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Mind and Body Interventions for Emotional Well-Being and Whole Person Health (R61/R33 Clinical Trial Required) is sponsored by National Center for Complementary and Integrative Health (NCCIH). This Notice of Funding Opportunity (NOFO) solicits applications for research on how mind and body interventions, such as mindfulness meditation, yoga, acupuncture, and massage, impact mechanisms of emotional well-being and their associations with whole person health.
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Opportunity Listing - Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required) Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required) Agency: National Institutes of Health Assistance Listings: 93.
213 -- Research and Training in Complementary and Integrative Health Last Updated: May 13, 2026 View version history on Grants.
gov The National Center for Complementary and Integrative Health (NCCIH) announces this Notice of Funding Opportunity (NOFO) to solicit applications for research on how mind and body interventions through psychological and/or physical inputs (e.g., mindfulness meditation, yoga, acupuncture, massage, and other brain and/or body based interventions) impact mechanisms of emotional well-being (EWB) and their associations with whole person health (WPH), consistent with the NIH priority to address the health needs of the American people and improve their well-being.
The NOFO will support rigorous and well-powered... mechanistic research studies that are supported by strong preliminary data. The studies should examine the effects of mind and body interventions on innovative mechanisms of EWB (as the primary outcome), as well as the associated relationship with the Whole Person Health Index (WPHI, as a secondary outcome).
To enhance research safety, rigor, and efficiency of NIH-funded mechanistic clinical trials, this initiative will use a two-phased award funding mechanism (R61/R33). The funding will support an initial phase (R61) to establish feasibility benchmarks for the proposed mechanistic clinical trial(s), followed by a second phase (R33) to complete the full-scale trials, which will be contingent upon successful completion of R61 milestones.
Applications should provide preliminary data that are comparable in quality and quantity to those expected for an R01 proposal.
Independent school districts Private institutions of higher education Public and state institutions of higher education Nonprofits non-higher education with 501(c)(3) Nonprofits non-higher education without 501(c)(3) Other Native American tribal organizations Public and Indian housing authorities City or township governments Special district governments Federally recognized Native American tribal governments For-profit organizations other than small businesses Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. Grantor contact information See Section VII.
Agency Contacts within the full opportunity announcement for all other inquires. File name Description Last updated PAR-25-449-Full-Announcement. html PAR-25-449 Full Announcement Text Sep 26, 2025 02:35 PM UTC Link to additional information https://grants.
nih. gov/grants/guide/pa-files/PAR-25-449. html Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: Eligible applicants include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Eligible Agencies of the Federal Government, Faith-b…. Confirm the full requirements in the official notice before applying.
Mind and Body Interventions for Emotional Well-Being and Whole Person Health (R61/R33 Clinical Trial Required) is funded by National Center for Complementary and Integrative Health (NCCIH). Verify program details on the funder's official page before applying.
This opportunity targets applicants in Alaska. If your organization operates elsewhere, check the official notice for location requirements.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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