocialResearch/ConferencesAndWorkshops. htm .

Research Scope for the FOA This FOA encourages research projects that (1) link the social, affective or economic neuroscience laboratory with population-based research, (2) cross traditional disciplinary barriers within the biological and behavioral sciences, or (3) offer bridges to translational efforts to improve economic behavior, socioemotional function, and enhance social roles in older adults.

This FOA is open to applications involving humans and animal models, and to applications examining social and economic behavior in both normal individuals and those with age-related neurodegenerative disorders. Applicants to this FOA need not have an established history of research on aging.

Use of the R21 mechanism is intended to encourage innovative research likely to lay the foundations for future research applications in social neuroscience or neuroeconomics of aging. [See Related R01 Announcement: PAR-11-337 ]. This FOA is intended to stimulate research on a broad range of topics in the social, affective and economic neurosciences of aging.

Examples of specific research needs include but are not limited to those listed Basic and translational research in social, affective and economic neurosciences of aging Research combining behavioral and neuroscience approaches to study age differences or age-related changes in economic behaviors including: reward sensitivity and in the function of neural systems for reward processing; inter-temporal choice and self-control; risk preferences and risk behaviors; and the susceptibility to gain-versus-loss framing effects.

Research combining behavioral and neuroscience approaches to study age differences or age-related changes in social influences on economic and moral behavior, including: altruism, cooperation, competition, and generativity; susceptibility to fraud or to specific marketing strategies; and sensitivity to the influence of advisors, family members, or authority figures Research on the influence of social, cultural, institutional, and situational contexts on economic and social behaviors of relevance to aging, and the application of neuroscience or genetic approaches to examine individual differences (including age differences) in susceptibility to context effects.

Research designed to identify core behavioral, psychological, and intermediate biological phenotypes linked to neurobiological processes that account for individual differences in social, emotional and economic behaviors of relevance to the health and well-being of middle-aged or older adults.

Research on the neurobiological and genetic mechanisms underlying the relation between social connectedness or loneliness and middle- and older age health and well-being.

Research examining the impact of age-related cognitive decline on the mental representation of financial risks and rewards and associated probabilities and expected utilities and the neurobiological correlates of Research on age differences or age-related changes in the reliance on affective vs. deliberative information processing in economic choice and social behavior, and the behavioral consequences and neurobiological correlates of these differences.

Research using humans or animal models to identify post-natal social processes and contexts that affect trajectories of later aging social processes, specifically those that directly impact developmental processes in neurobiological systems for social behaviors.

Research exploring gene-environment correlations and interactions, including studies of the effects of aging on the selection of social environments and how this impacts functional aging, and studies that elucidate how social behaviors at different life stages influence gene Research on how neural systems affected by neurodegenerative diseases of aging impact social, emotional and economic behaviors and Research on age-related changes and age differences in cellular and molecular mechanisms in neural systems that may impact social and economic behaviors and their consequences for social and emotional function and economic Research on the neural mechanisms underlying the effects of age-related sensory and/or motor changes on social, emotional and economic Methodological needs for advancing social, affective and economic neuroscience research on aging: Development of innovative methods for measuring core components (phenotypes) of social and economic behaviors of relevance to middle aged and older adults that can be translated across laboratory, field, and neuroimaging environments and enhance potential for application to genetic studies.

Longitudinal research in midlife or older age examining social and economic behaviors and their relation to neurobiological measures. Assessments of the reliability of neurobiological measures of social and economic behaviors over the short and long term. evolution and vitality of the biomedical sciences require a constant infusion of new ideas, techniques, and points of view.

These may differ substantially from current thinking or practice and may not yet be supported by substantial preliminary data.

By using the R21 mechanism, the NIH seeks to foster the introduction of novel scientific ideas, model systems, tools, agents, targets, and technologies that have the potential to substantially advance biomedical Application Types Allowed Glossary and the SF 424 (R&R) Application Guide provide details on Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations, and the submission of a sufficient number of meritorious Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year.

The scope of the proposed project should determine the project period. The total project period for an application submitted in response to this funding opportunity may not exceed 2 years. described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Nonprofits without 501(c)(3) IRS Status (Other than Institutions For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are eligible to Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Applicant organizations must complete the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award.

Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following Contractor Registration (CCR) must maintain an active registration, to be renewed at least annually All Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant organization.

All registrations must be completed by the application due date. Applicant organizations are strongly encouraged to start the registration process at least four (4) weeks prior to the application due date.

Eligible Individuals (Program Director(s)/Principal Investigator(s)) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director(s)/Principal Investigator(s) Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF 424 (R&R) This FOA does not require cost sharing as defined in the NIH Grants 3.

Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application. NIH will not accept any application that is essentially the same as one already reviewed.

Resubmission applications may be submitted, according to the NIH Policy on Resubmission Applications from the SF 424 (R&R) Application Guide. Section IV. Application and Submission Information Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the Apply for Grant Electronically button in this FOA or following the directions provided at Grants.

gov . 2. Content and Form of Application Submission It is critical that applicants follow the instructions in (R&R) Application Guide , except where instructed in this funding opportunity announcement to do otherwise.

Conformance to the requirements in the Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for For information on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electronic Submission of Grant Required and Optional Components The forms package associated with this FOA includes all applicable components, mandatory and optional.

Please note that some components marked optional in the application package are required for submission of applications for this FOA. Follow all instructions in the SF424 (R&R) Application Guide to ensure you complete all appropriate optional All page limitations described in the SF424 Application Page Limits must be followed.

PHS 398 Research Plan Component All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions: Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies; GWAS) as provided in the SF424 Do not use the appendix to circumvent page limits.

Follow all instructions for the Appendix as described in the SF424 (R&R) Foreign (non-US) institutions must follow policies described Grants Policy Statement , and procedures for foreign institutions described throughout the SF424 (R&R) Application Guide. Part I. Overview Information contains information about Key Dates.

Applicants are encouraged to submit in advance of the deadline to ensure they have time to make any application corrections that might be necessary for successful submission. Organizations must submit applications via Grants. gov , the online portal to find and apply for grants across all Federal agencies.

Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIH’s electronic system for grants are responsible for viewing their application in the eRA Commons to ensure accurate and successful submission. Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide. 4.

Intergovernmental Review This initiative is not subject to intergovernmental All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Pre-award costs are allowable only as described in the NIH Grants Requirements and Information Applications must be submitted electronically following the instructions described in the SF 424 (R&R) Application Guide.

Paper applications will not be accepted. Applicants must complete all required registrations before the application due date. Section III.

Eligibility Information contains information about registration. For assistance with your electronic application or for more information on the electronic submission All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF 424(R&R) Application Package .

Failure to register in the Commons and to include a valid PD(s)/PI(s) Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization’s profile in the eRA Commons and for the Central Contractor Registration (CCR).

Additional information may be found in the SF424 (R&R) Application Guide. tips for avoiding common errors. Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review, NIH.

Applications that are incomplete will not be reviewed. Post Submission Materials Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115 . Section V.

Application Review Information Only the review criteria described below will be considered in the review process.

As part of the NIH mission , all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer For this particular announcement, note the following: The R21 exploratory/developmental grant supports investigation of novel scientific ideas or new model systems, tools, or technologies that have the potential for significant impact on biomedical or biobehavioral research.

An R21 grant application need not have extensive background material or preliminary information. Accordingly, reviewers will focus their evaluation on the conceptual framework, the level of innovation, and the potential to significantly advance our knowledge or understanding.

Appropriate justification for the proposed work can be provided through literature citations, data from other sources, or, when available, from investigator-generated data. Preliminary data are not required for R21 applications; however, they may be included if available.

Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?

Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)?

If the project is collaborative or multi-PD(s)/PI(s), do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project? Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions?

Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed? Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project?

Are potential problems, alternative strategies, and benchmarks for success presented?

If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?

Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed?

Will the project benefit from unique features of the scientific environment, subject populations, or collaborative Additional Review Criteria As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact/priority score, but will not give separate scores for these items.

Protections for Human Subjects For research that involves human subjects but does not involve one of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.

For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to Subjects Protection and Inclusion Guidelines .

Inclusion of Women, Minorities, and When the proposed project involves clinical research, the committee will evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children. For additional information on review of the Inclusion section, please refer to the Human Subjects Protection and Inclusion Guidelines .

The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia.

For additional information on review of the Vertebrate Animals section, please for Review of the Vertebrate Animal Section . Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.

For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project. For Revisions, the committee will consider the appropriateness of the proposed expansion of the scope of the project.

If the Revision application relates to a specific line of investigation presented in the original application that was not recommended for approval by the committee, then the committee will consider whether the responses to comments from the previous scientific review group are adequate and whether substantial changes are clearly evident.

Additional Review Considerations As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact/priority score.

Applications from Foreign Reviewers will assess whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions that exist in other countries and either are not readily available in the United States or augment existing U.S. resources.

Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).

Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan ; 2) Sharing Model Organisms ; and 3) Genome Wide Association Studies (GWAS) .

Budget and Period of Support Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by the Center for Scientific Review, in accordance with NIH peer review policy and procedures , using the stated review criteria .

Review assignments will be shown in the eRA Commons. As part of the scientific peer review, all applications: May undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review), will be discussed and assigned an overall impact/priority Will receive a written critique.

Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board.

The following will be considered in making funding decisions: Scientific and technical merit of the proposed project as determined by scientific peer review. Relevance of the proposed project to program priorities. 3.

Anticipated Announcement After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) Information regarding the disposition of applications is available in the NIH Grants Administration Information If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described Grants Policy Statement .

A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee’s business official. Awardees must comply with any funding restrictions described in Section IV.

5. Funding Restrictions . Selection of an application for award is not an authorization to begin performance.

Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs. Any application awarded in response to this FOA will be subject to the DUNS, CCR Registration, and Transparency Act requirements as noted on the Award Conditions and Information for NIH Grants website.

National Policy Requirements All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities .

More information is Conditions and Information for NIH Grants .

Cooperative Agreement Terms and Conditions of Award When multiple years are involved, awardees will be required to submit the Non-Competing Continuation Grant Progress Report (PHS 2590) annually and financial statements as required in the NIH Grants A final progress report, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later.

All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www. fsrs. gov on all subawards over $25,000.

See the NIH Grants additional information on this reporting requirement. Section VII. Agency Contacts We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

Application Submission Contacts Customer Support (Questions regarding Grants.

gov registration and submission, downloading or navigating forms) GrantsInfo (Questions regarding application instructions and process, finding NIH grant resources) eRA Commons Help Desk(Questions regarding eRA Commons registration, tracking application status, post submission issues) Phone: 301-402-7469 or 866-504-9552 (Toll Free) Scientific/Research Contact(s) National Institute on Aging Telephone: (301) 402-4156 Examine your ERA Commons account for review assignment and contact information (information appears two weeks after submission