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NIH SBIR/STTR (NIH Seed Fund) is sponsored by U.S. National Institutes of Health (NIH). Federal grants for US small businesses developing health and life science products. Applications are due on three standard dates a year under NIH's SBIR and STTR funding opportunities.
This program supports the critical startup and development stages of health innovation.
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Or search similar grants →According to the current listing, eligibility includes: U.S. small businesses developing health and life science products. Small businesses with fewer than 500 employees, at least 50% of equity owned by U.S. citizens or permanent residents. Confirm the full requirements in the official notice before applying.
The current listing shows ~$300K Phase I / $2M+ Phase II (amounts vary per funding opportunity). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for NIH SBIR/STTR (NIH Seed Fund) are due January 5, 2027. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
NIH SBIR/STTR (NIH Seed Fund) is funded by U.S. National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
On November 2, 2026, NIH released NOT-OD-27-006, a draft update to its Policy for Data and Safety Monitoring. As summarized by Harvard's research integrity office, the draft would extend risk-based monitoring from clinical trials to all NIH-supported clinical research, drop the blanket DSMB requirement for Phase 3 and multi-site trials, and require an NIH-approved monitoring plan scaled to risk, effective for applications six months after the final policy. Comments are due January 6, 2027. What it changes and how to respond.
Read articleR&D World's count of NIH RePORTER data shows 13,686 new awards in FY2026, up 21% from 11,272 in FY2025, while total extramural grants fell to about 56,600. New R01s hit 4,960. What the split means for FY2027 applicants.
Read articleRFA-EB-28-004, NextTech: Translational Development of Next-Generation Diagnostic and Therapeutic Devices (R18), puts about $6 million into 8 to 12 BRAIN and HEAL Initiative device-development awards. Budgets should rarely exceed $750,000 in direct costs a year, projects run up to three years, nine institutes participate, and there are six due dates from February 1, 2027 through February 1, 2030. Here is what the program requires and how to write a competitive application.
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