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"Microbiome for early cancer prediction before the onset of disease" is currently closed and not accepting applications.
Microbiome for early cancer prediction before the onset of disease is sponsored by European Commission — Horizon Europe. Expected Outcome: Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes: Healthy people and in particular people at risk will benefit from microbiome tests and programmes that can discover and predict their transition to cancer before the onset of disease. People will have a better understanding of risks and will be enabled to address risks early by following treatments or adapting their lifestyles, including nutrition and other interventions. Physicians will be able to start cancer treatments earlier with a higher success rate. Policy makers and authorities will be enabled to develop and implement advanced and strategic programmes addressing cancer prevention. Scope: This topic will contribute to the achievement of the EU Cancer Mission’s objective to achieve better cancer prevention and early detection. The focus is on the development of validated microbiome tools, an assessment of predispositions, the comparison with other predictive tools and risk modelling approaches. Cancer often develops over several years and progresses silently before symptoms appear. Some cancers are diagnosed at a very late stage, when the disease is nearly incurable. Early and sensitive biomarkers are beneficial for preventive strategies and the survival of patients especially when tests are minimally invasive and simple to perform. The human microbiome is correlated with this process of oncogenesis and tumour progression. The deterioration of the human microbiome towards dysbiosis should be monitored and used as an early predictive biomarker. The potential of the microbiome should be exploited to deliver important contributions to cancer prevention and early detection strategies before the onset of disease especially for high-risk patients. Prevention of cancer through early detection is most efficient in fighting cancer and saving lives. Large microbiome biobanks and registries exist at national and international levels to collect and store microbial samples with the intention to analyse and share microbiome data for research and healthcare. The One Million Microbiomes from Human Project has been launched by several countries to build the largest human microbiome high quality database and to provide advanced life science tools for future healthcare. The intention is to accelerate the translation of microbiome knowledge to predict and prevent cancer earlier, before the onset of disease, through the development of personalised approaches and tools. The promise of these tools is evident because people could anticipate cancer while they would still have time to act before the onset of the disease. In case of certain types of cancer, earlier treatment could improve lives or even cure patients in line with the goal of the EU Cancer Mission. The tools should be based on the collection of a high number of longitudinal samples over several years, they should be validated and their prediction power compared with other minimally invasive (liquid biopsy) tests. To use the resources most efficiently, the tools should be supported by risk modelling approaches and AI technologies. Proposals should address all of the following: Development of microbiome tools for earlier, better and personalised prediction and prevention of cancer before the onset of the disease; if possible 2 years before the onset of the disease. Proposals should deal with several types of cancer if possible. Assessments of predispositions, AI risk modelling approaches and organ/body simulations. Collaboration with large cohorts/registries from different communities, usage of existing microbiome and clinical data in combination with and generation of new data. These data could include other predictive signs such as sensations of fatigue, unusual pain, weight loss or other body changes. Citizen engagement could be included with data and sample collections as well as educational programmes. Compari
Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Health
Keywords: Diagnostics, Oncology, Personalised prevention, Cancer onset, Microbiome, Predictive tests
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Or search similar grants →According to the current listing, eligibility includes: Open to legal entities established in EU Member States and countries associated to Horizon Europe (including EEA/EFTA countries, and other associated third countries). Action type: HORIZON-RIA HORIZON Research and Innovation Actions. Additional conditions: "> General conditions 1. Admissibility Conditions: Proposal page limit and layout described in Annex A and Annex E of the Horizon Europe Work Programme General Annexes. Proposal page limits and layout: described in Part B of the Application Form available in the Submission System. 2. Eligible Countries described in Annex B of the Work Programme General Annexes. A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making... See the official call documentation on the F&T Portal for full eligibility criteria and participation rules. Confirm the full requirements in the official notice before applying.
The current listing shows €124.2M total budget (~$134.1M USD) ; up to €5M per project ; ~3 grants expected. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was September 15, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Microbiome for early cancer prediction before the onset of disease is funded by European Commission — Horizon Europe. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Reinforcing EU autonomous access to space through EU-based spaceports is sponsored by European Commission — Horizon Europe. Expected Outcome: Project results are expected to contribute to all of the following outcomes: Reinforcing EU strategic autonomy by reducing non-EU dependencies for accessing space; Providing an EU access to space necessary for EU space missions through state of the art and innovative solutions; Diversifying the access to space providers in the EU; Contributing to expand commercial access to space offers and services in the EU; Reinforcing Access to Space to ensure that Europe maintains and improve autonomous, reliable and cost-effective access to space. Scope: The EU needs to improve the resilience of its access to space for the implementation of EU space programme. New entrants will contribute to this endeavour. Projects are expected to support EU launch service providers to set up launch pad(s) in the EU territory enabling to perform EU launch services. Projects are expected to contribute to the development of necessary ground facilities to conduct launch services from the EU territory; e.g. launch integration, storage and operation facilities, launch pad and complex, control command facility, payload processing and integration facilities, tracking means, safety means, propellant storage... EU launch service provider(s) are expected to be part of the project consortium and be the ultimate users of the resulting facilities making use of EU launch vehicles for providing EU launch services. Proposals under this topic should explore synergies and be complementary to past actions related to ground segment for launch services, in particular the topics: HORIZON-CL4-2023-SPACE-01-23 and HORIZON-CL4-2025-02-SPACE-11. All the activities should be complementary with national and ESA on-going or future activities, in particular those decided at the ESA council Ministerial Meeting in November 2025. In this topic, the integration of the gender dimension (sex and gender analysis) in research and innovation content should be addressed only if relevant in relation to the objectives of the research effort. Technology Readiness Level - Technology readiness level expected from completed projects Activities are expected to achieve TRL 8 by the end of the project. The reference TRL definition is the ISO 16290:2013 applicable to the space sector. Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Digital, Industry and Space
Space critical Equipment for EU non-dependence – Space Refuelling Interface is sponsored by European Commission — Horizon Europe. Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Reinforcing EU strategic autonomy by reducing non-EU dependencies on critical space Equipment and related technologies across their entire supply chain; Providing unrestricted access to critical space Equipment and related technologies relevant for EU space missions and pilots (e.g. In-Orbit Space Operations); Developing or regaining capacity to operate independently in space by developing resilient space Equipment and related technologies supply chains, relying on EU supply chains and/or trustable and reliable supply chains not affected by non-EU export restrictions; Enhancing competitiveness by developing products and capabilities reaching equivalent or superior performance level than those from outside the EU and compete at worldwide level. Scope: Unrestricted access to state-of-art space equipment and related technologies is a pre-requisite for the EU space industry responding to EU space missions. However, especially for some families of equipment, the available solutions in EU do not meet the current high-performance space requirements. Currently, alternative products sourced from outside EU, are either affected by non-EU export control, that limits its use, or present challenges in terms of trustable supply chains for the implementation of EU space missions with a security dimension. Within the frame of this topic, it is expected to finance and implement a development project aiming at maturing critical equipment with the final goal of lowering the dependency from outside EU. This will be done by establishing a long-term sustainable supply chain for supporting EU strategic autonomy in the space sector. The selection of the supply chains shall reflect this objective. Therefore, the supply chain shall preferably be built fully based in EU and when this can only be achieved partially, services procured from outside EU shall nevertheless ensure that the overall supply chain will remain trustable and not affected by non-EU export control. The latest scenario is subject to the approval of the granting authority (i.e. DG-DEFIS and HaDEA). The space equipment and related technologies relevant for this topic represent a direct implementation of the EU Observatory of Critical Technologies (OCT) Technology Roadmap, named Robotics Manipulators for Space Applications: Space Refuelling Interface . Further details will be provided at the latest at the opening of the Call, in a Guidance document published on the Funding & Tenders Portal. Space is a low volume market affected by a dynamic industrial landscape compared to the terrestrial market therefore, technological spin in and/or bilateral collaborations should be enhanced between European non-space and space industries. Furthermore, proposed activities should be complementary to relevant national or other activities at EU level. Complementary activities should be clearly identified, described and the proposal should report how the complementarity is ensured. To achieve the non-dependence objective, applicants are expected to include a dedicated proposal’s paragraph covering: The description of the technology and/or technology processes used for developing the equipment and high-level breakdown of the supply chain to be used. Applicants should demonstrate that the supply chain and final product are free of any legal export restrictions or limitations, such as those established in the International Traffic in Arms Regulations (ITAR) or equivalent instruments applicable in other non-EU jurisdictions. Applicants shall also report, in a dedicated subsection, if and which part of the supply chain is affected by non-EU export controls such as the Export Administration regulation (EAR) i.e. EAR99. The description of the suitable technology development process that has been identified and set up within the consortium for avoiding export restrictions of non-EU states and assess vulnerab Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Digital, Industry and Space, Space, including Earth Observation
IA Resilience call reinforcing Europe's strenght in health is sponsored by European Commission — Horizon Europe. Expected Outcome: the proposals under this call are expected to address one or more of the following subjects : • Enhanced personalized monitoring, care and treatments, focusing on the development of highly customized healthcare solutions, including the required research and diagnostic tools, tailored to individual needs, covering various scenarios such as chronic disease management, physiotherapy, precision diagnosis, personalized medicine/treatment, pre- and postoperative care, and daily assistance in homes and common spaces. It also targets effective management of chronic diseases and elderly care through personalized monitoring and interventions facilitated by advanced sensor technologies and edge-to-cloud solutions. This includes the development and integration of solutions for Hospitalization at Home, enabling patients to receive complex, remotely supervised care using intelligent medical devices capable of sensing, analysing, and transmitting real-time data. This requires a continuum, from in-hospital diagnostics to robust, long-term patient support at home via AI-driven care pathways and hospitalization at home. • Prevention and treatment of diseases, allowing the improved scientific understanding, early detection and proactive prevention of diseases through scientific research, continuous monitoring, predictive analytics, and timely alerts, possibly powered by AI algorithms. This preventive approach enables early intervention and significantly reduces risks associated with many illnesses such as viral infections (e.g. epi- and pan demics), cardiovascular diseases, diabetes complications affecting the health of the young and old. • Efficient, scalable, and cost-effective healthcare, demonstrating how ECS-based technologies can streamline clinical workflows, reduce administrative burdens, and improve resource allocation in healthcare systems. This includes automation and intelligent operations management across clinical, diagnostic, and homecare settings, ultimately improving cost-effectiveness and scalability. • Secure and compliant healthcare continuum, including solutions that ensure robust data protection and regulatory compliance (e.g. GDPR), particularly in handling sensitive health data. Projects should adopt privacy-by-design principles and implement secure data handling architectures using localized edge computing, encryption, authentication, and anonymization strategies within both clinical and assisted living environments. • Seamless interoperability across devices, systems, and platforms, addressing the integration of heterogeneous systems across the edge-to-cloud continuum. Solutions should rely on open standards and modular architectures to ensure interoperability, flexibility, and adaptability across various healthcare settings and use cases, fostering a unified European health-tech ecosystem. Programme areas: Horizon Europe (HORIZON), Global Challenges and European Industrial Competitiveness, Digital, Industry and Space
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