NEI Institutional Research Training Grants (T32) for Statistical Genetics and Genome Informatics

NEI Institutional Research Training Grants (T32) for Statistical Genetics and Genome Informatics is sponsored by National Eye Institute (NEI). This opportunity supports mission-aligned projects and measurable outcomes.

Expired RFA-EY-10-001: NEI Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32) for Statistical Genetics and Genome Informatics This notice has expired. Check the NIH Guide for active opportunities and notices.

Part I Overview Information Department of Health and Human Services Participating Organizations National Institutes of Health (NIH) ( http://www. nih. gov ) Participating Organizations National Eye Institute (NEI), ( http://www.

nei. nih. gov ) Title: NEI Ruth L.

Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32) for Statistical Genetics and Genome Informatics update relating to this announcement has been issued: May 12, 2011 - See Notice NOT-OD-11-076 This Notice informs prospective applicants that the required plans for instruction in the Responsible Conduct of Research (RCR) will have page limits separate from the page limits for other combined components that are limited to 25 pages.

August 16, 2010 - IMPORTANT NOTE! NIH has eliminated the error correction window for due dates of January 25, 2011 and beyond. As of January 25, all corrections must be complete by the due date for an application to be considered on-time.

See NOT-OD-10-123 . September 29, 2010 (NOT-OD-11-008) - Updated Electronic Application Forms Required for F, K, T and D Submissions with Due Dates of January 25, 2011 and Beyond. Adobe B1 forms are required for due dates on or after January 25, 2011.

Applications (RFA) Number: RFA-EY-10-001 NOTICE: Applications submitted in response to this Funding Opportunity Announcement (FOA) for Federal assistance must be submitted electronically through Grants. gov ( http://www. grants.

gov ) using the SF424 Research and Related (R&R) forms and the SF424 BE SUBMITTED IN PAPER FORMAT. in conjunction with the application guidelines included with this announcement for Grants (hereafter called Grants. gov/Apply).

is necessary before submission and applicants are highly encouraged to start the process at least four (4) weeks prior to the grant submission date. See Section IV . Domestic Assistance Number(s) Release/Posted Date: January 27, 2010 18, 2010 (Earliest date an application may be submitted to Grants.

gov) Letters of Intent Receipt Date(s): Not applicable NOTE: On-time submission requires that applications be successfully submitted to Grants. gov no later than 5:00 p. m.

local time (of the applicant institution/organization). Due Date(s): May 18 , 2010, 2011, and 2012 Peer Review Date(s): November/December 2010, 2011, Review Date(s): January 2011, 2012, 2013 Anticipated Start Date(s): April 1, 2011, 2012, 2013 Information To Be Available Date (Activation Date): Not Applicable Expiration Date: May 19 , Purpose .

The NEI Institutional Research T raining Grants (T32) for S tatistical Genetics and Genome Informatics is a Ruth L. Kirschstein National Research Service Award program that is intended to support predoctoral and postdoctoral training at institutions having the potential to develop meritorious training programs in genomic medicine, computational genomics, and statistical genetics.

The goal of this program is to initiate a training program to develop ophthalmic statistical genetics and bioinformatics research skills critical for investigators seeking to identify genes and genetic variations underlying ocular diseases.

This training program is designed to attract individuals in early career stages, in order to increase their knowledge and awareness of research in the genetics of ophthalmic disorders, and to encourage them to pursue research career opportunities in these scientific fields.

Such training will help meet a growing need for investigators trained in computational genomics related to basic biomedical, clinical, and translational ophthalmic research. The NEI plans a long-term commitment to this area. Trainee appointments will be determined by the institution and conducted in a manner that will include the recruitment of individuals from diverse backgrounds.

Mechanism of Support. This FOA will utilize the National Institutes of Health (NIH) Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) Funds Available and Anticipated Number of Awards.

Because the nature and scope of the proposed research training will vary from application to application, it is anticipated that the size and duration of each award will also vary. Although the financial plans of the NEI anticipate funding four applications, awards pursuant to this funding opportunity are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications. and Project Period.

Awards are expected to be up to $300,000 annual direct costs. Grants may be for project periods up to five years in duration. Strategy Length: The page limit for items 2-5 is 25 pages collectively (see Section 8 of the SF424 (R&R) Application Institutions/Organizations.

Institutions/organizations listed in Section III, 1. A. are eligible Eligible Project Directors/Principal Investigators (PDs/PIs).

I ndividuals with the skills, knowledge, successful past training record, expertise in statistical genetics or genome informatics, and resources necessary to carry out the proposed research, are invited to work with their institution/organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH umber of PDs/PIs. More than one PD/PI is of Applications. Applicants may submit only a single application Resubmissions.

Resubmission applications will be accepted. See new NIH policy on resubmission (amended) applications ( NOT-OD-09-003 , NOT-OD-09-016 ). Such application must include an Introduction addressing the previous peer review critique (Summary Statement).

applications are not permitted in response to this FOA. Materials. See Section IV.

1 for All applications, including resubmission, revision and renewal, submitted for due dates January 25, 2010 and beyond, must utilize the current forms General Information. For general information on SF424 (R&R) Application and Electronic Submission, see these Web sites: (R&R) Application and Electronic Submission Information: http://grants. nih.

gov/grants/funding/424/index. htm information on Electronic Submission of Grant Applications: http://era. nih.

gov/ElectronicReceipt/ Hearing Impaired. Telecommunications for the hearing impaired are available at: TTY: (301) 451-5936 Part I Overview Information Part II Full Text of Announcement Section I. Funding Opportunity Section II.

Award Information Section III. Eligibility Information 2. Cost Sharing or Matching 3.

Other-Special Eligibility Criteria Section IV. Application and 1. Request Application Information 2.

Content and Form of Application Submission 3. Submission Dates and Times A. Receipt, Review, and Anticipated B.

Submitting an Application Electronically to the NIH C. Application Processing 4. Intergovernmental Review 6.

Other Submission Requirements Section V. Application Review Information 2. Review and Selection Process A.

Additional Review Criteria B. Additional Review Considerations C. Resource Sharing Plan(s) Anticipated Announcement and Award Dates Section VI.

Award Administration 2. Administrative and National Policy Requirements 1. Scientific/Research Contact(s) Financial/Grants Management Contact(s) VIII.

Other Information - Required Federal Citations - Full Text of Announcement Section I. Funding Opportunity Description this NRSA program is to initiate programs to provide predoctoral and postdoctoral research training opportunities for individuals interested in pursuing research careers in statistical genetics and genome informatics applied to the visual system.

More information about NRSA programs in general may be found at http://grants. nih. gov/training/nrsa.

htm . Institutional Research Training Grants (T32) for Statistical Genetics and Genome Informatics are designed to allow the PD/PI to select the trainees and develop a curriculum of study and research experiences necessary to provide high quality research training.

The grant offsets the cost of stipends and tuition (which includes fees and health insurance) support for the appointed trainees in accordance with the approved NIH support levels (see Section II, accumulation of genomic information, there is a need for scientists trained in computational genomics and biostatistics to elucidate the molecular and genetic bases of the visual system functions in normal and disease states.

The purpose of this FOA is to initiate a program that will train individuals to develop novel approaches and methodologies for sequence analysis, gene mapping, complex trait mapping and genetic variation in the visual system.

These tools include mathematical and statistical methods for the identification of functional regulatory elements in complex genomes, for the identification of patterns in large datasets, for example, microarray gene expression data from genome-wide association (GWAS) studies and the mapping of complex traits loci and genetic variations.

The long-range goal of statistical genetic analysis is the identification of genetic effects (loci or alleles) that are responsible, at least in part, for the variation of a trait, or the susceptibility to the development of a disease.

The long-range goal of statistical genetic analysis is the identification of genetic effects (loci or alleles) that are responsible, at least in part, for the variation of a trait that may lead to either protection or susceptibility to the development of a disease.

also encourages training in the development of new tools for annotating complex genomes so as to expand their utility as well as the production of robust, exportable software that can be widely shared among different genomic databases.

Such bioinformatics resources are of critical importance for the vision scientific community to gain access to genomic data to determine genotype-phenotype relations, which will enable in understanding of disease traits pertaining to visual diseases and their analyses.

The analyses, in turn, will allow for the computer modeling and subsequent experimental validation of the complex pathway and network analysis that ultimately define the phenotype of a cell or the possible causes of many human diseases.

Objectives and Considerations program’s longstanding commitment to excellence and the projected long-term need for investigators well trained in ocular genomic medicine, PD/PIs must give attention to recruiting and retaining trainees from under-represented or disadvantaged backgrounds (See Section IV).

PI/PDs should also encourage and provide training in the skills necessary for trainees to apply for subsequent support through individual fellowship (F series), mentored careers development (K series) or independent research project grants. Research training PD/PIs should therefore develop methods for ongoing evaluation of the quality of the training program.

They should institute plans to obtain regular feedback from former trainees to help identify weaknesses in the program and provide suggestions for improvements. All applications must provide a teaching plan for review and an evaluation that will determine the effectiveness of all aspects anticipates a long-term commitment to vision research using genetic approaches.

The goal of this FOA is to establish a cadre of T32 programs that will train scientists in the fields of statistical genetics and genome informatics for vision research. It is anticipated that after five years of funding, successful programs will submit competitive renewal applications to the NEI under the parent T32 announcement.

See Section VIII, Other Information - Required Federal Citations , for policies related to this FOA will use the Ruth L. Kirschstein NRSA I nstitutional Research Training Grant (T32) award mechanism. Awards may be made for periods up to five years.

The PD/PI will be solely responsible for planning, directing, and executing the proposed project. This FOA uses Just-in-Time information concepts (see SF424 (R&R) Application Guide ) . It also uses the modular as well as the non-modular budget formats (see http://grants.

nih. gov/grants/funding/modular/modular. htm ) .

Specifically, a U.S. organization submitting an application with direct costs in each year of $250,000 or less (excluding consortium Facilities and Administrative [F&A] costs) must use the PHS398 Modular Budget component. financial plans of the NEI provide for support of three to four projects with up to $300,000 annual direct costs.

Future year amounts will depend on annual the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.

Although the financial plans of the IC(s) provide support for this program, awards pursuant to this funding opportunity are contingent upon the Stipends: Stipends are provided as a subsistence allowance for trainees to help defray living expenses during the research training experience and are based on a 12-month appointment period.

The stipend is not provided as a condition of employment with either the Federal Government or the grantee institution nor is it to be considered a payment for services performed. Stipends will be based on the annual NIH stipend levels at the time of award. Stipends may be adjusted only at the time of appointment or reappointment and may not be changed in the middle of an appointment period.

For appointments of less than a full year, the stipend will be based on a monthly or daily pro-ration of the annual amount. No departure from the established stipend schedule may be negotiated by the institution with the trainee. Current stipend levels for postdoctoral trainees are available at http://grants.

nih. gov/training/nrsa. htm .

Tuition and Fees: The combined cost of tuition and fees will be offset at the following rate for predoctoral trainees: an amount equal to 60% of the level requested by the applicant institution, up to $16,000 per year, will be provided. If the program supports formally combined dual-degree training (e.g., M. D.

-Ph. D. , D.

D. S. -Ph.

D), the amount provided per trainee will be up to $21,000 per year. If the program supports postdoctoral individuals in formal degree-granting training, the amount provided per trainee enrolled in a degree-granting program will be up to $16,000 per year. Costs associated with tuition and fees are allowable only if they are required for specific courses in support of the research training experience supported by the training grant.

For a full description of the NIH tuition policy, see NOT-OD-06-093 . Trainee Travel: The application may request funds to cover the costs of trainee travel, including attendance at scientific meetings that the organization determines is necessary to the individuals training.

Funds may not be expended to cover the costs of travel between the trainee’s place of residence and the training institution, except that the grantee organization may authorize a one-way travel allowance in an individual case of extreme hardship. The maximum allowable per trainee per year is $1,400. Support for travel to a research training experience away from the grantee organization may be requested.

This must be justified on the basis of the type of opportunities for training available at the parent and remote organizations, and the relationship of the proposed experience to the trainee’s career stage and career goals. If not known at the time of application, this type of research training and travel requires prior approval of the NEI.

Letters requesting such training may be submitted to the NEI Training Officer at any time during the appointment period. Training-Related Expenses , including Health Insurance (TRE): The applicant may request the NIH standard NRSA training-related expenses: $4,200 a year per predoctoral trainee and $7,850 a year per postdoctoral trainee.

This may help defray the costs of health insurance and other research training related expenses, such as staff salaries, consultant costs, equipment, research supplies, and staff travel.

Health insurance is an allowable expense that may be charged to the Training Related Expenses budget category but only to the extent that the same health insurance fees are charged to non-Federally-supported students and postdoctoral individuals (see NOT-OD-06-093 for additional information).

Funds are provided as a lump sum on the basis of the predetermined amount per predoctoral and postdoctoral trainee Under exceptional circumstances, such as accomodating the disabilities of a trainee, it is possible to request training-related expenses above the standard level. Requests for additional costs must be explained in detail and justified in the application.

Consultation with the NEI Training Officer in advance of such requests is strongly advised. Facilities and Administrative Costs: The Notice of Grant Award will provide facilities and administrative costs based on 8% of total direct costs, exclusive of tuition, fees and equipment.

Stipend Supplementation, Compensation, and Other Income: A full description of the NIH policy regarding NRSA supplementation and compensation can be found in the NIH Grants Policy Statement at: http://grants1. nih. gov/grantsolicy/nihgps_2003/NIHGPS_Part11.

htm The grantee institution is allowed to provide funds to an individual in addition to the stipends paid by the NIH. Such additional amounts either may be in the form of augmented stipends (supplementation) or in the form of compensation, such as salary or tuition remission for services such as teaching or serving as a laboratory assistant, provided the conditions described below are met.

Under no circumstances may the conditions of stipend supplementation or the services provided for compensation interfere with, detract from, or prolong the trainee's approved Supplementation : Grantees may supplement stipends from non-Federal funds provided the supplementation is without obligation to the trainee.

An organization can determine what amount of stipend supplementation, if any, will be provided according to its own formally established policies governing stipend support. These policies must be consistently applied to all individuals in a similar training status regardless of the source of funds.

Federal funds may not be used for stipend supplementation unless specifically authorized under the terms of the program from which funds are derived. An individual may use Federal educational loan funds or Veterans Administration (VA) benefits when permitted by those programs. Under no circumstances may Public Health Service (PHS) funds be used for supplementation.

Compensation : Funds characterized as compensation may be paid to trainees only when there is an employer-employee relationship, the payments are for services rendered, and the situation otherwise meets all of the conditions and policies in the NIH Grants Policy Statement.

Additionally, compensation must be in accordance with organizational policies consistently applied to both federally and non-federally supported activities and must be supported by acceptable accounting records that reflect the employer-employee relationship.

An institution may provide additional funds to a trainee in the form of compensation (as salary and/or tuition remission) for services performed outside of the responsibilities of the full-time NRSA-supported training such as teaching or serving as a research assistant.

A trainee may receive compensation for services as a research assistant or in some other position on a Federal research grant, including a DHHS research grant; however, compensated services should occur on a limited, part-time basis apart from the normal full-time research training activities.

In addition, compensation may not be paid from a research grant that supports the same research that is part of the trainee s planned training experience as approved in the institutional training grant application. The NEI Training Officer must approve all instances of employment on research grants to verify that the circumstances will not detract from or prolong the approved training program. Educational Loans or G.

I. Bill: An individual may make use of Federal educational loan funds and assistance under the Veterans Readjustment Benefits Act (G. I.

Bill). Such funds are not considered supplementation or compensation. Postdoctoral trainees in their first and third years of training may also be eligible to participate in the NIH Extramural Loan Repayment Program.

Information about this program is available at http://www. lrp. nih.

gov/ . grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in Section III.

Eligibility Information organizations/institutions are eligible to apply: Controlled Institutions of Higher Education Institutions of Higher Education Historically Black Colleges Tribally Controlled Colleges Alaska Native and Native Hawaiian Serving Institutions Only domestic, non-profit, private or public institutions may apply for grants to support National Research Service Award (NRSA) institutional research training programs.

The applicant institution must have a strong and high quality research program in statistical genetics and genome informatics and must have the requisite staff and facilities to conduct the proposed research training prog ram.

An eligible institution ( e.g. a university) may only submit a single application in response to this funding opportunity and may only have a single training program supported by this FOA institution may choose to partner with another institution(s) which can provide complementary expertise for programmatic activities.

An applicant institution may have other active NEI-supported training programs so long as the appropriate pools of faculty and students exist. Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the PD/PI is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply The Training PD/PI should be an established basic, behavioral, and/or clinical researcher with the skills, knowledge, a successful past training record, and available resources to conduct the proposed research training program at the sponsoring institution.

The research training director will be responsible for the selection and appointment of trainees to the NRSA research training grant and for the overall direction, management, and administration of the program, program evaluation, and the submission of all required forms in a timely Cost sharing is not required.

Training Program: Trainees appointed to the research training program must have the opportunity to carry out supervised biomedical, behavioral, or clinical research in ophthalmic genome informatics and statistical genetics, with the primary objective of developing or enhancing their research skills and knowledge in preparation for a health-related research career.

Trainees must be able to commit full-time effort, normally defined as 40 hours per week or as specified by the sponsoring institution in accordance with its own policies, to the program and its related research activities, consonant with NRSA guidelines.

Within the full-time training period, research trainees who are also training as clinicians must devote their time to the proposed research training and must confine clinical duties to those that are an integral part of the research training experience. Kirschstein-NRSA institutional research training grant must be used to support a program of full-time research training. It may not be used to support studies leading to the M.

D. , D. D.

S. , or other clinical, health-professional training except when those studies are part of a formal combined research degree program, such as the M. D.

/Ph. D. Similarly, trainees may not accept NRSA support for clinical training that is part of residency training leading to clinical certification in a medical or dental specialty or subspecialty.

It is permissible and encouraged, however, for clinicians to engage in NRSA supported full-time postdoctoral research training even when that experience is creditable toward certification by a clinical specialty or Trainee Appointments: All trainees are required to pursue their research training full time, normally defined as 40 hours per week, or as specified by the sponsoring institution in accordance with its own policies.

Appointments are normally made in 12-month increments, and no trainee may be appointed for less than 9 months during the initial period of appointment, except with prior approval of the NIH awarding unit, or when trainees are appointed to approved, short-term training positions.

No individual trainee may receive more than 5 years of aggregate NRSA support at the predoctoral level or 3 years of NRSA support at the postdoctoral level, including any combination of support from institutional training and individual fellowship awards.

Any exception to the maximum period of support requires a waiver from the NIH awarding component based on a review of the written justification from the individual trainee, and endorsed by the PD/PI and the sponsoring grantee institution.

Trainees seeking additional support are strongly advised to consult with the NIH awarding citizenship: At the time of appointment to the training trainee must be a citizen or non-citizen national of the United States or must have been lawfully admitted for permanent residence (i.e., in possession of a currently valid Permanent Resident Card (USCIS Form I-551), or some other legal verification of such status).

Non-citizen nationals are generally persons born in outlying possessions of the United States (e.g., American Samoa and Swains Island). Individuals on temporary or student visas are not eligible. Trainees must be in one of the following categories: A.

Predoctoral Trainees : Predoctoral trainees must have received a baccalaureate degree by the beginning date of their NRSA appointment, and must be training at the postbaccalaureate level and enrolled in a program leading to a Ph. D. in science or in an equivalent research doctoral degree program.

Health professional students, predoctoral students in the quantitative sciences, or individuals in postgraduate clinical training who wish to interrupt their studies for a year or more to engage in full-time research training before completing their formal training programs are also eligible. B. Postdoctoral Trainees : Postdoctoral trainees must have received, as of the beginning date of the NRSA appointment, a Ph.

D. , M. D.

, D. D. S.

, or comparable doctoral degree from an accredited domestic or foreign institution. Eligible doctoral degrees include, but are not limited to, the following: D. M.

D. , D. C.

, D. O. , D.

V. M. , O.

D. , D. P.

M. , Sc. D.

, Eng. D. , Dr. P.

H. , D. N.

Sc. , Pharm. D.

, N. D. (Doctor of Naturopathy), D.

S. W. , and Psy.

D. Documentation by an authorized official of the degree-granting institution certifying all degree requirements have been met prior to the beginning date of training is acceptable. trainee must have a mentor who is recognized as an accomplished investigator in genetics or bioinformatics research and who will assist the institution with the trainee's development and research plan.

Plans for academic year training should be developed jointly by the student and mentor. It is expected that the mentor(s) will guide the trainee through the initial training period and continue this interaction throughout the award.

The development of strong mentoring relationships is essential to the success of the trainees and the program, and multiple mentors or a mentoring committee may be appropriate in The applicant institution will identify and complete arrangements with an established ophthalmic genetics/bioinformatics research center(s) before submitting an application.

Arrangements between participating institutions for the recruitment of trainees and joint selection of trainers for the provision of training, and for ongoing cooperation and collaboration between the institutions in the implementation of the program should be clearly outlined in the application, if applicable. IV.

Application and Submission Information download a SF424 (R&R) Application Package and SF424 (R&R) Application Guide for completing the SF424 (R&R) forms for this FOA, use the Apply for Grant Electronically button in this FOA or link to http://www. grants. gov/Apply/ and follow the directions provided on that Web site.

registrations with Grants. gov and eRA Commons must be completed on or before the due date in order to successfully submit an application . Several of the steps of the registration process could take four weeks or more.

Therefore, applicants should immediately check with their business official to determine whether their organization/institution is already registered with both Grants. gov and the Commons . All registrations must be complete by the submission deadline for the application to be considered on-time (see 3.

C. 1 for more information about is required for institutions/organizations at both: Grants. gov ( http://www.

grants. gov/applicants/get_registered. jsp ) eRA Commons ( http://era.

nih. gov/ElectronicReceipt/preparing. htm ) The PD/PI should work with their institutions/organizations to make sure they are registered in the NIH eRA Commons.

additional separate actions are required before an applicant can submit an electronic application, as follows: Organizational/Institutional Registration in Grants. gov/Get Registered Your organization will need to obtain a Data Universal Number System (DUNS) number and register with the Central Contractor Registration (CCR) as part of the Grants. gov registration process.

If your organization does not have a Taxpayer Identification Number (TIN) or Employer Identification Number (EIN), allow for extra time. A valid TIN or EIN is necessary for CCR registration. The CCR also validates the EIN against Internal Revenue Service records, a step that will take an additional one to two business days.

Direct questions regarding Grants. gov registration to: Business Hours: M-F 7:00 a. m.

- 9:00 p. m. Eastern Time 2) Organizational/Institutional Registration in the eRA Commons To find out if an organization is already Commons-registered, see Organizations Registered in NIH eRA Commons.

Direct questions regarding the Commons registration to: Phone: 301-402-7469 or 866-504-9552 (Toll Free) Business hours M-F 7:00 a. m. 8:00 p.

m. Eastern Time Director/Principal Investigator (PD/PI) Registration in the NIH eRA Commons: Refer to the NIH eRA Commons System (COM) The individual designated as PD/PI on the application must be registered also in the NIH eRA Commons. hold a PD/PI account in the Commons.

Applicants should not share a Commons account for both an Authorized Organization Representative/Signing Official (AOR/SO) role and a PD/PI role; however, if they have both a PD/PI role and an NIH Internet Assisted Review (IAR) role, both roles should exist under one Commons account. This registration/affiliation must be done by the AOR/SO or his/her designee who is already registered in the Commons.

AOR/SO need separate accounts in the NIH eRA Commons since both are authorized to view the application image. Note: The registration process is not sequential. Applicants should begin the registration processes for both Grants.

gov and eRA Commons as soon as their organization has obtained a DUNS number. Only one DUNS number is required and the same DUNS number must be referenced when completing Grants. gov registration, eRA Commons registration and the SF424 (R&R) Request Application Information download the SF424 (R&R) application forms and the SF424 (R&R) Application Guide for this FOA through Grants.

gov/Apply . Note: Only the forms package directly attached to a specific FOA can be used. You will not be able to use any other SF424 (R&R) forms (e.g., sample forms, forms from another FOA), although some of the "Attachment" files may be useable for more than one assistance, contact GrantsInfo -- Telephone 301-710-0267; Email: [email protected] .

for the hearing impaired: TTY: (301) 451-5936 Content and Form of Application Submission Prepare all applications using the SF424 (R&R) application forms for this FOA through Grants. gov/Apply and in accordance with the SF424 (R&R) Application Guide ( http://grants. nih.

gov/grants/funding/424/index. htm ). Application Guide is critical to submitting a complete and accurate application to NIH.

Some fields within the SF424 (R&R) application components, although not marked as mandatory, are required by NIH ( e.g., the Credential log-in field of the Research & Related Senior/Key Person Profile component must contain the PD/PI’s assigned eRA Commons User ID ). Agency-specific instructions for such fields are clearly identified in the Application Guide.

For additional information, see Frequently Asked Questions Application Submission of Grant Applications . The SF424 (R&R) application has several components. Some components are required, others are optional.

The forms package associated with this FOA in Grants. gov/APPLY includes all applicable components, required and optional.

A completed application in response to this FOA includes the data in the following Project/Performance Site Locations Research & Related Other Project Information Research & Related Senior/Key Person Profile (Expanded) PHS 398 Research Training Program Plan PHS398 Cover Page Supplement Research & Related Subaward Budget Attachment(s) Submission Dates and Times See Section IV. 3. A.

for details. Submission, Review, and Anticipated Start Dates Date: A pril 1 8 , 2010 (Earliest date an application may be submitted to Grants. gov) Application Due Date(s): May 18 , 2010, 2011, 2012 Peer Review Date(s): November/December 2010, 2011, 2012 Review Date(s): January 2011, 2012, 2013 Earliest Anticipated Start Date(s): April 1, 2011, 2012, 2013 letter of intent is not required for the funding