Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed)

Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed) is sponsored by National Center for Advancing Translational Sciences (NCATS), NIH.

This grant program supports institutional research training grants to create, provide, and disseminate clinical and translational science training and career support programs for individuals seeking a PhD or an equivalent research health professional degree.

PAR-25-194: Limited Competition: Ruth L. Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed) This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

Department of Health and Human Services Part 1. Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Center for Advancing Translational Sciences ( NCATS ) Funding Opportunity Title Limited Competition: Ruth L.

Kirschstein National Research Service Award (NRSA) Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program (T32 Clinical Trial Not Allowed) T32 Institutional National Research Service Award (NRSA) Notices of Special Interest associated with this funding opportunity March 31, 2025 - This funding opportunity was updated to align with agency priorities.

Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 .

Funding Opportunity Number (FON) Companion Funding Opportunity Only one application per UM1 applicant institution is allowed, as defined in Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) Funding Opportunity Purpose The National Center for Advancing Translational Sciences (NCATS) will award Ruth L.

Kirschstein National Research Service Award (NRSA) Predoctoral Institutional Research Training Grants for the Clinical and Translational Science Awards (CTSA) Program (T32) to eligible institutions to create, provide, and disseminate clinical and translational science training and career support programs for individuals seeking a PhD or an equivalent research health professional degree and help ensure a pool of clinical and translational scientist trainees who are equipped with the knowledge, skills and abilities (KSAs) to advance diagnostics, therapeutics, clinical interventions, and behavioral modifications aimed at improving health and support meaningful translational science research projects that address demonstrable needs among stakeholder communities.

NCATS will not accept applications proposing combined predoctoral and postdoctoral training under this Notice of Funding Opportunity (NOFO). Applications proposing postdoctoral research training should apply to the Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Institutional Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program ( PAR-25-195 ).

Applicants interested in providing short-term research experiences should apply to the companion NCATS Clinical and Translational Science Award (CTSA) Program Research Education Grants Programs (R25) ( PAR-25-197 ) . A short-term research experience is one where the participant is full-time (40 hours per week) for a period of 10 to 15 weeks, or as specified by the sponsoring institution in accordance with its own policies.

The proposed institutional research training program may complement other ongoing research training and career development programs at the applicant institution, but must be clearly distinct from related programs currently receiving Federal support.

This NOFO does not allow appointed Trainees to lead an independent clinical trial, but does allow them to obtain research experience in a clinical trial on which the PI is a mentor or co-mentor. NIH strongly supports training towards a career in clinically relevant research and so gaining experience in clinical trials under the guidance of a mentor or co-mentor is encouraged.

This limited competition NOFO is part of a required set of companion applications: the Clinical and Translational Science Award (UM1) and companion Institutional Career Development Award (K12). The remaining NOFOs in the suite are optional and include the Ruth L.

Kirschstein National Research Service Award (NRSA) institutional training programs (T32 predoctoral and T32 postdoctoral), the Research Education Grant (R25), and the Specialized Innovation Program (RC2). These optional NOFOs are only available to CTSA Program UM1 applicants and award recipients. Applications to the companion NOFOs cannot be awarded until an award has been issued for the UM1.

(See Section III. Eligibility Information of this NOFO and the respective NOFOs for more information). Funding Opportunity Goal(s) The mission of the National Center for Advancing Translational Sciences (NCATS) is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

Open Date (Earliest Submission Date) Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the Training (T) Instructions in the How to Apply Application Guide, except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply Application Guide, and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply Application Guide, as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply Application Guide, , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Workspace to prepare and submit your application and eRA Commons to track your application. Part 1.

Overview Information Part 2. Full Text of Announcement Section I. Funding Opportunity Description Section II.

Award Information Other Award Budget Information Section III. Eligibility Information Section IV. Application and Submission Information Section V.

Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII.

Other Information Part 2. Full Text of Announcement Section I. Funding Opportunity Description The overall purpose of the NIH Ruth L.

Kirschstein National Research Service Award (NRSA) program is to help ensure that a pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs. In order to accomplish this goal, NRSA training programs are designed to train individuals to conduct research and to prepare for research careers.

More information about NRSA programs may be found at the Ruth L. Kirschstein National Research Service Award (NRSA) website. Purpose and Background Information The NRSA program has been the primary means of supporting predoctoral and postdoctoral research training programs since enactment of the NRSA legislation in 1974.

Research training activities can be in basic biomedical or clinical sciences, in behavioral or social sciences, in health services research, or in any other discipline relevant to the NIH mission.

Institutional NRSA programs allow the Training Program Director/Principal Investigator (Training PD/PI) to select the trainees and develop a program of coursework, research experiences, and technical and/or professional skills development appropriate for the selected trainees. Each program should provide high-quality research training and offer opportunities in addition to conducting mentored research.

Trainees should develop the ability to work effectively in teams with colleagues from a variety of backgrounds, and to promote safe and supportive scientific research environments. The grant offsets the cost of stipends, tuition and fees, and training related expenses, including health insurance, for the appointed trainees in accordance with agency-approved support levels.

This Notice of Funding Opportunity (NOFO) provides an opportunity for the Hub to create, provide, and disseminate clinical and translational science training and career support programs for translational scientists and to support meaningful translational science research projects that address demonstrable needs among stakeholder communities. The goal of the Ruth L.

Kirschstein National Research Service Award (NRSA) Institutional Predoctoral Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program is to equip trainees with the knowledge, skills and abilities (KSAs) to advance diagnostics, therapeutics, clinical interventions, and behavioral modifications that improve health.

The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH), is transforming the translational science process so that new treatments and cures for disease can be delivered to patients faster.

NCATS strives to develop innovations to reduce, remove or bypass costly and time-consuming bottlenecks in the translational research pipeline in an effort to speed the delivery of new drugs, diagnostics and medical devices to patients. Translation, translational research, and translational science are related but different.

Translation turns observations in the laboratory, clinic, and community into diagnostics, therapeutics, medical procedures, and behavioral changes that improve people’s health. Translational research moves a project to the next step in the translational process. Translational science enables these projects to reach their goals faster and more efficiently.

At NCATS, we define translational science as the field that generates scientific and operational innovations that overcome the long-standing barriers along the translational research pipeline. With its focus on improving the process, translational science ultimately leads to more treatments for all people more quickly. The NCATS Translational Science Principles characterize effective approaches for advancing translational progress.

These principles are described on the NCATS website ( https://ncats. nih. gov/about/about-translational-science/principles ).

These principles are intentionally broad and apply to research anywhere along the translational continuum. While they exemplify translational science approaches, they are not intended to be comprehensive.

The NCATS Clinical and Translational Science Awards (CTSA) Program is designed to develop innovative solutions that will improve the efficiency, quality and impact of the process for turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public.

Sustaining a vibrant clinical and translational research enterprise requires a 21st century workforce that can advance clinical and translational science (CTS) that will, in turn, increase the efficiency and efficacy of translation, with the ultimate goal of getting more treatments to more patients more quickly.

Clinical and translational scientists will possess both deep scientific domain expertise and systems understanding, and their research is expected to be designed to produce discoveries that are simultaneously important for their discipline(s) and contribute to other disciplines, thus intentionally advancing the translational process as a whole.

These characteristics will be required to successfully prepare trainees to transition into the many and varied productive career paths available to clinical and translational scientists within the translational science spectrum.

Proposed training programs are expected to help trainees develop the following characteristics independent of their particular area(s) of expertise: Domain Expert : Possesses deep disciplinary knowledge and expertise within one or more of the domains of the translational science spectrum ranging from basic to clinical to public health research and domains in between.

Boundary Crosser : Breaks down disciplinary silos and collaborates with others across research areas and professions to collectively advance the development of a medical intervention. Team Player: Practices a team science approach by leveraging the strengths and expertise and valuing the contributions of all players on the translational science team.

Has the ability to work effectively with colleagues from a variety of backgrounds, and to promote safe and supportive scientific research and training environments. Process Innovator : Seeks to better understand the scientific and operational principles underlying the translational process and innovates to overcome bottlenecks and accelerate that process.

Skilled Communicator : Communicates clearly with all stakeholders in the translational process across social, economic, and scientific backgrounds, including patients and community members.

Systems Thinker : Evaluates the complex external forces, interactions, and relationships impacting the development of medical interventions, including patient needs and preferences, regulatory requirements, current standards of care, and market and business demands.

Rigorous Researcher : Conducts research at the highest levels of rigor and transparency within their field of expertise, possesses strong statistical analysis skills, and designs research projects to maximize reproducibility. Applicants are expected to identify training needs and objectives (i.e., specific and measurable outcomes the program intends to achieve).

Applicants are expected to develop plans to implement evidence-informed training and mentoring activities (i.e., approaches that are grounded in the literature and from evaluations of existing relevant training programs). The plans are to describe how the participating faculty and preceptors are trained to use evidence-informed mentoring practices that promote the development of trainees.

The evidence-informed plans are to consider mentor training assessments that move beyond the faculty’s/preceptor’s participation satisfaction to self-reporting of perceived skills gained, self-reported changes in mentoring behaviors or self-reporting of effectiveness.

The plan is expected to include a built-in planned strategy to assess and monitor how well the faculty mentor/preceptor promotes a safe, and supportive research training environment. To the extent possible, the development plan is to include information on how trainees in mentoring dyads/teams are to corroborate mentor’s self-report of changes in mentoring behaviors.

Funded programs are expected to implement the following: Core Knowledge Expectations in Clinical and Translational Science Research : Ensure that by the end of the training period, trainees will have achieved sufficient breadth in clinical and translational science research areas to facilitate work that advances research along the translational continuum.

These research areas include preclinical research, clinical research, implementation science, and population science/public health research.

Trainees are expected to acquire knowledge in broad areas of research including, but not limited to: clinical research, regulatory science, biostatistics, epidemiology, telehealth and telemedicine, dissemination and implementation science research, bioinformatics, community engagement and training in translational team science, responsible conduct of research and rigorous research design, entrepreneurship, scientific communication, and leadership.

It is expected that customized curricula will be personalized for trainees to achieve domain-specific KSAs depending on the trainee’s desired career role or focused area of research.

Clinical and Translational Science Research is a Cross-Disciplinary Team-Based Endeavor : Ensure that trainees have mastered core competencies in their own discipline, while gaining knowledge of other disciplines and knowledge of the operational principles underlying at least two sectors of the translational science ecosystem.

These competencies and knowledge will confer the trainee’s ability and capacity to effectively communicate, collaborate, and break down barriers across multidisciplinary teams and the translational process. Clinical and translational science research is a team-based endeavor that requires input from many different disciplines, sectors, and points of view to be successful.

Programs should support partnerships that give trainees experience outside of their particular discipline, both within the academic domain and with stakeholders and sectors outside it, such as patients, non-profit organizations, regulatory agencies, and industry.

Building on Institutional Strengths in Clinical and Translational Science Research: Each NRSA (T32) Training program is to be innovative in its research training and career development program efforts so to impart to trainees the KSAs required for high quality clinical and translational science research.

To achieve this, programs are encouraged to build on the local strengths and demonstrated translational innovations of their companion CTSA Program hub (i.e., telehealth and telemedicine, rural health, community engagement, bioinformatics, dissemination and implementation, entrepreneurship, drug discovery, etc.) to effectively curate and foster the clinical and translational science researcher.

In this spirit, programs should identify training strengths, needs and objectives (i.e., specific and measurable outcomes the program intends to achieve) that will lead to the creation of a community of clinical and translational science research trainees that extends beyond the training program and across multiple schools (i.e., nursing, dental, engineering) and departments at the institution.

Building on institutional strengths can include approaches on how to expose trainees to a larger cadre of mentors with broad clinical expertise, experiences, resources, and backgrounds relevant to clinical and translational science and who can help the trainee transition to the next career phase.

Understanding Career Opportunities : The career outcomes of individuals supported by the NRSA Predoctoral Institutional Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program include both research-intensive careers in academia and industry and research-related careers in various sectors including academia, government, industry, and nonprofit.

Training programs should make available structured, career development advising and learning opportunities (e.g., workshops, discussions, grant-writing, Individual Development Plans).

Opportunities for trainees to gain direct experience with parts of the translational ecosystem outside academia are also important, such as research externships in industry, regulatory agencies, nonprofit patient-advocacy groups, or with other CTSA Program hubs and/or training programs with strengths different from their home hub.

Through such opportunities, trainees are expected to obtain a working knowledge of various potential career paths that would make strong use of the clinical and translational science knowledge and skills gained during research training and the steps required to transition successfully to the next stage of their chosen career.

Leadership and Management: In addition to the above referenced Fundamental Characteristics of a Translational Scientist, leadership is another essential characteristic of clinical and translational science scientists.

Leadership and management training should be infused into the research-focused career development program activities of the institutional research training (T32) program in Clinical and Translational Science Awards (CTSA) Program so that trainees can develop professional and leadership skills (e.g., emotional intelligence, eliminating barriers to participation including imposter phenomenon, conflict resolution, job offer negotiation, laboratory management, balancing competing priorities) to be effective leaders in clinical and translational science This NOFO does not allow appointed Trainees to lead an independent clinical trial,but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

NIH strongly supports training towards a career in clinically relevant research and so gaining experience in clinical trials under the guidance of a mentor or co-mentor is encouraged. Applications that do not contain all of the required attachments within the (R&R) Other Project Information form, Other Attachments section will be deemed incomplete and will not be reviewed.

Applications Not Responsive to this NOFO The following types of applications will be deemed nonresponsive and will not be reviewed: Applications that lack the required UM1 companion application PAR-21-293 or PAR-24-272 (Clinical and Translational Science Award). Applications proposing combined predoctoral and postdoctoral training under this NOFO.

Applications that propose short-term research experiences ( experiences in which the participant is full-time (40 hours per week) for a period of 10 to 15 weeks, or as specified by the sponsoring institution in accordance with its own policies ) . Applications proposing postdoctoral research training must apply to the Ruth L.

Kirschstein National Research Service Award (NRSA) Postdoctoral Institutional Research Training Grant for the Clinical and Translational Science Awards (CTSA) Program ( PAR-25-195 ).

However, team-based training models that include partnerships with postdoctoral trainees are allowed with the following caveats: 1) the T32 predoctoral application includes stipend and other budget support for predoctoral trainees only; and 2) all aspects of the training program, such as mentors, evaluation, descriptions of candidate pools, training program plan, and information collected and presented in data tables provide details specific for predoctoral trainees only.

Application information, including Frequently Asked Questions and Technical Assistance Webinars, are found on https://ncats. nih. gov/research/research-activities/ctsa/applicant-information.

See Section VIII. Other Information for award authorities and regulations. Section II.

Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed Resubmission - Resubmission Applications for PAR-21-337 and this NOFO The OER Glossary and the How to Apply Application Guide, provide details on these application types. Only those application types listed here are allowed for this NOFO.

Not Allowed: Only accepting applications that do not propose clinical trials. Note: Appointed Trainees are permitted to obtain research experience in a clinical trial led by a mentor or co-mentor. Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are not limited, but need to reflect the actual needs of the proposed project.

Application budgets are to reflect no more than 4 trainee slots for Hub Tier G; 6 trainee slots for Hub Tier T; 8 trainee slots for Hub Tier C; and 10 trainee slots for Hub Tier A per budget period. NCATS will not award more than these noted slots to a NRSA T32 predoctoral program under this NOFO. Hub tiers must be ascertained in order to determine the maximum budget that can be requested for the UM1 companion application.

Please see Clinical and Translational Science Award (UM1 Clinical Trial Optional) ( PAR-21-293 and PAR-24-272 ). Budget tier requests (A, C, G, or T) of the optional T32 application submitted must be the same budget tier of the respective UM1. Funding tiers for any new or resubmitted T32 application submitted within the UM1 7-year award project period will be tied to the awarded UM1 tier size (A, C, T or G).

For example, if the UM1 was funded at a Tier G level then a new or resubmitted T32 predoctoral application from the UM1 prime applicant institution must request an application budget that aligns with the Tier G level (4 predoctoral trainee slots). Please note that slots awarded under this program cannot be increased through cost sharing.

Voluntary committed cost share should not be used as a means for increasing the number of trainee slots beyond the expected Tier slot number caps. Application budgets should request NCATS funding support for all trainee slots requested using applicable NRSA funding levels.

Recipients are expected to be familiar with and comply with applicable cost policies and the NRSA Guidelines ( NIH Grants Policy Statement - Institutional Research Training Grants ).

Funds may be used only for those expenses that are directly related to and necessary for the research training and must be expended in conformance with OMB Cost Principles, the NIH Grants Policy Statement , and the NRSA regulations, policies, guidelines, and conditions set forth in this document. The project period duration may be up to 5 years. Other Award Budget Information Stipends, Tuition, and Fees Ruth L.

Kirschstein-NRSA awards provide stipends as a subsistence allowance to help defray living expenses during the research training experience. NIH will contribute to the combined cost of tuition and fees at the rate in place at the time of award. Stipend levels, as well as funding amounts for tuition and fees and the institutional allowance are announced annually in the NIH Guide for Grants and Contracts, and are also posted on the Ruth L.

Kirschstein National Research Service Award (NRSA) webpage . Travel for trainees to attend scientific meetings and workshops that the institution determines to be necessary for the individual’s research training experience is an allowable expense for predoctoral trainees. Trainees must be appointed to the training grant at the time of the actual travel for this to be an allowable cost.

NCATS will provide up to $1,500 per trainee to travel to scientific meetings. Trainee travel to attend scientific meetings and workshops that the institution determines to be necessary for the individual’s research training experience is an allowable trainee expense for predoctoral trainees. Trainees must be appointed to the training grant at the time of the actual travel for this to be an allowable cost.

Training Related Expenses NIH will provide funds to help defray other research training expenses, such as health insurance, staff salaries, consultant costs, mentor training activities, equipment, research supplies, and faculty/staff travel directly related to the research training program.

The most recent levels of training related expenses are announced annually in the NIH Guide for Grants and Contracts, and are also posted on the Ruth L. Kirschstein National Research Service Award (NRSA) webpage .

Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs (exclusive of tuition and fees, consortium costs in excess of $25,000, and expenditures for equipment), rather than on the basis of a negotiated rate agreement. NCATS does not permit automatic carryover from one budget period to the next.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO. Section III. Eligibility Information All Clinical and Translational Science Award (UM1 Clinical Trial Optional) (PAR-21-293, PAR-24-272) applicant organizations and active award recipients for are eligible to apply under this NOFO.

Only the primary UM1 CTSA hub organization is eligible to apply. Partner/Partnering and/or Collaborator/Collaborating institutions are not eligible. Predoctoral T32 applications submitted in response to this NOFO are optional companion applications to the Clinical and Translational Science Award (UM1 Clinical Trial Optional) application.

Such T32 applications may be submitted in response to this NOFO under one of the following scenarios: concurrently with the UM1 while the UM1 application is under review consideration while the UM1 is under consideration for funding after the UM1 application is funded Predoctoral T32 applications will only be awarded if there is an awarded UM1 application from the applicant organization.

The sponsoring institution must assure support for the proposed program. Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program. Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide , to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted.

Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2. 3.

9. 2 Electronically Submitted Applications for additional information. System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually .

The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.

Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM. gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants. gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.

Grants. gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role.

Obtaining an eRA Commons account can take up to 2 weeks. Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research training program as the Training Program Director/Principal Investigator (Training PD/PI) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide .

The PD/PI should be an established investigator in the scientific area in which the application is targeted and capable of providing both administrative and scientific leadership to the development and implementation of the proposed program.

The PD/PI will be responsible for the selection and appointment of trainees to the approved research training program, and for the overall direction, management, administration, and evaluation of the program. The PD/PI will be expected to monitor and assess the program and submit all documents and reports as required.

The PD/PI has responsibility for the day to day administration of the program and is responsible for appointing members of the Advisory Committee (when applicable), using their recommendations to determine the appropriate allotment of funds. The UM1 PD(s)/PI(s) may not be a PD(s)/PI(s) on the T32 application or award in order to ensure the PD(s)/PI(s) have adequate time to devote to the respective programs.

This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1. 2 Definition of Terms . Voluntary committed cost share will not be accepted and will not be considered in the review score for the NRSA trainee stipends, travel, training related expenses, and/or tuition and fees.

Any applicant identifying voluntary committed cost share in the budget sections of the application will be bound to the cost share commitment for the entire approved project period. All costs included in the budget section of the application must be allowable costs per the NOFO. Unallowable costs will be removed prior to award.

Applicants should describe other institutional support available to enhance the training experience in the Facilities & Other Resources attachment and/or the Institutional Environment and Commitment to Training section of the application. 3. Additional Information on Eligibility Applicant organizations may NOT submit more than one application.

NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2. 3. 7.

4 Submission of Resubmission Application . This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous