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NIH Complement Animal Research in Experimentation NAMs Reduction to Practice Challenge is sponsored by Department of Health and Human Services - National Institutes of Health. Recent technological advances have set the stage for a renewed focus on human-based solutions called new approach methodologies (NAMs) that can complement, and in some cases replace, animal models in research and regulatory testing.
These NAMs generally span advanced cell-tissue-organoid ( in vitro ), computational modeling ( in silico ), and cell-free biochemical analysis ( in chemico ) techniques, with each type of NAM offering different advantages.
A combination and integration of multiple NAMs elements into a synergistic approach that augments gaps and/or deficiencies in individual NAMs approaches is a “combinatorial NAM” and could ultimately allow for improved predictions of human clinical response.
Although many combinatorial NAMs are still early in development, not validated and standardized, nor available to the market broadly, combinatorial NAMs can potentially transform the way biomedical research, drug development, and clinical trials are conducted.
To accelerate development and validation of combinatorial NAMs for human-based scientific and regulatory purposes, the National Institutes of Health (NIH) Common Fund’s Complement-Animal Research In Experimentation (Complement-ARIE) program in collaboration with the Food and Drug Administration (FDA) and Environmental Protection Agency (EPA), is launching the Reduction to Practice (RTP) Challenge.
This challenge invites innovative combinatorial NAMs solutions from multidisciplinary teams who can successfully demonstrate implementation of their human-based solution in a practical and usable form within a 3-year period.
Solvers will have the chance to win up to $1,430,000 in cumulative cash prizes and have their solution provided validation and/or qualification support by the Complement-ARIE Validation and Qualification Network (VQN). This Challenge is open to the public. Participants and winners from the Complement-ARIE Ideation Challenge launched in November 2023 are also encouraged to apply.
The Reduction to
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Or search similar grants →According to the current listing, eligibility includes: To be eligible to win a prize under this Challenge, a Participant (whether participating as a Team or Entity) — a. Shall have registered to participate in the Challenge under the rules promulgated by the National Institutes of Health (NIH) as published in this announcement; b. Shall have complied with all the requirements set forth in this announcement; c. In the case of an Entity, shall be incorporated in and maintain a primary place of business in the United States. In the case of a Team, the Team Leader shall be a citizen or permanent resident of the United States. However, non-U.S. citizens and non - permanent residents can participate as a member of a Team or Entity that otherwise satisfies the eligibility criteria. Non-U.S. citizens and non-permanent residents are not eligible to win a monetary prize (in whole or in part). Their participation as part of a winning Team or Entity, if applicable, may be recognized when the results are announced. d. Shall not be a federal entity or federal employee acting within the scope of their employment; e. Shall not be an employee of the Department of Health and Human Services (HHS, or any other component of HHS) acting in their personal capacity; f. Who is employed by a federal agency or entity other than HHS (or any component of HHS), should consult with an agency ethics official to determine whether the federal ethics rules will limit or prohibit the acceptance of a prize under this Challenge; g. Shall not be a judge of the Challenge, or any other party involved with the design, production, execution, or distribution of the Challenge or the immediate family of such a party (i.e., spouse, parent, step-parent, child, or step-child). h. Shall be 18 years of age or older at the time of submission. Confirm the full requirements in the official notice before applying.
The current listing shows $7,000,000. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for NIH Complement Animal Research in Experimentation NAMs Reduction to Practice Challenge are due August 2, 2028. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Yes — NIH Complement Animal Research in Experimentation NAMs Reduction to Practice Challenge is offered by Department of Health and Human Services - National Institutes of Health and this listing comes from Challenge.gov, an official U.S. federal source. Federal applications generally require registrations (for example SAM.gov or an agency submission portal), so allow extra lead time.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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