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The NIH SBIR and STTR omnibus solicitations are the largest single source of non-dilutive funding for AI and machine learning companies working in health, and the FY2026-2027 cycle refreshed them as PA-27-100 (Parent SBIR, R43/R44), PA-27-102 (Parent STTR, R41/R42), PAR-27-098 (Commercialization Readiness Pilot) and PA-27-101 (SBIR Phase IIB Strategic Breakthrough Award).
Unlike a targeted RFA, the omnibus is investigator-initiated across essentially the whole NIH mission, which means an AI company can propose clinical decision support, medical imaging models, drug discovery platforms, digital diagnostics, biosignal analysis or health data infrastructure and route it to whichever institute owns the disease area.
Phase I is capped at 323,090 dollars and Phase II at 2,153,927 dollars, with standard receipt dates of 5 September, 5 January and 5 April. Several FY2026 changes materially affect planning and are easy to miss. HHS now limits each small business, including affiliates, to nine SBIR/STTR submissions per fiscal year across all opportunities.
Small business applications no longer qualify for the late-submission extension that other NIH applicants receive, so the deadline is absolute. And all senior and key personnel must have ORCID iDs linked to their eRA Commons profiles before submission, a registration step that takes days and blocks submission if left to the last week.
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Or search similar grants →According to the current listing, eligibility includes: Applicants must be U.S. small business concerns meeting SBA size and ownership requirements: no more than 500 employees, with the majority ownership and control tests specified in the SBIR/STTR policy directive. For SBIR (PA-27-100), the PI's primary employment must generally be with the small business; for STTR (PA-27-102), the project must be conducted jointly with a U.S. research institution which performs at least 30 percent of the work while the small business performs at least 40 percent. Phase I budgets are capped at 323,090 dollars over six months to two years and Phase II at 2,153,927 dollars over one to three years, with higher caps available only for topics on NIH's published waiver list. Standard application due dates are 5 September, 5 January and 5 April, shifting to the next business day when they fall on a weekend or holiday. Three FY2026 rule changes apply: HHS limits submissions to nine per small business per fiscal year across all SBIR/STTR activity codes including affiliates; small business applications are no longer eligible for the late-submission policy; and all senior/key personnel must have ORCID iDs linked to eRA Commons profiles before submission. AI and machine learning projects are eligible across the full NIH mission - clinical decision support, imaging, drug discovery, digital health and health data infrastructure. Verify caps, due dates and institute-specific interests in the current omnibus funding opportunity on grants.nih.gov before applying. Confirm the full requirements in the official notice before applying.
The current listing shows phase I awards are capped at 323,090 US dollars over six months to two years and Phase II awards at 2,153,927 dollars over one to three years, so amount_min is 323,090 and amount_max is 2,153,927. Two further tracks sit above this band and are worth knowing about before you plan a company roadmap: the Commercialization Readiness Pilot (PAR-27-098) runs to 4,191,495 dollars over up to three years, and the SBIR Phase IIB Strategic Breakthrough Award (PA-27-101) reaches up to 30,000,000 dollars over four years but requires matching funds equal to at least 100 percent of the grant, which makes it an instrument for companies that have already raised, not a substitute for raising. NIH will consider budgets above the statutory Phase I and Phase II caps for topics on its published waiver list, but exceeding a cap without a listed waiver is a common and avoidable cause of administrative withdrawal. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for NIH, CDC and FDA SBIR and STTR FY2026-2027 Omnibus Solicitations (PA-27-100 and PA-27-102) for AI and Machine Learning in Biomedical Products are due January 5, 2027. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
NIH, CDC and FDA SBIR and STTR FY2026-2027 Omnibus Solicitations (PA-27-100 and PA-27-102) for AI and Machine Learning in Biomedical Products is funded by U.S. National Institutes of Health (NIH), with CDC and FDA; Department of Health and Human Services. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
The NSF Computer and Information Science and Engineering: Future Computing Research (Future CoRe) program (NSF 25-543) supports foundational computing research and education with a strong emphasis on AI and machine learning. The program funds research that advances the foundations of computing including AI/ML theory, algorithms, systems, and applications. Future CoRe supports small to medium-sized research projects that can have significant impact on computing foundations. The program has target dates of February 5, 2026 and September 10, 2026 for proposal submissions (note: these are target dates, not deadlines, meaning proposals may be submitted at any time but will be reviewed in batches around these dates). Investigators may not serve as PI, co-PI, or Senior/Key Personnel on more than two proposals submitted within any consecutive 12-month period across all Future CoRe programs. This is one of NSF's primary mechanisms for funding fundamental AI and machine learning research at U.S. academic institutions, covering areas such as machine learning theory, natural language processing, computer vision, robotics foundations, and human-AI interaction.
The ONR Long Range Broad Agency Announcement (N00014-25-S-B001) is the Office of Naval Research's primary mechanism for soliciting research proposals across all naval science and technology priority areas. The BAA accepts proposals on a rolling basis through September 30, 2026 and covers ONR's full spectrum of research interests with particular emphasis on AI-related topics including autonomous maritime systems, human-machine teaming, machine learning for sensor fusion, cooperative autonomous swarm technology, undersea autonomy, and AI-enabled decision superiority. Proposals can be funded through multiple mechanisms including individual investigator grants, the Young Investigator Program (~$510K over 3 years for early-career faculty), and Multidisciplinary University Research Initiative (MURI) awards ($1.5M/year for 3-5 years for research teams). ONR recommends contacting relevant program officers before submitting to discuss alignment with current research priorities. The BAA supports basic research (6.1), applied research (6.2), and advanced technology development (6.3) across the full range of naval-relevant science and engineering disciplines.
DE-FOA-0003600 is the DOE Office of Science's FY 2026 open, rolling solicitation for financial assistance, providing roughly $500 million across seven program areas: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. AI and machine learning research is supported directly through Advanced Scientific Computing Research, while Biological and Environmental Research funds atmospheric process research, environmental systems process research, and earth-energy systems modeling — making this a major channel for AI-enhanced climate and earth system modeling work. DOE anticipates 200 to 350 new awards ranging from $5,000 to $5 million each, with project periods from six months to five years. The FOA opened September 30, 2025 and accepts applications on a rolling basis through the end of FY 2026.
The Health and Extreme Weather highlighted topic went live September 1, 2026 with eleven awarding institutes and expires May 1, 2028. There is no set-aside, no separate deadline, and no review criteria — which makes the institute-by-institute language the only real signal, and it is not uniform.
Read articleThe NOURISH Autoimmunity Digital Health Challenge runs three phases to August 2028: 10 winners at $20,000, then 5 at $30,000, then 3 at $100,000. It is a prize competition, not a grant — no indirect costs, no cost reimbursement, and a rule that quietly disqualifies the obvious applicant.
Read articleThe CDC's Notice of Funding Opportunity CDC-RFA-JG-26-0056, Continuing to Enhance Global Health Security, closes for applications on June 25, 2026, with $75 million on the table and eight cooperative agreements anticipated. The NOFO sits inside an unusually compressed window for global health implementing partners — after the USAID dismantling and the 2025 CDC reorganization, this is one of the largest remaining flexible federal vehicles for outbreak-prevention work executed through bilateral partnerships with foreign health ministries. Here is what the solicitation requires, why the eligibility design favors specific applicant types, and what to do if you are still considering whether to apply.
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