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Bridge2AI is the NIH Common Fund's flagship program for making biomedical data usable by artificial intelligence, and on 29 January 2026 the NIH Council of Councils approved its advance to Stage 2 with approximately $130,000,000 over four years, pending appropriations.
The strategic shift in Stage 2 is significant and worth understanding before applying: Stage 1 was about generating flagship AI-ready datasets across domains such as voice as a biomarker, salutogenesis, cellular maps, and critical care. Stage 2 moves downstream to building things with them. Two initiatives are named.
Innovation Funnels will use AI-ready datasets, including those produced in Stage 1, to create tools, devices, and novel insights that apply AI to improve health - the channel for diagnostic algorithms, drug discovery platforms, and clinical decision support that can demonstrate measurable health impact.
The Network for AI Health Science will assemble scientific experts to develop safety measures for responsible AI use and research, giving the program an explicit AI safety and governance component alongside its translational aims. As of writing, Stage 2 funding opportunity announcements had not been posted to the Bridge2AI funding page; based on the Stage 1 timeline, RFAs were anticipated around mid-2026.
Prospective applicants should join the NIH Bridge2AI listserv and monitor commonfund. nih. gov/bridge2ai/funding, since Common Fund RFAs typically allow short preparation windows relative to their scale.
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Or search similar grants →According to the current listing, eligibility includes: Eligibility criteria for Stage 2 have not been published, as the funding opportunity announcements were not yet posted at time of writing. NIH Common Fund programs of this type are typically open to domestic and, in some cases, foreign institutions of higher education, nonprofit organizations, for-profit organizations including small businesses, and government entities, with a strong expectation of multidisciplinary teams spanning biomedical domain science, data science, AI/ML methods, and ethics. Stage 2 comprises two initiatives - Innovation Funnels and a Network for AI Health Science. Interested applicants should subscribe to the NIH Bridge2AI listserv and monitor the Bridge2AI funding page for the RFAs and their specific eligibility and budget terms. Confirm the full requirements in the official notice before applying.
The current listing shows the NIH Council of Councils approved approximately $130,000,000 over four years for Bridge2AI Stage 2, pending appropriations. This figure is the total program commitment - per-award budget caps have not yet been published because the Stage 2 funding opportunity announcements were not yet posted at time of writing. For reference, Stage 1 Data Generation Projects were funded at roughly $16,000,000 to $25,000,000 each over four years. Verify award ceilings, matching requirements, and allowable costs in the official notice.
NIH Common Fund Bridge to Artificial Intelligence (Bridge2AI) Stage 2 for AI Tools, Devices and Safety Frameworks in Biomedical Research is funded by U.S. National Institutes of Health (NIH), Common Fund. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
The ONR Long Range Broad Agency Announcement (N00014-25-S-B001) is the Office of Naval Research's primary mechanism for soliciting research proposals across all naval science and technology priority areas. The BAA accepts proposals on a rolling basis through September 30, 2026 and covers ONR's full spectrum of research interests with particular emphasis on AI-related topics including autonomous maritime systems, human-machine teaming, machine learning for sensor fusion, cooperative autonomous swarm technology, undersea autonomy, and AI-enabled decision superiority. Proposals can be funded through multiple mechanisms including individual investigator grants, the Young Investigator Program (~$510K over 3 years for early-career faculty), and Multidisciplinary University Research Initiative (MURI) awards ($1.5M/year for 3-5 years for research teams). ONR recommends contacting relevant program officers before submitting to discuss alignment with current research priorities. The BAA supports basic research (6.1), applied research (6.2), and advanced technology development (6.3) across the full range of naval-relevant science and engineering disciplines.
PRIMED-AI is a new NIH Common Fund programme, Precision Medicine with AI: Integrating Imaging with Multimodal Data, which combines medical imaging with other health data to build AI-powered clinical decision support tools for personalised medicine. This opportunity, RFA-RM-27-014, funds the programme's Validation Center: a dedicated hub that independently evaluates and characterises the AI-enabled, image-based multimodal clinical decision support tools developed elsewhere in the consortium. The structural logic matters for applicants. NIH has separated tool-building from tool-validation and is paying separately for the second, which signals institutional recognition that self-reported performance claims from developing teams are not sufficient evidence for clinical AI. The Center's remit covers verification, validation, interoperability and uncertainty quantification, so the deliverable is a reproducible evaluation capability rather than a set of papers. It operates as a U54 cooperative agreement, meaning NIH staff are substantively involved and the Center must work in concert with the PRIMED-AI Logistics Center and the Data-to-Model and Model-to-Clinic award recipients. The RFA was released on 30 June 2026 with applications due 2 October 2026. For academic groups that have built credible AI evaluation methodology, particularly in radiology, imaging informatics or biostatistics, this is an unusually direct route to becoming the reference evaluator for a major federal AI health programme, and the position carries influence over how clinical AI performance gets measured well beyond the life of the award.
RFA-RM-27-015 funds a single Logistics Center as the coordinating hub of the NIH Common Fund's PRIMED-AI program, Precision Medicine with AI: Integrating Imaging with Multimodal Data. The award is a cooperative agreement, meaning substantial NIH scientific and programmatic involvement is built in rather than incidental, and it is administered by NIBIB on behalf of the Common Fund. The Center operates through three integrated cores: Administration, which runs the steering committees and develops consortium policies; Evaluation, which assesses progress across the funded portfolio; and Outreach, which maintains a web portal for sharing AI-based clinical decision support tools and facilitates engagement between researchers, clinicians and patient communities. The strategic point for applicants is that this is the only coordinating award in a multi-award program whose other components, the Data-to-Model Academic-Industrial Partnerships, Model-to-Clinic and Multi-use Frameworks Playbook RFAs, are separately competed and separately funded. The Logistics Center therefore does not generate its own AI models; it is scored on its capacity to run a consortium, set data and tool-sharing policy, and build infrastructure that makes other teams' clinical decision support tools discoverable and reusable. Applications are due by 5:00 PM local time of the applicant organization on the date specified for the relevant review cycle, with an earliest project start date of 2 October 2026 and a maximum project period of five years.
NOT-RM-26-004 asks the public for NIH-wide research challenges worth a 10-year, cross-institute program. There is no budget, no biosketch, no page limit, and no award. What there is: the five criteria every Common Fund investment has met since 2006, a new bullet about small-lab burden, and a fund whose FY 2026 request came in at $347.4 million — down 49.3 percent.
Read articleThe NIH Common Fund launched PRIMED-AI — Precision Medicine with AI: Integrating Imaging with Multimodal Data — as five coordinated funding opportunities (RFA-RM-27-011 through -015) that build a full pipeline from standards to clinic. Here is how the Playbook, Data-to-Model partnerships, Model-to-Clinic translation, Validation Center, and Logistics Center fit together, what each pays, who is eligible, and how to position before the October 2026 deadlines.
Read articleAvoid common NIH grant proposal mistakes including vague specific aims, weak methodology, and poor budget justification that lead to rejection.
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