Native American Research Centers for Health (NARCH) (S06)

Native American Research Centers for Health (NARCH) (S06) is sponsored by Indian Health Service, National Institute on Minority Health and Health Disparities, National Institutes of Health, U.S. Department of Health and Human Services. This grant supports health-related research, research career enhancement, and research infrastructure enhancement activities to meet the health needs of American Indian/Alaska Native (AI/AN) communities.

Expired PAR-13-239: Native American Research Centers for Health (NARCH) (S06) This notice has expired. Check the NIH Guide for active opportunities and notices. of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Indian Health Service ( IHS ) Components of Participating National Institute of General Medical Sciences ( NIGMS ) National Heart, Lung and Blood Institute ( NHLBI ) (Now Participating per NOT-AI-13-050 ) National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) (Now Participating per NOT-AI-13-050 ) National Institute of Allergy and Infectious Diseases ( NIAID ) (Now Participating per NOT-AI-13-050 ) National Institute of Arthritis and Musculoskeletal and National Institute of Dental and Craniofacial Research ( NIDCR ) National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ) National Institute on Drug Abuse ( NIDA ) National Institute of Environmental Health Sciences ( NIEHS ) (Now Participating per NOT-AI-13-050 ) National Institute of Mental Health ( NIMH ) (Now Participating per NOT-AI-13-050 ) National Center for Complementary and Alternative Medicine ( NCCAM ) Funding Opportunity Title Native American Research Centers for Health (NARCH) (S06) S06 Research-Related Programs May 27, 2016 - This PA has been reissued as PAR-16-297 .

June 14, 2013 - See Notice NOT-AI-13-050. Notice of Multiple Institutes' Participation. Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity Additional Information on Eligibility .

Catalog of Federal Domestic Assistance (CFDA) Number(s) 93. 859, 93. 846, 93.

279, 93. 121, 93. 847, 93.

213, 93. 837, 93. 838, 93.

839, 93. 233, 93. 273, 93.

855, 93. 856, 93. 113, 93.

242 Funding Opportunity Purpose The purpose of this funding opportunity announcement (FOA) is to encourage grant applications for new or continued Native American Research Centers for Health (NARCH). The NARCH program supports opportunities for conducting research and research training to meet the needs of American Indian/Alaska Native (AI/AN) communities.

This FOA is issued by the National Institute of General Medical Sciences in conjunction with the other Institutes/Centers of the National Institutes of Health (NIH) and the Indian Letter of Intent Due Date(s) AIDS Application Due Date(s) Required Application Instructions It is critical that applicants follow the instructions in Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. While some links are provided, applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review. Looking ahead : NIH is committed to transitioning all grant programs to electronic submission using the SF424 Research and Related (R&R) format and is currently investigating solutions that will accommodate NIH’s multi-project programs.

NIH will announce plans to transition the remaining programs in the NIH Guide to Grants and Contracts and on NIH’s Applying Part 1. Overview Information Part 2. Full Text of Announcement Section I.

Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Full Text of Announcement Section I.

Funding Opportunity Description The purpose of the Native American Research Centers for Health (NARCH) initiative is to reduce health disparities, support health research projects prioritized by the tribal communities, enhance health research partnerships and reduce distrust of research by American Indian/Alaska Native (AI/AN) communities while developing a cadre of AI/AN scientists and health research professionals.

The AI/AN Tribal nations and communities have long experienced disparities in health compared with other Americans. Health disparities of AI/ANs are related to a complex set of factors and the paucity of health research within these populations may contribute to the situation.

One approach that reduces this distrust of research within the AI/AN communities is to ensure that Tribes and Tribal Organizations are the managing partners in research and training involving them.

To that end, NIH, in collaboration with IHS, has issued the NARCH funding opportunity announcement (FOA) in which collaborations between Federally recognized AI/AN Tribes or Tribal organizations (including national and area Indian health boards, and Tribal colleges meeting the definition of a Tribal organization as defined by 25 U.S.C.

1603(d) or (e)) and institutions that conduct intensive academic-level biomedical, behavioral and health services research will be supported to conduct research and training in AI/AN communities. Areas of research proposed in the application will be selected by the AI/AN tribes and While characterized by many strengths, the AI/AN population has long experienced health status worse than that of other Americans.

AI/AN have higher rates of disease across many areas of health such as: diabetes, HIV/AIDS, dental disease, certain cancers, mental health and substance use ( http://www. cdc. gov/omhd/amh/dbrf.

htm , and http://www. cancer. gov/cancertopics/factsheet/disparities/cancer-health-disparities ).

Unfamiliarity with modern health care may adversely influence health status and also may reduce the acceptability of health research. These rates of disparities in health mask sources of strength in AI/AN communities. Identifying and utilyzing these strengths may contribute to reducing the health disparities that exist within the community.

The daunting tasks confronting Tribes, researchers, and health care and public health programs are to decrease the health disparities and improve overall health among the AI/AN populations, maintain and strengthen resiliency factors and train a new generation of researchers and health care workers from within the communities.

Factors known to contribute to health status and disparities are complex, and include social and historical factors, ethnicity, culture, historical trauma, socioeconomic status, gender/sex, sexual orientation, age, geographical access to care, and levels of insurance as well as underlying biology, physiology, and genetics. Additional interacting factors known to contribute to health status and disparities include, but not limited to: 1.

Family, home, and work environments; 2. General or culturally specific health practices; 3. Social support systems; 4.

Lack of access to culturally appropriate health 5. Attitudes toward health. The NARCH program seeks to build upon strengths in combating health disparities, support research alliances between AI/AN communities and research intensive partners and increase the pool of trained AI/AN scientists and research professionals.

Due to the complexity of factors contributing to the health and disease of AI/ANs, and to their health disparities compared with other Americans, the collaborative efforts of the agencies of the Department of Health and Human Services (HHS) and the collaboration of researchers and AI/AN communities are needed to achieve significant improvements in the health status of AI/AN people.

To accomplish this goal, in addition to objectives set by the Tribe, Tribal organization or Indian health boards, the NARCH program will pursue the following program objectives: To gain a better understanding of strengths and resilency factors: An understanding of how to enhance the strengths and resilience within the AI/AN communities and individuals may help reduce health disparities.

While AI/AN communities have relied on health research and medical science to promote overall healthful behaviors, they have also relied on their own psychological, organizational, and cultural assets and strengths to survive major harms and disruptions over the centuries, and to rebound from insults to health.

Strengthen partnerships and AI/AN community engagement in health research: Fully utilizing all cultural and scientific knowledge, strengths, and competencies, such partnerships can lead to better understanding of the biological, genetic, behavioral, psychological, cultural, social, and economic factors either promoting or hindering improved health status of AI/ANs, and generate the development and evaluation of interventions to improve their health status.

Community distrust of research and researchers will be reduced by giving the Tribe greater control over the research process as well as providing the opportunity to set the priority areas of scientific reseach for their NARCH. Recently published work on community-based participatory research suggests that AI/AN communities work collaboratively in partnership with health researchers to further the research needs of AI/ANs ( Thomas DM .

Research partnerships between academic institutions and American Indian and Alaska Native Tribes and organizations: effective strategies and lessons learned in a multisite CTN study. Am J Drug Alcohol Abuse. 2011 Sep;37(5):333-8).

Helpful guidelines for community leaders and health researchers conducting research within the AI/AN communities can be found at http://www. ncaiprc. org/research-curriculum-guide and http://www.

ncaiprc. org/research-regulation . Promoting AI/AN scientists and health research professionals: Opportunities are needed to increase the cadre of AI/AN scientists and health professionals engaged in health research, and to conduct biomedical, clinical, behavioral and health services research that is responsive to the needs of the AI/AN community and the goals of this initiative.

Faculty/researchers and students at each proposed NARCH can develop investigator-initiated, scientifically meritorious research projects, including pilot research projects, and may be supported through science education projects designed to increase the numbers of, and to improve the research skills of, AI/AN investigators and investigators involved with AI/ANs.

By involving and training people from within the community in areas of health research, a better understanding of community health concerns and needs regarding health research is attained.

The approach in which the community is empowered in the research is beneficial in both designing research relevant to the health needs of the communities and providing sustainability of addressing these needs with trained researchers from Tribal communities.

By involving the AI/AN community in the research agenda for the proposed NARCH application, it is not the intent of NIH that all projects be Community Based Participatory Research (CBPR) projects. Research projects ranging from basic science to clinical investigation are welcome and encouraged.

The following can be proposed in the NARCH application: Administrative Core: An administrative core can provide oversight of the different components, coordination of communication among the different components and guidance in evaluation planning. Student Development: Student development projects work toward accomplishing the goals of the NARCH FOA in developing a cadre of AI/AN researchers and health research professionals.

Faculty/Researcher Development: Faculty/Researcher development projects work toward providing research skills, experiences and methodologies to AI/AN investigators and investigators involved with AI/AN tribes/organizations.

Capacity Building: Capacity Building Projects build research infrastructure to foster health related research or development of AI/AN students and or faculty in health related fields by providing access to biomedical resources and strengthening the research capabilities of the communities and their research faculty.

Pilot/Research Projects: Research/Pilot projects are intended to provide a better understanding of basic biological processes as well as factors that promote or hinder the health status of AI/ANs, and to develop and evaluate interventions to improve their health status. NIH and IHS are vested in working toward eliminating health disparities while supporting an understanding of elements that contribute to health and well being.

Specifically, the mission of NIH is to acquire new knowledge that will lead to better health by understanding the processes underlying health and disease that in turn will help prevent, detect, diagnose, and treat disease and disability.

In the NIH Revitalization Act of 1993, NIH was encouraged to increase the number of under-represented minorities participating in biomedical, clinical, and behavioral research and the examination of the role of resiliency in the prevention and treatment of those conditions. In the Indian Health Care Improvement Act, Public Law 94 437 (as amended), IHS was legislatively mandated to improve the delivery of effective health care to AI/ANs.

More recently an emphasis was placed on promoting and understanding preventive care by the President in the Affordable Care Act ( http://www. healthcare. gov/news/factsheets/2010/07/preventive-care-background.

html ). In response to these priorities, NIH in collaboration with IHS continues to support the NARCH program. The NARCH initiative works toward the overall mission of NIH by supporting research that discovers the interrelationships among the many factors that contribute to health and disease, and by helping to train and promote AI/AN researchers and researchers concerned with AI/AN health.

Below is a list of more explicit scientific areas of research interests expressed by NIH Institutes, Centers and Offices: National Center for Complementary and Alternative Medicine NCCAM is particularly interested in supporting research projects in the following categories: 1) Utilization of systems of healing and health practices outside the conventional medical care by Native American/American Indian communities; 2) Extent and use of self-care and health practices, integrative health practices, conventional medical care, or a combination of the two by Native American/American Indian communities.

Specific areas of focus include symptoms management (Pain, HIV/AIDS), and special populations (older adults, military/veterans). All applications must be aligned encouraged to establish research collaborations with NCCAM-funded investigators as well as NCCAM’s Research Center Programs ( http://nccam. nih.

gov/research/centers ). For the NARCH program, NCCAM will not consider applications proposing interventional clinical trials.

National Institute of Arthritis and Musculoskeletal and Skin The NIAMS supports efforts to conduct research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of research progress to improve the public health.

Goals specific to the AI/AN communities involve research addressing the training of underrepresented minority AI/AN researchers and ensuring inclusion of Native communities in clinical research studies. Details of NIAMS's research interests can be found at http://www. nigms.

nih. gov/Training/NARCH/NARCHInterestAreas. htm .

National Institute of Dental and Craniofacial Research NIDCR is committed to reducing the disproportionate burden of oral diseases experienced by AI/ANs.

The focus of NIDCR’s health disparities research is on improving oral health status and quality of life by understanding and addressing oral diseases that are prevalent in AI/AN communities, specifically caries (including early childhood caries), oral and pharyngeal cancer, and periodontal disease.

For research related to oral health, note that the NIDCR does not accept applications that include clinical trials in response to trans-NIH FOAs. Applicants proposing a clinical trial should refer to the following NIDCR websites: http://www. nidcr.

nih. gov/clinicaltrials/ and http://grants. nih.

gov/grants/guide/pa-files/PAR-11-338. html . National Institute on Drug Abuse (NIDA) Neuroscience and Drug Abuse Research NIDA is committed to reducing health disparities in drug abuse and related health and social consequences among AI/AN.

Further, the Institute supports methodologies required by the NARCH, expecting that studies be developed and implemented using community participatory approaches. Details of NIDA's research interests can be found at http://www. nigms.

nih. gov/Training/NARCH/NARCHInterestAreas. htm .

National Institute of Diabetes and Digestive and Kidney The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) conducts and supports medical research and research training and disseminates science-based information on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases, to improve people’s health and quality of life.

Many of these chronic and costly diseases disproportionately afflict AI/AN communities; the Institute, therefore, supports basic, translational, and clinical research across a broad spectrum of research topics to reduce the health disparities especially as relates to the Native American communities. NIDDK website: ( http://www. niddk.

nih. gov/ ) National Instute of General Medical Sciences (NIGMS) Training, Workforce Development and Diversity NIGMS is committed to reducing health disparities that affect the AI/AN populations while supporting training and capacity building within these communities. Examples of NIGMS's research interest can be found at http://www.

nigms. nih. gov/Training/NARCH/NARCHInterestAreas.

htm . Participation by additional NIH Institutes will be announced A listing of grants recently funded by NIH may be found at Research Portfolio Online Reporting Tools (RePORT), a searchable database of Federally-funded biomedical research projects conducted at universities, hospitals, and other research institutions. It may be accessed at http://report.

nih. gov/ . Section II.

Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed Glossary and the PHS 398 Application Guide provide details on these application Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

NIH/IHS intends to fund an estimate of five to fifteen awards, corresponding to a total of $100,000-$1,100,000, for fiscal year 2014. Future year amounts will depend on annual appropriations.

FOA with multiple ICs/components (choice 1, FOA with multiple ICs/components (choice 2, not preferred; use if ICs/components are not showing each contribution in the FOA) Application budgets are not limited, but need to reflect the actual needs of the proposed project.

A minimum of 30 percent of the grant funds must be budgeted in the application to remain with the eligible AI/AN organization(s); that is, no more than 70 percent of the application’s total budget may be contained in subcontract budgets of the non-eligible subcontracting partner institutions or organizations .

Since awards will be issued and managed by IHS, HHS grants policies as described in the HHS Grants Policy Statement will apply to the applications submitted and awards made The proposed NARCH must be a working partnership of the eligible AI/AN tribes/organization and of the research institution. The AI/AN applicant must be one of the following: A federally recognized AI/AN Tribe, as defined under 25 U.S.C.

A Tribal organization, as defined under 25 U.S.C. 1603(e), including Tribal colleges or health boards meeting this definition; or A consortium of two or more of those Tribes or Tribal organizations.

Applicants other than Tribes must provide proof of non-profit The Research-Intensive Partner must be an accredited public or private nonprofit university, academic medical center, or other institution that has an established record of conducting research into the health problems of AI/AN; has demonstrated a commitment to enhancing the capability of AI/AN faculty/researchers, students, investigators, and communities to engage in biomedical, behavioral, social, clinical and health services research; and has demonstrated a commitment to mentoring AI/AN faculty/researchers, students, and As the grantee, the eligible AI/AN tribe/organization will define criteria and eligibility for participation in all aspects of the partnership, consistent with this announcement.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible Foreign components, as defined in the HHS Grants Policy Statement , are not allowed. Applicant organizations must complete the following registrations as described in the PHS 398 Application Guide to be eligible to apply for or receive an award.

Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following Management (SAM) must maintain an active entity registration (formerly CCR registration), to be renewed at least annually. Use the Sam. gov Manage Entity function to manage your entity registrations.

See the Grants Registration User Guide at SAM. gov for additional information. All Principal Investigators (PIs) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant All registrations must be completed by the application due date.

Applicant organizations are strongly encouraged to start the registration process at least6 weeks prior to the application due date. Eligible Individuals (Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Principal Investigator(s) (PI(s)) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Additional Eligible requirements for the NARCH include: The PI, the individual responsible for the administration (including fiscal management) of the overall project, must have his/her primary appointment with the AI/AN applicant organization.

Special arrangements of employment, such as inter-organizational personnel agreements, are permissible. The PI may be, but is not required to be, the NARCH Program Coordinator or a Research Project Leader.

The NARCH PI may or may not have formal academic/research credentials, but if not, then the NARCH Program Coordinator must be so The NARCH Program Coordinator is the individual responsible for the day-to-day leadership and management of the research and training programs within the proposed NARCH.

The Program Coordinator may be, but is not required to be, the Student and Faculty/Researcher Development Director or a Research Project Leader. The NARCH Program Coordinator may or may not have formal academic/research credentials, but if not, then the PI must be so qualified. This FOA does not require cost sharing as defined in the HHS Grants 3.

Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

NIH/IHS will not accept any application that is essentially the same as one already reviewed within the past thirty-seven months (as described in the HHS Grants Policy Statement ), except for submission: To an RFA of an application that was submitted previously as an investigator-initiated application but not paid; Of an investigator-initiated application that was originally submitted to an RFA but not paid; or Of an application with a changed grant activity code.

If a new Student and/or Faculty/Researcher Development Program is proposed in the current application, then that Development Project Leader is expected to be the NARCH Student and Faculty Development Director.

In order to be included as the Student and Faculty Development Director, the prospective director must have a faculty/researcher appointment at the research-intensive institution (or equivalent appointment at the AI/AN organization or other consortium partner) and must demonstrate that he/she has the knowledge, skills, and capabilities to mentor students and faculty/researchers and to generate and direct development and mentoring programs.

The Student and Faculty Development Director may be the proposed NARCH Program Coordinator. Faculty/Researchers and Students should be supported in research education activities that improve their skills and abilities to be successful at the next stage of their professional development.

To be included as a participant for faculty/researcher development in the proposed NARCH, the individual must have a faculty/researcher appointment at the research-intensive institution or equivalent appointment at the AI/AN organization or consortium In order to be included as a Research Project Leader in the NARCH, a prospective investigator must have a faculty appointment at the research-intensive institution or equivalent appointment at the AI/AN organization or other Section IV.

Application and Submission Information Applicants are required to prepare applications according to the current PHS 398 application forms in accordance with the PHS 398 2. Content and Form of Application Submission It is critical that applicants follow the instructions in Application Guide , except where instructed in this funding opportunity announcement to do otherwise.

Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed activity Name(s), address(es), and telephone number(s) of the PI Names of other key personnel Participating institution(s) Number and title of this funding opportunity The letter of intent should be sent to: Division of Training, Workforce Development and National Institute of General Medical Sciences 45 Center Drive, 2nd Floor Applications must be prepared using the PHS 398 research grant application forms and instructions for preparing a research grant application.

Submit a signed, typewritten original of the application, including the checklist, and three signed photocopies, including appendices (3 CDs), Center for Scientific Review National Institutes of Health 6701 Rockledge Drive, Room 1040, MSC 7710 Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail) Bethesda, MD 20817 (for express/courier service; non-USPS service) Two additional paper copies of the application with Appendix files (2CDs) must be submitted for forwarding to IHS.

This is in addition to the original application with the appendix files submitted to CSR. Please send the Division of Training, Workforce Development and National Institute of General Medical Sciences 45 Center Drive, 2nd Floor All page limitations described in the PHS 398 Application Page Limits must be followed, in addition the following page limitations to the Research Strategy section of each component of the application.

Administrative Core: 6 page maximum Student Development Projects: 6 pages Faculty/Researcher Development Projects: 6 pages Capacity Building Projects: 6 pages Research/Pilot Projects: 6 pages Instructions for the Submission of Multi-Component The following section supplements the instructions found in the PHS398 Application Guide, and should be used for preparing a multi-component application.

The application should consist of the following components: Administrative Core (required) Student Development Projects (optional) Faculty/Researcher Development Projects (optional) Capacity Building Projects (optional) Research/Pilot Projects (optional): A maximum of five (5) regular Research Projects and a maximum of five (5) Pilot Research Projects may be All instructions in the PHS398 Application Guide must be followed, with the following additional instructions, as noted.

Face Page ( Center Overview) All instructions in the PHS 398 Application Guide Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic Stem Cells (Center Overview) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Description: Provide a succint but accurate description of the overall NARCH application addressing the major, overall aims and goals to be accomplished.

Sites: All sites proposed to be involved in the NARCH application should be listed in this section.

Personnel: All key Personnel involved in the proposed NARCH application, including the individual components, should be included in this Key personnel and key sites involved in individual projects and cores should be re-listed in those specific components in addition Table of Contents (Center Overview) All instructions in the PHS 398 Application Guide Bearing in mind that the application will be scientifically reviewed project by project and core by core, prepare a detailed Table of Contents that will enable reviewers to readily locate specific information pertinent to the overall application as well as to each component research/pilot or development project and core.

A page reference should be included for the budget for each project and each core. Further, each research/pilot project should be identified by number (e.g. Project 1), title, and responsible Project Leader. The page location of a COMPOSITE BUDGET should be indicated in the "Table of Contents."

Detailed Budget for Initial Budget All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Although each project should have an individualized budget, the center overall budget section should reflect a culmination of all the projects and cores porposed in the Budget for Entire Proposed Period of Support (Center Overview) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: The entire proposed budget section should again be a culmination of all individual projects or cores proposed in the grant application.

Travel costs for the investigator(s) and staff are permitted to required meetings or when direct benefits to the program are expected, and when adequate justification is provided. Research project applications should also include costs associated with attendance for key personnel and presenters to the annual scientific meeting.

NARCH core and/or training budgets should include these travel costs for key NARCH personnel and trainees who are not associated with specific research projects.

Biographical Sketch (Center Overview) All instructions in the PHS 398 Application Guide Resources (Center Overview) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Thissection should provide information regarding all resources available in the individual Research Plan (Center Overview) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Aims: The specific aims should briefly indicate the goals of Strategy: A description should be provided of the current state of the research and research training enterprise at the proposed NARCH site and its institutional and community partners, including faculty/researcher and student profiles.

Please provide the following information: Documentation should be provided to establish that the research intensive partner is an institution with a record of conducting research into the health of AI/ANs, and that it has a demonstrated commitment to the special encouragement of, and assistance to, AI/AN faculty/researchers, students, investigators, and communities for enhancing their capacity to engage in biomedical, behavioral and health services research.

Documentation about the nature of the partnership itself should be included, such as: the process to develop the application and proposed NARCH itself, the past and future efforts to increase the capacity of the partners to improve their partnership, and efforts to contribute to the success of the Brief description of each component of the application and of how the components help meet the purposes of the NARCH initiative.

Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the PHS 398 Application Guide, with the following modification: Generally, Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and GWAS Sharing Plan) are expected, but they are not All instructions in the PHS398 Application Guide must be followed, with the following additional instructions, as noted.

Face Page (Administrative Core) All instructions in the PHS 398 Application Guide Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic Stem Cells (Administrative Core) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Description: Provide a brief description of the role of the Administrative Core in addressing the major, overall aims and goals to be accomplished by the proposed NARCH.

Sites: List any sites proposed that will be involved in the Administrative functions of the proposed NARCH. Personnel: In this section, list only Key Personnel that will be in the Administrative Core. Table of Contents (Administrative Core) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: Prepare a Table of Contents for the Administraive Core only for this section.

Detailed Budget for Initial Budget Period (Administrative Core) All instructions in the PHS 398 Application Guide must be followed, with the following additional instructions: A detailed Budget for the Administrative Core should only include budget items specific to the running of the Administrative Core.

The Administrative Core should include only budget items associated with the support and oversight of administrative functions, training or other items that are non-essential to the research Budget for Entire Proposed Period of Support (Administrative