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Find similar grantsNational Institute of Standards and Technology (NIST) Small Business Innovation Research (SBIR) Program is sponsored by National Institute of Standards and Technology (NIST). NIST's SBIR program allocates funding to small businesses for research and development related to artificial intelligence, medical diagnostics, biotechnology, semiconductors, quantum, and other key technologies.
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Credit: metamorworks/Shutterstock GAITHERSBURG, Md. — The U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) is allocating funding totaling $3. 19 million to eight small businesses in seven states under the Small Business Innovation Research") (SBIR) program.
This funding will support research and development related to artificial intelligence, medical diagnostics, biotechnology, semiconductors, quantum and other key technologies. The winning projects were competitively selected in September 2025 following a call for innovative proposals that address technical needs related to NIST’s research areas.
These are Phase II SBIR awards, which fund research and development prototyping of innovative technologies proposed during Phase I. Phase II projects cover a period of 24 months from the date of the grant. After Phase II is complete, selected grantees will move to Phase III, which involves funding by non-SBIR sources.
## 2025 Phase II SBIR Grantees **AMAG Consulting LLC**(Schenectady, New York) — $400,000 _Scanning electron microscope simulation charging validation and improvements:_ AMAG sells SimuSEM, a software package that simulates how the electron beams in electron microscopes interact with materials. To improve its product, AMAG will add the ability to model charging effects and magnetic interactions.
This will allow the software to add magnetic field and surface roughness effects to its simulations, resulting in more accurate and useful images.
**Applied Imaging Solutions LLC** (Quincy, Massachusetts) — $400,000 _Online short-wave infrared hyperspectral imaging system with machine learning (SWIR-HSI/AI)_ _for measuring quality attributes in NISTmAb-producing NISTCHO cell cultures:_ This project will develop a new imaging system that uses short-wave infrared hyperspectral imaging and AI machine learning to monitor cell cultures used in the production of biopharmaceuticals.
By allowing contactless monitoring of cell viability, metabolite levels and other critical factors, this technology will enable more precise control of bioreactors. Developed using NISTCHO cell cultures, this project aims to advance the development of life-saving drugs while improving the efficiency and safety of biopharmaceutical manufacturing.
**Calimetrix LLC** (Madison, Wisconsin) — $399,998 _Quantitative phantom for multimodality magnetic resonance imaging and computed tomography measurements of steatotic tissue:_ Calimetrix will design and develop imaging test objects, called phantoms, that mimic human anatomy and are used to enhance the accuracy of medical imaging tests like MRI and CT scans.
These phantoms, which mimic the characteristics of fatty liver tissue, can facilitate medical research and help improve patient care by ensuring that scans taken at different times and using different vendor platforms can be meaningfully compared. **HighRI Optics Inc.** (Oakland, California) — $399,858.
96 _Binary pseudo-random array (BPRA) for the enhancement of optical images:_ HighRI Optics is developing a commercial imaging system equipped with a calibration standard and specialized data reconstruction software. This innovation aims to substantially enhance the resolution capabilities of virtually any imaging system, including those used in health care, scientific research, manufacturing and defense.
**Icarus Quantum Inc.** (Boulder, Colorado) — $400,000 _Noise-free excitation of semiconductor quantum dots:_ This project will develop a turnkey photon source based on semiconductor quantum dots technology. The platform, which is engineered for scalability in both fabrication and performance, can house multiple high-efficiency photon sources on a single chip.
As a plug-and-play solution, it will help researchers and developers integrate quantum interconnects into their systems, accelerating the development of quantum technologies. **MyExposome Inc.** (Philadelphia, Pennsylvania) — $395,814.
74 _Using silicone wristbands as personal monitors of PFAS exposures:_ Silicone wristbands are used as wearable monitoring devices that record a person’s exposure to environmental chemicals, including certain per- and polyfluoroalkyl substances (PFAS). This project proposes using wristbands combined with novel, solvent-free extraction methods to expand the spectrum of detectable PFAS.
Successful implementation of this project will support both research and consumer markets by providing a cost-effective tool for personal exposure monitoring. **ObjectSecurity LLC** (San Diego, California) — $399,908.
58 _Operational technology artificial intelligence_—_NIST Compliance Tool (OTAI-NCT):_ The OTAI-NCT tool evaluates the cybersecurity practices of hardware and software manufacturers to produce a cyber-hygiene score that consumers can use to make informed purchasing decisions.
The tool, which uses authoritative data sources such as the National Vulnerability Database (NVD), CISA’s Known Exploited Vulnerabilities Catalog and other publicly available datasets, will empower users while helping to safeguard national security and public safety.
**Universal Schedule and Booking LLC** (Harpers Ferry, West Virginia) — $400,000 _Phase II home-by-home residential building energy-load profile optimizations:_ Homeowners face rising energy costs due to surging electricity demand. Energy sensors, if widely installed, can be used to optimize energy use. However, the cost and skills needed to install them present a barrier to their widespread use.
This project addresses this challenge by developing a smart digital infrastructure that estimates energy consumption in homes without auxiliary hardware sensors. This will accelerate the adoption of new technologies, enabling a more efficient and resilient electricity grid that benefits U.S. manufacturers, businesses and homeowners.
According to the current listing, eligibility includes: U. S. small businesses meeting SBA size standards, with the principal investigator employed at least 51% by the applicant during the project. Confirm the full requirements in the official notice before applying.
The current listing shows phase I: Up to $100,000; Phase II: Up to $400,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
National Institute of Standards and Technology (NIST) Small Business Innovation Research (SBIR) Program is funded by National Institute of Standards and Technology (NIST). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Violence Against Women Discretionary Grants for Indian Tribal Governments is sponsored by Department of Justice. To increase tribal capacity to respond to violent crimes against Indian women, and to develop and strengthen victim services in cases involving violent crimes against Indian women. This listing is currently active. Program number: 16.587. Last updated on 2024-11-26.
The NSF CISE Future Computing Research (Future CoRe) program supports research in computing and communication foundations, intelligent systems, and network systems. The program funds innovative research that advances the frontiers of computing including artificial intelligence, machine learning, computer vision, natural language processing, and robotics. This is one of NSF's largest computing research programs with $280 million in total budget. Projects can address fundamental computing challenges, novel AI architectures, scalable intelligent systems, and next-generation network infrastructure.
NIST is pausing all submissions under the CRDO Broad Agency Announcement (2025-NIST-CHIPS-CRDO-01) on September 15, 2026 for system upgrades — no white papers, no pre-negotiation packages, no investment fund applications until roughly November. Here is what the pause means for a $10M-minimum rolling BAA that runs through 2029, and how to use the dark window.
Read articleThe FY2026 MEP Center State Competition ran in two rounds: eight states worth $139.1 million, then fourteen more worth $232.4 million, both closing August 21, 2026. That's 43 percent of the national network recompeted in twelve months, under a 50 percent non-federal cost share, while the administration's own budget request proposed eliminating the program. Here's what the award tables reveal, why incumbents are genuinely at risk, and how to position for the FY2027 wave.
Read articleNIST's July 2026 MEP funding opportunity opens 14 state and territory centers — from California's $15.6M to Alaska's $706K — to new operators under cooperative agreements requiring a 50% nonfederal match. Applications are due August 21, 2026, with a July 28 webinar. Here is who can compete, how the match works, and why this recompete matters for every small manufacturer in those 14 states.
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