NIA-Funded Alzheimer's Disease Research Centers (ADRCs)

NIA-Funded Alzheimer's Disease Research Centers (ADRCs) is sponsored by National Institute on Aging (NIH). These centers serve as a national resource for research on the nature of Alzheimer's disease (AD) and AD-related dementias (ADRD) and the development of more effective approaches to prevention, diagnosis, care, and therapy.

This repository is under review for potential modification in compliance with Administration directives. [](https://dss. niagads.

org/) NIAGADS Data Sharing Service * Acknowledgment Generator * For Grant Applications (NIH DMSP) # NIA Alzheimer’s Disease Research Centers (ADRC) The NIA ADRC cohort included subjects ascertained and evaluated by the clinical and neuropathology cores of the 32 NIA-funded ADRCs. Data collection is coordinated by the National Alzheimer’s Coordinating Center (NACC).

NACC coordinates collection of phenotype data from the 32 ADRCs, cleans all data, coordinates implementation of definitions of AD cases and controls, and coordinates collection of samples.

The ADRC cohort consists of autopsy-confirmed and clinically-confirmed AD cases, and cognitively normal elders (CNEs) with complete neuropathology data who were older than 60 years at age of death, and living CNEs evaluated using the Uniform dataset (UDS) protocol who were documented to not have mild cognitive impairment (MCI) and were between 60 and 100 years of age at assessment.

Based on the data collected by NACC, ADSP Phenotype Harmonization Consortium (ADSP-PHC) derived inclusion and exclusion criteria for AD and control samples. Clinical AD cases were demented according to NACC’s cognitive status of dementia at UDS visit with a primary etiologic diagnosis of Alzheimer’s Dementia. Controls did not meet dementia or MCI criteria and exhibited no etiologic diagnoses.

Neuropathologic definition of cases and control followed NIA-AA Alzheimer’s disease neuropathologic change (ADNC) scores (ABC method), with intermediate or higher ADNC scores classified as Cases and low ADNC scores labeled Controls.

When ADNC scores were not available, a similar approach was used with BRAAK and CERAD scores, with Cases possessing a BRAAK Stage greater than or equal to III and a CERAD score of either moderate or frequent neuritic plaques. Consistent with the ADNC definition, if a participant was lower on BRAAK or CERAD they were given a Control diagnosis (equivalent to a low score on ADNC).

Individuals missing an ADNC score and either BRAAK or CERAD score were not given a neuropathologic diagnosis. Persons with Down’s syndrome, neuropsychiatric, neurodegenerative, and neurologic disorders, brain structure abnormalities, non-AD tauopathies and synucleinopathies were excluded from both clinical and autopsy diagnoses of cases and controls. All autopsied controls had a clinical evaluation within two years of death.

An autopsy-confirmed variable was derived from matching neuropath and clinical diagnoses when available. All cases and controls were required to be >60 years of age. ADRCs sent frozen tissue from autopsied subjects and DNA samples from some autopsied subjects and from living subjects to the ADRCs to the National Cell Repository for Alzheimer’s Disease (NCRAD).

DNA was prepared by NCRAD for genotyping and sequencing.

* NG00020 – NIA AD-FBS GWAS The goal of the National Institute of Aging Alzheimer’s Disease Family Based Study, NIA AD-FBS (formerly National Institute on Aging Genetics Initiative for Late-Onset Alzheimer’s Disease, NIA-LOAD) is to identify… Learn more * NG00022 – ADC1 – Alzheimer’s Disease Center Dataset 1 This GWAS dataset, ADC1, is the first set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00023 – ADC2 – Alzheimer’s Disease Center Dataset 2 This GWAS dataset, ADC2, is the second set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00024 – ADC3 – Alzheimer’s Disease Center Dataset 3 This GWAS dataset, ADC3, is the third set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00035 – GWAS of CSF tau levels identifies risk variants for Alzheimer’s Disease Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer’s disease (AD) and have been used as quantitative traits for genetic analyses.

This… Learn more * NG00067 – ADSP Umbrella This dataset includes sequencing data and harmonized phenotypes from cohorts sequenced by the Alzheimer’s Disease Sequencing Project and other AD and Related Dementia’s studies.

Samples are processed using a common… Learn more * NG00068 – ADC4 – Alzheimer’s Disease Center Dataset 4 This GWAS dataset, ADC4, is the fouth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00069 – ADC5 – Alzheimer’s Disease Center Dataset 5 This GWAS dataset, ADC5, is the fifth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00070 – ADC6 – Alzheimer’s Disease Center Dataset 6 This GWAS dataset, ADC6, is the sixth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00071 – ADC7 – Alzheimer’s Disease Center Dataset 7 This GWAS dataset, ADC7, is the seventh set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00116 – Resolving Mutations in Challenging Genomic Regions to Test Association with Disease Phenotypes Many regions of the human genome present challenges that prohibit scientists from discovering potential disease-causing mutations.

We developed methods to characterize mutations in these regions to rescue mutations that are… Learn more * NG00136 – ADC8 – Alzheimer’s Disease Center Dataset 8 This GWAS dataset, ADC8, is the eighth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00137 – ADC9 – Alzheimer’s Disease Center Dataset 9 This GWAS dataset, ADC9, is the ninth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00138 – ADC10 – Alzheimer’s Disease Center Dataset 10 This GWAS dataset, ADC10, is the tenth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00139 – ADC11 – Alzheimer’s Disease Center Dataset 11 This GWAS dataset, ADC11, is the eleventh set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00140 – ADC12 – Alzheimer’s Disease Center Dataset 12 This GWAS dataset, ADC12, is the twelfth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00149 – ADC13 – Alzheimer’s Disease Center Dataset 13 This GWAS dataset, ADC13, is the thirteenth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00150 – ADC14 – Alzheimer’s Disease Center Dataset 14 This GWAS dataset, ADC14, is the fourteenth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00151 – ADC15 – Alzheimer’s Disease Center Dataset 15 This GWAS dataset, ADC15, is the fifteen set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing… Learn more * NG00176-CNVs from ADSP WES data using CANOES software This dataset contains Copy Number Variation (CNV) calling from the Whole Exome Sequencing (WES) from multiple distinct Alzheimer Disease (AD) sequencing projects: both discovery and replication ADSP family dataset, ADSP… Learn more * sa000003 - Alzheimer’s Disease Genetics Consortium (ADGC) The ADGC is a large U.S. based consortium formed to collaboratively use the collective resources of the AD research community to resolve Alzheimer’s disease (AD) genetics.

Working with the National… Learn more * sa000001 - Alzheimer’s Disease Sequencing Project (ADSP) Background An initiative in response to the National Alzheimer’s Project Act (NAPA) has been working towards new biological insights and cures for Alzheimer’s Disease (AD) since its introduction by NIH… Learn more * sa000013 - APOE Extremes WGS Study The APOE extremes whole genome sequencing (WGS) study entails Alzheimer’s disease (AD) case-control association analysis using an age extremes sampling approach stratified by APOE genotype, comparing younger onset AD cases… Learn more * sa000008 - Charles F.

and Joanne Knight Alzheimer’s Disease Research Center (Knight ADRC) The search for novel risk factors for Alzheimer disease relies on access to accurate and deeply phenotyped datasets.

The Memory and Aging Project at the Knight-ADRC (Knight ADRC-MAP) collects plasma,… Learn more * sa000023 - Dissecting the Genomic Etiology of non-Mendelian Early-Onset Alzheimer Disease (EOAD) and Related Phenotypes Background: Genomic studies of Alzheimer’s disease (AD) have primarily focused on non-Hispanic White (NHW) participants affected by the late-onset form of the disease (LOAD; onset age: >65), or the study… Learn more * sa000081 - Extremely Rare CNVs and Alzheimer’s Disease Risk: Analysis of ADSP WES Data The purpose of this study is to find new Alzheimer related variants and genes, by combining exome data from healthy controls and Alzheimer patients from different studies.

CNV calling was… Learn more * sa000063 - National Institute of Aging Alzheimer’s Disease Family Based Study (NIA AD-FBS) The National Institute on Aging Alzheimer's Disease Family Based Study (NIA AD-FBS) is the largest collection of multiplex AD families recruited and longitudinally assessed worldwide.

Since 2003, the central goal… Learn more * sa000015 - NIH, CurePSP and Tau Consortium PSP WGS Progressive supranuclear palsy (PSP) is the most common frontotemporal lobar degeneration associated with tau pathology.

The majority of patients with PSP can be accurately diagnosed antemortem due to a characteristic… Learn more * sa000042 - Resolving mutations in challenging genomic regions to test association with disease phenotypes Many regions of the human genome present challenges that prohibit scientists from discovering potential disease causing mutations.

We developed methods to characterize mutations in these regions to rescue mutations that… Learn more * snd10000 - ADSP Discovery The initial phase of the ADSP research plan is called the Discovery Phase.

Samples were selected from well-characterized study cohorts of individuals with or without an AD diagnosis and the… Learn more * snd10001 - ADSP Extension The ADSP Discovery Family-Based Extension Study: To further assess the genomes in multiply affected families, under funding provided by NHGRI, an additional 427 samples were whole genome sequenced.

This included… Learn more * snd10003 - ADGC AA WES ADGC African American samples were sequenced at University of Miami on the HiSeq3000 machine. 3226 samples were sequenced using the Agilent WES v6 target capture kit. BAM files from hg37… Learn more * snd10013 - NACC Genentech WGS NACC Genentech WGS samples were whole-genome sequenced at Illumina on the HiSeq2000 machine.

Samples in either format (BAM files from hg37 build and FASTQ files) were sent to GCAD for… Learn more * snd10015 - PSP NIH-CurePSP-Tau WGS PSP NIH, CurePSP and Tau consortium samples were whole-genome sequenced at USUHS on the HiSeqX machine. FASTQ files were sent to GCAD for processing on the VCPA1. 1 pipeline.

617 samples… Learn more * snd10020 - ADSP FUS1 WGS The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD).

A concern in AD genetic studies is… Learn more * snd10031 - ADSP-FUS2 WGS The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… Learn more * snd10032 - EOAD1 WGS The EOAD samples were sequenced at USUHS on the NovaSeq machine.

3176 samples were sequenced and FASTQ files were sent to GCAD for processing on the VCPA 1. 1 pipeline.

A… Learn more * snd10058 - ADGC ADC Round 1 The ADC1 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Infinium HD Human660W-Quad (Human660W-Quad_v1_A) BeadChip which captures genotype data… Learn more * snd10059 - ADGC ADC Round 2 The ADC2 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Infinium HD Human660W-Quad (Human660W-Quad_v1_A) BeadChip which captures genotype data… Learn more * snd10060 - ADGC ADC Round 3 The ADC3 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Human OmniExpress (HumanOmniExpress-12v1_A) BeadChip which captures genotype data on… Learn more * snd10061 - ADGC ADC Round 4 The ADC4 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Human OmniExpress (HumanOmniExpress-12v1_H) BeadChip which captures genotype data on… Learn more * snd10062 - ADGC ADC Round 5 The ADC5 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Human OmniExpress (HumanOmniExpress-12v1_H) BeadChip which captures genotype data on… Learn more * snd10063 - ADGC ADC Round 6 The ADC6 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Human OmniExpress (HumanOmniExpress-12v1_H) BeadChip which captures genotype data on… Learn more * snd10064 - ADGC ADC Round 7 The ADC7 sample set was genotyped using the Infinium HumanOmniExpressExome (HumanOmniExpressExome-8v1-2_a) BeadChip, which captures genotype data on 964,193 genomic SNPs.

This includes a selected subset of 273,246 functional exonic variants… Learn more * snd10065 - ADGC ADC Round 8 The ADC8 sample set was genotyped using the Illumina Human OmniExpressExome BeadChip, which captures genotype data on 964,193 genomic SNPs.

This includes a selected subset of 273,246 functional exonic variants… Learn more * snd10066 - ADGC ADC Round 9 The ADC9 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Infinium GSAMD-24v1-0_20011747_A1 BeadChip which captures genotype data on 700,078… Learn more * snd10067 - ADGC ADC Round 10 The ADC10 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Infinium Global Screening Array (GSAMD-24v1-0_20011747_A1) BeadChip which captures genotype… Learn more * snd10068 - ADGC ADC Round 11 The ADC11 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Infinium Global Screening Array (GSAMD-24v2-0_20024620_A1) BeadChip which captures genotype… Learn more * snd10069 - ADGC ADC Round 12 The ADC12 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Infinium GSAMD-24v2-0_20024620_A1 BeadChip which captures genotype data on 759,993… Learn more * snd10070 - ADGC ADC Round 13 The ADC13 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Infinium GSA-24v3-0_A1 BeadChip which captures genotype data on 654,027… Learn more * snd10071 - ADGC ADC Round 14 Sample selection and genotyping was coordinated and paid for by the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD).

NCRAD supported genotyping of samples from subjects with diagnoses… Learn more * snd10072 - ADGC ADC Round 15 Sample selection and genotyping was coordinated and paid for by the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD).

NCRAD supported genotyping of samples from subjects with diagnoses… Learn more * snd10074 - Camouflaged Variants Provided here are variant calls in VCF format for 14,526 samples derived from the ADSP whole-exome and whole-genome sequencing dataset (available via DSS: NG00067).

Learn more * snd10094 - ADSP-FUS3 WGS The ADSP-FUS is a National Institute on Aging (NIA) initiative focused on identifying genetic risk and protective variants for late-onset Alzheimer Disease (LOAD). A concern in AD genetic studies is… Learn more * snd10095 - EOAD2 WGS 1,264 samples were sequenced at USUHS on the NovaSeq machine. FASTQ files were sent to GCAD for processing on the VCPA 1.

1 pipeline. A total of 1,183 samples passed sequencing… Learn more * snd10111 - Knight ADRC GWAS of CSF Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses.

This… Learn more * snd10139 - CNV Calling from ADSP Whole-Exome Sequencing (WES) Data This dataset comprises CNV calls from Whole Exome Sequencing (WES) across multiple distinct Alzheimer’s Disease (AD) sequencing projects, including the discovery and replication ADSP family datasets, the ADSP case-control dataset,… Learn more * snd10144 - NIA AD-FBS GWAS Genotyping done by the Center for Inherited Disease Research (CIDR) was performed using the Illumina Infinium II assay protocol with hybridization to Illumina Human 610Quadv1_B Beadchips.

When first deposited in… Learn more The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site