National Cancer Institute Youth Enjoy Science Research Education Program (R25 Clinical Trial Not Allowed)

The National Cancer Institute Youth Enjoy Science (YES) Research Education Program (R25) is a grant from the National Institutes of Health that funds educational programs engaging students from underrepresented and health disparity populations in cancer research careers. Eligible applicants include nonprofits with 501(c)(3) status, Native American tribal organizations, and state, county, and local governments.

Programs should provide exposure to biomedical research, mentoring, and cancer biology education for youth. The application deadline is September 28, 2026, and awards vary based on project scope and activities.

RFA-CA-24-026: National Cancer Institute Youth Enjoy Science Research Education Program (R25 Clinical Trial Not Allowed) This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Cancer Institute ( NCI ) Funding Opportunity Title National Cancer Institute Youth Enjoy Science Research Education Program (R25 Clinical Trial Not Allowed) March 31, 2025 - This funding opportunity was updated to align with agency priorities.

Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 July 11, 2024 - Notice of Correction to RFA-CA-24-026, National Cancer Institute Youth Enjoy Science Research Education Program (R25 Clinical Trial Not Allowed).

See Notice NOT-CA-24-080 August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198 . August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy.

See Notice NOT-OD-22-189 . July 22, 2019 - Requirement for ORCID iDs for Individuals Supported by Research Training, Fellowship, Research Education, and Career Development Awards Beginning in FY 2020. See Notice NOT-OD-19-109 .

Funding Opportunity Number (FON) Companion Funding Opportunity See Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) Funding Opportunity Purpose The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.

The overarching goal of this R25 program is to encourage individuals who have not had substantial biomedical research experience, or who have the potential to significantly benefit from additional biomedical research experience to pursue further studies or careers in research.

To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on: Curriculum or Methods Development The NCI’s mission is to conduct and support research, training, health information dissemination, and other programs concerning cancer.

This funding opportunity seeks to facilitate educational activities that encourage students to become knowledgeable about cancer and available to focus on cancer later in their careers.

To promote broad interest in pursuing a career in biomedical research via early intervention strategies, the NCI Youth Enjoy Science (YES) Program will support efforts to create and maintain an institutional program to engage grades 6-12 and/or undergraduate students in cutting edge cancer research experiences.

The proposed institutional programs may also provide research experiences for the grade 6-12 teachers and undergraduate faculty members. The goals are to inspire interest in biomedical sciences, help envision research as a career path, and strengthen practical research and career skills.

In alignment with these goals, institutions may develop unique programs that capitalize on their research strengths and are responsive to their target populations. Open Date (Earliest Submission Date) Letter of Intent Due Date(s) Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. No late applications will be accepted for this Notice of Funding Opportunity (NOFO).

Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Workspace to prepare and submit your application and eRA Commons to track your application. Part 1.

Overview Information Part 2. Full Text of Announcement Section I. Funding Opportunity Description Section II.

Award Information Other Award Budget Information Section III. Eligibility Information Section IV. Application and Submission Information Section V.

Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII.

Other Information Part 2. Full Text of Announcement Section I. Funding Opportunity Description The NIH Research Education Program (R25) supports research educational activities that complement other formal training programs in the mission areas of the NIH Institutes and Centers.

The overarching goal of this R25 program is to encourage individuals who have not had substantial biomedical research experience, or who have the potential to significantly benefit from additional biomedical research experience to pursue further studies or careers in research.

The NIH Research Education Program (R25) supports research educational activities that complement other formal training programs in the mission areas of the NIH Institutes and Centers.

To accomplish the stated over-arching goal, this NOFO will support creative educational activities with a primary focus on: Research Experiences: The NCI Youth Enjoy Science (YES) Program supports efforts to create and maintain programs to engage grades 6-12 and/or undergraduate students in cancer research experiences.

Grades 9-12 and undergraduate students, teachers, and faculty members are expected to gain research experience in individually mentored cancer research environments. In addition to participating in individual research projects, students are expected to enhance relevant research and career skills and participate in peer networking and interactions.

Curriculum or Methods Development: For programs that support grades 6-12 teachers and undergraduate faculty, these participants are expected to use their Research Experiences to develop and take back to their classrooms novel instructional approaches that improve science teaching.

For programs that support students only, applicants are expected to develop educational tools to enhance their research experiences and academic and career advancement.

Outreach: Proposed programs are expected to include activities that enhance general science/health education or disseminate biomedical, behavioral, and clinical research findings to particular population groups, health practitioners, or the public, not necessarily in preparation for careers in science.

Outreach activities should help the participants better understand the significance and impact of the Research Experiences and the YES program. Grade 6-8 students are expected to be exposed to various aspects of cancer research in an organized manner that will inspire continued interest and motivation to progress academically and scientifically.

Programs that support grades 6-12 students are expected to include activities that meaningfully engage and help educate their families and communities on the importance of science education so that the students may carry out the Research Experiences in supportive environments. A multifaceted approach is needed to engage students at the earliest levels of schooling to overcome persistent barriers to retention in the biomedical sciences.

NCI supports cancer researchers throughout their careers, from middle school to graduate school, postgraduate training, and independent researcher status. NCI funds training grants, fellowships, research career development awards, and education research grants for students and scientists at all career levels. ( National Cancer Plan, 2023; AACR Cancer Disparities Progress Report 2024 | Cancer Progress Report ).

Every facet of the United States scientific research enterprise, from basic, clinical, and translational research to policy formation, requires superior intellect, creativity, and a wide range of skill sets and viewpoints. NIH’s ability to help ensure that the nation remains a global leader in scientific discovery and innovation depends upon a pool of highly talented scientists who will help further NIH's mission.

This NCI YES program supports early intervention strategies that actively engage students as early as middle school years in cancer research experiences to improve recruitment and retention of students in biomedical research. Applicants are expected to develop holistic approaches that have a sustained impact on student retention in the biomedical research career.

While matriculation through the academic levels is a requisite milestone for students' progress, other predictors of success in terms of interest and retention in research careers should also be considered and addressed. Applicants should consider the substantial literature that addresses these factors and design their approaches with these in mind.

Applications that engage in interdisciplinary approaches to cancer and cancer health disparities research are encouraged. Applications that enhance collaborative efforts within the YES community are also encouraged. Tracking student participants for at least 15 years is strongly encouraged.

Within seven years of making awards under this program, NCI will assess the program's overall outcomes, gauge its effectiveness in meeting the program goals, and consider whether there is a continuing need for the program. Upon the completion of this evaluation, NCI will determine whether to (a) continue the program as currently configured, (b) continue the program with modifications, or (c) discontinue the program.

Non-Responsive Applications: Applications with one or more of the characteristics listed below will be considered non-responsive and will not be reviewed: Proposed research experiences are not cancer-focused. Proposed research education program does not have all three required components of Research Experiences, Curriculum or Methods Development, and Outreach.

Research education programs may complement ongoing research training and education occurring at the applicant institution, but the proposed educational experiences must be distinct from those training and education programs currently receiving Federal support. R25 programs may augment institutional research training programs (e.g., T32, T90) but cannot be used to replace or circumvent Ruth L.

Kirschstein National Research Service Award (NRSA) programs. See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed Renewal of applications submitted in response to PAR-17-059 The OER Glossary and the How to Apply - Application Guide provide details on these application types.

Only those application types listed here are allowed for this NOFO. Not Allowed: Only accepting applications that do not propose clinical trial(s). Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. The maximum budget is $400,000 in direct costs/year. The budget request for a given application needs to be adequately justified and reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period. The maximum project period is 5 years. Other Award Budget Information Individuals designing, directing, and implementing the research education program may request salary and fringe benefits appropriate for the person months devoted to the program.

Salaries requested may not exceed the levels commensurate with the institution's policy for similar positions and may not exceed the congressionally mandated cap. (If mentoring interactions and other activities with participants are considered a regular part of an individual's academic duties, then any costs associated with the mentoring and other interactions with participants are not allowable costs from grant funds).

Total allowable personnel (including consultants) cost is proportional to the number of participants in the program. For each participant, up to $4,500 (Direct Costs) is allowed for personnel (including consultant) costs per year. All personnel and consultant costs must be adequately justified and take into consideration yearly fluctuations in required effort.

Participants may be compensated for participation in activities specifically required by the proposed research education program, if sufficiently justified. Participant costs must be itemized in the proposed budget. Allowable participant costs depend on the educational level/career status of the individuals to be selected to participate in the program.

While generally not an allowable cost, with strong justification, participants in the research education program may receive per diem unless such costs are furnished as part of the registration fee. Participants may also receive funds to defray partial tuition and other education-related expenses. Expenses for foreign travel must be exceptionally well justified.

Individuals supported by NIH training and career development mechanisms (K, T, or F awards) may receive, and indeed are encouraged to receive, educational experiences supported by an R25 program, as participants, but may not receive salary or stipend supplementation from a research education program.

Because the R25 program is not intended as a substitute for an NRSA institutional training program (e.g.,T32), costs to support full-time participants (supported for 40 hours/week for a continuous, 12-month period) are not allowable. Other Program-Related Expenses Consultant costs, equipment, supplies, travel for key persons, and other program-related expenses may be included in the proposed budget.

These expenses must be justified as specifically required by the proposed program and must not duplicate items generally available at the applicant institution.

Up to $1,500 per participant per year is allowed for research education-related expenses, such as lab supplies, poster production costs, books, registration and travel to attend and present research at a professional meeting, etc. A housing allowance can be requested by the program each year. The average cost for the housing allowance may not exceed $1,000 per participant.

Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs (exclusive of tuition and fees, expenditures for equipment and consortium costs in excess of $25,000), rather than on the basis of a negotiated rate agreement. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO. Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations The sponsoring institution must assure support for the proposed program.

Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program. Institutions with existing Ruth L.

Kirschstein National Research Service Award (NRSA) institutional training grants (e.g., T32) or other Federally funded training programs may apply for a research education grant provided that the proposed educational experiences are distinct from those training programs receiving federal support.

In many cases, it is anticipated that the proposed research education program will complement ongoing research training occurring at the applicant institution. Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are not allowed.

Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.

Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2. 3. 9.

2 Electronically Submitted Applications for additional information. System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) – A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide .

The PD/PI should be an established investigator in the scientific area in which the application is targeted and capable of providing both administrative and scientific leadership to the development and implementation of the proposed program. The PD/PI will be expected to monitor and assess the program and submit all documents and reports as required.

PD(s)/PI(s) with a currently funded NCI R25 award may submit an additional application to this NOFO only if new and innovative research experiences that are distinctly different from their currently funded project are proposed. This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1. 2 Definition of Terms .

3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review. ( see NIH Grants Policy Statement 2. 3.

9. 4 Similar, Essentially Identical, or Identical Applications ) Mentors should have research expertise and experience relevant to the proposed program. Mentors must be committed to continue their involvement throughout the total period of the mentee’s participation in this award.

The 6-12 grade and undergraduate students must be currently enrolled and in good standing at their respective middle or high school or undergraduate institutions. Teachers and faculty members must be currently employed at their respective schools or institutions and engaged in the teaching of the sciences.

Student, teacher and faculty participants must be citizens or non-citizen nationals of the United States or individuals who have been lawfully admitted for permanent residence in the United States (i.e., in possession of a Permanent Resident Card, Form I-551). Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.

gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed in this Notice of Funding Opportunity to do otherwise. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions will not be reviewed. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review. By the date listed in Part 1.

Overview Information, prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed activity Name(s), address(es), and telephone number(s) of the PD(s)/PI(s) Names of other key personnel Participating institution(s) Number and title of this funding opportunity The letter of intent should be sent to: National Cancer Institute (NCI) All page limitations described in the How to Apply - Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission The following section supplements the instructions found in the How to Apply - Application Guide and should be used for preparing an application to this NOFO. Follow all instructions provided in the How to Apply - Application Guide . SF424(R&R) Project/Performance Site Locations Follow all instructions provided in the How to Apply - Application Guide .

SF424(R&R) Other Project Information Component Follow all instructions provided in the How to Apply - Application Guide with the following additional modifications: Facilities & Other Resources. Describe the educational environment, including the facilities, laboratories, participating departments, computer services, and any other resources to be used in the development and implementation of the proposed program.

List all thematically related sources of support for research training and education following the format for Current and Pending Support. Appropriate institutional commitment should include the provision of adequate staff, facilities, and educational resources that can contribute to the planned research education program. An Advisory Committee is a required component of an YES Research Education program.

Provide a plan for the appointment of an Advisory Committee to monitor progress of the research education program. The composition, roles, responsibilities, and desired expertise of committee members, frequency of committee meetings, and other relevant information should be included. Describe how the Advisory Committee will evaluate the overall effectiveness of the program.

Proposed Advisory Committee members should be named in the application if they have been invited to participate at the time the application is submitted. Renewal applications with Advisory Committees should include the names of all committee members during the past project period. Please name your file “Advisory_Committee.

pdf”. The filename provided for each “Other Attachment” will be the name used for the bookmark in the electronic application in eRA Commons. SF424(R&R) Senior/Key Person Profile Expanded Follow all instructions provided in the How to Apply - Application Guide .

List Program Faculty whose role is to develop, implement, direct, monitor, mentor, evaluate, consult, etc., in the proposed program as Key Personnel. Follow all instructions provided in the How to Apply - Application Guide with the following additional modifications: Include all personnel other than the PD(s)/PI(s) in the Other Personnel section, including clerical and administrative staff.

Use the section on Participant/Trainee Support Costs to include all allowable categories of funds requested to support participants in the program. PHS 398 Cover Page Supplement Follow all instructions provided in the How to Apply - Application Guide .

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: The Research Strategy section must be used to upload the Research Education Program Plan, which must include the following components described below: Proposed Research Education Program Program Director/Principal Investigator Institutional Environment and Commitment Plan for Instruction in the Responsible Conduct of Research Research Education Program Plan Proposed Research Education Program.

While the proposed research education program may complement ongoing research training and education occurring at the applicant institution, the proposed educational experiences must be distinct from those research training and research education programs currently receiving federal support.

When research training programs are on-going in the same department, the applicant organization should clearly distinguish between the activities in the proposed research education program and the research training supported by the training program. As a reminder, applicants may choose to address one or more of the activities listed in Section I. Funding Opportunity Description.

Applicants are expected to develop holistic approaches that have sustained impact in student retention in the biomedical research pipeline. Clearly state the goals and objectives of the proposed program and how they advance the mission of the NCI. Provide the underlying rationale and evidence supporting the need for the program.

Clearly articulate the integration of the Research Experiences, Curriculum or Methods Development, and Outreach activities. Applications must include detailed plans of student recruitment and mentor matching. Applications in support of rising tenth grade students and above must include plans for assigning an individual, academic-level appropriate, mentored research project for each participant.

In addition, applications may include, but are not limited to, plans for orientation, education that enhances participants' research skills, and peer interactions and networking opportunities. Applications in support of Grades 6-12 students must include plans to meaningfully engage the teachers, families and communities.

All applications are encouraged to include plans for tracking of participating students for up to at least fifteen years after completion of the program, as well as plans for evaluation of the impact of the program, including the benchmarks to be used to assess program success. Applications are encouraged to include plans for collaboration within the YES community.

Consider potential problems that may be encountered and describe alternative strategies that could be employed. Program Director/Principal Investigator. Describe arrangements for administration of the program.

Provide evidence that the Program Director/Principal Investigator is actively engaged in research and/or teaching in an area related to the mission of NIH, and can organize, administer, monitor, and evaluate the research education program. For programs proposing multiple PDs/PIs, describe the complementary and integrated expertise of the PDs/PIs, their leadership approach, and governance appropriate for the planned project.

Provide evidence that an appropriate level of effort will be devoted by the program leadership to ensure the program's intended goal is accomplished Program Faculty. Faculty and mentors should have research expertise and experience relevant to the proposed program and demonstrate a history of, or the potential for, their intended roles.

List the Program Faculty whose role is to develop, implement, direct, monitor, mentor, evaluate, consult, etc., in the proposed research experiences program as Key Personnel and provide their biographical sketches. Describe the experience of the participating faculty in teaching and mentoring, as well as their ability to serve as good role models for the participants by virtue of their own scientific accomplishments.

Program Participants. Applications must describe the intended participants, and the eligibility criteria and/or specific educational background characteristics that are essential for participation in the proposed research education program. Identify the career levels for which the proposed program is planned.

Provide details about the pool of expected participants in the research experiences program and the sources of the applicant pool. Provide the criteria and strategy as to how the participants will be selected. Please note that consistent with NIH practice and applicable law, funded programs may not use the race, ethnicity, or sex of prospective program participants or faculty as an eligibility or selection criteria.

The race, ethnicity, or sex of candidates will not be considered by NIH in the application review process or when making funding decisions. Institutional Environment and Commitment. Describe the institutional environment, reiterating the availability of facilities and educational resources (described separately under “Facilities & Other Resources”), that can contribute to the planned Research Education Program.

Evidence of institutional commitment to the research educational program is required. A letter of institutional commitment must be attached as part of Letters of Support (see below). Appropriate institutional commitment should include the provision of adequate staff, facilities, and educational resources that can contribute to the planned research education program.

Where appropriate, describe any unique features of the scientific environment, subject populations, or collaborative arrangements that may be leveraged to the advantage of the proposed program. If multiple sites are participating, describe how this will enhance the quality of the program, as well as how activities will be coordinated and effective communication maintained among the multiple sites.

Plan for Instruction in the Responsible Conduct of Research. All applications must include a plan to fulfill NIH requirements for instruction in the Responsible Conduct of Research (RCR).

The plan must address the five, required instructional components outlined in the NIH policy: 1) Format - the required format of instruction, i.e., face-to-face lectures, coursework, and/or real-time discussion groups (a plan with only on-line instruction is not acceptable); 2) Subject Matter - the breadth of subject matter, e.g., conflict of interest, authorship, data management, human subjects and animal use, laboratory safety, research misconduct, research ethics; 3) Faculty Participation - the role of the program faculty in the instruction; 4) Duration of Instruction - the number of contact hours of instruction, taking into consideration the duration of the program; and 5) Frequency of Instruction – instruction must occur during each career stage and at least once every four years.

See also NOT-OD-10-019 . The plan should be appropriate and reasonable for the nature and duration of the proposed program. Renewal (Type 2) applications must, in addition,