Maine Technology Institute (MTI) Business Innovation Programs

Supply chain resilience CSA is sponsored by European Commission — Horizon Europe. Expected Outcome: The action should establish a supply chain data platform, as a digital twin of the semiconductor supply chain, which should: • Gather secure, anonymized data shared by companies, coming from both upstream and downstream industries. • Possibly make use of an existing digital reference14 of the semiconductor supply chain (based on semantic web technologies). • Be managed by a trusted intermediary and hosted on a trusted data sharing infrastructure (potentially leveraging secure Multi-Party Computation). • Provide access to each participating company (providing its data) to its own data and aggregate anonymised data. The action should support the data gathering from the companies involved. The action should support a global mapping of the semiconductor value chain, as regards to the capabilities and the products of each main company and its supply chain relationships. The action should also support conducting stress tests of the supply chain and develop risk analysis of the EU semiconductor supply chain. Finally, the action needs to support issuing early warnings and recommendations for proactive measures to the Commission and Member States to avoid any potential crisis activation according to Article 23 of the Chips Act. Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Digital, Industry and Space

Boosting biorefinery competitiveness through biotech is sponsored by European Commission — Horizon Europe. Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing, the EU Life Sciences Strategy, the updated EU Bioeconomy Strategy, the EU Biotechnology Act, the Clean Industrial Deal, the European Chemical Industry Action Plan and the upcoming EU Circular Economy Act. Projects results are expected to contribute to the following expected outcomes: Full industrial scale biorefinery and related value chain(s) for the sustainable production of bio-based products using biotech as a key enabling technology. Availability of bio-based products meeting market and technical performance requirements as relevant for their respective application areas. Improvement of sustainability, circularity and resource efficiency compared to relevant benchmark(s). Contribution to increasing the EU’s strategic autonomy, resilience and competitiveness. Scope: Biorefineries integrating biotechnologies, underpinned by sustainably sourced bio-based feedstock, have a huge potential to transform the EU manufacturing landscape, spurring socio-economic growth, fostering job creation and contributing to defossilisation of the EU economy. Europe is strong in life sciences including industrial biotechnology. However, research results often struggle to be deployed to the market; in most cases, scale-up needs de-risking and requires overcoming challenges in large-scale process and reactor design, cell productivity, efficient use of feedstock, operative condition stability, reactor sterility and efficient integration of downstream operations among others. Proposals under this topic should: Demonstrate (at TRL 8) a sustainable and robust biomanufacturing route to obtain bio-based product(s). The proposal should focus on processes in which biotechnology is the key enabling technology; the integration of (upstream and/or downstream) supporting unit operations based on technologies other than biotechnology is in scope. Products in scope include chemicals, intermediates, polymers, ingredients and enzymes. Food and feed ingredients as main application are out of scope. Optimisation of selected cells, enzymes and/or microorganisms is also in scope provided that the starting TRL is at least 6. Demonstrate (at TRL 8) the further conversion or use of the obtained biorefinery product(s) into at least one end-product driving the business case; validate it (TRL 6 and above) in relevant market applications. Additional end-product(s) with high prospective market potential can be targeted, reaching at least TRL 6. In addition to the specific requirements applicable for the type of action, as described in section 2.2.3.1 of the CBE JU Annual Work Programme 2026 [1] , proposals under this topic should: As part of the multi-actor approach (MAA), ensure adequate involvement of all key actors in the value chains relevant for this topic and across the sustainable circular bio-based system, including feedstock providers, policymakers and end users. Address compliance with EU regulatory frameworks as relevant for targeted products and applications, identify potential gaps and provide recommendations to overcome them. Perform a risk assessment on impacts, potentially deriving from the use of biotechnology, on human and ecosystem safety and identify adequate mitigation measures. Assess the adequacy of policy and regulatory means to manage these risks and provide recommendations to overcome potential identified bottlenecks. Include a task to apply the SSbD framework, developed by the European Commission, for the assessment of the production process of targeted biorefinery product(s) as well as the chosen derived end product(s). For more information on the SSbD framework and criteria, refer to Safe and sustainable by design . Seek complementarities and avoid overlaps with past and ongoing R&I projects addressing similar challenges, including those funded by BBI JU/CBE JU and under Horizon 2020/Horizon Europe (under Cl Programme areas: Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Bio-based Innovation Systems in the EU Bioeconomy, Horizon Europe (HORIZON) Keywords: Applied and industrial chemistry, Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation, Industrial bioengineering, Industrial biotechnology, bio-based feedstock, bio-based products, bio-conversion, bioreactors, biorefineries, downstream technologies, safe and sustainable by design, STEP-Biotech

Pushing the frontier of knowledge and conservation action for deep sea ecosystems is sponsored by European Commission — Horizon Europe. Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Member States and Associated Countries contribute to the implementation of area-based management tools, such as protection targets and adaptive management approaches for deep-sea regions under the Treaty on Biodiversity Beyond National Jurisdiction (BBNJ) and the Kunming-Montreal Global Biodiversity Framework (GBF), for Regional fisheries Management Organisations (RFMOs) and for transitions areas with the EU exclusive economic zone notably by identifying Ecologically and biologically significant marine areas (EBSAS), and informing the next Global Assessment of Biodiversity and Ecosystem Services; Public Authorities prioritise deep sea areas for inclusion in their 30% protection target while enhancing maritime spatial planning achieved through science-based information, habitat mapping and ecosystem-based approach, aligned with the EU strategies for biodiversity and climate adaptation by 2030. Scope: The deep sea represents 90% of the Ocean volume and remains the least explored biome of the planet. Nevertheless, we know that the deep sea forms an extensive and complex ensemble of ecosystems which functioning is crucial to the rest of the biosphere, global biogeochemical cycles and ecosystems upon which much terrestrial life, including human civilisation, depends. The critical limiting factors in the definition and implementation of protection and restoration measures are the lack of biodiversity knowledge and appropriate monitoring, especially in layers below 1000 m. The main reasons are the limited access and high cost of explorations of the diversity of biotopes in the deep sea, and the resources available to identify organisms across the full range of sizes (from microorganisms to megafauna) and describe ecosystems functioning. In line with the objectives and targets of the EU biodiversity strategy for 2030, the EU Nature Restoration Regulation, the Marine Strategy Framework Directive, the EU climate adaptation strategy, the strategy for European life sciences, the European Ocean Pact, the Treaty on Biodiversity Beyond National Jurisdiction (BBNJ) and the Kunming-Montreal Global Biodiversity Framework (GBF), proposals should: fill the gaps in geographical coverage in habitats mapping, species inventory, genetic diversity, ecological functioning, food webs and ecological connectivity (including migratory species) of deep sea ecosystems in the bathypelagic and abyssopelagic zones (abyssal seafloor, hydrothermal sites, seamounts, canyons and across the water column) between them and with shallower ocean zones (mesopelagic, epipelagic, coastal...); develop, integrate and deploy imaging, acoustic, multi-omics, genomics and taxonomic technologies and methodologies for the inventory and fast identification of deep-sea marine species from microbes, invertebrates to migratory species, apex predators such as sharks and mammals, corals and other habitat-forming species, generating reference datasets from identified voucher specimens and novel methods to improve biodiversity monitoring and inventory and the discovery of novel biological traits, enhancing understanding of ecosystem resilience to climate and anthropogenic pressures; contribute to the Global Taxonomy Initiative of the Convention on Biological Diversity (CBD) and to free and open access to the Global Biodiversity Information Facility’s biodiversity data; establish baselines, spatial and temporal dynamics, assess and predict the cumulated impacts from climate change and other anthropogenic stressors including underwater noise, on ecosystems functioning and services, including the biological carbon pump fisheries stock; describe holistic interactions between the deep sea, Ocean and planetary health and propose actionable knowledge by involving multiple stakeholders for identifying adaptive management approaches, and mitigation and conservation scenarios for prioritised deep Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Food, Bioeconomy Natural Resources, Agriculture and Environment, Seas, Oceans and Inland Waters Keywords: Biochemistry and molecular biology, Biodiversity conservation, Biophysics, Deep-sea ecosystems, Earth and related environmental sciences, Ecology, Genetics and heredity, Marine biology, BBNJ, Deep sea, EBSAS, Ecological functioning, Ecosystem-based approach, Habitats mapping, High-Seas, Kunming Montreal Global Biodiversity Framework, Species inventories