NIH Pragmatic Trials Conducted in Health Care Systems

NIH Pragmatic Trials Conducted in Health Care Systems is sponsored by National Institutes of Health (NIH). This funding opportunity will support large-scale pragmatic trials that test intervention effectiveness in routine clinical care and/or implementation trials that evaluate strategies for delivering interventions within health care settings.

These trials are intended to directly inform decision-makers about the comparative benefits, burdens, and risks of biomedical or behavioral interventions.

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gov to verify your identity and manage your account securely. You don't need a separate username or password for this site. NIH Pragmatic Trials Conducted in Health Care Systems Agency: National Institutes of Health Assistance Listings: 93.

473 -- Complementary and Integrative Health - Research Projects 93. 213 -- Research and Training in Complementary and Integrative Health Last Updated: May 13, 2026 View version history on Grants.

gov The National Institutes of Health intends to publish a Notice of Funding Opportunity (NOFO), Pragmatic and Implementation Trials Conducted in Health Care Settings This funding opportunity will support large-scale pragmatic trials that test intervention effectiveness in routine clinical care and/or implementation trials that evaluate strategies for delivering interventions within health care settings.

These trials are intended to directly inform decision-makers (e.g., patients, clinicians, administrators, policymakers, and payers) about the comparative benefits, burdens, and risks of biomedical or behavioral interventions.

To enhance real-world relevance and generalizability, applicants are encouraged to: 1) Select care settings where the target condition is commonly seen (e.g., emergency departments, primary care, public health clinics). 2) Include multiple health system types (e.g., academic centers, federally qualified health centers, integrated networks, VA Medical Centers).

3) Assess adaptation across systems and regions to ensure intervention effectiveness and implementation feasibility. Interventions under study should be embedded in routine care. Trials may integrate one or more interventions with established efficacy into appropriate health care settings or implement system-level changes to improve health outcomes.

This phased award will use a milestone-driven cooperative agreement mechanism, supporting a planning phase and a phase for full trial execution. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

Investigators with expertise and insights into this area are encouraged to begin to consider applying for this NOFO.

For-profit organizations other than small businesses Independent school districts Private institutions of higher education Federally recognized Native American tribal governments Public and Indian housing authorities Other Native American tribal organizations Nonprofits non-higher education with 501(c)(3) Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Grantor contact information NCCIH Division of Extramural Research Program Officer Please contact via e-mail. No documents are currently available.

Link to additional information Estimated Application Due Date : Estimated Due Date Description : Estimated Project Start Date : Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.