NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed)

NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed) is sponsored by National Institute of General Medical Sciences (NIGMS), NIH. This R24 grant program supports shared research resources that serve a broad community of biomedical researchers across multiple states (regional) or nationwide (national).

PAR-25-416: NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed) Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Institute of General Medical Sciences ( NIGMS ) Funding Opportunity Title NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed) R24 Resource-Related Research Projects June 24, 2025 Notice of Correction to Key Dates in PAR-25-416 "NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed)".

See Notice NOT-GM-25-020 . April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 .

August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198 . August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy.

See Notice NOT-OD-22-189 . Funding Opportunity Number (FON) Companion Funding Opportunity See Section III. 3.

Additional Information on Eligibility. Assistance Listing Number(s) Funding Opportunity Purpose This Notice of Funding Opportunity (NOFO) encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional (multi-state) or national user base.

Only those resources with technical capabilities that fall within the NIGMS-supported program areas are eligible for awards. The resources should already be established or may be formed through consolidation of existing local or regional facilities.

The intent is to provide resource access to investigators without regard to the specific biomedical focus of their research, while not duplicating or replacing resources supported by sources such as other NIH Institutes and Centers (ICs) or host institutions.

The resource is expected to be maintained or upgraded to current best practices, make its capabilities and availability known to the biomedical research community through a robust web presence and outreach activities, and provide user training and support. The NOFO does not support major new research and development efforts. Stand-alone data resources and databases are not eligible.

Funding Opportunity Goal(s) The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.

NIGMS also supports research in specific clinical areas that affect multiple organ systems: anesthesiology and peri-operative pain; clinical pharmacology ​common to multiple drugs and treatments; and injury, critical illness, sepsis, and wound healing. ​ NIGMS-funded scientists investigate how living systems work at a range of levels — from molecules and cells to tissues and organs — in research organisms, humans, and populations.

Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in supporting the training of future scientists and developing research capacity throughout the country.

Open Date (Earliest Submission Date) Dates in bold and italics reflect changes per NOT-GM-25-020 Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Workspace to prepare and submit your application and eRA Commons to track your application. Part 1.

Overview Information Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II.

Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V.

Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII.

Other Information Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description National and Regional Resources (NRRs) enable access to state-of-the-art technologies, methods and expertise essential to advancing biomedical research that may not be widely available to individual laboratories.

Moreover, regional (multi-state) or national resources can achieve economies of scale by serving substantial numbers of users more efficiently and economically than activities that are maintained by individual institutions, each with its administrative, equipment, staffing and maintenance needs.

The primary goal of this NOFO is to support NIGMS mission-related resources that can add value and achieve economies of scale by serving a demonstrated, substantial number of investigators (typically >100) at a national or regional (multi-state) level. The intent is to provide access to investigators without regard to the particular biomedical focus of their research.

This program provides support to established resources and new ones formed through consolidation of multiple existing regional or local facilities. Only those resources with technical capabilities that fall within the program areas supported by NIGMS are responsive to this NOFO.

This initiative complements the Mature Synchrotron Resources and the National Centers for Cryoelectron Microscopy programs, which specifically address those technologies. Applications to support synchrotron-based resources will not be accepted under this NOFO.

For this NOFO, a resource is defined as an activity that provides research capabilities and expertise to a large number of researchers and is available to any qualified investigator. Resources supported under this NOFO should be essential to making the most impactful, timely, rigorous, reproducible, and cost-efficient progress in a field within NIGMS-supported program areas.

Priority for resource access should be given to NIH-funded researchers and other United States-based academic researchers, but should be available to other qualified scientists. Plans for sustainable financial support of the resource can include fees for service if they are well justified. User fees may be scaled to different classes of users.

For more information, see FAQs for Core Facilities section B. Charges to NIH Supported Users.

Benefit a large number (typically >100) of investigators Support NIGMS-mission related technologies Provide access to technologies, services and/or assets that are not already widely and economically available to most users Provide state-of-the-art technical capabilities Support technologies that are unlikely to become obsolete in the near future Be properly designed for efficient use Be appropriately staffed to ensure resource maintenance and user support Have quality control measures in place Offer equal-opportunity access to users external to the host institution through an open application process.

At least 75% of active instrument time should be dedicated to open access use. Maximize effective use through outreach and training Resources can be physical or computational, or a combination of both.

Examples of items that resources may provide include, but are not limited to: High-end instruments and equipment Computational hardware and software Research materials, such as rare or specialized reagents, and libraries Research tools for data generation and analysis Access to specialized methods and expertise Repositories for research organisms, cell lines, and other non-clinical biologicals Stand-alone data resources (databases, data repositories, and knowledge bases) will not be supported by this NOFO.

These can be supported through existing NIH-wide programs initiatives organized through the Office of Data Science Strategy (e.g., PAR-23-236 and PAR-23-237 ). Applications may include databases essential to other resource capabilities. Clinical biospecimen repositories will not be supported by this NOFO.

A National Resource may be focused on one or multiple experimental techniques or technologies that are only available at a limited number of sites in the United States. A Regional Resource can include capabilities that are available in certain geographic areas, but not in others, or that by centralization can achieve significant economies of scale.

Resources should support substantial user bases at multiple institutions in multiple states. The number of users who can access the resource's services will be considered during peer review and in funding decisions. Resources that provide access to technologies or methods that are already accessible at reasonable cost to most potential users will not be supported by this NOFO.

Non-Responsiveness Criteria The following types of resources are non-responsive to this NOFO and will not be reviewed: Those with technical capabilities that are not within the program areas supported by NIGMS Synchrotron-based resources Stand-alone data resources (databases, data repositories, and knowledge bases) Those that collect, maintain and distribute clinical samples (biospecimen repositories) Resources should already be developed and only require support to maintain current best practices, state-of-the-art technologies, defray operating expenses, provide user training, and publicize the services provided.

The following activities are supported: Maintenance of instrumentation, data collection, data reduction, and analysis Resource implementation, including process refinement, methods improvement, and software development for optimal operations Improvements that may involve limited engineering or development, particularly to increase efficiency of operations Resources with technologies that require major development or optimization can be supported through the Biomedical Technology Optimization and Dissemination Centers (BTOD, RM1) or NIGMS Technology Development (R21 and R01 ) programs.

Additionally, staff at NIGMS-supported NRRs are eligible to apply for the NIGMS Technology Development (R21 and R01 ) program to support new technology development activities. Potential applicants are encouraged to contact the Scientific/Research Contact for this NOFO for further clarification.

In the case of research materials collections and repositories, support can be requested to maintain and extend the collections through the production or the acceptance of new material donations. Support for quality control, cataloging, propagation, and distribution of materials can also be provided.

In the case of computational facilities and software resources, support can include hardware upgrades or migration to cloud-based or other computational environments. Optimization of computer code, implementation or integration of complementary software developed with other funding, and maintenance and updating of required databases could also be included.

This program is intended to support state-of-the-art resources that have demonstrated capacity to serve a substantial user base.

NIGMS anticipates that support for resources will be renewable provided that they remain in high demand by a substantial user community (i.e. a typical user base of greater than 100 per year, or, if less than 100, with strong justification) and their service(s) cannot be provided through other cost-efficient means, such as commercial vendors.

Resources that are capable of transitioning to other mechanisms of support, such as fee-for-use or commercialization, should work toward achieving that goal. Technologies and other resources that become widely available in the scientific community will no longer be supported through this NOFO.

Each resource should have a website that provides up-to-date and complete information about facilities and services, policies, and the user access and application process. The PD/PI is required to devote at least 2. 4 person-months (20% full-time effort) to provide overall scientific guidance and resource management.

At least one additional senior scientist is required to devote a minimum of 6 person-months effort (>50% full-time effort) to managing the resource. The PD/PI and senior scientist must be distinct individuals. An external scientific advisory board is required, but members of the board should not be named in the application or contacted prior to completion of peer review unless they are already in place for the existing resource.

Students, postdoctoral fellows and other trainees should only be involved in the operation of the resource under rare, extremely well-justified circumstances. In cases where trainees are to be involved in resource operations, a strong institutional letter describing how these activities are integral to the students' or trainees' overall training goals is required.

Users can acknowledge resource staff in their papers and must cite the facility's grant as providing support for their work. Resource staff are employed to provide users with efficient and productive service and normally should not be included as authors on users' publications that result from resource use.

They may have other independently supported research commitments that enable them to lead their own research projects and to collaborate on resource users' projects that require effort beyond normal resource services. Any access to the resource for resource staff projects must be obtained through the normal user application process, and in competition with all other user applications.

Resources must have plans in place to avoid prioritizing projects simply because they would result in staff co-authorship. NIGMS will monitor the resource utilization based on information provided in annual progress reports and publications that were enabled by the service, which should be cited accordingly. See Section VIII.

Other Information for award authorities and regulations. Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO. Not Allowed: Only accepting applications that do not propose clinical trials.

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the number of meritorious applications. Application budgets are not limited but need to reflect the actual needs of the proposed project.

A project period of up to five years may be requested. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO. Section III.

Eligibility Information Higher Education Institutions - Includes all types Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are not allowed. Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications for additional information System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually .

The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.

Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM. gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants. gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.

Grants. gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role.

Obtaining an eRA Commons account can take up to 2 weeks. Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide . For this NOFO, at least one of the PDs/PIs must devote at least 2. 4 person-months.

At least one senior scientist , an individual distinct from the PD/PI , must devote at least 6 person-months to the resource. This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1. 2 Definition of Terms.

3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.

gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed. For this specific NOFO, the Research Strategy section is limited to 30 pages.

Instructions for Application Submission The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO. All instructions in the How to Apply - Application Guide must be followed. SF424(R&R) Project/Performance Site Locations All instructions in the How to Apply - Application Guide must be followed.

SF424(R&R) Other Project Information All instructions in the How to Apply - Application Guide must be followed. Other Attachments: The attachment listed below must be included in the application. Applications that do not include this attachment will be withdrawn without review.

Publications Enabled by the Resource: If the proposed resource is already established or is newly formed through consolidation of existing local or regional facilities, provide a bibliography of publications enabled by the resource or facilities during the previous five years.

Highlight five highly impactful publications at the top of the list and include a two sentence description of the importance of the work to the field for each of these five publications. Use the standard NIH reference format. For renewal applications only, all publications that have resulted from the last funding period should be included.

This attachment should be titled “Publications Enabled by the Resource”. SF424(R&R) Senior/Key Person Profile All instructions in the How to Apply - Application Guide must be followed. All instructions in the How to Apply - Application Guide must be followed.

The PD/PI is required to devote at least 2. 4 person-months to provide overall scientific guidance and resource management. Additionally, at least one other senior scientist is required to devote at least 6 person-months to managing the resource.

Personnel costs commensurate with the effort stipulated for the PD/PI and senior scientist may be requested in the budget. In the budget justification, applicants must provide names (if available), person months effort, and the role on the project for all contributing personnel.

Applicants should present a single overall budget including funding requests for all activities of the resource and provide a single budget justification that includes the justification of specific subaward items. Funding may be requested for the supported activities described in Section I or other well-justified activities.

This NOFO will not support research and development activities, except for limited technology optimization needed to improve user service and resource efficiency . In the budget justification, provide detailed information about support received or anticipated from other entities. This could include, for example, additional funding from another government agency, user fees, or institutional support.

When transition to other means of support is feasible, the funding requested should align with a transition plan. A reduction in requested support as the project period progresses and the resource transitions to other sources of support is appropriate. All instructions in the How to Apply - Application Guide must be followed.

PHS 398 Cover Page Supplement All instructions in the How to Apply - Application Guide must be followed. All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: Specific Aims: Describe the overall aims of the Resource. If more than one technology or other service is included, present each as a separate aim.

Include as specific sub-aims each planned improvement intended to maintain the facility at the state-of-the-art and to achieve efficiencies or economies of scale.

Research Strategy: Use the following headings in the Research Strategy: Resource Capabilities and Improvements Operation and Maintenance Plan User Training and Outreach Evaluation and Reporting Plans Describe the overall objectives of the resource and discuss the importance of this particular resource to biomedical research as well as its relationship to other similar resources within the US and world.

Note that a resource is not required to be unique, although that may be an asset. Discuss how the proposed activities and components integrate to form a coherent resource, while providing a brief summary of each resource activity, including its administration.

Provide evidence that summarizes the impact, high demand for, and productivity of the resource over the last 3 years and for the project period: The summary should include data with projections of how the resource achieves or will achieve economies of scale: (a) Existing resources should document their support of a substantial number of users (typically >100 per year) at institutions throughout a region or the nation.

Applications for resources with fewer than 100 users should provide a strong justification that support for a resource with this smaller user base is warranted; (b) For new resources resulting from consolidation of multiple regional or local facilities, applicants should provide well-documented projections of a substantial user base for the consolidated resource and describe the economies of scale that would result from consolidation.

Existing resources should also include outcomes of advisory board evaluation, review processes, etc., specified for each of the resource's capabilities.

Additional evidence that should be provided but does not substitute for the actual or projected resource utilization as described above may include: (a) the number of publications enabled by the resource through collaboration or service activities, (b) service hours provided, (c) number of users, (d) summaries of instrument use time logs, (e) requests for access, and (f) white papers and editorials that demonstrate community interest.

Provide a timeline for implementation of the resource activities. Note that for this NOFO , "Innovation" is defined as a coherent plan to ensure that independently funded investigators have cost-effective access to biomedical technologies and expertise that are not widely available and will enable biomedical research within the NIGMS-mission areas. II.

Resource Capabilities and Improvements 1. Resource Capabilities: Summarize the scientific and technological capabilities of the resource, including instrumentation and facilities, collections of materials and other research tools, supporting computational and data reduction infrastructure, hardware and software, and expertise of interest to the user community.

Describe the experimental station(s) and workspace(s) that users will directly access Document user interfaces, which should be straightforward, and user-friendly If applicable, provide details of any remote access processes, procedures, and interfaces Summarize planned improvements intended to maintain the facility at the state-of-the art and to achieve efficiencies If relevant, indicate how the proposed resource plans to utilize open-source software and/or equipment that can be commercially obtained or has been previously developed If applicable, provide plans for data storage and transfer to users Describe how the technological capabilities and services are sufficiently stable with regard to major developments so that only implementation of upgrades and minor optimization, rather than substantial new technological development, is necessary Delineate the role and contributions of personnel in the technological and scientific operations of the resource.

Do not repeat information included in the biosketches Summarize planned improvements intended to maintain the facility at the state-of-the art and to achieve efficiencies Describe any plans to implement emerging technological and methodological refinements that enhance the impact for the user community and improve the utility or efficiency of the resource Provide details of any improvements that involve extensive engineering, including information about appropriate technical review boards or other expertise to be consulted to obtain adequate feedback through the development and implementation stages For improvements that involve software development, describe plans to ensure that industry programming standards are met, provide software portability when appropriate, and document and make software readily available to the user community.

Sharing of source code is encouraged. Applicants are encouraged to discuss planned improvements of their technologies with Scientific/Research staff prior to submission to ensure that they conform to the requirements of this NOFO. 1.

Resource Organizational Structure Define the roles and contributions of personnel in the technological and scientific operations of the resource. Do not repeat information included in the biosketches.

Describe how the PD(s)/PI(s), the technical operations leaders, and other key personnel are appropriately trained for their respective roles, able to devote adequate effort to the resource activities, and have a history of performing services for the scientific community at large Outline how the PD(s)/PI(s) and the proposed resource staff will be organized with respect to its activities: technical operations, user service, maintenance or upgrade projects, administration, user training, and outreach activities Describe how staff with appropriate skills and knowledge will be recruited and retained Describe the relationship of the resource to the administrative structure of the grantee organization(s) 3.

External Scientific Advisory Board Describe in general terms how members of the required External Scientific Advisory Board would be chosen and how the board would operate, but do not include names of specific individuals unless they have already been involved with the resource in the past few years and would therefore be in conflict for review IV. Operation and Maintenance Plan 1.

Resource Operation, Maintenance and Contingency Plans Outline plans for how resources will be maintained for continuous operation, including routine equipment service and calibration, adding new materials to existing collections, or improving upon established procedures. This description should include plans for quality control and assurance.

Provide plans for operations during resource downtime including, if appropriate, alternative resources that users may access Provide contingency plans for unexpected shutdowns or equipment failures Describe details of service contracts that provide emergency repair services.

To sustain efficient management of the resource, include a contingency plan in the event that the PD/PI or the Senior Scientist or other key staff can no longer fulfill their obligations due to health, retirement, or other unforeseeable circumstances Describe procedures for handling requests for resource use, and for the adequate distribution of resource time and access Describe plans for ensuring broad access for institutions and regions across the country and not just for highly-resourced institutions.

Providing resource service to as many meritorious users as possible is an important goal of this initiative and applications should clearly describe how the proposed resource will meet this goal 3. Resource Sustainability Applicants are strongly encouraged to develop and include additional plans to sustain resources. For example, non-prohibitive cost recovery charges ("co-pays") are encouraged and should be discussed in the application.

However, if the application proposes co-pay fees, they should either be sufficiently low so as not to serve as a barrier to access for users at lower resourced institutions or a system should be proposed to provide low/no-cost access to meritorious researchers who do not have sufficient support to pay the requested fees.

The application should include a clear plan if the resource plans to transition to other sources of support at the end of the award period. NIGMS encourages exploring the potential of