Native American Research Centers for Health (NARCH) (S06)

Native American Research Centers for Health (NARCH) (S06) is sponsored by National Institutes of Health (NIH), Indian Health Service (IHS), National Institute on Minority Health and Health Disparities. NARCH grants provide funding for new or continued centers that support health-related research, research career enhancement, and research infrastructure enhancement activities to meet the health needs of American Indian/Alaska Native (AI/AN) communities.

Expired PAR-16-297: Native American Research Centers for Health (NARCH) (S06) This notice has expired. Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Indian Health Service ( IHS ) of Participating Organizations National Institute of General Medical Sciences ( NIGMS ) National Cancer Institute ( NCI ) National Institute of Allergy and Infectious Diseases ( NIAID ) National Institute of Arthritis and Musculoskeletal and Skin Diseases ( NIAMS ) National Institute of Dental and Craniofacial Research ( NIDCR ) National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ) National Institute on Drug Abuse ( NIDA ) National Institute of Environmental Health Sciences ( NIEHS ) National Institute of Mental Health ( NIMH ) National Institute on Aging ( NIA ) National Institute on Minority Health and Health Disparities ( NIMHD ) Office of Research on Women’s Health ( ORWH ) National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) Eunice Kennedy Shriver National Institute of Child Health and Human Development ( NICHD ) Funding Opportunity Title Native American Research Centers for S06 Research-Related Programs March 5, 2020 - This PAR has been reissued as PAR-20-125 .

May 25, 2017 - Notice of NICHD's Participation in PAR-16-297. See Notice NOT-HD-17-013 . March 29, 2017 - Notice of NIAAA's Participation in PAR-16-297.

See Notice NOT-AA-17-001 . November 08, 2016 - Notice of Participation of the National Institute on Aging (NIA) in PAR-16-297. See Notice NOT-AG-16-081 .

Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity Additional Information on Eligibility . Catalog of Federal Domestic Assistance (CFDA) Number(s) 93. 859, 93.

313, 93. 307, 93. 398, 93.

121, 93. 846, 93. 113, 93.

242, 93. 856, 93. 855, 93.

847, 93. 279, 93. 866, 93.

273, 93. 865 Funding Opportunity Purpose The purpose of this funding opportunity announcement (FOA) is to encourage grant applications for new or continued Native American Research Centers for Health (NARCH).

The NARCH program supports opportunities for conducting research and career enhancement to meet the health needs of American Indian/Alaska Native (AI/AN) communities and the scientists conducting research on the health needs of these communities.

This FOA is issued by the National Institute of General Medical Sciences in conjunction with the other Institutes/Centers of the National Institutes of Health (NIH) and the Indian Health Service (IHS). Open Date (Earliest Submission Date) Letter of Intent Due Date(s) 30 days prior to the application due date July 27, 2016; June 24, 2017, by 5:00 PM local time of applicant organization.

All types of non-AIDS applications allowed for this funding opportunity announcement are due on Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. AIDS Application Due Date(s) July 27, 2016; July 24, 2017, by 5:00 PM local time of applicant organization.

All types of AIDS and AIDS-related applications allowed for this funding opportunity announcement are due on these dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

October 2016; October 2017 January 2017; January 2018 ** ELECTRONIC APPLICATION SUBMISSION REQUIRED** NIH’s new Application Submission System & Interface for Submission Tracking (ASSIST) is available for the electronic preparation and submission of multi-project applications through Grants. gov to NIH. Applications to this FOA must be submitted electronically; paper applications will not be accepted.

ASSIST replaces the Grants. gov downloadable forms currently used with most NIH opportunities and provides many features to enable electronic multi-project application submission and improve data quality, including: pre-population of organization and PD/PI data, pre-submission validation of many agency business rules and the generation of data summaries in the application image used for review.

Required Application Instructions It is critical that applicants follow the instructions in (R&R) Application Guide , except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ) and where instructions in the Application Guide are directly related to the Grants. gov downloadable forms currently used with most NIH opportunities.

Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review. Part 1. Overview Information Part 2.

Full Text of the Announcement I. Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Full Text of Announcement Section I.

Funding Opportunity Description The purpose of the Native American Research Centers for Health (NARCH) initiative is to support health research projects prioritized by the tribal communities, work toward reducing health disparities in the AI/AN populations, enhance health research partnerships and reduce distrust of research by AI/AN communities, while promoting a cadre of scientists and health research professionals interested in AI/AN health research.

The AI/AN Tribal nations and communities have long experienced disparities in health compared with other Americans. Health disparities of AI/ANs are related to a complex set of factors and the paucity of health research within these populations may contribute to the situation.

One approach to reduce this distrust of research within the AI/AN communities is to ensure that Tribes and Tribal Organizations are the managing partners in research and career enhancement involving their communities.

To that end, NIH in collaboration with IHS has issued the NARCH funding opportunity announcement in which Federally recognized AI/AN Tribes or Tribal organizations (including national and area Indian health boards, and Tribal colleges meeting the definition of a Tribal organization as defined by 25 U.S.C.

1603(14) or (26)) may partner with institutions that conduct intensive academic-level biomedical research to conduct research focused on AI/AN health disparities as well as promote research career enhancement for students and scientists interested in AI/AN health. Areas of research proposed in the application will be selected by the AI/AN tribes and communities.

While characterized by many strengths, the AI/AN population has long experienced a disparity in certain health conditions compared with other Americans. AI/AN have higher rates of disease across many areas of health such as: diabetes, HIV/AIDS, dental disease, certain cancers, mental health and substance use ( http://www. cdc.

gov/omhd/amh/dbrf. htm , and http://www. cancer.

gov/cancertopics/factsheet/disparities/cancer-health-disparities ). Unfamiliarity with health care options may adversely influence health status and also may reduce the acceptability of health research. Identifying and utilizing existing strengths in AI/AN communities may contribute to reducing the health disparities that exist within the community.

The daunting tasks confronting Tribes, researchers, and health care and public health programs are to decrease the health disparities and improve overall health among the AI/AN populations, maintain and strengthen resiliency factors and develop a new generation of researchers and health care workers interested in research focused on AI/AN Factors known to contribute to health status and disparities are complex, and include social and historical factors, ethnicity, culture, historical trauma, socioeconomic status, gender/sex, sexual orientation, age, geographical access to care, and levels of insurance as well as underlying biology, physiology, and genetics.

Additional interacting factors known to contribute to health status and disparities include, but are not limited to: Family, home, and work environments; General or culturally specific health practices; Lack of access to culturally appropriate health care; and The NARCH program seeks to build upon strengths in the AI/AN communities in combating health disparities, support research alliances between AI/AN communities and research intensive partners and enhance the pool of trained scientists and research professionals interested in AI/AN health needs.

Due to the complexity of factors contributing to the health and disease of AI/ANs, and to their health disparities compared with other Americans, the collaborative efforts of the agencies of the Department of Health and Human Services (HHS) and the collaboration of researchers and AI/AN communities are needed to achieve significant improvements in the health status of AI/AN people.

To accomplish this goal, in addition to objectives set by the Tribe, Tribal organization or Indian health boards, the NARCH program will pursue the following program objectives: To gain a better understanding of strengths and resiliency factors: An understanding of how to enhance the strengths and resilience within the AI/AN communities and individuals may help reduce health disparities.

While AI/AN communities have relied on health research and medical science to promote overall healthful behaviors, they have also relied on their own psychological, organizational, and cultural assets and strengths to survive major harms and disruptions over the centuries, and to rebound from insults to health.

Strengthen partnerships and AI/AN community engagement in health research: Fully utilizing all cultural and scientific knowledge, strengths, and competencies, such partnerships can lead to better understanding of the biological, genetic, behavioral, psychological, cultural, social, and economic factors either promoting or hindering improved health status of AI/ANs, and generate the development and evaluation of interventions to improve their health status.

Community distrust of research and researchers will be reduced by giving the Tribe greater control over the research process as well as providing the opportunity to set the priority areas of scientific research for their NARCH grant. Published work on community-based participatory research suggests that AI/AN communities should work collaboratively in partnership with health researchers to further the research needs of AI/ANs.

Helpful guidelines for community leaders and health researchers conducting research within the AI/AN communities can be found at http://www. ncaiprc. org/research-curriculum-guide and http://www.

ncaiprc. org/research-regulation .

Promote the enhancement of student and/or faculty research scientists interested in addressing the health issues within the AI/AN communities: Opportunities are needed to enhance the cadre of scientists and health professionals engaged in health research focused on AI/AN health needs, and to conduct biomedical, clinical and behavioral research that is responsive to the needs of the AI/AN community and the goals of this initiative.

Faculty/researchers and students at each proposed NARCH can develop investigator-initiated, scientifically meritorious research projects, including pilot research projects. Career enhancement projects may also be proposed to improve the research skills of investigators involved with AI/AN communities.

By involving people in the community in areas of health research, a better understanding of community health concerns and needs regarding health research is attained.

The approach in which the community is empowered in the research is beneficial in both designing research relevant to the health needs of the communities and providing sustainability of addressing these needs with trained researchers concerned with the health needs of the Tribal communities.

By involving the AI/AN community in the research agenda for the proposed NARCH application, NIH is not limiting proposed projects to only Community Based Participatory Research (CBPR) projects. Research projects ranging from basic science to clinical investigation are welcome and encouraged.

The following must be proposed in the NARCH application: Administrative Core (Required): An administrative core can provide oversight of the different proposed components and projects, coordination of communication among the different proposed components and projects and guidance in evaluation planning.

In addition, one or more of the following may be proposed: Student Enhancement Projects: Projects that work toward accomplishing the goals of the NARCH FOA in providing opportunities for enhancement of a cadre of researchers and health research professionals focused on addressing the health needs of the AI/AN communities.

Faculty/Researcher Enhancement Projects: Discrete projects that work toward providing research skills, experiences and methodologies to investigators involved in research with AI/AN tribes/organizations.

Capacity Building Projects: Capacity Building Projects build research infrastructure to foster health related research or opportunities to enhance the cadre of students and or faculty in health related fields by providing access to biomedical resources and strengthening the research capabilities of the communities and their research faculty.

Pilot Projects: Pilot projects prioritized by the AI/AN communities are intended to provide a better understanding of basic biological processes as well as factors that promote or hinder the health status of AI/ANs, and to develop and evaluate interventions to improve their health status. Pilot projects are smaller in size compared with Research Projects and limited to $75,000 direct costs per year per project.

Research Projects: Research projects prioritized by the AI/AN communities are intended to provide a better understanding of basic biological processes as well as factors that promote or hinder the health status of AI/ANs, and to develop and evaluate interventions to improve their health NIH and IHS are vested in working toward eliminating health disparities in AI/AN communities while supporting an understanding of elements that contribute to health and well-being.

Specifically, the mission of NIH is to acquire new knowledge that will lead to better health by understanding the processes underlying health and disease that in turn will help prevent, detect, diagnose, and treat disease and disability. In the Indian Health Care Improvement Act, Public Law 94 437 (as amended), IHS was legislatively mandated to improve the delivery of effective health care to AI/ANs.

More recently an emphasis was placed on promoting and understanding preventive care by the President in The Affordable Care Act ( http://www. healthcare. gov/news/factsheets/2010/07/preventive-care-background.

html ). In response to these priorities, NIH in collaboration with IHS continues to support the NARCH program, focused on addressing the health disparities of the AI/AN communities.

The NARCH initiative works toward the overall mission of NIH by supporting research that discovers the interrelationships among the many factors that contribute to health and disease, and by promoting the enhancement of researchers with an interest in AI/AN health..

Below is a list of more explicit scientific areas of research interests expressed by NIH Institutes, Institute of General Medical Sciences (NIGMS) reducing health disparities that affect AI/AN populations, while supporting research opportunities for the enhancement of students, faculty and researchers concerned with AI/AN health.

NIGMS also supports capacity/infrastructure building within AI/AN communities to ensure sustainability of biomedical research, and the ability to address pertinent health issues within the communities. Examples of NIGMS's research interest can be found at: https://www. nigms.

nih. gov/about/overview/Pages/default. aspx .

Institute on Minority Health and Health Disparities (NIMHD) research to improve minority health and reduce health disparities, to realize an America in which all populations will have an equal opportunity to live long, healthy, and productive lives.

To accomplish this, NIMHD raises national awareness about the prevalence and impact of health disparities and disseminates effective individual-, community-, and population-level interventions to reduce and encourage elimination of health disparities. NIMHD is interested in projects including, but not limited to, the following: Interventions derived from local culture in strategies, process, implementation and evaluation.

Projects that directly address methodological issues inherent in research small populations such as those in many native communities. Culturally-leveraged community based interventions focused on existing practices that support strengths and resilience factors that may be applicable and useful in other communities.

Projects that collect data to address risk factors for health disparities where aggregated data obscure disparities and data gaps. Projects that document efficacy and monetize traditional healing practices for coverage by insurance.

Projects that develop innovative approaches to the provision of non-stigmatizing and resilience supportive prevention and treatment Projects that build community understanding and capacity for equal participation in health promotion and disease prevention research, including development of community health needs assessment, tribal health research review capacity, and tribal Institutional Review Board capacity.

Office of Research on Women’s Health (ORWH) applications that address issues associated with women’s health and/or sex and for Women’s Health Research to determine if an application addresses the ORWH mission: http://orwh. od. nih.

gov/research/strategicplan/ORWH_StrategicPlan2020_Vol1. pdf." supporting research to address the significant disparities and needs of the American Indian/Alaska Native (AI/AN) population in terms of cancer prevention and health promotion and treatment.

NCI will support the NARCH initiative through its Center to Reduce Cancer Health Disparities (CRCHD) and Division of Cancer Control and Population Sciences (DCCPS). Health Disparities (CRCHD) CRCHD is committed to the NCI's efforts to reduce the unequal burden of cancer in our society and train the next generation of competitive researchers from diverse populations in cancer and cancer health disparities research.

As such, the CRCHD initiates, integrates, and engages in collaborative research studies with NCI divisions and NIH Institutes and Centers, and outside partners to promote research and training in cancer and cancer health disparities research and to identify new and innovative scientific opportunities to improve cancer outcomes in communities experiencing an excess burden of cancer.

scientifically meritorious projects that have direct relevance to the understanding of the basic, clinical, populations and translational sciences of cancer and cancer health disparities among AI/AN populations.

CRCHD will assist in achieving these purposes by supporting projects developed by each NARCH Division of Cancer Control and Population Sciences (DCCPS) The mission of the DCCPS is alleviating the burden of cancer through research in epidemiology, behavioral and social sciences, health services, surveillance, and cancer survivorship.

Cancer control research aims to generate basic knowledge about how to monitor and change individual and collective behavior, and to ensure that knowledge is translated into practice and policy rapidly, effectively, and efficiently.

DCCPS also has been through other program announcements trying to enhance the research with Native American communities to address the challenges of cancer surveillance program has noted that Native American populations have the lowest 5-year cancer survival rate and highest percentage of disseminated and ill-defined cancers of any subpopulation in the U.S. Poorer cancer survival rates have been attributed to many factors, among them inadequate access to health care, geographic isolation, later stage of detection, underutilization of treatment, poverty, and social and cultural barriers.

The DCCPS is interested in applications that focus on both individual and community factors that affect cancer control and prevention. It is important that researchers consider the context in which people live (place, built environment, etc.) and develop programs that can improve overall health and result in improved health outcomes as they relate to cancer and cancer survivorship.

Institute of Mental Health (NIMH) Mental Disorders: The CDC Health Disparities and Inequalities Report United States, 2013, indicates that, when compared to the white population, American Indians and Alaska Natives (AI/AN), experience disproportionately higher rates of psychological distress, higher drug-related deaths and death by suicide. American Indian and Alaska Native youth, in particular, suffer disproportionately from suicide.

From 2005-2009, AI/ANs between the ages of 15-34 had the highest rates of suicide of any racial or ethnic group.

Multiple factors contribute to the high rates of suicide among AI/AN populations, including individual-level factors (e.g., alcohol and substance abuse and mental illness), family or peer-level factors (e.g., family disruption or suicidal behavior of others) and societal-level factors (e.g., poverty, unemployment, discrimination and historical trauma defined as the cumulative emotional and psychological wounding across generations).

There is a paucity of empirical data on the incidence and prevalence of mental disorders, tools to pre-empt or prevent disorders, barriers to and facilitators of receipt of and retention in treatment and effective treatments for mental disorders among the various AI/AN populations, nationwide.

NIMH encourages Develop culturally congruent preventive interventions that reduce Develop strategies to enhance mental health service engagement across tribes and geographic regions, with cultural or other adaptations to existing evidence-based engagement approaches justified by empirical and theoretical evidence of the need for adaptation.

Empirically determine the most effective strategies for the scale-up and implementation of evidenced-based interventions that treat, pre-empt or prevent mental disorders Identify and test the appropriate application of technology to extend mental health human resources in remote rural settings.

Identify factors that may prevent mental disorders in AI/AN populations and could be target mechanisms for future intervention development NIMH strongly encourages the establishment of collaborative research partnerships which will provide the researchers of AI/AN mental health the capacity to investigate multiple units of analysis across domains/constructs that moderate intervention effects (e.g., stress, distress, cognition, social processes).

HIV/AIDS: Even though AI/AN HIV/AIDS cases comprise less than 1 percent of total cases in the United States, AI/AN communities are disproportionately impacted by the disease. American Indians and Alaska Natives have a 40 percent higher rate of AIDS than non-Hispanic white Americans, and the AIDS rate among Native women is 2. 8 times that of non-Hispanic white women.

American Indian and Alaska Native communities experience significant health disparities and face high rates of substance abuse and sexually transmitted infections, which increase the risk of HIV transmission. Several dimensions of the AIDS epidemic for AI/AN groups are especially concerning including rapid progression from HIV infection to AIDS-defining illness and low survival rates after AIDS diagnosis is made.

Additionally, many AI/AN individuals, like other Americans, do not know that they are infected and are therefore more likely to spread the disease. Relevant factors that place these individuals at risk and present barriers to prevention include poverty, high rates of sexually transmitted diseases, substance abuse, violence, stigma, denial and concern about confidentiality in smaller reservation and rural communities.

Because HIV infection is a continuing health crisis in indigenous people, research on AI/ANs has been identified as one of the overarching research priorities of the FY 2016 Trans-NIH Plan for HIV-Related Research, section on Racial and Ethnic Populations in Areas of Special Interest (http://www. oar. nih.

gov/strategicplan/fy2016/pdf/FY-2016-Trans-NIH-Plan-for-HIV-Related-Research. pdf). To reduce the impact of the HIV/AIDS epidemic among indigenous communities in the United States, NIMH/DAR-supported HIV/AIDS research in AI/AN communities should be responsive to high priority research as indicated in NIH HIV/AIDS Research Priorities and Guidelines for Determining AIDS Funding https://grants.

nih. gov/grants/guide/notice-files/NOT-OD-15-137. html.

Proposed research should have the following objectives: Rapidly expand the HIV prevention intervention portfolio for gay men and other high-risk vulnerable individuals from indigenous communities.

Address integrated continuum of care model (i.e., testing, linkage, retention, adherence, viral suppression) and identify mechanisms to explain differences in HIV-related disparities (e.g., factors like social/sexual networks, access to and quality of health care, characteristics Develop and advance multilevel preventive intervention programs, address consequences of HIV and incorporate community-based participatory principles that ensure bidirectional benefit and investment of community and Examine utility of combination behavioral-biomedical interventions and treatment as prevention approaches.

Explore operations research to focus on barriers, facilitating factors and outcomes of scaling-up HIV prevention interventions with known efficacy; improve uptake and effectiveness of efficacious interventions. For these research objectives to be realized, it will be necessary to strengthen the workforce of HIV investigators through programs that develop a cadre of investigators in http://www. nimh.

nih. gov/about/organization/dar/aids-research-centers-program/aids-research-centers-program. shtml.

NIMH recommends that both non-AIDS and AIDS applications that propose an adaptation to existing interventions provide an empirical rationale for the need for and focus of the adaptation, consistent with the NAMHC Workgroup Report recommendations on intervention adaptation, and in consultation with relevant Institute staff.

Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) The NIAMS supports efforts to conduct research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of research progress to improve the public health.

Goals specific to the AI/AN communities involve research addressing the career enhancement of researchers and ensuring inclusion of Native communities in clinical research studies. Details of NIAMS's research interests can be found at: http://niams. nih.

gov/Funding/Funding_Opportunities/Supported_Scientific_Areas/default. asp Institute on Drug Abuse (NIDA) NIDA is interested in supporting research that will reduce health disparities in drug abuse and related health and social consequences among AI/AN. Studies should employ the methodologies required by the NARCH, including that studies be developed and implemented using community based participatory approaches.

Details of NIDA's research interests can be found at https://www. nigms. nih.

gov/Research/CRCB/NARCH/Pages/NARCHInterestAreas. aspx . Information for award authorities and regulations.

Section II. Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed Glossary and the SF424 (R&R) Application Guide provide details on Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

The annual budgets must not exceed $1 million in direct costs. A minimum of 30 percent of the grant funds must be budgeted in the application to remain with the eligible AI/AN organization(s); that is, no more than 70 percent of the application’s total budget may be contained in subcontract budgets of the non- eligible subcontracting partner institutions The project period is limited to 4 years.

described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA. The applicant must be one of the following: A federally recognized AI/AN Tribe, as defined under 25 U.S.C. A Tribal organization, as defined under 25 U.S.C.

1603(26), including Tribal colleges or health boards meeting this definition; or A consortium of two or more of those Tribes or Tribal organizations. Applicants other than Tribes must provide proof of non-profit The proposed NARCH may be a working partnership of the eligible AI/AN tribes/organization and of a research institution, with the federally recognized tribe/tribal organization being the grant applicant.

The Research-Intensive partner must be an accredited public or private nonprofit university, academic medical center, or other institution that has an established record of conducting research into the health problems of AI/AN; has demonstrated a commitment to enhancing the capability of faculty/researchers, students, investigators, and communities to engage in biomedical, behavioral, and clinical research related to AI/AN health needs; and has demonstrated a commitment to enhancing the career of faculty/researchers, students, and investigators, including those engaged in or interested in AI/AN The grantee will determine the appropriate partners and partnerships for the proposed application.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible Foreign components, as defined in the NIH Grants Policy Statement , are not allowed. Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number.

After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application. System for Award Management (SAM) (formerly CCR) Applicants must complete and maintain an active registration, which requires renewal at least annually .

The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.

must have an active DUNS number and SAM registration in order to complete the eRA Commons registration. Organizations can register with the eRA Commons as they are working through their SAM or Grants. gov registration.

eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to must have an active DUNS number and SAM registration in order to complete the Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 The PD(s)/PI(s) must have a primary appointment with the federally recognized AI/AN applicant organization. Special arrangements of employment, such as inter-organizational personnel agreements, are permissible.

The PD/PI may be, but is not required to be, the NARCH Program Coordinator or a This FOA does not require cost sharing as defined in the NIH Grants Policy Statement . 3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

However, each organization may receive only one NARCH award. The NIH will not accept duplicate or highly overlapping applications under review at the same time.

This means that the NIH will A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-11-101 ). To be included as a participant for a faculty/researcher enhancement project in the proposed NARCH, the individual must have a faculty/researcher appointment at a research-intensive institution or equivalent appointment at an AI/AN organization or consortium partner.

In order to be a Research Project Leader in the NARCH, a prospective investigator must have a faculty appointment at the research-intensive institution or equivalent appointment at the AI/AN organization or other consortium partner. Section IV.

Application and Submission Information Applicants can access the SF424 (R&R) application package associated with this funding opportunity using the Apply for Grant Electronically button in this FOA or following the directions provided at Grants. gov . Most applicants will use NIH’s ASSIST system to prepare and submit applications through Grants.

gov to NIH. Applications prepared and