1,000+ Opportunities
Find the right grant
Search federal, foundation, and corporate grants with AI — or browse by agency, topic, and state.
This listing may be outdated. Verify details at the official source before applying.
Find similar grantsMechanisms addressing the causal relationships of sleep, circadian rhythms, and cardiometabolic health is sponsored by National Heart, Lung, and Blood Institute (NHLBI). This opportunity supports mission-aligned projects and measurable outcomes.
Get a weekly digest of new grants like this
A free weekly digest of new foundation and federal funding opportunities as they're added to Granted. Unsubscribe anytime.
Or search similar grants →Extracted from the official opportunity page/RFP to help you evaluate fit faster.
Goal 1: Sleep and Circadian Mechanisms Underlying Health and Disease | NHLBI, NIH Divisions, Offices and Centers Division of Lung Diseases National Center on Sleep Disorders Research National Institutes of Health Sleep Research Plan Goal 1: Sleep and Circadian Mechanisms Underlying Health and Disease Sleep and Circadian Mechanisms Underlying Health and Disease Identifying mechanisms underlying sleep and circadian biology is essential for prediction and early detection of health-to-disease transitions.
Last updated December 13, 2021 Goal 1: Sleep and Circadian Mechanisms Underlying Health and Disease Goal 1: Elucidate the Sleep and Circadian Mechanisms Underlying Health and Disease National surveillance data from the Center for Disease Control and Prevention estimates that more than 30% of U.S. adults and more than 65-80% of teens nationwide report sleep deficiency (e.g., insufficient sleep, irregular timing of sleep, poor quality of sleep).
Chronic diseases and social determinants of health (e.g., race and ethnicity, housing and the built environment, lifestyle and occupational factors, psychosocial stressors) are all associated with sleep deficiency and circadian misalignment – the mistiming of internal biological cycles relative to external environmental or behavioral factors.
Identifying mechanisms underlying sleep and circadian biology is essential for predicting responses to influences that might disrupt regulation of these systems and ultimately lead to early detection of health-to-disease transitions.
These mechanistic insights could enable earlier and more precisely targeted interventions that could leverage methodological and technological advances in optogenetics, functional brain imaging, wearable devices, and informatics. Ultimately such refined interventions could be implemented at a population level.
Better define the biological processes involved in maintaining sleep and circadian health to enable early detection of their disruption and the consequent transition to disease. Promote health and resilience against disease by leveraging these processes.
High-Priority Research Areas Basic Mechanistic Studies Identify non-neuronal cellular and molecular mechanisms, and inter-organ alignment and crosstalk underlying sleep and circadian biological processes. Identify the complex interactions of circadian rhythms across various organ systems through computational and mathematical modeling (systems biology) and identify emergent phenomena that influence health and disease.
Explore mechanisms underlying the bidirectional relationship of the aging process and circadian rhythms. Advance mechanistic understanding of the pathways modulating pain, reward, sleep, and circadian rhythms to identify new therapies.
Identification of Disease Processes and Biomarkers Identify sleep and circadian influences on the biology underlying obesity and cardiometabolic risk in humans and develop preclinical models to better tailor interventions in clinical-translational studies.
Understand the interplay between intermittent hypoxia, sympathetic activation, the microbiome, and endogenous stem/progenitor cells, and how this interplay contributes to disease progression. Develop and test preclinical models of sleep and circadian disturbances in relation to critical illness (e.g., sepsis) and identify novel targets for drug discovery and therapeutic management.
Explore single-cell analytics to understand the cellular phenomena of sleep and circadian rhythms and enable discovery of surrogate biomarkers for sleep and circadian disorders. Pathogenic Effects of Sleep and Circadian Disruption Determine the brain mechanisms and effects of sleep and circadian rhythms on development, illness course, and treatment of mental health disorders, and identify the genetic basis of such interactions.
Explore the mechanistic basis for circadian rhythm and/or sleep disruption and cancer risk. Identify the effects of sleep disruption on reproductive development and function. Explore the role of sleep and circadian rhythms in blood brain barrier regulation as it affects drug efficacy.
Explore the genetic, epigenetic, molecular, cellular, and systemic mechanisms that determine sex-related differences in sleep and circadian disorders. Define the sex-related differences in sleep quality and quantity in relationship to autoimmune disease. Identify the neural mechanisms and bidirectional interactions between sleep deprivation or disruption, and mental health disorders, including emotional dysregulation and mood disorders.
Long Term Environmental and Population Effects Understand the effects of developmental alcohol exposure on sleep patterns later in life, and the mechanisms of alcohol-related sleep disorders. Examine mechanisms underlying sleep-related pathology contributing to risk for Alcohol Use Disorder (AUD) and the role of persistent sleep problems emerging during abstinence from alcohol use in relapse.
Elucidate multilevel and multifactorial causal pathways for disparities in sleep and circadian disorders. For example, examine the role of sociocultural and physical/built environmental determinants on population sleep disparities.
Explore the effects of environmental exposures (e.g., particulates, pathogens, temperature, light exposure, humidity) on sleep and circadian rhythms, and downstream consequences on health, such as for poor diet, physical inactivity, sedentary behaviors, organ dysfunction and disease.
Explore the effects of substance use such as alcohol, cigarettes, and illicit drugs (e.g., methamphetamine, cocaine, heroin, fentanyl) and misuse of psychotherapeutic drugs (e.g., prescription opioids and stimulants) and how disrupted sleep contributes to addiction.
NIH Sleep Research Plan Strategic Goals Goal 1: Sleep and Circadian Mechanisms Underlying Health and Disease Goal 2: Risk Reduction and Treatment of Sleep and Circadian Disorders Goal 3: Clinical Implementation of Sleep and Circadian Research Goal 4: Sleep and Circadian Disruptions and Health Disparities Goal 5: Sleep and Circadian Biology Research Workforce Development Tactics to Address Research Goals in Sleep and Circadian Biology
According to the current listing, eligibility includes: Not specified in the provided text, but generally NIH grants are open to institutions of higher education, non-profits, for-profits, and government agencies. Confirm the full requirements in the official notice before applying.
Mechanisms addressing the causal relationships of sleep, circadian rhythms, and cardiometabolic health is funded by National Heart, Lung, and Blood Institute (NHLBI). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Five NHLBI Catalyze Product Definition RFAs — HL-26-016 through HL-26-020 — carry an October 21, 2026 receipt date, budget caps of $300,000 to $400,000 per year, and roughly 8 new awards annually. The science is not the gate. An Accelerator Partner and a 0.25:1 non-federal cost match are, and both take longer to line up than the nine weeks you have left.
Read articleThe $46M FSHARP program is creating shelf-stable synthetic blood from freeze-dried components. A new SWiFT SBIR topic opened May 6 for autonomous field transfusion devices. What grant seekers in biomedical engineering need to know.
Read articleDARPA MTO opened six FY26 SBIR topics on May 27 with a June 24 deadline — nanopore proteomics, compact RF filters, 800°C ICs, passive thermal spreaders, radiation-hardened codesign, and low-resource computing. The topics read like a wishlist for the next decade of contested-environment microelectronics. Here is what each one is actually asking for, and how small businesses should triage the four-week window.
Read article