Mid-scale Research Infrastructure-2 (Mid-scale RI-2)

Mid-scale Research Infrastructure-2 (Mid-scale RI-2) is sponsored by NSF Directorate for Biological Sciences (BIO). Supports the development of mid-scale research infrastructure projects in biological sciences.

Mid-scale Research Infrastructure-2 (Mid-scale RI-2) | NSF - U.S. National Science Foundation Mid-scale Research Infrastructure-2 (Mid-scale RI-2) Important information for proposers and award recipients All proposals must be submitted in accordance with the requirements specified in the funding opportunity and in the Proposal & Award Policies & Procedures Guide (PAPPG) and its supplements .

All NSF grants and cooperative agreements are subject to the applicable set of NSF award terms and conditions . NSF has updated its research security policies for NSF funded projects. Supports the implementation of research infrastructure — including equipment, cyberinfrastructure, large-scale datasets and personnel — whose total project costs fall between $20 million and $100 million.

Supports the implementation of research infrastructure — including equipment, cyberinfrastructure, large-scale datasets and personnel — whose total project costs fall between $20 million and $100 million. NSF-supported science and engineering research increasingly relies on cutting-edge infrastructure.

With its Major Research Instrumentation (MRI) program and Major Multi-user Research Facility projects (Major Facilities), NSF supports infrastructure projects at the lower and higher ends of infrastructure scales across science and engineering research disciplines.

The Mid-scale Research Infrastructure Programs are intended to provide NSF with an agile, Foundation-wide process to fund experimental research capabilities in the mid-scale range between the MRI and Major Facilities thresholds.

In alignment with NSF’s goal to bring together diverse disciplinary perspectives to support convergent research, proposals submitted in response to this solicitation will be managed by a cross-disciplinary team of NSF Program Directors. NSF defines Research Infrastructure (RI) as any combination of facilities, equipment, instrumentation, or computational hardware or software, and the necessary human capital in support of the same.

Major facilities and mid-scale projects are subsets of research infrastructure. The NSF Mid-scale RI-2 Program supports the implementation of unique and compelling RI projects. Mid-scale RI-2 projects may include any combination of equipment, instrumentation, cyberinfrastructure, broadly used large-scale data sets, and the commissioning and/or personnel needed to successfully complete the project.

Mid-scale RI-2 projects should fill a research community-defined scientific need, or address an identified national research priority, that enables current and next-generation U.S. researchers and a diverse STEM workforce to remain competitive in a global research environment.

Mid-scale RI-2 projects will directly enable advances in any of the research domains supported by NSF, including STEM education research, and translational research. Projects may also include upgrades to existing research infrastructure. The total cost for Mid-scale RI-2 projects ranges from $20 million to below the threshold for a Major Facility Project, currently $100 million.

Preliminary and full proposals to the Mid-scale RI-2 Program with total project costs outside this solicitation's budgetary limits will be returned without review.

The Mid-scale RI-2 Program emphasizes projects that have strong scientific merit, respond to an identified need of the research community, demonstrate technical and project management readiness for implementation, include a well-developed plan for student training in all activities leading to and including the implementation of the mid-scale research infrastructure , and involve a diverse workforce in mid-scale research infrastructure development, and/or associated data management.

Training of students in design and implementation of the research infrastructure is essential. The Mid-scale RI-2 Program seeks to broaden the representation of PIs and institutions in its award portfolio, including a geographically diverse set of institutions (especially those in EPSCoR jurisdictions).

PIs who are women, early-career researchers, members of groups that are underrepresented in STEM, and persons with disabilities are especially encouraged to apply. To improve participation in science and engineering research for persons with disabilities, Mid-scale RI-2 encourages PIs to incorporate accessibility as part of a Mid-scale RI-2 project.

Please consult NSF’s Research Infrastructure Guide (RIG) NSF 21-107 , (formerly the Major Facilities Guide) for definitions of certain terms used in this solicitation, such as the Project Execution Plan (PEP). Section 5 of the RIG provides guidance specific to Mid-scale Research Infrastructure Projects, including references to other parts of the RIG, as needed.

Note that the PEP should be appropriately scaled for the complexity of the project and may not require all of the elements described in the RIG, Section 4. Project teams are strongly encouraged to include professional project management expertise at the earliest stages of proposal development.

Mid-scale RI-2 will consider only the implementation (typically construction or acquisition) stage of a project, including a limited degree of final development or necessary production design immediately preparatory to implementation.

It is thus intended that Mid-scale RI-2 will support projects in well-developed states of project management and technical readiness for implementation, i.e., those that have already matured through previous developmental investments. Accordingly, Mid-scale RI-2 does not support pre-implementation (early-stage design or development) activities.

Mid-scale RI-2 also does not support post-implementation research, operations or maintenance, the anticipated source(s) of support for which are expected to be discussed in the proposal.

Note: Research infrastructure and instrumentation in the range just above the current Major Research Instrumentation Program threshold and below the Mid-scale RI-2 threshold is the subject of the Mid-scale Research Infrastructure-1 solicitation (NSF 22-637).

Updates and announcements Spring 2025 update on Mid-scale RI-2 competition Mid-scale Specific Guidance from the Research Infrastructure Guide (with PEP Template) July 19, 2022 - DBI Virtual Office Hour: Instrumentation Awards made through this program Browse projects funded by this program Map of recent awards made through this program Office of Integrative Activities (OD/OIA)