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NIH HEAL Initiative®: A Promising Path Forward for Pain Research (SBIR/STTR Programs) is sponsored by National Institutes of Health (NIH) - HEAL Initiative. The HEAL Initiative's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Program develops novel pain therapies, diagnostics, and medical devices. These programs provide early-stage funding to U.
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Or search similar grants →According to the current listing, eligibility includes: U. S. -based small businesses. Confirm the full requirements in the official notice before applying.
The current listing shows phase I: up to $323,090; Phase II: up to $2,153,927. Verify award ceilings, matching requirements, and allowable costs in the official notice.
NIH HEAL Initiative®: A Promising Path Forward for Pain Research (SBIR/STTR Programs) is funded by National Institutes of Health (NIH) - HEAL Initiative. Verify program details on the funder's official page before applying.
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The HEAL Initiative's Studies to Enable Analgesic Discovery award (RFA-NS-25-023) puts federal money exactly where private capital won't go — the assay-building, screening, and hit-characterization stage of non-opioid pain therapeutics. It's a phased R61/R33, up to $350,000 in direct costs per year, with the next application deadline September 17, 2026. Here is how the two-phase structure works, who's eligible, and how to build a proposal that survives the R61-to-R33 milestone gate.
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