National Cancer Center Research Grant Awards

National Cancer Center Research Grant Awards is sponsored by National Cancer Center. Supports research fellows pursuing promising and innovative cancer research, including projects in liver cancer. An example project focuses on targeting cysteine catabolism to induce ferroptosis in liver cancer.

National Cancer Institute (NCI) | Grants & Funding U.S. Department of Health and Human Services National Institutes of Health National Cancer Institute (NCI) NCI Policy Considerations Additional Information by Funding Category The NCI Mission is to lead, conduct, and support cancer research across the nation to advance scientific knowledge and help all people live longer, healthier lives.

Cancer Biology : Supports research that advances fundamental understanding of the causes and biology of cancer, including cancer genomics, to improve prevention, detection, diagnosis, and treatment. Cancer Prevention : Supports cancer prevention research to identify factors that cause cancer in humans and to develop risk-reduction strategies and preventive interventions.

Cancer Screening and Early Detection Research: Supports a variety of programs designed to improve early detection and enhance cancer screening. Cancer Treatment, Diagnosis and Prognosis : Supports research to advance cancer treatment and disease control, as well as improve diagnosis, prognosis, screening, and early detection.

Cancer Control, Population Sciences, Survivorship, and Outcomes Research : Supports research to reduce cancer burden and improve quality of life for cancer survivors through effective methodology, interventions, and dissemination on a population-wide scale. Cancer Training: Provides support to nonprofit and for-profit institutions and to individuals for biomedical training opportunities supporting careers in cancer research.

Assistance listings are detailed public descriptions of federal programs used across government agencies that provide grants, loans, scholarships, insurance, and other types of assistance awards. They are maintained in the System for Award Management (SAM) and can be used to search for opportunities in Grants. gov .

View NCI Assistance Listing Numbers 93. 393 - Cancer Cause and Prevention Research 93. 394 - Cancer Detection and Diagnosis Research 93.

395 - Cancer Treatment Research 93. 396 - Cancer Biology Research 93. 397 - Cancer Centers Support Grants 93.

398 - Cancer Research Manpower Highlighted Topics identify timely or emerging research priorities across one or more NIH Institutes, Centers, or Offices (ICOs). Use Parent Announcements or other broad NIH opportunities to submit investigator-initiated applications on a topic. While Highlighted Topics do not affect referral or review, some include dedicated funding.

See the Highlighted Topic FAQs NCI Grant Funding Opportunity Notices in the NIH Guide for Grants and Contracts NCI Policy Considerations All NIH ICOs follow a set of NIH-wide policies . These ICO-specific considerations build on those policies.

NCI General Funding Policies NCI Data Repository Requirements Additional Information by Funding Category Administrative Supplements In addition to our Administrative Supplements overview, consider the following NCI-specific information. Administrative Supplement Interest Areas: NCI prioritizes funding new, renewal and ongoing grants and cooperative agreements The institute has limited flexibility to support administrative supplements.

Given this prioritization, the number of successful administrative supplement applications will likely be low in any given year. Examples of unsolicited administrative supplement requests that NCI will generally consider are replacement of critical lab equipment and resources. Administrative Supplement Due Dates: NCI will accept and consider administrative supplement requests at any time through July 31.

Requests received after July 31 will not be considered for funding. Administrative Supplement Contact: The NCI Program Official for the parent award Grants Management Contact Office of Grants Administration Email: [email protected] In addition to our Conferences and Meetings overview, consider the following NCI-specific information.

Conferences and Meetings Interest Areas: Conferences and meetings may address any area of cancer research, including cancer biology, prevention, diagnosis, treatment, and cancer control. Appropriate topics include basic, translational, clinical, population-based, interdisciplinary, and emerging research that advances understanding of cancer etiology, progression, detection, survivorship, treatment and outcomes.

Meetings may focus on presenting, developing, disseminating, or critically evaluating scientific knowledge; integrating emerging technologies, methods, or clinically relevant models; or advancing collaborative, multidisciplinary research. Topics may also address health drivers, implementation science, data and AI-driven research, workforce development, and HIV-associated cancers when directly relevant to cancer research.

Applications not aligned with cancer research objectives are not responsive. Applicants are encouraged to contact NCI ( [email protected] ) at least six weeks prior to submission for guidance. Conferences and Meetings Budget Considerations: NCI has limited discretionary funds to support conferences and meetings that advance its mission to drive progress in cancer research.

Budgets must be well justified and aligned with the meeting’s scope, scale, and expected impact. Awards depend on fiscal constraints and program priorities. Applicants should contact NCI ( [email protected] ) at least six weeks before submission for guidance.

Conferences and Meetings Key Date Considerations: Consistent with the associated R13/U13 NOFO and NIH policy, NCI will not issue a conference grant award unless the Federal award date precedes the conference start date. Conferences and Meetings Project Period Considerations: NCI typically considers applications requesting one year of support.

Applicants seeking up to five years in a single application should consult with NCI ( [email protected] ) at least six weeks before submission. The associated R13/U13 NOFO requires additional details for each proposed future year to inform peer review.

Conferences and Meetings Contacts: Scientific Program Contact: Grants Management Contact: Office of Grants Administration Individual Career Development In addition to our Individual Career Development , consider the following NCI-specific information.

Individual Career Development Interest Areas: The National Cancer Institute (NCI) supports individual career development awards in all areas of cancer research, including but not limited to cancer prevention, control, behavioral sciences, population sciences, fundamental cancer biology, and translational research.

In addition to requirements outlined in the NOFOs, NCI will consider applications and awards from: K01 and K08 candidates who have not already been promoted to Associate Professor or an equivalent position at the time of the award.

K08 candidates with an active U.S. clinical license for the duration of the award and can provide a copy of active U.S. licensure, surgical training (if applicable) and relevant information K01 Mentored Research Scientist Development Award – NCI will prioritize funding consideration for: early career-stage cancer researchers, including postdoctoral scholars and non-tenured junior faculty (e.g., Assistant Professor or equivalent) research in the areas of cancer control and population sciences, molecular cancer prevention and cancer data science K08 Mentored Clinical Scientist Career Development Award – NCI supports all areas of cancer research, including patient-oriented research.

Individual Career Development Salary Fringe Benefits: NCI will provide salary support up to the limit that is specified below plus fringe benefits: K08: up to the NIH salary cap per year K32: up to $80,000 per year K01, K25, K99: up to $100,000 per year The requested salary must be consistent with a) the established salary structure at the institution and b) with salaries provided by the institution from its own funds to other staff members with equivalent qualifications, rank, and responsibilities in the department concerned.

Individual Career Development Other Program Related Expenses: NCI will provide research development support up to the limit that is specified below: K32 and Phased individual career development awards (K99/R00): Up to $30,000 per year for the K99 phase All other individual career development awards (K01, K08, K25): Up to $50,000 per year Individual Career Development Research Effort Considerations: NCI candidates must commit a minimum of 9 person months (75%) full-time professional effort for all individual career development awards.

K08: For U.S. licensed surgeon-scientists with active surgical duties, a minimum of 6 person months (50%) full-time professional effort must be devoted to research and career development activities: NOT-CA-21-054 .

Individual Career Development Contacts: NCI K01 Program Director(s) NCI K08 Program Director(s) NCI K25 Program Director(s) NCI K32 Program Director(s) NCI K99/R00 Program Director(s) NCI Early K99/R00 Program Director(s) In addition to our Individual Fellowships Overview, consider the following NCI-specific information.

Individual Fellowships Interest Areas: The National Cancer Institute (NCI) supports fellowships in all areas of cancer research, including cancer prevention, control, behavioral sciences, population sciences, and translational research. NCI supports funding for topics with a clear cancer focus in the research training plan.

For the F99/K00, NCI will support applications in which the proposed postdoctoral research project (K00 phase) is cancer-focused, while the dissertation research project conducted during the F99 phase may be in any area of biomedical research.

Individual Fellowships Key Date Considerations: F99/K00: K00 applications must be submitted directly to the assigned F99 Program Director six (6) months prior to the proposed activation date of the K00 award. This will also ensure the transition to the K00 postdoctoral phase takes place without interruption in funding. K00 applications may only be submitted by PIs with an F99 award.

Individual Fellowships Project Period Considerations: NCI may limit project periods for specific education activities, as follows: F99/K00 : K00 project period is three (3) years with the possibility to request adding a fourth year with strong justification for an additional year of training. These requests will be evaluated by program on a case-by-case basis.

Individual Fellowships Budget Considerations: In addition to current NRSA stipends, tuition/fees, and other budgetary levels, NCI may apply the following limits to applicable awards: Travel to mandatory NCI annual meeting during F99 (year 1) and following transition to K00 award (year 1): $1,500 Salary: up to $80,000/year with budget justification.

Salary support must be commensurate with the base salary that would have been paid by the institution with which the individual is affiliated with when the award is issued. Research and career development: $30,000/year NCI gives funding priority to applications that: Indicate funds are available to support the candidate’s research training plan throughout the duration of the award.

The proposed scientific research question or approach is distinct from the mentor’s pending or active grants, and there is no substantial text duplication of the mentor’s specific aims.

Individual Fellowships Contacts: NCI F30 Program Director(s) Email: [email protected] NCI F31 Program Director(s) NCI F99/K00 Program Director(s) Email: [email protected] Institutional Career Development and Other Training In addition to our Institutional Career Development and Other Training , consider the following NCI-specific information.

Institutional Career Development and Other Training Interest Areas: NCI supports institutional career development programs (K12) that prepare clinician-scientists for independent cancer research careers. NCI encourages applications that propose creative transdisciplinary and innovative institutional research career development programs in the mission area(s) of NCI.

Programs may include, but are not limited to: Community oncology and cancer prevention, screening, treatment, and control research Cancer care delivery and implementation science Integration of cancer health disparities research across clinical trials and population-based studies Transdisciplinary approaches spanning fundamental, prevention, treatment, and survivorship research Clinical and translational research incorporating innovative patient engagement strategies Institutional Career Development and Other Training Contacts: Paul Calabresi K12 Program Director(s) Worta McCaskill-Stevens K12 Program Director(s) In addition to our Institutional Training , consider the following NCI-specific information.

Institutional Training Interest Areas: T32 : NCI supports institutions to develop and enhance extensive research training opportunities for pre- and post-doctoral fellows to be trained in all areas of cancer research.

Research training programs are expected to be unique, innovative, rigorous, and incorporate engaging, didactic, research, and career development elements to prepare trainees for careers that will have a significant impact on the cancer research needs of the Nation. Institutional Training Participants: NCI prioritizes funding for the following trainees: T32 : Training program may support up to 6 trainee slots per year.

Institutional Training Budget Considerations: T32 : Funds that may be requested annually to defray travel costs: $800 per predoc; $1,000 per postdoc Institutional Training Contacts: NCI T32 Program Director(s) Investigator-Focused Awards In addition to our Investigator-Focused Awards , overview, consider the following NCI-specific information.

Investigator-Focused Awards Interest Areas: NCI participates in the following programs: NIH Director’s Pioneer Award (DP1): NCI administers and funds DP1 applications submitted in response to funding announcements released by the Common Fund High-Risk, High-Reward Program . NCI prioritizes funding for meritorious DP1 applications which are responsive to the NCI mission.

NIH Director’s New Innovator Awards (DP2): NCI administers and funds DP2 applications submitted in response to funding announcements released by the Common Fund High-Risk, High-Reward Program . NCI prioritizes funding for meritorious DP2 applications which are responsive to the NCI mission.

Investigator-Focused Award (R35): NCI uses the R35 award to support the majority of an investigator's independent cancer research program rather than individual research projects. The award is intended for investigators whose record of creativity and productivity commensurate with their career stage, demonstrates that they will benefit from sustained, flexible support.

Of particular interest are investigator laboratories that focus on: Cancer Biology : Research that advances foundational understanding of cancer and provides new insights into cancer prevention, detection, diagnosis, and treatment. Cancer Prevention : Research to identify factors that cause cancer in humans and to develop risk-reduction strategies and preventive interventions.

Cancer Screening and Early Detection Research: Research to improve early detection and enhance cancer screening. Cancer Treatment, Diagnosis and Prognosis : Research to advance cancer treatment and disease control, as well as improve diagnosis, prognosis, screening, and early detection.

Cancer Control, Population Sciences, Survivorship, and Outcomes Research : Research to reduce cancer burden and improve quality of life for cancer survivors through effective methodology, interventions, and dissemination on a population-wide scale. Highlighted Topics : Research in scientific areas with NCI participation.

Investigator Effort Considerations: Investigator-Focused Award (R35) Applicants are expected to devote at least 6 months of calendar effort per year for the award (i.e., the equivalent of 50% effort for a 12-month appointment).

Applicants are allowed to be Co-Investigators and receive funding on NCI Specialized Center (P50) and Specialized Center-Cooperative Agreements (U54) awards provided they have the level of effort required available. Recipients are allowed to apply to and hold awards from NCI NOFOs that specify R35 awardees and applicants are eligible to apply. Funding applications over $750,000 in Direct Costs per year.

Investigator-Focused Awards Contacts: Office of Grants Administration In addition to our Research Education overview, consider the following NCI-specific information. Research Education Interest Areas: The National Cancer Institute (NCI) supports research education in all areas of cancer research, including cancer prevention, control, behavioral sciences, population sciences, and translational research.

The NCI provides support for educational activities that complement and/or enhance the training of a cancer research workforce to meet the nation’s biomedical, behavioral and clinical research needs.

Funding consideration is given to application that propose innovative, state-of-the-art programs that explore cancer mechanisms, address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

The NCI encourages entrepreneurial education programs that equip graduate students and postdoctoral researchers with the skills needed to pursue careers in commercializing cancer-relevant technologies. In the notice of funding opportunity for the Courses for Skills Development and Curriculum or Methods Development, NCI will prioritize funding of applications that are focused on Courses for Skills Development.

In the notice of funding opportunity for Mentoring Activities & Networks, NCI will prioritize funding applications that are focused on preparing postdoctoral scholars for scientific research careers and applications focused on preparing early career faculty for establishing and running an academic research lab.

The NCI Youth Enjoy Science program supports multi-component applications with educational activities such as research experiences, curriculum or methods development, and outreach. These programs should inspire middle school, high school, and undergraduate students to pursue biomedical cancer research, outline career paths across the cancer continuum, and strengthen research skills.

Research experiences can also include middle and high school teachers and undergraduate faculty.

Research Education Participants: NCI prioritizes funding for participants in the following areas: Other Healthcare providers and allied health professionals; Middle school and high school students and teachers (NCI Youth Enjoy Science program) Research Education Budget Considerations: NCI may limit budgets for specific education activities, as follows: Courses for Skills Development: $300,000 Curriculum or Methods Development: $150,000 Research Experiences: $300,000 Mentoring Activities & Networks: $300,000 Youth Enjoy Science program : $400,000 Research Education Personnel, Participant, and Other Program-Related Costs: NCI may limit awarded budgets for personnel, participant, and other costs, as follows: Courses for Skills Development and Mentoring Activities & Networks Up to $150,000 Direct Costs/Year, Including Consultants Up to 3 Calendar Months for Total PD/PI(s) Effort Course-Related Expenses: Up to $500 Housing and Per Diem: Up to $300 per day of the course Round-Trip Travel to/from R25 Course Site, as needed Other program-related expenses: Travel, Equipment, Supplies, Consultants (subject to personnel budget cap), etc. Curriculum or Methods Development Personnel costs: As Appropriate Participant costs: Not Applicable Other program-related expenses: Travel, Equipment, Supplies, Consultants, etc. Personnel costs: Based on Number of Participants (N): Up to ($4,500 x N) Direct Costs/Year, Including Consultants Subsistence: Up to $15/Hour or $9,000 for 15 Weeks Full-time Research Education-Related Expenses: Up to $1,000 Housing Allowance: Up to $1,000 Round-Trip Travel to/from R25 Course Site, as needed Other program-related expenses: Travel, Equipment, Supplies, Consultants, (subject to personnel budget cap), etc. Youth Enjoy Science program Personnel Costs: Up to $4,500 (Direct Costs) is allowed for personnel (including consultants) Participant Costs: Allowable participant costs depend on the educational level/career status of the individuals to be selected to participate in the program.

Other program-related expenses: Up to $1,500 per participant per year is allowed for research education-related expenses, such as lab supplies, poster production costs, books, registration and travel to attend and present research at a professional meeting. Housing allowance: up to $1,000 per participant.

Research Education Funding Instruments: NCI awards Research Education Cooperative Agreements (UE5) NCI awards Research Education Grant Projects (R25) Research Education Contacts: NCI R25 Program Director(s) Email: [email protected] NCI Youth Enjoy Science Program Director(s) In addition to our Small Business overview, consider the following NCI-specific information.

Small Business Interest Areas: NCI supports the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs across the United States to develop innovative technologies to reduce or eliminate the burden of cancer.

Technical areas of interest include, but are not limited to, novel therapeutics, medical devices for cancer treatment (including radiation therapy), in vitro and in vivo diagnostics, cancer imaging technologies, cancer research tools, cancer prevention, and digital health technologies.

Priority is given to projects that have a clear commercial product focus, address significant unmet medical needs, and have a well thought out pathway to commercialization. Priority is given to technologies exploiting novel targets, novel mechanisms of action, and precision medicine-based approaches. Supporting companies and teams new to SBIR and STTR funding is also of interest.

For the Commercialization Readiness Pilot (CRP) Program, the NCI will prioritize applications from companies that can accomplish significant commercial milestones through a CRP award, for example completing a clinical trial, and that demonstrate strong commercial readiness.

Evidence of commercial readiness may include, but is not limited to, raised funds from third party investors, formed strategic partnerships with established commercial players, completed some meetings with FDA, and awarded intellectual property patents. For the Strategic Breakthrough program, the NCI is focused on supporting late-stage clinical trials of drugs and devices for rare and pediatric cancers.

Projects should demonstrate a clear regulatory path, strong scientific rationale, matching funds, and potential to improve survival in areas of unmet need where standard of care has not advanced. This initiative is designed to incentivize private-sector investment in rare and pediatric cancer by partnering with the NCI. Applications for non-pediatric or non-rare adult cancer indications will not be considered.

Approved Topics for Awards Over Statutory Budget Guidelines: A. Therapeutics (e.g., Small Molecules, Biologics, Radiomodulators, Gene/Cell-based Therapies and Drug Development-Related Tools, and Algorithm Development) B. In Vitro and In Vivo Diagnostics (e.g., Companion Diagnostics, Prognostic Technologies, Treatment Monitoring and Diagnostic-Related Tools, and Algorithm Development) C.

Imaging Technologies (e.g., Agents, Devices, Software Tools, Algorithm Development, and Image-Guided Interventions) D. Devices for Cancer Therapy (e.g., Interventional Devices, Drug Delivery Devices, Software Tools, Algorithm Development, Surgical, Radiation, and Ablative Therapies) E. Agents for Cancer Prevention (e.g., Vaccines, but not “Technologies for Cancer Prevention”) F.

Development of Low-Cost Technologies for Low-Resource Settings G.

Development of Digital Health Tools Phase IIB & Commercialization Readiness Pilot (CRP): NCI accepts Phase IIB SBIR projects NCI accepts Commercialization Readiness Pilot (CRP) projects NCI accepts clinical trials through the SBIR programs NCI accepts clinical trials through the STTR programs NCI accepts clinical trials through the Phase IIB SBIR program NCI accepts clinical trials through the Commercialization Readiness Pilot (CRP) Commercialization Readiness Pilot (CRP) Program: NCI generally supports CRP projects that include clinical trials, clinical validation studies, or other later-stage commercialization-focused research and development activities up to the SBA guideline maximum of $4,191,495.

NCI generally supports up to $500,000 of technical assistance activities in CRP projects.

Project Period Considerations: Generally, NCI supports Phase I projects of 1 or 2 years Generally, NCI supports Phase II projects of 2 or 3 years Generally, NCI supports CRP projects of 2 or 3 years Generally, NCI supports Phase IIB Strategic Breakthrough projects of 4 years NCI SBIR Development Center National Cancer Institute (NCI) Just getting started and want to discuss your research idea?

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