Medical Research Study Pre-Request

Medical Research Study Pre-Request is sponsored by Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation.

The Foundation seeks highly innovative and groundbreaking medical research proposals from top-tier institutions in both basic biological and applied research that will have the greatest impact on scientific knowledge and human health.

Medical Research - Robert J. Kleberg, Jr. and Helen C. Kleberg FoundationRobert J.

Kleberg, Jr. and Helen C. Kleberg Foundation At this time, the Foundation will not be accepting applications or pre-requests for medical research studies from organizations that have not received any funding in the past ten years.

The Foundation is seeking highly innovative and groundbreaking medical research proposals from top tier institutions in both basic biological and applied research that will have the greatest impact on scientific knowledge and human health. Proposals should be distinctive and novel in their approaches, question the prevailing paradigm, and lead to advancement of knowledge in the field.

A highly qualified scientific advisory committee will review all proposals. Applications are highly competitive. Priority is given to organizations with whom the Foundation has had a long-standing relationship, preferably in Texas.

All applications must be approved by the University Provost or the Vice President of Research, and should be submitted through the office of sponsored research or like office that provides institutional approval for the request. Studies selected through an internal competition are preferred. Applications submitted by an individual researcher will NOT be considered.

Medical research institutions may submit one application each grant cycle, regardless if they have an open grant, and regardless of the number of affiliated entities within the institution. The medical research study application has a format similar to that of NIH. There is a separate application called Medical Research-Other that should be used for medical research-related requests other than medical research studies.

This application is restricted and requires an access code. Please contact Foundation staff at margretb@alexventures. com or call Margret at 210-316-8398 before you set up a new account in the online system, begin a Medical Research Study Pre-Request , if you have any questions, i f you are unsure which application to use or whether you are eligible to apply, or to obtain the access code.

Please review the grant guidelines and the PDF documents below to be sure to submit a complete application: Application Content and Attachments – Medical Research Medical Research Study Application – List of Questions Online Application Instructions 2025 Medical Research Awards Organization Name Amount Baylor College of Medicine, Houston, TX S.

Boeynaems – Toxic Positivity: Antimicrobial peptides driving maladaptive neuroinflammation – 3 Years $1,500,000 Johns Hopkins University, Baltimore, MD S. Watanabe – Continuation: A potential novel bioactive molecule in neurodegeneration – 2 Years $689,049 Mayo Clinic, Rochester, MN A.

Revzin – Novel mass spectrometry analysis of cancer biomarkers on extracellular vesicles – 3 Years $1,274,229 Memorial Sloan Kettering Cancer Center, New York, NY B. Greenbaum – Structure-guided TCR specification and design for precision immunotherapy – 3 Years $1,500,000 Rice University, Houston, TX R. Richards-Kortum – Access BreastDX to Expand Breast Cancer Diagnosis – 3 Years $1,560,108 Stanford University, Stanford, CA J.

Wu – Engineering Human Heart Models for Cardiovascular “Clinical Trials in-a-Dish” – 3 Years $1,500,000 Texas A&M Foundation, College Station, TX K. Hobbs – Immediate and Sustained Methods for Protecting the Vasculature After Snake Bite – 1 Year $80,266 University of California, San Francisco, CA J. Reiter – Cilia as Cancer’s Achilles’ Heel: New Therapeutic Strategies for Medulloblastoma – 3 Years $1,500,000 Washington University, St.

Louis, MO M. Chheda – IND-enabling studies and a first in human trial of Zika virus in brain cancer – 3 Years 2024 Medical Research Awards Organization Name Amount Baylor College of Medicine, Houston, TX A. Maresso – Phage Therapy Induced Vaccination Against Pandemic Drug-Resistant Bacteria – 3 Years S.

Gunter – A Citizen Science Approach to Collect Ticks as Proof-of-Concept – 2 Years $1,536,475 $499,557 J. David Gladstone Institutes, San Francisco, CA L. Shipman – Engineering Approaches to Phage Therapy – 3 Years $803,403 Johns Hopkins University, Baltimore, MD Inoue/Leung – Shattering the Paradigm of Translation Regulation for Health and Diseases – 3 Years $997,957 Massachusetts Eye and Ear, Boston, MA J.

Arboleda-Velasquez – Antibody Targeting APOE Interactions for Alsheimer’s – 2 Years $1,200,000 Rice University, Houston, TX H. Xiao – Overcoming the Blood-Brain Barrier in Effective Treatments for Brain Metastasis – 3 Years $1,500,000 Thomas Jefferson University, Philadelphia, PA K. Bussard – Reducing Osteolytic Bone Destruction in Bone Metastatic Breast Cancer – 3 Years $1,246,824 University of California, San Francisco, CA D.

Fujimori – A Chemical Biology Approach to Stimulate Antitumor Immunity – 3 Years $1,500,000 University of Pennsylvania, Philadelphia, PA S. Berger – Epigenetic Dysfunction Drives Alzheimer’s Disease – 3 Years $1,050,000 University of Texas at Austin, TX A. Ellington – Microbial Delivery of mRNA Vaccines and Therapeutics – 2 Years $484,642 Vanderbilt University Medical Center, Nashville, TN B.

Park – Overcoming Immune Exclusion in Microsatellite Stable Colon Cancer – 3 Years 2023 Medical Research Awards Organization Name Amount Baylor College of Medicine, Houston, TX S. E. Crawford – Using Novel Tools to Achieve a Hepatitis B Virus Functional Cures – 3 Years S.

Gunter – A citizen science approach to collect adequate ticks as proof-of-concept – 1 Year $1,182,523 $197,036 Boston Children’s Hospital, Boston, MA M. Moses – A dual targeted theranostic approach to the treatment of pancreatic cancer – 3 Years $1,500,000 Fred Hutchinson Cancer Research Center, Seattle, WA K.

Cheung – Interrogating intercellular signaling in triple-negative breast cancer – 3 Years $1,000,000 Texas A&M Foundation, College Station, TX J. Hyde – Early Lyme Disease Diagnostic to Detect Viable B. burgdorferi – 3 Years $782,899 Thomas Jefferson University, Philadelphia, PA A.

Snook – Universal Cell Therapy for Cancer – 3 Years $1,329,030 University of California, San Francisco, CA B. Javid – A generalized strategy for bacterial antivirulence therapy – 3 Years $1,299,259 University of Texas at Austin, TX D. Ghosh – mRNA delivery of intrabodies against the intracellular targets of cancer – 3 Years $759,000 University of Texas MD Anderson Cancer Center, The, Houston, TX J.

Hu – Tackling cancer therapy-induced central nervous system deficits – 3 Years $1,944,130 University of Texas Rio Grande Valley, McAllen, TX Luminary Scholars Program – 4 Years $1,000,000 UT Southwestern Medical Center, Dallas, TX D. Greenberg – Antisense Antibiotics for Drug-Resistant Pseudomonas aeruginosa – 3 Years J.

Herz – Restoring Endolysosomal pH Homeostasis to Prevent Alzheimer’s Disease – 3 Years $1,500,000 $1,500,000 Vanderbilt University Medical Center, Nashville, TN B. Park – Blocking the evolution of drug resistance in cancer – 3 Years 2022 Medical Research Awards Organization Name Amount Fred Hutchinson Cancer Research Center, Seattle, WA J.

Lee – Disrupting ERAP activity to advance immunotherapy in prostate cancer – 3 Years $750,000 Johns Hopkins University, Baltimore, MD S. Watanabe – A potential novel bioactive molecule in neurodegeneration – 1 Year $332,718 Monell Chemical Senses Center, Philadelphia, PA B. Kimball – Classification of Febrile Disease via Detection of Urinary or Saliva Volatiles – 1 Year $439,028 Rice University, Houston, TX J.

Chappell – Smart RNA antibiotics: trojan horse drugs selective for pathogenic microbes – 3 Years $1,500,000 Stanford University, Stanford, CA C. Curtis – Measuring the repeatability of clonal evolution and defining its contingencies – 3 Years $1,500,000 University of California, San Francisco, CA K. Shokat – A chemical-genetic approach to elucidate healthspan regulation – 3 Years J.

Bondy-Denomy – Factors that antagonize bacteriophage infection in a human pathogen – 3 Years $1,487,701 $1,081,838 University of Texas at Austin D. Taylor – Structure-based design of next-generation versatile, high-fidelity Cas9 variants – 3 Years $397,449 University of Texas Health San Antonio D.

Halff – Transplantation Matching Decisions: Surgeon-AI Collaborative Platform – 3 Years 2021 Medical Research Awards Organization Name Amount Baylor College of Medicine, Houston, TX A. Maresso – Designer Medicines for Evolving Pathogens – 3 Years P. Hotez – Chagas Disease Vaccine Combining RNA and Protein Technologies – 1 Year $996,678 $674,504 Boston Children’s Hospital, Boston, MA L.

Zon – Strategies for Bone Marrow Inflammation in Clonal Hematopoiesis and Leukemia – 3 Years $1,500,000 Massachusetts Eye and Ear, Boston, MA J. Arboleda-Velasquez – Antibody Targeting APOE Interactions with Glycosaminoglycans – 3 Years $1,200,000 Memorial Sloan Kettering Cancer Center, New York, NY G. Diehl – Developmental Regulation of Microbiota Specific Inflammatory T Cells – 3 Years $1,499,940 Rice University, Houston, TX G.

Bao – A Generalizable Platform for In Vivo Genome Editing – 3 Years $900,000 Stanford University, Stanford, CA M.

Wernig – Towards Next Generation Brain Cell Therapies- 3 Years $1,200,000 The University of Texas Medical Branch, Galveston, TX Pei-Yong Shi – Development of an Engineered Zika Virus for Glioblastoma Therapy – 2 Years $1,000,000 The University of Texas Rio Grande Valley, McAllen, TX Obstetrics & Gynecology Residency Program in the Mid-Rio Grande Valley – 3 Years $3,000,000 Vanderbilt University Medical Center, Nashville, TN Pietenpol and Cortez – Defining a New Pathway to Treat MYC-Driven Cancers – 3 Years 2020 Medical Research Awards Organization Name Amount Baylor College of Medicine, Houston, TX P.

Hotez – Advancing an RBD-based Vaccine Against COVID-19 – 1 Year $765,278 Fred Hutchinson Cancer Research Center, Seattle, WA A. Hsieh – Protein Synthesis Dynamics in Advanced Bladder Cancer – 3 Years $862,020 Memorial Sloan Kettering Cancer Center, New York, NY C. Rudin – Using new tools to deeply interrogate drivers of lung cancer metastasis – 3 Years $1,500,000 Monell Chemical Senses Center, Philadelphia, PA B.

Kimball – Classification of Febrile Disease via Detection of Urinary or Saliva Volatiles – 2 Years $889,299 Rice University, Houston, TX J. Miller – A throughput system to test antiviral compounds against virus-infected mosquitoes – 3 Years $1,500,000 Stanford University, Stanford, CA H.

Nakauchi – Redefining mammalian pluripotent stem cell states – 3 Years $950,000 Texas Bomedical Research Institute, San Antonio, TX Recruitment of Virologist Dr. Martinez-Sobrido – 4 Years $1,000,000 University of Pennsylvania, Philadelphia, PA S. Berger – Epigenetic Dysfunction Drives Alzheimer’s Disease – 3 Years $1,050,000 University of Texas at San Antonio, San Antonio, TX J.

Hsieh – A Personalized Approach to Alzheimer’s Disease in Hispanic Families – 3 Years G. Perry – Amyloidß Protective Hypothesis: A Cure for Alzheimer’s Disease – 3 Years $1,200,000 $1,200,000 University of Texas MD Anderson Cancer Center, The, Houston, TX P.

Sharma – Improving anti-tumor responses to immunotherapy using ARID1A + CXCL13 – 3 Years The Kleberg Innovator/Investigator Award – 3 Years $3,000,000 $750,000 UT Southwestern Medical Center, Dallas, TX E.

Maher – Matching IDH Driver Status to Treatment Timing in Glioma – 1 Year $396,714 $15,063,311 2019 Medical Research Awards Organization Name Amount Monell Chemical Senses Center, Philadelphia, PA Dr. Preti – Effective Ovarian Cancer Screening Diagnostic $300,000 Stanford University, Stanford, CA Dr. Weissman – Profiling Immune Responses to Lyme Disease and How They Impact Treatment Efficacy Dr. Monje – Targeting Ion Channel Physiology in Malignant Glioma Through Neurological Drug Repurposing $500,000 $900,000 University of Pennsylvania, Philadelphia, PA Dr. Brinster – Altering the Genes of Farm Animals $549,474 University of California, San Francisco, CA Dr. McManus – Evolving CRISPR Therapies $1,500,000 University of Texas Medical Branch, Galveston, TX Dr. Shi – A Universal Vaccine Platform $590,000 $4,339,474 2018 Medical Research Awards Organization Name Amount Johns Hopkins University, Baltimore, MD Targeting Mitophagy as a New Strategy to Treat Non-Alcoholic Steatohepatitis $745,536 Texas A&M Foundation, College Station, TX Innovative Technologies to Minimize the Risk for the Re-Emergence of Bovine Babesiosis in the U.S. (Includes Contingency Award for Years 2 and 3) $723,565 University of California, San Francisco, CA Early Detection and Removal of High-Risk Pre-Cancer, Cancer and Metastatic Lesions Using Engineered Immune Cells $1,199,967 University of Pennsylvania, Philadelphia, PA Epigenetic Dysfunction in Human Alzheimer’s Disease $1,050,000 University of Texas, Austin, TX Improving the Efficiency and Specificity of Cas9 Enzymes $673,828 $4,392,896 2017 Medical Research Awards Organization Name Amount Baylor College of Medicine, Houston, TX Impact of Microbiota Driven T Cell Selection on Inflammatory Disease $900,000 Fred Hutchinson Cancer Research Center, Seattle, WA Infusion of Off the Shelf Ex Vivo Expanded Cryopreserved Progenitor Cells for Single Cord Blood Transplant in Patients with Hematologic Malignancies $500,000 Houston Methodist Hospital Foundation, Houston, TX New Mechanisms and Strategies in Prevention of Transplant Rejection A New Biomimetic Approach in the Treatment of Cardiovascular Inflammation $867,583 Memorial Hermann Foundation, Houston, TX Plasma Exchange to Treat Alzheimer’s Disease $249,968 Memorial Sloan Kettering Cancer Center, New York, NY Mechanistic Analyses of Pancreatic Cancer Evolution $1,500,000 Rice University, Houston, TX Design and Fabrication of Interpenetrating Vascular Networks in Lung Tissue Mimics $400,000 Texas A&M Foundation, College Station, TX Transformative and Affordable Medical Technologies and Systems to Improve Diabetes Health $957,789 Texas Children’s Hospital, Houston, TX Network Systems Biology to Identify and Test Novel Multivalent mRNA Lipopolyplex Vaccines Against Chagas Disease $1,854,896 Texas Heart Institute, Houston, TX Targeting the Cardiovascular Inflammatory Receptor to Enhance Stem Cell Transplantation in Cancer $473,872 University of Houston, Houston, TX Gravin Signalosome: A Novel Therapeutic Drug Target for the Treatment of Heart Failure $475,000 University of Texas at Austin, Austin, TX A Personalized Approach to T Cell Receptor Re-Directed Adoptive Cell Transfer Therapy in Cancer $787,844 University of Texas at San Antonio, San Antonio, TX Accelerating Research in Brain Health $2,689,350 University of Texas Medical Branch, Galveston, TX A Rapid Zika Diagnostic Assay for Patients Innovative Methods to Disrupt Acquisition and Transmission of Viruses by Mosquitoes and Ticks $200,000 $200,000 UT Southwestern Medical Center, Dallas, TX Matching IDH Driver Status toTreatment Timing in Glioma $1,190,445 Vanderbilt University Medical Center, Nashville, TN Accelerating the Transition from Discovery to Clinical Implementation in Precision Medicine $1,000,000 Washington University, St.

Louis, MO Using Zika Virus to Treat Glioblastoma $588,513 $15,435,260