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NIH Common Fund PRIMED-AI Development and Testing of a Multi-use Frameworks Playbook is sponsored by National Institutes of Health (NIH) Common Fund. This program supports the development and preliminary validation of standardized frameworks for the responsible and effective use of multimodal artificial intelligence in precision medicine.
It aims to create practical guidelines, protocols, and standard operating procedures to move AI-based clinical decision-support tools toward reliable real-world clinical use.
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Or search similar grants →According to the current listing, eligibility includes: Public and private institutions of higher education, nonprofit and eligible for-profit organizations (including small businesses), and eligible U.S. governmental and tribal organizations. Clinical trials are not allowed. Confirm the full requirements in the official notice before applying.
The current listing shows up to $300,000 direct costs per year; 2-year max project. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was October 9, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
NIH Common Fund PRIMED-AI Development and Testing of a Multi-use Frameworks Playbook is funded by National Institutes of Health (NIH) Common Fund. Verify program details on the funder's official page before applying.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Past winners and funding trends for this program
NOT-RM-26-004 asks the public for NIH-wide research challenges worth a 10-year, cross-institute program. There is no budget, no biosketch, no page limit, and no award. What there is: the five criteria every Common Fund investment has met since 2006, a new bullet about small-lab burden, and a fund whose FY 2026 request came in at $347.4 million — down 49.3 percent.
Read articleThe NIH Common Fund launched PRIMED-AI — Precision Medicine with AI: Integrating Imaging with Multimodal Data — as five coordinated funding opportunities (RFA-RM-27-011 through -015) that build a full pipeline from standards to clinic. Here is how the Playbook, Data-to-Model partnerships, Model-to-Clinic translation, Validation Center, and Logistics Center fit together, what each pays, who is eligible, and how to position before the October 2026 deadlines.
Read articleAvoid common NIH grant proposal mistakes including vague specific aims, weak methodology, and poor budget justification that lead to rejection.
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