NIDA Research Education Grants in Drug Abuse and Addiction (R25)

NIDA Research Education Grants in Drug Abuse and Addiction (R25) is sponsored by National Institutes of Health. This clinically-focused, curriculum and/or research-program building mechanism is designed to foster the development of clinical and health services researchers in drug abuse and addiction.

Expired PAR-07-221: NIDA Research Education Grants in Drug Abuse and Addiction (R25) This notice has expired. Check the NIH Guide for active opportunities and notices. Part I Overview Information of Health and Human Services National Institutes of Health (NIH), ( http://www.

nih. gov ) Participating Organizations National Institute on Drug Abuse (NIDA), ( http://www. nida.

nih. gov ) Research Education Grants in Drug Abuse and Addiction This is a reissuance of PAR-06-550 which was previously released September 18, 2006. Update: The following updates relating to this announcement have been issued: August 16, 2010 - IMPORTANT NOTE!

NIH has eliminated the error correction window for due dates of January 25, 2011 and beyond. As of January 25, all corrections must be complete by the due date for an application to be considered on-time. See NOT-OD-10-123 .

April 20, 2010 - This PAR has been expired and reissued as (PAR-10-173). This FOA has been updated to reflect the new requirements from NIH’s Enhancing Peer Review Initiative. The new requirements are effective for submissions intended for due dates January 25, 2010 and beyond.

If submitting an application intended for a due date of January 25, 2010 and beyond, follow the guidance below and be sure to use the Adobe-Forms-B version of the application forms and instructions. If applying for a due date before January 25, 2010, follow the guidance in the archived version of this FOA and be sure to use the Adobe-Forms-A version of the application forms and instructions.

September 17, 2007 - Expiration Date adjusted to accommodate recent changes to standing submission deadlines, per NOT-OD-07-093. NOTICE: Applications submitted in response to this Funding Opportunity Announcement (FOA) for Federal assistance must be submitted electronically through Grants. gov ( http://www.

grants. gov ) using the SF424 Research and Related (R&R) forms and the SF424 (R&R) APPLICATIONS MAY NOT BE SUBMITTED IN PAPER FORMAT. This FOA must be read in conjunction with the application guidelines included with this announcement in Grants.

gov/Apply for Grants (hereafter called Grants. gov/Apply). A registration process is necessary before submission and applicants are highly encouraged to start the process at least four weeks prior to the grant submission date.

See Section IV . Domestic Assistance Number(s) Release/Posted Date: February 16, 2007 Opening Date: February 16, 2007(Earliest date an application may be of Intent Receipt Date(s): 30 days prior to the application submission date NOTE : On time submission requires that applications be successfully submitted to Grants. gov no later than 5:00 p.

m. local time (of the applicant institution/organization). Application Submission/Receipt Date(s): Standard dates apply, please see http://grants1.

nih. gov/grants/funding/submissionschedule. htm AIDS Application Submission/Receipt Date(s): Standard dates apply, please see http://grants1.

nih. gov/grants/funding/submissionschedule. htm#AIDS .

Peer Review Date(s): Standard dates apply, please see http://grants1. nih. gov/grants/funding/submissionschedule.

htm#reviewandaward Council Review Date(s): Standard dates apply, please see http://grants1. nih. gov/grants/funding/submissionschedule.

htm#reviewandaward Earliest Anticipated Start Date(s): Standard dates apply, please see http://grants1. nih. gov/grants/funding/submissionschedule.

htm#reviewandaward Additional Information To Be Available Date (URL Activation Date): Not Applicable Expiration Date: (Now Expired April 21, 2010 per issuance of PAR-10-173 ); Original: May 2, 2010 (now May 8, 2010 per NOT-OD-07-093 ) The National Institute on Drug Abuse (NIDA) Research Education grant is a clinically-focused, curriculum and/or research-program building mechanism designed to foster the development of clinical and health services researchers .

Although participants may receive a salary/subsistence allowance, this mechanism of support is not to be used for long-term support of participants, and is thus distinct from training mechanisms such as the Ruth L. Kirschstein National Research Service Award (NRSA) and career development awards . Any duration of funding of an individual participant that is longer than two years may be considered long-term support.

Therefore, applicants should obtain prior approval in writing from NIDA if an extension of support beyond the two-year period is required. invites applications focused on research education and research curriculum development and/or program building in the area of drug abuse and addiction research.

The focus should be primarily on clinical research, with preclinical research included to directly inform or provide a mechanistic foundation and/or for the purposes of supporting translational research training . of Support. This FOA will use the NIH Research Education (R25) grant mechanism.

Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. and scope of the proposed research education program will vary from application to application, it is anticipated that the size and duration of each award will project period for an application submitted in response to this funding opportunity may not exceed five years.

The direct costs are limited to $350,000 annually . A ll personnel costs (including administrative and clerical costs , as well as salaries of the PD/PI and other investigators/faculty ) associated with directing, coordinating, and administering the program should be justified and reasonable . Institutions/Organizations.

Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; State Government; Eligible agencies of the Federal government; Faith-based or community based organizations.

Foreign institutions are not Director/Principal Investigator (PD/PI): Any individual with the skills, knowledge, and resources necessary to carry out the proposed research education program is invited to work with his or her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

This FOA is restricted to a single PI. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct.

programs may not be transferred from one institution to another (see Section Materials. See Section IV. 1 for application materials.

The SF424 (R&R) Application Guide for this FOA is located at these Web sites: http://grants1. nih. gov/grants/funding/424/SF424_RR_Guide_General_Ver2.

doc (MS Word) http://grants1. nih. gov/grants/funding/424/SF424_RR_Guide_General_Ver2.

pdf Information. For general information on SF424 (R&R) Application and Electronic Submission, see these Web sites: SF424 (R&R) Application and Electronic Submission Information: http://grants. nih.

gov/grants/funding/424/index. htm information on Electronic Submission of Grant Applications: http://era. nih.

gov/ElectronicReceipt/ Hearing Impaired. Telecommunications for the hearing impaired is available at: TTY 301-451-5936. merit review will be convened by the NIDA Office of Extramural Affairs .

Part II Full Text of Announcement Section I. Funding Opportunity Section II. Award Information 2.

Cost Sharing or Matching 3. Other - Special Eligibility Criteria Section IV. Application and 1.

Request Application Information 2. Content and Form of Application Submission 3. Submission Dates and Times A.

Submission, Review, and B. Submitting an Application Electronically to the NIH C. Application Processing 4.

Intergovernmental Review 6. Other Submission Requirements Section V. Application Review 2.

Review and Selection Process A. Additional Review Criteria B. Additional Review Considerations D.

Sharing Research Resources 3. Anticipated Announcement and Award Dates Section VI. Award Administration 2.

Administrative and National Policy Requirements Section VII. Agency Contact(s) 1. Scientific/Research Contact(s) 2.

Peer Review Contact(s) 3. Financial/Grants Management Contact(s) Section VIII. Other Information - Required Federal Citations - Full Text of Announcement Section I.

Funding Opportunity Description FOA invites applications using the R25 mechanism that will focus on developing curricula to provid e education al and/or research experiences to clinically focused scientists at all levels of professional career development (e.g., independent scientists, postdoctoral fellows, clinical residents, medical students and/or graduate students).

Educational/research activities and experiences must be designed to enhance the participation and commitment of clinical researchers to careers in Clinical research is defined in this FOA as: patient-oriented clinical research conducted with human subjects, or research on the causes and consequences of disease in human populations involving material of human origin (such as tissue specimens and cognitive phenomena) for which an investigator or colleague directly interacts with human subjects in an outpatient or inpatient setting to clarify a problem in human physiology, pathophysiology or disease, or epidemiologic or behavioral studies, outcomes research or health services research, or developing new technologies, therapeutic interventions, or clinical trials.

It is expected that these institutional research sites will develop or enhance research training opportunities for individuals, selected by the institution, who are training for careers as clinical researchers, clinicians, or optimally as a combination of the two.

Educational partnerships between institutions such as, research institutions, drug abuse treatment organizations, primary care organizations--are highly encouraged in order to broaden research training and educational opportunities and, as a result, increase the number of well-trained clinical and health services researchers in the drug abuse and addiction field at large.

Education Program Objectives: There is a serious shortage of well-qualified individuals prepared to conduct needed clinical, prevention, health services, and treatment research with drug abusers and those affected by drug abuse, including underserved populations of children and adolescents, women, elderly, and racial and ethnic minorities.

At present, few academic institutions have a coordinated curriculum and other essential elements relevant to preparing individuals for a career in clinical research with drug abusers and related populations. A related need is for increased numbers of service providers who are sufficiently sophisticated consumers of research to evaluate and apply research-based findings.

This mechanism may be used to provide drug addiction research education to those in clinical training , translational research training, or in a clinical research track within a clinical training program. This mechanism may not be used for support of non-research clinical training.

Formats for the research education programs may vary to include either a series of short courses, seminars, workshops, or structured short-term or long-term research experiences; or curriculum development, design, implementation and evaluation and tracking . institutions to propose their own research education programs.

Educational/research activities and experiences are expected to enhance the participation and commitment of clinical researchers to careers in addiction potential educational programs include, but are not limited to, the following : Provide mentored clinical research opportunities designed specifically for students enrolled in medical or graduate school degree programs and clinical residents.

Encourage clinical doctoral-level or equivalent (e.g., MD, PhD, MD/PhD, DO, DSW, DSN, DDS) students and/or postdoctoral fellows/residents to embark on research projects directly applicable to clinical practice. Develop or enhance the research curricula and mentoring provided during residency training and/or create research training tracks within residency programs.

Improve the quality of mentoring in drug abuse and addiction research areas, particularly improvements in the retention and advancement of physician scientists as well as adolescent, pediatric, and Provide educational experiences relevant to the conduct of drug abuse related clinical, prevention, treatment Provide clinical research career enhancement opportunities for new clinical doctoral -level or equivalent students at the intersection of basic, clinical, treatment and services Interdisciplinary educational and research experiences that prepare drug abuse and addiction researchers to conduct interdisciplinary research (e.g., behavioral, neuroscience, genetic, epidemiological, clinical, etc.) or to translate approaches from basic behavioral, social science, neuroscience, and biomedical fields to clinical, prevention, treatment and services research.

Examples of interdisciplinary and translational approaches include: The use of cognitive, affective, and social neuroscience in the development and evaluation of behavioral and pharmacological treatment interventions for drug abuse and addiction.

Interdisciplinary approaches to the development, adaptation, and modification of treatment and preventive interventions to enhance and facilitate the rapid advancement of research from bench to clinical research settings and then to comm unity treatment programs and requisite investigators/faculty and the commitment of sufficient investigators/faculty time are critical factors for this educational program.

Graduates of the program should have some fundamental knowledge of at least the following areas, as they relate to drug abuse and addiction, with in-depth knowledge of some of them: affective, and social neuroscience Genetic and environmental Principles of pharmacology, including the pharmacokinetics and pharmacodynamics of major drugs of abuse.

Clinical aspects of drug abuse, including knowledge of screening, assessment, and diagnostic methods, direct and indirect effects of drug abuse, major prevention and treatment (e.g., behavioral, pharmacological) modalities, consequences of drug use (e.g., medical, psychiatric, social), treatment of drug abusers with comorbid medical and/or psychiatric disorders and development of modes of integrated care.

Research methodologies such as epidemiology, biostatistics, structural equation modeling, multilevel analysis, IRT, Rasch, qualitative and quantitative measurement models applied to research design and analysis, drug abuse surveillance, and data use.

including prevention, referral, screening, assessment, and treatment; organizational dynamics, culture, and climate; quality management; provider career development; patient satisfaction, financing; cost-effectiveness; and dissemination of research to practice. Prevention science and health education; developmentally appropriate intervention design and strategies. disparity, cultural, developmental, and gender issues.

Protection of human subjects and related ethical issues in the conduct of research.

This FOA further encourages collaborative programs involving academic clinical research and basic science departments, clinical or community treatment settings and primary care organizations , multiple academic or research institutions such as schools of public health and departments of preventive and community medicine, or other entities with appropriate expertise for the development and establishment of educational training programs in drug abuse clinical, prevention, health services, and treatment research and practice .

If multiple sites are involved in the research education program, the applicant institution must be one of the sites.

Applicants should describe planned processes for: (a) conducting and monitoring recruitment and selection of participants , (b) planning research activities and selecting mentors for participants , (c) evaluating student progress, (d) coordinat ing among existing training or research activities available at the site and (e ) assessing the quality and effectiveness of the overall training program.

Schools, departments, and clinical sites participating in the joint applications should be involved in the planning, implementation, and assessment Inter disciplinary educational programs are likely to involve active collaborations or special arrangements between institutions and/or departments with drug abuse research programs , schools of public health, departments of community and preventive medicine, and other departments and institutions that have the necessary expertise and resources to fulfill the objectives of this FOA.

Any of these entities may act as the applicant organization, as long as the qualifications of the participants and the focus of the program are on the training of clinical researchers to work with drug abusing and related The NIH encourages all proposed programs to foster the participation of individuals from racial and ethnic groups underrepresented in biomedical and behavioral research, individuals from disadvantaged backgrounds, individuals with disabilities, and Testing Policy for the National Institute on Drug Abuse : Researchers funded by NIDA who are conducting research in community outreach settings, clinical, hospital settings, or clinical laboratories and have ongoing contact with clients at risk for HIV infection, are strongly encouraged to provide HIV risk reduction and counseling education.

HIV counseling should include offering HIV testing available on-site or by referral to other HIV testing service for persons at risk for HIV infection including injecting drug users, crack cocaine users, and sexually active drug users and their sexual partners. For more information see http://grants. nih.

gov/grants/guide/notice-files/NOT-DA-01-001. html . National Advisory Council on Drug Abuse Recommended Guidelines for the Administration of Drugs to Human Subjects : The National Advisory Council on Drug Abuse recognizes the importance of research involving the administration of drugs to human subjects and has developed guidelines relevant to such research.

Potential applicants are encouraged to obtain and review these recommendations of Council before submitting an application that will administer compounds to human subjects. The guidelines are available on NIDA's following the Funding hyperlink to NACDA Guidelines, or may be obtained by Section VIII, Other Information - Required Federal Citations , for policies related to this announcement.

This FOA will use the NIH Research Education Grant (R25) award mechanism. As an applicant, you will be solely responsible for planning, directing, and executing the proposed project. This FOA uses just-in-time concepts.

It also uses the non-modular budget format. Applicants must complete and submit budget requests using the SF424 Research and Related (R&R) Budget Component found in the application package for this FOA. Research education grant support is renewable.

Resubmission applications must include an Introduction addressing the previous peer review critiques. Because the nature and scope of the proposed research education program will vary from application to application, it is anticipated that the size and duration of each award will also vary.

Although the financial support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. total project period for an application submitted in response to this funding opportunity may not exceed 5 years.

Although the size of award may vary with the scope of the research education program proposed, applications must adhere to the following budgetary guidelines: direct costs are limited to $350,000 annually. Applications that do not follow these guidelines will be returned without review.

NIH grants policies as described in Grants Policy Statement will apply to the applications submitted and awards made in response to this funding opportunity Facilities and Administrative (F&A) costs requested by consortium participants, if applicable, are not included in the direct cost limitation. See NOT-OD-05-004 . awards are subject to the availability of funds .

1. A.

Eligible Institutions You may submit an application(s) if your organization has any of the following characteristics: Controlled Institution of Higher Education Institution of Higher Education 501(c)(3) IRS Status (Other than Institution of Higher Education) Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations Foreign institutions are not eligible to apply in response to this It is anticipated that a substantial number of program investigators/faculty will have active research projects in which participants may gain relevant experiences consistent with their research interests and goals.

Institutions with existing Ruth L. Kirschstein National Research Service Award (NRSA) institutional training grants (e.g., T32) or other federally funded training programs may apply for a research education grant provided that the proposed educational experiences are distinct from those training programs receiving NIH support.

Furthermore, the proposed research education program must complement these other ongoing research training and career development awards, and explicit details about how these programs complement each other must be provided. Moreover, the R25 mechanism is not intended to support long-term training of individuals and may not be used to circumvent or supplement Ruth L. Kirschstein NRSA research training mechanisms.

A ny duration of funding for a specific participant that is longer than two years may be considered long-term support . Therefore, applicants should obtain prior approval in writing from NIDA if an extension of support for a specific participant beyond the two-year period is required. If multiple sites are involved in the research education program, the applicant institution must be one of these sites for the program.

The need for and use of multiple sites must be justified. Any individual with the skills, knowledge, and resources necessary to carry out the proposed research education program as the Project Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. The PD/PI will be expected to monitor and assess the program, submitting annual reports as required.

( See Section The PD/PI should be an established investigator in the scientific area of the application and must demonstrate capability of providing both administrative and scientific leadership for the development and implementation of the proposed research education program. This program does not require cost sharing as defined Grants Policy Statement .

Sponsoring Institution : The sponsoring institution must assure support for the proposed research education project. Appropriate institutional commitment to the project includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned research education project. Participants : Participants are those individuals who benefit from the proposed research education program.

Describe who the intended participants are, and what eligibility and/or specific educational background characteristics are essential for participation in the proposed program. This FOA will support the research education of United States citizens only. are required to include a plan for Training in the Responsible Conduct of Research (see Section IV.

6). must contain an evaluation and tracking plan. Applications submitted without these sections will not be reviewed.

Applicants may submit more than one application, provided each application is scientifically distinct.

In many cases, it is anticipated that the proposed research education program will complement other ongoing research training occurring at the applicant institution and that a substantial number of program investigators/faculty will have active research projects in which participants may gain relevant experiences consistent with their research Section IV.

Application and Submission Information To download a SF424 (R&R) Application Package and SF424 (R&R) Application Guide for completing the SF424 (R&R) forms for this FOA, link to http://www. grants. gov/Apply/ and follow the directions provided on that Web site.

A one-time registration is required for institutions/organizations at both: Grants. gov ( http://www. grants.

gov/GetStarted ) eRA Commons ( http://era. nih. gov/ElectronicReceipt/preparing.

htm ) PD/PIs should work with their institutions/organizations to make sure they are registered in the eRA Commons. Several additional separate actions are required before an applicant institution/organization can submit an electronic application, as 1) Organizational/Institutional Registration in Grants.

gov/Get will need to obtain a Data Universal Number System (DUNS) number and register with the Central Contractor Registration (CCR) as part of the Grants. gov registration process. does not have a Taxpayer Identification Number (TIN) or Employer Identification Number (EIN), allow for extra time.

A valid TIN or EIN is necessary for CCR validates the EIN against Internal Revenue Service records, a step that will take an additional one to two business days. regarding Grants. gov registration to: Grants.

gov Customer Support Business Hours: M-F 7:00 a. m. - 9:00 p.

m. Eastern Time 2) Organizational/Institutional Registration in the eRA Commons organization is already Commons-registered, see the " List of Grantee Organizations Registered in NIH eRA Commons. regarding the Commons registration to: Phone: 301-402-7469 or 866-504-9552 (Toll Free) Business hours M-F 7:00 a.

m. 8:00 p. m.

Eastern Time 3) Project Director/Principal Investigator (PD/PI) Registration in the NIH eRA Commons: Refer to the NIH eRA Commons System (COM) designated as the PD/PI on the application must also be registered in the NIH eRA Commons. It is not necessary for PDs/PIs to register with Grants. gov. PD/PI account in the Commons and must be affiliated with the applicant organization.

This account cannot have any other role attached to it other than registration/affiliation must be done by the Authorized Organization Representative/Signing Official (AOR/SO) or their designee who is already registered in the Commons. AOR/SO need separate accounts in the NIH eRA Commons since both are authorized to view the application image.

Note that if a PD/PI is also an NIH peer-reviewer with an individual DUNS and CCR registration, that particular DUNS number and CCR registration are for the individual reviewer only. These are different than any DUNS number and CCR registration used by an applicant organization.

Individual DUNS and CCR registration should be used only for the purposes of personal reimbursement and should not be used on any grant applications submitted to the Several of the steps of the registration process could take four weeks or more. Therefore, applicants should immediately check with their business official to determine whether their organization/institution is already registered in both Grants. gov and the Commons .

The NIH will accept electronic applications only from organizations that have completed all 1. Request Application Information Applicants must download the SF424 (R&R) application forms and SF424 (R&R) Application Guide for this FOA through Grants. gov/Apply .

Note: Only the forms package directly attached to a specific FOA can be used. You will not be able to use any other SF424 (R&R) forms (e.g., sample forms, forms from another FOA), although some of the "Attachment" files may be useable for more than For further assistance, contact GrantsInfo: Telephone 301-710-0267, Email: [email protected] .

Telecommunications for the hearing impaired: TTY Content and Form of Application Submission Prepare all applications using the SF424 (R&R) application forms and in accordance with the SF424 (R&R) Application Guide ( MS The SF424 (R&R) Application Guide is critical to submitting a complete and accurate application to NIH.

There are fields within the SF424 (R&R) application components that, although not marked as mandatory, are required by NIH ( e.g., the Credential log-in field of the Research & Related Senior/Key Person Profile component must contain the PD/PIs assigned eRA Commons User ID ). Agency-specific instructions for such fields are clearly identified in the Application Guide.

For additional information, see Tips and Tools for Navigating Electronic Submission on the Submission of Grant Applications . The SF424 (R&R) application is comprised of data arranged in separate components. Some components are required, others are optional.

The forms package associated with this FOA in Grants. gov/APPLY will include all applicable components, required and optional.

A completed application in response to this FOA will include the following components: SF424 (R&R) (Cover component) Research & Related Project/Performance Site Research & Related Other Project Information Research & Related Senior/Key Person Research & Related Budget PHS398 Cover Page Supplement Research & Related Subaward Budget Attachment(s) the proposed research education program may complement other, ongoing research training and education occurring at the applicant institution, the proposed educational experiences must be distinct from those research training and research education programs currently receiving federal support.

Plans for the coordination of the proposed research education program with other training and career development award programs otherwise available to participants must be If multiple sites are involved in the research education program, the applicant institution must be one of these sites for the program. The need for and use of multiple sites must be justified.

The Biographical Sketches of proposed investigators/faculty, including a complete listing of active research grant support, must be provided. In addition, the applicant should specify their roles, if any, in ongoing research training (such as mentorship on research training grants or sponsorship of individual fellowships) at the institution.

Evaluation Plan and Tracking education grants require an evaluation and tracking plan in order to determine the degree of success or failure. A plan must be provided for program evaluation. Benchmarks should be specified, and specific plans and procedures must be described to capture, analyze and report outcome measures that would determine the success of the research education program in achieving its objectives.

In addition, the application must describe a system for tracking each participant during the time they are on the R25 award and for a period of 5 years (subject to annual reporting) following each participants termination from this R25 award. The evaluation component must include information on the career trajectories of the participants, including positions obtained, publications, and independent research grant submissions/awards.

The evaluation and tracking plan should address whether the program is enhancing the participation and commitment of future clinical researchers into careers in drug abuse and addiction research. costs must be consistent with NIH policy and be reasonable, allocable, well documented and fully justified for the research education program proposed in the application.

Grant funds may not be used to supplant funds otherwise available at the applicant institution. Personnel: Individuals participating in the design and implementation of the research education program may request salary and fringe benefits appropriate for the person months devoted to the program. These expenses must be itemized in Sections A and B, as appropriate, of the Research & Related Budget.

Salaries requested may not exceed the levels commensurate with the institution's policy for similar positions and may not exceed the congressionally mandated cap. (If mentoring interactions and other activities with students/participants are considered a regular part of an individual's academic duties, then mentoring and other interactions with students/participants are non-reimbursable from grant funds).

administrative and clerical salary costs associated distinctly with the program that are not normally provided by the applicant organization may be direct charges to the grant only when specifically identified and justified.

personnel costs (including administrative and clerical costs, as well as salaries of the PD/PI and other investigators/faculty) associated with directing, coordinating, and administering the program should be justified and reasonable.

Program-Related Expenses: Consultant costs, equipment, supplies, travel for key persons, and other program-related expenses must be justified as specifically required by the proposed research education program and must not duplicate items generally available for educational programs at the applicant institution. These expenses must be itemized, as appropriate, in Sections C. (Equipment), D.

(Travel), and F. (Other Direct Costs) of the Research & Related Budget. Participant Costs: Participants are those individuals who benefit from the proposed research education program.

Participant costs must be justified as specifically required for the proposed research education program. Participant costs must be itemized in Section E. (Participant/Trainee Support Costs) of the Research & Related research education program may receive a salary/subsistence allowance, including costs of meals and lodging unless such costs are furnished as part of the registration fee.

Participants may also receive funds to defray partial tuition, other education-related, and travel expenses. Expenses for foreign travel must be exceptionally well justified. Funds will not be provided for fringe benefits or health insurance for participants in any research education program.

Individuals supported by NIH training and career development mechanisms (K, T, or F awards) may receive, and indeed are encouraged to receive, educational experiences supported by the R25 mechanism, as participants, but may not receive salary supplementation from a research education program. Note that the R25 mechanism is not intended to support long-term training of participants.

Funding for a specific participant that is longer than two years may be considered long-term support. Therefore, applicants should obtain prior approval in writing from NIDA if an extension of support beyond the two-year period for a specific participant is required.

Institutional Commitment: Evidence of institutional commitment to the research educational program is Facilities and Administrative (F&A) Costs: F&A costs for the applicant organization and consortium participants will be reimbursed at 8 percent of modified total 3. Submission Dates and Times Submission, Review, and Anticipated Start Dates Opening Date: February 16, 2007 (Earliest date an application may be submitted to Grants.

gov) of Intent Receipt Date(s): 30 days before the submission date Application Submission/Receipt Date(s): Standard dates apply, please see http://grants. nih. gov/grants/funding/submissionschedule.

htm AIDS Application Submission Date(s): Standard dates apply, please see http://grants1. nih. gov/grants/funding/submissionschedule.

htm#AIDS Peer Review Date(s): Standard dates apply, please see http://grants1. nih. gov/grants/funding/submissionschedule.

htm#reviewandaward Council Review Date(s): Standard dates apply, please see http://grants1. nih. gov/grants/funding/submissionschedule.

htm#reviewandaward Earliest Anticipated Start Date: Standard dates apply, please see http://grants1. nih. gov/grants/funding/submissionschedule.

htm#reviewandaward Prospective applicants are asked to submit a letter of intent that includes the following information: telephone number of the PD/PI. this funding opportunity. Although a letter of intent is not required,