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Find similar grantsNIH Director's Transformative Research Awards (R01) is sponsored by National Institutes of Health (NIH) Common Fund. The NIH Director's Transformative Research Awards program supports exceptionally innovative and unconventional research projects that have the potential to create new paradigms or to break through existing barriers in biomedical and behavioral research.
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NIH Director's Transformative Research Award | NIH Common Fund NIH Director's Transformative Research Award NIH Director's Transformative Research Award FY2026 NIH Director’s Transformative Research Award informational video Part of the High-Risk, High-Reward Research program, the NIH Director's Transformative Research Award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.
Part of the High-Risk, High-Reward Research program , the award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.
Open to all career stages Open to individuals or teams No preliminary data required Research effort commensurate to project needs No prior approval required for large budget requests See the Award Overview for more information. Applications due September 3, 2026.
Application & Award Guide Recent News & Announcements Scientists Discover Possible Anti-Aging Treatment in Mouse Cells A Genetic Checkpoint that Could put Alzheimer’s Disease to REST NIH to award over $207 million to support highly innovative biomedical and behavioral research projects This page last reviewed on
According to the current listing, eligibility includes: Applications may be submitted by institutions/organizations. Individual scientists or groups of scientists with or without preliminary data. Confirm the full requirements in the official notice before applying.
The published deadline was September 3, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
NIH Director's Transformative Research Awards (R01) is funded by National Institutes of Health (NIH) Common Fund. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
NOT-RM-26-004 asks the public for NIH-wide research challenges worth a 10-year, cross-institute program. There is no budget, no biosketch, no page limit, and no award. What there is: the five criteria every Common Fund investment has met since 2006, a new bullet about small-lab burden, and a fund whose FY 2026 request came in at $347.4 million — down 49.3 percent.
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