New AHRQ R01: Systems-Based Approaches to Improve Patient Safety by Improving Healthcare Worker Safety and Well-Being

New AHRQ R01: Systems-Based Approaches to Improve Patient Safety by Improving Healthcare Worker Safety and Well-Being is sponsored by Agency for Healthcare Research and Quality (AHRQ). AHRQ is seeking applications for funding support that propose approaches to improve the interrelated systems and processes embedded in healthcare delivery to support healthcare worker safety and well-being in various health settings.

Expired PA-24-093: Systems-Based Approaches to Improve Patient Safety by Improving Healthcare Worker Safety and Well-Being (R01 Clinical Trial Optional) This notice has expired. For NIH, in limited situations, applications may be accepted on a case-by-case basis for a short period after expiration to accommodate NIH late or continuous submission policies . Contact the eRA Service Desk for any submission issues.

Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1. Overview Information Participating Organization(s) Agency for Healthcare Research and Quality ( AHRQ ) NOTE: The policies, guidelines, terms, and conditions stated in this Notice of Funding Opportunity (NOFO) may differ from those used by the NIH.

Where this NOFO provides specific written guidance that may differ from the general guidance provided in the grant application form, please follow the instructions given in this NOFO. Also note that AHRQ may have different page limits than NIH for the application Research Strategy, which can be found within each individual NOFO.

of Participating Organizations Funding Opportunity Title Systems-Based Approaches to Improve Patient Safety by Improving Healthcare Worker Safety and Well-Being (R01 March 17, 2026 - Notice of Early Expiration PA-24-093--Systems-Based Approaches to Improve Patient Safety by Improving Healthcare Worker Safety and Well-Being (R01 Clinical Trial Optional) .

See Notice NOT-HS-26-010 March 31, 2025 - This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

See Notice NOT-OD-24-084 2023 - Special Emphasis Notice: AHRQ Announces Interest in Health Services Research to Advance Health and Healthcare Equity. See NOT-HS-23-013. 6, 2023 - Salary Limitation on AHRQ FY2023 Grants, Cooperative Agreements, and Contracts.

See NOT-HS-23-005 . - Competitive Revision Supplements to Existing AHRQ Grants and Cooperative Agreements to Enhance Workforce Diversity in Health Services Research. See PA-22-175 11, 2019 - AHRQ Announces Change in Grant Recipient Purchasing of Identifiable CMS Data, effective FY2019 .

5, 2016 - AHRQ Policy Guidance Regarding Inflationary Increases (aka, cost-of-living adjustments, or COLAs) beginning in Fiscal Year 2017. See NOT-HS-17-001 . Funding Opportunity Number (FON) Companion Notice of Funding Additional Information on Eligibility .

Assistance Listing Number(s) Funding Opportunity Purpose The purpose of this Notice of Funding Opportunity (NOFO) is to advance system-level approaches to improve patient safety by improving healthcare worker safety and well-being. Patient safety cannot be fully achieved without healthcare worker safety and well-being.

This NOFO will contribute to AHRQ’s goal of reinvigorating the patient safety movement by adding fresh perspectives and insights of healthcare professionals to efforts to improve patient safety. Patient safety requires a foundation of safe and healthy healthcare workers.

Healthcare workers' well-being depends, in part, on their ability to provide high-quality, safe care, and to have control and empowerment to impact the systems that affect this ability.

Healthcare delivery systems can support or limit the ability of healthcare workers to provide such care, and healthcare workers have unique insights into the capabilities and hazards of healthcare delivery systems, along with varying opportunities to improve Healthcare delivery involves dynamic interactions between various groups of healthcare workers (e.g., actions of hospital healthcare workers may impact emergency department healthcare workers) as well as interactions between different types of healthcare providers, and different organizational or administrative levels.

AHRQ encourages grant applications that are designed to improve the interrelated systems and processes embedded in healthcare delivery in various healthcare settings (e.g., ambulatory, prehospital, emergency, various inpatient services, post-acute or long-term care, including medical, surgical, and mental health care settings) in order to support healthcare worker safety and well-being, and, ultimately, patient safety.

Grant applications must include licensed healthcare professionals (e.g., physicians, nurses, pharmacists, social workers, therapists) affiliated with eligible organizations as PIs, Co-PIs, Senior and/or Key Personnel in the application's proposed development and implementation activities. Open Date (Earliest Submission Date) Letter of Intent Due Date(s) 30 days prior to the application due date dates apply.

The first standard application due date for this NOFO All applications are due by 5:00 PM local time of the applicant Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s) Generally, four months after the receipt date Generally, four months after the peer review date New Date March 17, 2026 per issuance of NOT-HS-26-010 . (Original Expiration Date: January 20, 2029 ) It is critical that applicants follow the Research (R) Instructions (R&R) Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV and follow the AHRQ Grants Policy and Guidance found on the AHRQ website at http://www. ahrq.

gov/funding/policies/nofoguidance/index. html . the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

do not comply with these instructions may be delayed or not accepted for review. Part 1. Overview Information Part 2.

Full Text of the Announcement I. Notice of Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Section I.

Notice of Funding Opportunity Description The mission of the Agency for Healthcare Research and Quality (AHRQ) is to produce evidence to make health care safer, higher quality, and more accessible, equitable, and affordable, and to work within the U.S. Department of Health and Human Services and with other partners to make sure the evidence is understood and used.

Many factors and conditions must align effectively to enable patient safety, including access to capable, motivated and healthy healthcare workers.

However, the safety and well-being of healthcare workers, and therefore their ability to provide safe care for patients is challenged by many conditions, including limited resources, conflicting clinical goals (e.g., taking the best care of each patient versus being the best steward of healthcare resources, being efficient versus being thorough, caring for patients despite personal risk of injury or illness), changing priorities (e.g., emergencies can necessitate rapid changes in prioritization, with cascading effects on other patients and other providers), poorly designed or implemented technologies, tools and processes, time pressures, shift work and changing schedules, and lack of personal physical and psychological safety.

Numerous studies have documented that lack of healthcare worker safety and well-being are important current problems, with measurable adverse effects not only on healthcare workers, but also on patient care, patient experiences, and patient outcomes.

In recognition of the important consequences of these relationships, improving healthcare worker safety and well-being are pillars of both the Quadruple Aim and the National Action Plan to Advance Patient Safety. Systems-based approaches to improve healthcare worker safety and well-being are essential and are expected to provide valuable benefits for both healthcare workers and patients.

Research is urgently needed to better understand the effectiveness of systems-based interventions designed to improve healthcare worker safety and well-being, and to explore their impacts on healthcare workers and on patients. The overarching goal of this NOFO is to improve healthcare worker safety and well-being so as to improve patient safety.

Providing safe care for patients in all care delivery settings is not just about avoiding harm and attempting to prevent errors. Safe care should also be considered from a resilience engineering perspective as attempting to ensure "as many things as possible go right" so that healthcare delivery achieves outcomes that are successful for healthcare workers as well as patients and their families.

worker safety and well-being The National Academy of Medicine states that healthcare workers are among the most educated and dedicated workers in any industry. However, many healthcare workers struggle with burnout, moral injury, emotional exhaustion, depersonalization, and low levels of personal accomplishment.

Burn-out is an occupational syndrome resulting from chronic workplace stress that has not been successfully addressed, characterized by 1) feelings of energy depletion or exhaustion; 2) increased mental distance from one’s job, or feelings of negativism or cynicism related to one's job; and 3) reduced professional efficacy.

Moral distress, which can progress to moral injury, can manifest when healthcare workers are unable to provide the ethically driven quality of care they were trained to provide because of structural barriers and challenges. Sustained moral distress can lead to moral injury, which has been linked to feelings of profound guilt, shame, anger, and other psychological impacts.

In contrast, definitions of healthcare worker well-being are evolving.

A proposed conceptual definition suggests that well-being (wellness) is defined by quality of life, which includes the absence of ill-being and the presence of positive physical, mental, social, and integrated well-being experienced in connection with activities and environments that allow healthcare workers to develop their full potentials across personal and work-life domains.

Poor healthcare worker well-being is often associated with medical errors and patient safety incidents (which may or may not involve errors). Patient safety and healthcare worker safety and well-being are synergistic, and excessive workload, long hours, burgeoning bureaucracy, physical hazards, bullying, and burnout experienced by healthcare workers have adverse effects on patient outcomes.

Accordingly, efforts to minimize harm and provide safe care for patients must include efforts to address healthcare worker safety and well-being.

Factors that threaten healthcare worker safety and well-being extend beyond physical hazards and include moral distress, pandemic-related exhaustion, time pressure, lack of psychological safety, shortages of staff, equipment and supplies, poorly designed or poorly implemented technology, workflow, tools and processes, increasing patient acuity and complexity, structural racism and health inequities, conflicting clinical goals, excessive clerical and administrative burdens, and financial pressures.

Furthermore, challenges with work life balance, the healthcare worker's own illness or disability, caregiving responsibilities for children, older adults, and other family members, and lack of sensitivity to each of these factors can also contribute to burnout. Although these challenges were exacerbated during the COVID-19 pandemic, the issues are not new.

These factors impact individual healthcare workers, care teams, and entire healthcare While the importance of healthcare worker well-being is frequently recognized, efforts to achieve well-being often focus on supporting the individual healthcare worker’s use of coping mechanisms such as yoga, physical exercise, and meditation.

While these interventions may be helpful, they do not address the systemic factors that challenge healthcare worker Applications responding to this NOFO must test strategies to improve healthcare delivery system safety by addressing the factors that weaken healthcare worker safety and well-being and/or by making systemic changes to improve healthcare worker safety and well-being.

Applications must include an operational definition of healthcare worker safety or well-being. Several organizations, including AHRQ, the National Academy of Medicine, the World Health Organization, and the Institute for Healthcare Improvement, as well as the US Surgeon General and others, have recommended system approaches to improve patient safety through efforts targeting healthcare worker safety and well-being.

This NOFO encourages applications focused on improving healthcare worker safety and well-being as a path to improving patient Healthcare delivery occurs in systems that are simultaneously complex and adaptive.

Healthcare delivery is affected by the difficulty, urgency and resource requirements of the intended task, and the availability, accessibility, capabilities and characteristics of patients and the care team, technology, tools and devices, and medications, diverse patient care settings, physical plants and organizational cultures, and the environment, processes, policies, and expectations within the healthcare organization, as well as the requirements and expectations placed on the organization from owners, payers and payment structures, regulators, and others.

Relationships, resources, and patient care goals change over time - sometimes slowly and sometimes abruptly. Each of these factors impacts healthcare worker and patient experiences, and each, in turn, is impacted by healthcare worker and patient experiences. In complex systems, the consequences of decisions and actions may emerge in unpredictable, non-linear ways.

Although subsystem analysis may provide rich insights, the whole of healthcare delivery cannot be completely understood by deconstruction into subsystem components.

Because of the complexity and adaptive nature of healthcare delivery, and to ensure that healthcare worker well-being enhancements are effective and sustainable, the input and unique insights of healthcare workers must be included in the development and implementation of system level improvements.

Involving licensed healthcare professionals in the development and implementation of interventions to support healthcare worker safety and well-being will take advantage of their lived experiences, address competing priorities, and increase their investment in improvement processes and sustainable outcomes.

AHRQ requires applications to include licensed healthcare professionals in project planning and the development of interventions or strategies, including those who deliver care in ambulatory, prehospital, emergency, inpatient, post-acute or long-term care settings, including medical, surgical, and mental health care, to patients of any age.

AHRQ encourages research projects that address more effective ways to improve healthcare worker safety and well-being and promote the wide-scale adoption of evidence-based approaches. This NOFO will support Large Research Projects (R01) in areas of healthcare worker safety and well-being focused on healthcare delivery system processes and informed by the participation of licensed healthcare professionals.

This NOFO invites applications that seek to improve healthcare worker safety and well-being by: 1) improving healthcare delivery systems with collaboration at multiple levels, which may include some combination of unit, specialty, department, facility and/or organizational systems, and 2) requiring licensed healthcare professional participation as project PIs, Co-PIs, Senior and/or Key Personnel, to benefit from their input, experience and insights in the development and implementation of improvements, to optimize both healthcare worker capabilities and patient The involvement of many other people who provide essential contributions to patient safety, such as executive leaders, administrators, healthcare delivery support staff (e.g., staff providing environmental and security services, and information technology, biomedical, equipment, and supply resources), and patients, families, and their communities, may also be components of applications responding to this NOFO.

Healthcare workers, as individuals and members of teams, fulfill a variety of roles with a range of responsibilities, thus affording diverse insights into hazards and latent safety threats, first-hand understanding of work-as-done, and invaluable perspectives about potential interventions to enhance patient safety through interventions targeting healthcare worker safety and well-being.

of activities responsive to this NOFO In the following examples, the first list includes processes or qualities that may be desirable, and the second list includes processes or qualities that can be problematic. Researchers may address one or more items from one or both lists. The lists are not intended to be exclusive.

Examples of factors relevant to this NOFO include, but are not limited to, processes, interventions or insights related to understanding, developing, improving, assessing, or maintaining: 1) healthcare worker safety, well-being, satisfaction, joy, recognition, engagement, respect, management of work-home 2) healthcare worker autonomy, flexibility, agency, 3) organizational resilience, reliability, learning 4) care planning, transitions (e.g., anticipatory planning or transfers of responsibility such as discharges, handoffs, 5) adaptation, margin (e.g., capacity for adaptive response), or graceful degradation (e.g., ability to prioritize, and defer less essential tasks, but not collapse under pressure) 6) value, priority alignment (e.g., ability to address or resolve conflicting patient care goals) 7) collegiality, fairness, respect 8) user-friendly/user-informed processes (e.g., clinical decision support, or other electronic or non-electronic processes), user-friendly/user-informed technology 9) meaningful documentation Processes, interventions or insights related to understanding, assessing, preventing, managing, or mitigating the following healthcare worker concerns are also examples of factors relevant to this NOFO: 2) goal conflicts, such as between efficiency and 3) gridlock, brittleness (e.g., propensity for processes to collapse under pressure) 5) fragmented care delivery 6) non-productive work effort Grant applications may address conditions and circumstances such as patient care surges, acute or chronic crises, and resource limitations as well as ordinary and/or successful work.

Grant applications may address, but are not limited to, cognitive, physical, or social/ behavioral processes. Research, measurement, and practice improvement to enhance healthcare worker safety and well-being may address adverse events and harms or may encompass approaches that support learning from how and why things go right and how to anticipate, recognize, monitor, and respond to hazards and opportunities.

Projects can be designed from a Safety-I or a Safety-II lens. The Safety-I perspective typically addresses what went wrong and attempts to prevent future occurrences of similar adverse events, generally by means of constraints. Grant applications may address preventing or mitigating conditions or processes that adversely impact healthcare worker well-being.

The Safety-II perspective seeks a deep understanding of what went well with an appreciation of the importance of adaptability in both ordinary and extraordinary healthcare delivery. Healthcare workers doing complex everyday work are successful more often than they are unsuccessful.

Studying how healthcare workers constantly adapt to create successful outcomes despite dynamic environments, incomplete information and limited resources may help define and further improve the factors and conditions that underpin that success. Methods may include the use of simulation and/or debriefing as interventions or research methodologies.

A variety of surveys are available, addressing burnout, fulfillment, work environments, and healthcare worker and organizational safety, such as components of AHRQ’s Surveys on Patient Safety Culture (SOPS).

Less traditional research methods, such as stepped wedge cluster randomized trial, statistical process control, adaptive trials, agile design, implementation, mixed methods or solely qualitative research methods (e.g., interviews, observation, ethnography) may be appropriate. All research methods must be justified and include a theoretical or conceptual justification.

To increase the consideration of scientific principles from diverse sciences or industries that design or implement methods to improve safety for humans, applicants must include collaboration with safety experts outside of surgery, internal medicine, pediatric, pathology or other traditional medical fields.

Examples of collaborators include, but are not limited to, engineers with human factors, systems or industrial safety expertise, design or implementation scientists, informatics experts, social scientists such as anthropologists and sociologists, architects, economists, and psychologists with expertise in safety for humans.

Seek to improve healthcare delivery systems to improve healthcare worker safety and well-being; Include an operational definition of healthcare worker Include at least one PI, Co-PI, Senior and/or Key Person who is a licensed healthcare professional in project planning and the development of interventions or strategies, Include at least one PI, Co-PI, Senior and/or Key Person from outside of traditional medical fields who has unique knowledge relevant to healthcare worker safety and well-being.

VIII. Other Information for award authorities and regulations. Section II.

Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.

Optional: Accepting applications that either propose or do not propose clinical trial(s) determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The number of awards is contingent upon AHRQ appropriations and the submission of a sufficient number of meritorious Future year funding is contingent upon the availability of funds for each year of support.

Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total costs (direct and indirect) for a project awarded under this NOFO will not exceed $500,000 in any given year and $2 million for the entire project period. An application with a budget that exceeds $500,000 total costs in any given year will not be reviewed.

Funds may be used only for those expenses that are directly related and necessary to the project and must be expended in compliance with applicable Uniform Administrative Requirements, Cost Principles, and Audit Requirements for HHS Awards (45 CFR Part 75) and the The project period may not These projects are being funded pursuant to 42 U.S.C.

299a, which provides that AHRQ shall conduct and support research, support demonstration projects, and disseminate information on health care and on systems for the delivery of such care, including activities with respect to the quality, effectiveness, efficiency, appropriateness, and value of health care services.

All applications submitted and AHRQ grants made in response to this NOFO are subject to 45 CFR Part 75 (Uniform Administrative Requirements, Cost Principles and Audit Requirements for HHS Awards; https://www. ecfr. gov/cgi-bin/text-idx?

node=pt45. 1. 75) , the HHS Grants Policy Statement (see https://www.

ahrq. gov/funding/policies/hhspolicy/index. html ), and the terms and conditions set forth in the Notice of Award.

Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Nonprofits without 501(c)(3) IRS Status (Other than Institutions City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations AHRQ's authorizing legislation does not allow for-profit organizations to be eligible to lead applications under this research mechanism.

For-profit organizations may participate in projects as members of consortia or as subcontractors only. Because the purpose of this program is to improve healthcare in the United States, foreign institutions may participate in projects as members of consortia or as subcontractors only. Applications submitted by for-profit organizations or foreign institutions will not be reviewed.

Organizations described in section 501(c) 4 of the Internal Revenue Code that engage in lobbying are not eligible. HHS grants policy requires that the grant recipient perform a substantive role in the conduct of the planned project or program activity and not merely serve as a conduit of funds to another party or parties.

If consortium/contractual activities represent a significant portion of the overall project, the applicant must justify why the applicant organization, rather than the party(s) performing this portion of the overall project, should be the recipient and what substantive role the applicant organization will play.

Justification can be provided in the Specific Aims or Research Strategy section of the PHS398 Research Plan Component sections of the SF424 (R&R) application. There is no budget allocation guideline for determining substantial involvement; determination of substantial involvement is based on a review of the primary project activities for which grant support is provided and the organization(s) that will be performing those activities.

Non-domestic (non-U.S.) Entities (Foreign Organizations) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted.

Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Award Management (SAM) Applicants must complete and maintain an active registration, at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Entity Identifier (UEI) - A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an Applicants must have an active SAM registration in order to complete the Grants. gov Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role.

Obtaining an eRA Commons account can Eligible Individuals (Program Director/Principal At least one PI, Co-PI, Senior and/or Key Person must be a licensed healthcare professional.

At least one PI, Co-PI, Senior and/or Key Person must have unique knowledge outside of traditional medical fields that will contribute to Directors/Principal Investigators (PD(s)/PI(s)) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide. The AHRQ multiple PDs/PIs policy can be found at https://grants. nih.

gov/grants/guide/notice-files/NOT-HS-16-018. html . This NOFO does not require cost sharing.

While there is no cost sharing requirement included in this NOFO, AHRQ welcomes applicant institutions, including any collaborating institutions, to devote resources to this effort. An indication of institutional support from the applicant and its collaborators indicates a greater potential of success and sustainability of the project.

Examples of institutional support would include: donated equipment and space, institutional funded staff time and effort, or other resource investments. Applicant institutions should indicate institutional support by outlining the specific contributions to the project and providing assurances that their organization and any collaborators are committed to providing these funds and resources to the project.

This information can be included at the end of the budget justification section of the application, but institutional support dollars are not to be shown/included in the detailed budget request. 3. Additional Information Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

AHRQ will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement 2. 3. 7.

4 Submission of Resubmission Application . This means that the AHRQ will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application. Section IV.

Application and Submission Information 1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution.

Links to apply using ASSIST or Grants. gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system 2.

Content and Form of Application It is critical that applicants follow the Research (R) Instructions to Apply - Application Guide , except where instructed in this notice of funding opportunity to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows AHRQ staff to estimate the potential review workload By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed activity Name(s), address(es), and telephone number(s) of the PD(s)/PI(s) Names of other key personnel Participating institution(s) Number and title of this funding opportunity The letter of intent should be emailed to: Name: Ellen’s Deutsch, MD, MS O/C Division: General Patient Safety All page limitations described in the How to Apply Application Guide of Page Limits must be followed.

For this specific NOFO, the Research Strategy section is Instructions for Application Submission The following section supplements the instructions found in the How to Apply Application Guide and should be used for preparing an application to All instructions in the SF424 (R&R) Application Guide SF424(R&R) Project/Performance Site Locations All instructions in the SF424 (R&R) Application Guide must SF424(R&R) Other Project Information All instructions in the SF424 (R&R) Application Guide SF424(R&R) Senior/Key Person Profile All instructions in the SF424 (R&R) Application Guide All instructions in the SF424 (R&R) Application Guide must Budget Component: Special Instructions for AHRQ applications AHRQ is not using the Modular Grant Application and Award Process.

Applicants applying for funding from AHRQ are to ignore application instructions concerning the Modular Grant Application and Award Process, and prepare applications using instructions for the Research and Related Budget Components of the SF 424 (R&R). Applications submitted in the Modular format will not be reviewed.

All instructions in the SF424 (R&R) Application Guide must PHS 398 Cover Page Supplement All instructions in the SF424 (R&R) Application Guide All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following modification: Submission of a data management plan is required.

AHRQ applicants are reminded to refer to NOT-HS-20-011: The Agency for Healthcare Research and Quality Data Management Plan Policy (https://grants. nih. gov/grants/guide/notice-files/NOT-HS-20-011.

html) for additional information on how to incorporate their data management plan into the resource sharing plan. Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) PHS Human Subjects and Clinical Trials Information When involving human subjects research, clinical research, and/or clinical trials (and