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Find similar grantsNIH Director's Transformative Research Award (R01) is sponsored by National Institutes of Health (NIH) Common Fund. This award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.
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NIH Director's Transformative Research Award | NIH Common Fund NIH Director's Transformative Research Award NIH Director's Transformative Research Award FY2026 NIH Director’s Transformative Research Award informational video Part of the High-Risk, High-Reward Research program, the NIH Director's Transformative Research Award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.
Part of the High-Risk, High-Reward Research program , the award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.
Open to all career stages Open to individuals or teams No preliminary data required Research effort commensurate to project needs No prior approval required for large budget requests See the Award Overview for more information. Applications due September 3, 2026.
Application & Award Guide Recent News & Announcements Scientists Discover Possible Anti-Aging Treatment in Mouse Cells A Genetic Checkpoint that Could put Alzheimer’s Disease to REST NIH to award over $207 million to support highly innovative biomedical and behavioral research projects This page last reviewed on
According to the current listing, eligibility includes: Open to investigators at all career stages, individuals or teams. No preliminary data is required. Confirm the full requirements in the official notice before applying.
Applications for NIH Director's Transformative Research Award (R01) are due September 3, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
NIH Director's Transformative Research Award (R01) is funded by National Institutes of Health (NIH) Common Fund. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
NIH Director's Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional) (RFA-RM-27-003) is sponsored by National Institutes of Health (NIH) Common Fund. This award supports individual scientists or groups proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new paradigms in infectious biology and beyond.
NIH Director's New Innovator Award (DP2) is sponsored by National Institutes of Health (NIH) Common Fund. The NIH Director's New Innovator Award, part of the High-Risk, High-Reward Research program, supports early-career investigators of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the NIH mission. This award explicitly does not require preliminary data and encourages risky, transformative ideas. Research areas relevant to AI are included.
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward advances in AI and data science for biomedical and public health research. Projects must cross disciplinary boundaries.
Innovation Grant is a grant from the Delta Dental of Arizona Foundation that funds nonprofit organizations pursuing unique, high-impact projects that improve health and wellness in Arizona communities. This two-year award supports original initiatives with measurable real-world impact, including programs serving underserved and uninsured populations through oral health education, disease prevention, and nutritional access. Projects must demonstrate the potential to make a meaningful difference in the community and stand apart from conventional approaches. Eligible applicants are Arizona-based nonprofit organizations. Awards total $100,000 per recipient over two years. The 2026 application cycle closed October 16, 2025, with recipients notified in late 2025 and funding made available shortly after.
The NIH Common Fund launched PRIMED-AI — Precision Medicine with AI: Integrating Imaging with Multimodal Data — as five coordinated funding opportunities (RFA-RM-27-011 through -015) that build a full pipeline from standards to clinic. Here is how the Playbook, Data-to-Model partnerships, Model-to-Clinic translation, Validation Center, and Logistics Center fit together, what each pays, who is eligible, and how to position before the October 2026 deadlines.
Read articleAvoid common NIH grant proposal mistakes including vague specific aims, weak methodology, and poor budget justification that lead to rejection.
Read articleThe NIH Director's New Innovator Award (DP2, RFA-RM-27-002) closes August 17, 2026, offering roughly 30 Early Stage Investigators up to $475,000 in direct costs a year for five years — $2.375 million total — to pursue bold ideas without the preliminary data a standard R01 demands. Here is how the High-Risk, High-Reward program actually evaluates applications, who qualifies, and why the usual R01 instincts will sink you.
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