NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)

NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed) is sponsored by National Institutes of Health. Provides funding for research software engineers to enhance open science infrastructure.

RFA-OD-24-011: NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed) This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations Office of Data Science Strategy ( ODSS ) National Eye Institute ( NEI ) National Heart, Lung, and Blood Institute ( NHLBI ) National Human Genome Research Institute ( NHGRI ) National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) National Institute of Arthritis and Musculoskeletal and Skin Diseases ( NIAMS ) National Institute of Biomedical Imaging and Bioengineering ( NIBIB ) Eunice Kennedy Shriver National Institute of Child Health and Human Development ( NICHD ) National Institute of Dental and Craniofacial Research ( NIDCR ) National Institute of Diabetes and Digestive and Kidney Diseases ( NIDDK ) National Institute on Drug Abuse ( NIDA ) National Institute of Environmental Health Sciences ( NIEHS ) National Institute of Mental Health ( NIMH ) National Institute of Neurological Disorders and National Institute on Minority Health and Health Disparities ( NIMHD ) National Library of Medicine ( NLM ) National Center for Complementary and Integrative Health ( NCCIH ) National Cancer Institute ( NCI ) Funding Opportunity Title NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed) R50 Research Specialist Award August 28, 2025 -Notice of Change to Resubmission Receipt Dates and Additional Information for Eligibility Requirements in RFA-OD-24-011 "NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)".

See Notice NOT-OD-25-147 May 14, 2025 - Notice of Correction to Application Due Dates for RFA-OD-24-011 "NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)". See Notice NOT-OD-25-089 March 31, 2025 - This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 November 15, 2024 - Notice of Change to Research & Related (R & R) Budget guidance in RFA-OD-24-011 "NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)". See Notice NOT-OD-25-027 .

March 7, 2023 - Notice of Special Interest (NOSI): Administrative Supplements to Enhance Software Tools for Open Science. See Notice NOT-OD-23-073 . August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023.

See Notice NOT-OD-22-198 . August 8, 2022 - New NIH "FORMS-H" Grant Application Forms and Instructions Coming for Due Dates on or after January 25, 2023. See Notice NOT-OD-22-195 .

August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189 . Funding Opportunity Number (FON) Companion Funding Opportunity See Part 2, Section III.

3. Additional Information on Eligibility. Assistance Listing Number(s) 93.

310, 93. 867, 93. 172, 93.

242, 93. 398, 93. 279, 93.

396, 93. 847, 93. 286, 93.

113, 93. 879, 93. 121, 93.

853, 93. 273, 93. 846, 93.

866, 93. 213, 93. 307, 93.

233, 93. 837, 93. 838, 93.

839, 93. 840, 93. 865 Funding Opportunity Purpose The purpose of this notice of funding opportunity (NOFO) is to provide salary support for exceptional Research Software Engineers (RSEs) that contribute their skills to the development and dissemination of biomedical, behavioral or health related software, tools, and algorithms as well as to the training of prospective users of these tools.

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) 30 days prior to the application due date Dates in bold and italics reflect changes per NOT-OD-25-147 . New/Renewal/Resubmission/Revision, All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Workspace to prepare and submit your application and eRA Commons to track your application. Part 1.

Overview Information Part 2. Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II.

Award Information Section III. Eligibility Information Section IV. Application and Submission Information Section V.

Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII.

Other Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description The purpose of this notice of funding opportunity (NOFO) is to support the ability of exceptional Research Software Engineers (RSEs) to contribute their skills in the development and dissemination of NIH-funded biomedical, clinical, behavioral or health related research software, tools, and algorithms as well as to the training of prospective users of these tools.

The Research Software Engineer (RSE) Award is designed to provide salary support for RSEs involved in research and positioned to make outstanding contributions to NIH-funded biomedical, clinical, behavioral or health related research software, tools, and algorithms, but who are not in a traditional independent investigator career path.

This NOFO will use the NIH Research Specialist Award (R50) mechanism to provide up to 3 years of funding to encourage the development of stable research career opportunities for exceptional RSEs who want to contribute to scientific research.

It is intended to provide incentives to participate in a research career path, with some level of autonomy so that the individuals are not solely dependent on grants held by others for their career continuity. Supporting RSEs in this manner is integral to NIH’s strategic goal of creating a sustainable ecosystem of high-quality research software tools that can enhance research across projects and domains.

The rapid growth in technology has been met with an increasing recognition of the need for research software and tools, and the important role of the people who create, maintain, and contribute to the research software ecosystem to effectively solve research problems.

While researchers can, and do contribute valuable software to scientific research, the discipline of software engineering enhances the scalability, reusability, and reproducibility of research software through careful design, identification of and adherence to prevailing standards and practices, good documentation and code structure, employment of proper testing and build procedures, and other practices that ensure efficient and sustainable software.

The notion of the role of Research Software Engineer (RSE) has evolved to capture the importance of these factors to scientific research. RSEs are not only a key part of a research team, but also are part of a parallel discipline that has its own specialized practices and standards. RSEs enhance the research within a particular project through the creation of new tools.

In addition, RSEs contribute tools and services to the larger research software ecosystem in a form that makes these tools broadly usable and sustainable, encouraging use in a new research context. This ability to ‘bridge’ between a project and the broader research software ecosystem is unique to the RSE role.

The research ecosystem is enhanced when a project-specific tool can be transformed into a widely shared capability, catalyzing new discoveries and collaborations.

In the past, traditional grant funding process has emphasized innovation for research progress over the use of robust software engineering practices that have become increasingly essential for generating reliable, efficient, and scalable software tools in an era of large-scale data and integrated data analytics. New challenges have arisen as research is carried out across diverse cloud and on-premises environments.

However, there have been few practical ways to support RSEs to develop and refine research software tools according to well-recognized software engineering best practices and design principles.

The extramural community has largely addressed the growing need for RSEs that serve multiple NIH-funded research programs, but these positions do not provide the RSE with adequate recognition or opportunities for career continuity that will attract and retain the best RSEs.

To transition to operational efficiency and sustainability that is envisioned by the NIH, new ways to support RSEs, and the software and tools they produce to process, manage, mine, analyze, visualize, and interpret biomedical, clinical, behavioral, and health related data, are critical. The NIH also recognizes the key role RSEs play in supporting and sustaining NIH-funded research and programs designed to improve health.

To help bridge scientists and software engineers and encourage their collaborations in research software development efforts, the NIH Office of Data Science Strategy (ODSS) has previously issued four rounds of software supplement Notices of Special Interest (NOSIs; NOT-OD-23-073 , NOT-OD-22-068 , NOT-OD-21-091 , and NOT-OD-20-073 ) to support the use of software development best practices to update, refactor and enhance the design, implementation, and cloud-readiness of research software and build new communities for open science.

Projects which received supplemental support have encompassed a wide range of research and translational projects reaching across NIH Institutes, Centers, and Offices (ICOs). This program announcement builds upon these past programmatic activities to further the advancements in these areas. Software engineers working in research are an increasingly vital part of the research enterprise.

This NOFO is expected to give the exceptional RSE protected time to make a transformative impact in developing well-engineered, sustainable software in the context of an existing NIH-funded biomedical, clinical, behavioral, or health-related research project and to help retain these skilled individuals in academic settings by enhancing their professional standing and recognition.

The award is intended for RSEs with significant, relevant experience, who have shown clear evidence of productivity and research excellence in the implementation of NIH-funded research and development within their institution.

The proposed award is intended to provide salaries and sufficient autonomy so that individuals are not solely dependent on NIH-funded grants held by others or other sources of support for health-related research career continuity. All applications must identify and describe the research projects engaging the RSE, including their specific role in the project(s).

Applicants must demonstrate clear evidence of skills, expertise, experience, productivity, and research ability to advance an existing NIH-supported research project by supporting best practices in software development and the RSE must document their accomplishments that support their career level. The RSE must have a full-time, non-tenure track position in an academic institution.

Two types of letters will be required, (1) a letter of support from an NIH-funded project PI with whom the RSE will collaborate, and (2) two letters of recommendation from key personnel of other projects who can attest to the RSE’s expertise and experience as outstanding software professionals and record of contribution as relevant to the project. Once awarded, a change of PD/PI will not be allowed.

Budgets may request salary support for the RSE commensurate with the level of funded effort (at least 6 person-months per year) on NIH-funded research grants. Travel expenses will be allowed up to $2,500/year. No other research expenses will be covered under this award.

Applications Not Responsive to the NOFO An application will be considered non-responsive to this NOFO and will not be reviewed if it: Does not specify the Research Software Engineer (RSE) as the contact PD/PI of the application. Does not include a letter of support from an NIH-funded project PI (Other Significant Contributor) with whom the RSE will collaborate.

Does not include at least two letters of recommendation from PDs/PIs or equivalent from other research programs, employers, or mangers, who can attest to the RSE's qualifications and contributions to research (see Section IV. 2). Is not relevant to an existing NIH-funded biomedical, clinical, behavioral, or health-related research project.

Prospective applicants are urged to consult with the scientific contact listed in Section VII of this NOFO early in the pre-submission process to ensure the application is responsive to the NOFO. Non-responsive applications will not be reviewed. See Section VIII.

Other Information for award authorities and regulations. Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO. Not Allowed: Only accepting applications that do not propose clinical trials.

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The NIH ODSS intends to commit up to $6 million in FY25 to fund 18-20 awards. The combined budget for direct costs for up to a three-year project period may not exceed $300,000.

No more than $200,000 direct costs may be requested in any single year. A project duration of up to three years may be requested. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed. Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications for additional information System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually .

The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.

Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM. gov registration process. The same UEI must be used for all registrations, as well as on the grant application.

eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants. gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.

Grants. gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role.

Obtaining an eRA Commons account can take up to 2 weeks. Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

The Research Specialist (in this case the RSE) must be the PD/PI of the application. A PI from the NIH-funded project with whom the RSE will collaborate must be included in the list of Senior/Key Personnel as an Other Significant Contributor (no salary support allowed) and must provide an NIH Biosketch as part of the application.

Additional Eligibility Requirements: The RSE must have a full-time, non-tenure track position at the academic or research institution; and must have been at that institution for at least 1 year. The RSE must have demonstrated outstanding research software engineering accomplishments, documented by relevant publications, peer-reviewed conference proceedings, and hyperlinks and URLs to code samples in the application .

The RSE must commit a minimum of 6-person month effort during the life of the R50 award. The RSE must not have served as contact PI on funded independent NIH grant support application, including, but not limited to, R-series mechanisms (e.g., R01, R34, R21, R03), within the past five years.

Additional NIH-project PI (“Other Significant Contributor”) Requirements: The Other Significant Contributor must be the PD/PI of a NIH-funded research grant that will have at least one full funding year remaining (exclusive of no cost extension and supplements) in the current competitive segment at the time the R50 is awarded. The Other Significant Contributor must be committed to both the RSE and the RSE's proposed research.

This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1. 2 Definition of Terms. 3.

Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2. 3.

7. 4 Submission of Resubmission Application . This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application. An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3.

9. 4 Similar, Essentially Identical, or Identical Applications ). Section IV.

Application and Submission Information 1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution.

Links to apply using ASSIST or Grants. gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise. Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed. Instructions for Application Submission The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO.

All instructions in the How to Apply - Application Guide must be followed. SF424(R&R) Project/Performance Site Locations All instructions in the How to Apply - Application Guide must be followed. SF424(R&R) Other Project Information All instructions in the How to Apply - Application Guide must be followed.

SF424(R&R) Senior/Key Person Profile All instructions in the How to Apply - Application Guide must be followed. All instructions in the How to Apply - Application Guide must be followed.

The application budget may request only the following two expenses in direct costs per year: Salary support for the RSE commensurate with their level of funded effort on NIH-funded research grants during Federal Fiscal Year 2023; and Travel costs to attend research meetings/conferences not to exceed $2,500 per year. All instructions in the How to Apply - Application Guide must be followed.

PHS 398 Cover Page Supplement All instructions in the How to Apply - Application Guide must be followed. All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: Applications should clearly detail the following in the corresponding sections: Specific Aims: Do not include the Specific Aims page as specific aims are not allowed.

Research Strategy: The Research Strategy should be uploaded as a single attachment and organize using the instructions provided below. Start each section with the appropriate section heading: Research Program(s) engaging the Research Software Engineer’s activity/effort: Describe the scope of the NIH-funded research program(s) which the RSE supports (citing NIH grant numbers and PD/PI names) or is likely to support in the future.

Role of the Research Software Engineer in Research Program(s): Describe the activity and the kind of contributions the RSE applicant provides in the NIH-funded research program(s) described above and how they will be likely to contribute to the research in the future to ensure success of the program(s).

Describe the RSE's plans for meeting the objectives of the various NIH-funded research program(s) (citing NIH grant numbers and PD/PI names) over the next 3 years. This section should also describe the RSE's qualifications, expertise, experience, productivity, accomplishments, and ability to achieve the research goals of the proposed research project(s).

Describe the RSE’s history of significant contributions to software and tool development to advance health-related research goals including dissemination and reuse of research software through development of software dissemination plans and leadership roles in community software projects.

Career Goals and Objectives of the Research Software Engineer : Describe the RSE’s career goals and objectives for this Research Specialist (R50) Award and how this aligns with the project PI’s NIH-funded research program(s).

This section should also explain how this award will enable the RSE to accomplish their short- or long-term goals, any skills they expect to gain during the funding period, and how this award will enhance their career. The RSE may consider including a timeline with plans to apply for subsequent grant support as appropriate.

Letters of Support: Institutions must include Letters of Support for the applicant who is applying for the Research Specialist (R50) Award. Applications that are missing Letters of Support will not be reviewed. Two (2) types of Letters of Support are required for this application: 1.

A letter of support from the NIH-funded PI (“Other Significant Contributor”), which must detail the following: The relevance of their NIH-funded project to the RSE's area of expertise, including a high-quality research environment (may include a broader network of collaborators, as appropriate, outside of the NIH-funded PI’s institution) with key faculty members and other investigators capable of productive collaboration with the RSE.

Sufficient research support (i.e., at least one full funding year remaining on their NIH-funded award, excluding no cost extensions and supplements) to cover the potential research costs associated with the work proposed in the R50 application. The nature of the collaboration between the RSE and the Other Significant Contributor, including the length of time that they have been working together.

Institutional commitment to the RSE’s professional and career development. 2. At least two letters of recommendation from PDs/PIs or equivalent from other research programs, employers, or mangers, who can attest to the RSE's qualifications and contributions to research.

Resource Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide . Specific to this funding opportunity : A Resource Sharing Plan is not applicable.

Other Plan(s): Note: Effective for due dates on or after January 25, 2023, the Data Management and Sharing Plan will be attached in the Other Plan(s) attachment in FORMS-H application forms packages. All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions: A Data Management and Sharing Plan is not applicable for this NOFO.

Appendix: Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the How to Apply - Application Guide . No publications or other material, with the exception of blank questionnaires or blank surveys, may be included in the Appendix.

PHS Human Subjects and Clinical Trials Information When involving human subjects research, clinical research, and/or NIH-defined clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply - Application Guide , with the following additional instructions: If you answered “Yes” to the question “Are Human Subjects Involved?

” on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record. Study Record: PHS Human Subjects and Clinical Trials Information All instructions in the How to Apply - Application Guide must be followed.

Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply - Application Guide must be followed. PHS Assignment Request Form All instructions in the How to Apply - Application Guide must be followed.

3. Unique Entity Identifier and System for Award Management (SAM) See Part 2. Section III.

1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants. gov 4. Submission Dates and Times Part I.

contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday , the application deadline is automatically extended to the next business day.

Organizations must submit applications to Grants. gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIH’s electronic system for grants administration.

NIH and Grants. gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.

gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications .

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission. Information on the submission process and a definition of on-time submission are provided in the How to Apply – Application Guide . 5.

Intergovernmental Review (E. O. 12372) This initiative is not subject to intergovernmental review.

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement . Pre-award costs are allowable only as described in the NIH Grants Policy Statement Section 7. 9.

1 Selected Items of Cost . All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement . Pre-award costs are allowable only as described in the NIH Grants Policy Statement .

It is anticipated that the terms of award will include, but not be limited to, the following: If applicable, funds on the Other Significant Contributor's NIH award(s) that are freed up through salary support provided by the R50 will be restricted from any other use without NIH prior approval. The requested salary support for the RSE may not exceed the current NIH salary cap, as defined in the NIH Grants Policy Statement.

In addition to salary support for the RSE, the application may include a request for travel funds to be used by the RSE. Research expenses are not allowable under this mechanism. An RSE would have the option, with prior NIH approval, to move to another research program or institution (e.g., if the Other Significant Contributor's laboratory or group that houses the RSE is closed).

The R50 must be relinquished if any other independent NIH grant support is obtained by the RSE. The R50 Other Significant Contributor must continue to report the RSE as a Participant on any NIH-funded grant on which the RSE dedicates effort. Non-competing segments of the R50 will be contingent upon the RSE's ability to continue devoting at least 6 person-months to the activities supported by the R50.

A change of the PD/PI (the RSE) will not be allowed on the