Native American Research Centers for Health (NARCH)

Native American Research Centers for Health (NARCH) is sponsored by National Institute of Mental Health (NIMH). This program supports research activities relevant to Native American communities, which can include mental health.

PAR-23-166: Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional) This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Institute of General Medical Sciences ( NIGMS ) National Human Genome Research Institute ( NHGRI ) National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) National Institute of Allergy and Infectious Diseases ( NIAID ) August 20, 2024 - Participation added ( NOT-AI-24-073 ) National Institute of Arthritis and Musculoskeletal and Skin Diseases ( NIAMS ) Eunice Kennedy Shriver National Institute of Child Health and Human Development ( NICHD ) National Institute of Dental and Craniofacial Research ( NIDCR ) National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ) National Institute on Drug Abuse ( NIDA ) National Institute of Environmental Health Sciences ( NIEHS ) National Institute of Mental Health ( NIMH ) National Institute of Neurological Disorders and National Institute on Minority Health and Health Disparities ( NIMHD ) National Institute of Nursing Research ( NINR ) National Center for Complementary and Integrative Health ( NCCIH ) National Cancer Institute ( NCI ) National Heart, Lung, and Blood Institute ( NHLBI ) All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers.

The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Office of Research on Women's Health ( ORWH ) Office of Data Science Strategy ( ODSS ) Funding Opportunity Title Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional) S06 Research-Related Programs Notices of Special Interest associated with this funding opportunity January 28, 2026 - NIH Removing AIDS Application Due Dates from NOFOs.

See Notice NOT-OD-26-029 March 31, 2025 - This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

See Notice NOT-OD-24-084 August 20, 2024 - Notice of Participation of the National Institute of Allergy and Infectious Diseases (NIAID) in PAR-23-166, Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional). See Notice NOT-AI-24-073 June 4, 2024 - Clarification of Data Management and Sharing Plan Instructions in PAR-23-166 Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional).

See Notice NOT-GM-24-034 December 26, 2023 - Notice of NHLBI Participation in PAR-23-166 Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional). See Notice NOT-HL-23-126 November 28, 2023 - Native American Research Centers for Health (NARCH) Planning Grants (R34 - Clinical Trial Not Allowed).

See Announcement PAR-24-041 July 14, 2023 - Notice of NINR Participation in PAR-23-166, Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional) . See Notice NOT-NR-23-013 October 26, 2022 - Reminder: FORMS-H Grant Application Forms & Instructions Must be Used for Due Dates On or After January 25, 2023 - New Grant Application Instructions Now Available. See Notice NOT-OD-23-012 .

August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198 . August 8, 2022 - New NIH "FORMS-H" Grant Application Forms and Instructions Coming for Due Dates on or after January 25, 2023.

See Notice NOT-OD-22-195 . August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189 .

Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity See Section III. 3. Additional Information on Eligibility.

Assistance Listing Number(s) 93. 859, 93. 242, 93.

846, 93. 273, 93. 279, 93.

853, 93. 307, 93. 866, 93.

399, 93. 113, 93. 310, 93.

172, 93. 847, 93. 313, 93.

213, 93. 865, 93. 361, 93.

837, 93. 838, 93. 839, 93.

840, 93. 233, 93.

855 Funding Opportunity Purpose The purpose of the Native American Research Centers for Health (NARCH) program is to fund federally-recognized American Indian/Alaska Native (AI/AN) Tribes and Tribal colleges or universities, Tribal health programs, or Tribal organizations (collectively, federally-recognized Tribes and Tribal Entities) to support health-related research, research career enhancement, and research infrastructure enhancement activities.

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) Renewal / Resubmission / Revision (as allowed) All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the Multi-Project (M) Instructions in the SF424 (R&R) Application Guide , except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Part 1. Overview Information Part 2.

Full Text of Announcement Section I. Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Part 2.

Full Text of Announcement Section I. Funding Opportunity Description The NARCH program was launched in 2000 to promote Tribal health research prioritized and led by eligible federally-recognized Tribes and Tribal Entities, and ultimately to improve Tribal health. To enhance the program’s efficacy in meeting its goals, NIGMS completed a comprehensive NARCH program evaluation culminating in a formal Tribal Consultation in 2021.

Taking into account recommendations received through the Consultation, this Funding Opportunity Announcement (FOA) will strengthen NARCH’s support for health-related research, research career enhancement, and research infrastructure enhancement projects prioritized and led by eligible Tribal Entities.

A NARCH award supports health-related research, research career enhancement, and/or research infrastructure enhancement projects at one or more eligible Tribal Entities (See Part II. Section III. Eligibility Information.

An applicant organization must be one of the eligible Tribal Entities, and must be committed to supporting a NARCH and its goals. The applicant organizations should also have the research administrative infrastructure to manage the multiple-component grant.

An applicant organization (see Section III, Eligibility Information), may partner with other eligible federally-recognized Tribes and Tribal Entities as well as additional non-tribal organizations. In such cases, 60% or more of requested funds must remain with the eligible federally-recognized Tribes and Tribal Entities.

A NARCH supports an Administrative Core and one or more of the following components: Pilot Project Program (PPP) Career Enhancement Projects (CEPs) Research Infrastructure Enhancement Projects (RIEPs) Each proposed component must contribute toward the overall goals of the NARCH. Each proposed component should be led by an individual with relevant expertise and experience.

The PD(s)/PI(s) of the NARCH award may lead other proposed components in addition to the Administrative Core. Each proposed component will be reviewed on its own merit and may be selected for funding even if other components in the same application are not. Administrative Core (Required) : The Administrative Core (AC) manages the NARCH award and coordinates the Center’s activities.

Its responsibilities include, but are not limited to, managing the NARCH's budget, preparing and submitting accurate and timely program and financial reports, ensuring all activities supported by the award are compliant with federal regulations, organizing and coordinating Center-wide activities such as seminars and workshops for research and career development, and coordinating activities of the proposed components.

The AC is located within the applicant organization, led by a PD/PI, and supported by a staff needed to carry out the responsibilities. The AC should work closely with relevant components of the grantee organization, such as the Sponsored Programs Administration or Grants and Contracts Office, as well as those at any sub-contracting organizations, in order to carry out its functions.

Research Projects (RPs) : RPs support innovative and culturally appropriate health-related research prioritized by the applicant organization and partner organizations that are eligible federally-recognized Tribes and Tribal Entities, if applicable.

The research project(s) should focus on issues related to Tribal health including strengths and resiliency factors contributing to and conditions hindering Tribal health, mechanisms underlying diseases or conditions that are prevalent in federally-recognized Tribal communities, and/or the development, implementation, and evaluation of interventions that address health challenges faced by the Tribal communities.

The scope of a project should be appropriate for 5 years of funding concurrent with the NARCH award. The RP Leader (RPL) should have expertise in the subject area. If the research involves human subjects, gaps in the RPL’s scientific and regulatory knowledge relevant to the study must be adequately addressed through mentorship, collaboration, and training.

A NARCH may support up to three RPs. A RPL may not lead another RP or a pilot project supported by NARCH grants awarded to the same grantee organization simultaneously. Pilot Project Program (PPP) : A NARCH award may support a PPP to fund exploratory and/or preparatory research as Pilot Projects (PPs).

PPs should be limited in scope compared to RPs but with the potential to develop into RPs. Each PP may have up to two years of support and should be led by Early Stage Investigators (ESIs) or New Investigators as defined by NIH. The PPP Director (PPPD) should have experience in mentoring, health-related research, and knowledge in culturally appropriate research approaches.

The PPPD manages the solicitation and review of PP applications, and selection of meritorious projects for funding. The PPPD also assumes oversight responsibilities of funded PPs, including those with human subjects. A PP Leader (PPL) may not lead more than one PP nor a RP supported by NARCH grants awarded to the same grantee organization simultaneously.

The PPPD is ineligible to receive a PP from the NARCH. Career Enhancement Projects (CEPs) : A CEP supports culturally appropriate career development programs to enhance knowledge and research skills of current and/or next generation participating health researchers.

Participants of a CEP may be early career investigators, post-doctoral fellows, graduate students, undergraduate students, and/or high school students interested in Tribal health-related research. Proposed program activities may include, but are not limited to, research internships, workshops, and courses.

A CEP may support participants to attend career enhancement programs sponsored by organizations other than those supported by the NARCH award. A CEP Leader (CEPL) should be an investigator with experience in mentoring, career development, research, and knowledge of culturally appropriate research, mentoring and educational approaches. A NARCH can support up to two CEPs.

Research Infrastructure Enhancement Projects (RIEPs) : RIEP projects aim to address a specific research infrastructural need of the NARCH.

Examples of an RIEP can include, but are not limited to, support of technological or methodological cores that develop or strengthen technical capacity needed for health-related research at the applicant and partner organizations that are eligible Tribal Entities; research resources such as a bio- or data-repository; or research administration infrastructure such as Tribal Institutional Review Boards (IRBs).

An RIEP leader should have expertise in the appropriate area of scientific capacity building. A NARCH can support up to two RIEPs. While NIGMS leads this FOA and will manage the NARCH awards, NIH Institutes, Centers, and Offices (ICOs) participating in the FOA are committed to fund meritorious components that align with their research interests .

A description of the participating NIH ICO's areas of scientific interest for this FOA can be found at Research Interests of NIH Institutes, Centers, and Offices Participating in NARCH . See Section VIII. Other Information for award authorities and regulations.

Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. Section II. Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this FOA. Optional: Accepting applications that either propose or do not propose clinical trial(s).

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the number of meritorious applications. Application budgets must not exceed $1.

3 million in annual direct costs, excluding consortium facilities and administrative (F&A) costs. For Centers that include partner organizations that are not eligible Tribal Entities, the requested combined total direct costs of subcontracts to these organizations must be 40 percent or less of the application’s overall direct cost budget, excluding consortium F&A. The project period is limited to 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA. Section III. Eligibility Information The applicant organization must meet one of the following criteria: A federally-recognized AI/AN Tribe, as defined under 25 U.S.C.

1603(14); or A Tribal college or university, a Tribal health program, or a Tribal organization as defined under 25 U.S.C. 1603 (24), (25), and (26), respectively; or A consortium of two or more of those Tribal Entities. Specifically, an application may include foreign components only if one or more federally-recognized Tribes with ancestral catchment areas crossing the U.

S. border will participate in the proposed NARCH. Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed. Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

System for Award Management (SAM) Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

NATO Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM. gov registration process.

The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants. gov registration; all registrations must be in place by time of submission.

eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants. gov Applicants must have an active SAM registration in order to complete the Grants.

gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons.

If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide. The PD(s)/PI(s) of the NARCH award assumes overall scientific and administrative leadership of the Center, including oversight responsibilities of research activities involving human subjects.

The contact PD/PI must have a primary appointment with the applicant organization. For multi-PD/PI applications, a non-contact PD/PI's primary appointment may be with the applicant organization or a partner organization that is one of the eligible federally-recognized Tribes and Tribal Entities.

PDs/PIs employed at eligible Tribal Entities through special employment arrangements, such as inter-organizational personnel agreements among federally-recognized Tribes, are allowable. This FOA does not require cost sharing as defined in the NIH Grants Policy Statement . 3.

Additional Information on Eligibility The NIH will not accept duplicate or highly overlapping applications under review at the same time, per 2. 3. 7.

4 Submission of Resubmission Application . This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). An eligible federally-recognized Tribe or Tribal Entity that is not being supported by an active NARCH award may submit up to two applications in the same submission round, provided there are no overlapping components in the applications.

An applicant organization that plans to submit two applications should discuss these plans with NIGMS Scientific/Research Contact listed in Section VII. Agency Contacts .

An eligible federally-recognized Tribe or Tribal Entity that is being supported by an active NARCH award, either as a recipient organization or a partner organization, is eligible to submit one more application, either as an applicant or a partner organization, provided there are no overlapping components between the application and the active award .

An eligible federally-recognized Tribe or Tribal Entity that is currently supported by an active NARCH award (including No Cost Extension (NCE)) should discuss plans to submit a new application with the NIGMS Scientific/Research Contact listed in Section VII. Agency Contacts .

An eligible federally-recognized Tribe or Tribal Entity that is being supported by two active NARCH awards (including awards in a funded extension or in an NCE) either as a recipient organization and/or a partner organization, cannot receive a new NARCH award as the recipient/applicant organization or a partner organization.

If such an organization submits applications in anticipation of expiration of one or both of its current NARCH awards, a new award can only be made after a current one is terminated. Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this FOA. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions in the SF424 (R&R) Application Guide , except where instructed in this funding opportunity announcement to do otherwise and where instructions in the Application Guide are directly related to the Grants. gov downloadable forms currently used with most NIH opportunities.

Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed activity Name(s), address(es), and telephone number(s) of the PD(s)/PI(s) Names of other key personnel Participating organizations(s) Number and title of this funding opportunity The letter of intent should be sent to: National Institute of General Medical Sciences All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

Component Type for Submission Career Enhancement Projects Research Infrastructure Enhancement Projects Instructions for the Submission of Multi-Component Applications The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing a multi-component application.

The application must consist of the following components: At least one of the following components is also required. If more than one of these components is proposed, any combination is allowable: Career Enhancement Projects Research Infrastructure Enhancement Projects When preparing your application, use Component Type Overall .

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted. SF424(R&R) Cover (Overall) PHS 398 Cover Page Supplement (Overall) Note: Human Embryonic Stem Cell lines from other components should be repeated in cell line table in Overall component. Research & Related Other Project Information (Overall) Follow standard instructions.

Project/Performance Site Locations (Overall) A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.

Research and Related Senior/Key Person Profile (Overall) Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this FOA) for the entire application. A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon submission.

The only budget information included in the Overall component is the Estimated Project Funding section of the SF424 (R&R) Cover. A budget summary in the Overall section of the assembled application image in eRA Commons compiled from detailed budget data collected in the other components will be generated upon submission.

PHS 398 Research Plan (Overall) Introduction to Application: For Resubmission applications, an Introduction to Application is required in the Overall component. Specific Aims: . Provide specific aims for the overall Center.

Research Strategy: This section should describe: The goal of the proposed Center and its alignment with those of the NARCH program in advancing research, research career enhancement, and research infrastructure enhancement prioritized by the federally-recognized Tribal community. The applicant organization's plans for advancing Tribal health-related research and its commitment to support the proposed Center.

The current state of the health-related research enterprise at the applicant organization and, if applicable, partner organizations that are eligible federally-recognized Tribes or Tribal Entities. The grants administration infrastructure of the applicant organization, including areas of weakness and plans to address them if the application is funded. The overall organization of the Center.

How each proposed component contributes to the overall goals of the Center and will help advance the health of the federally-recognized Tribal communities the Center will serve. How the Center will support the proposed projects' ability to incorporate and address cultural considerations in their approaches.

For applications that include partner organizations, past collaborations with the partner organizations, accomplishments of these collaborations, and how the partner organizations will contribute to the proposed Center. Plans for ensuring that the research, career development and capacity building agendas are set by the federally-recognized Tribe(s) involved and that appropriate credit will be given for work conducted by Tribal members.

Letters of Support: Tribal Resolutions or Tribal Letters of Support for the application and any specific components should be included in this section and should include the proposed Center’s name, grant application title, and any relevant component or project title name.

All projects proposed in the application should have the approval of the Tribal governments with jurisdiction over each federally-recognized Tribe involved in the Center. If an application includes partner organizations, a letter (or resolution) of support from each of these organizations should also be included and should contain the title of the application and the name of the specific projects.

The roles and commitments of the partner organization should be clearly described in the letter/resolution. Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide. Note: Effective for due dates on or after January 25, 2023, the Data Management and Sharing Plan will be attached in the Other Plan(s) attachment in FORMS-H application forms packages.

If required, the Data Management and Sharing (DMS) Plan must be provided in the Overall component. All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions: NIH requires a consolidated DMS attachment which must include a plan for each research component.

Please note, NIH recognizes Tribal sovereignty and the rights associated with Tribal sovereignty around data collection, data management and sharing of data and has published a supplemental Notice regarding the DMS Plan for federally-recognized Tribal populations, NOT-OD-22-214 . Only limited items are allowed in the Appendix.

Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide; any instructions provided here are in addition to the SF424 (R&R) Application Guide instructions.

PHS Human Subjects and Clinical Trials Information (Overall) When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions: If you answered Yes to the question Are Human Subjects Involved?

on the R&R Other Project Information form, there must be at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record within the application. The study record(s) must be included in the component(s) where the work is being done, unless the same study spans multiple components.

To avoid the creation of duplicate study records, a single study record with sufficient information for all involved components must be included in the Overall component when the same study spans multiple components. Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the SF424 (R&R) Application Guide must be followed.

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the SF424 (R&R) Application Guide must be followed. PHS Assignment Request Form (Overall) All instructions in the SF424 (R&R) Application Guide must be followed.

When preparing your application, use Component Type Admin Core. All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted.

SF424 (R&R) Cover (Administrative Core) Complete only the following fields: Type of Applicant (optional) Descriptive Title of Applicant’s Project Proposed Project Start/Ending Dates PHS 398 Cover Page Supplement (Administrative Core) Enter Human Embryonic Stem Cells in each relevant component. Research & Related Other Project Information (Administrative Core) Human Subjects: Answer only the Are Human Subjects Involved?

and 'Is the Project Exempt from Federal regulations? questions. Vertebrate Animals: Answer only the Are Vertebrate Animals Used?

question. Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required.

However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components. Project /Performance Site Location(s) (Administrative Core) List all performance sites that apply to the specific component. Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachments for additional entries.

Research & Related Senior/Key Person Profile (Administrative Core) In the Project Director/Principal Investigator section of the form, use Project Role of Other with the Category of Core Lead and provide a valid eRA Commons ID in the Credential field. In the additional Senior/Key Profiles section, list Senior/Key persons that are working in the component.

Include a single Biographical Sketch for each Senior/Key person listed in the application, regardless of the number of components in which they participate. When a Senior/Key person is listed in multiple components, the Biographical Sketch can be included in any one component. If more than 100 Senior/Key persons are included in a component, the Additional Senior Key Person attachments should be used.

A PD/PI is required to serve as the Administrative Core (AC) leader, being assisted by a staff needed to manage the grant and activities of the Center. Budget (Administrative Core) Budget forms appropriate for the specific component will be included in the application package. The AC budget may not exceed $100,000 direct costs (DC) per year, excluding consortium F&A.

Funds may be requested for: Compensation for the PD(s)/PI(s) effort devoted to the Center. Support of other staff critical to fulfilling the functions of the AC such as managing the Center’s budget, organizing workshops and retreats, and overseeing the Center’s project evaluations. Hiring advisors or consultants to provide counsel to the PD/PI on scientific and/or administrative matters.

Covering costs of activities organized for the AC and Center staff, such as career and skills development workshops and seminars. PD/PI travel to Center relevant meetings. Funds from the AC budget cannot be used for project leaders travel or expenses for non-AC activities.

An honorarium is not an allowable expense when the primary intent is to confer distinction on, or to symbolize respect, esteem, or admiration for, the