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NIH Small Business Innovation Research and Small Business Technology Transfer Programs is sponsored by National Institutes of Health (NIH). NIH's SBIR and STTR programs support research and development in small businesses with a focus on biomedical/behavioral research areas, including health tech/AI.
This could involve AI for digital health, such as AI diagnostics or mobile health apps, and AI techniques for characterizing and minimizing errors in health-related datasets.
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Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) | National Institute of General Medical Sciences NIH has congressionally mandated set-aside programs for U.S. small businesses to engage in research and development activities that have strong potential for commercialization. Awards are intended to: Stimulate technological innovation. Use small business to meet federal research and development needs.
Increase private sector commercialization of innovations derived from federal research and development. The NIH SBIR/STTR program consists of two phases: Phase 1 (R41/R43) establishes the scientific and technical merit and feasibility as well as the potential for commercialization of the proposed Phase 2 (R42/R44) continues research or research and development (R&D) efforts initiated in Phase 1.
NIH SBIR/STTR grant solicitation announcements and additional information are website. You can also find information on the difference between SBIR and STTR application requirements . NIGMS-Specific SBIR Guidance The goal of NIGMS is to support innovative SBIR projects that could benefit the research communities related to its mission.
SBIR/STTR grant applications are accepted in most of the scientific areas for which the Institute provides support. Specific topics of research interest to NIGMS [PDF] . The NIGMS SBIR program like the vast majority of NIGMS-funded research is investigator-initiated.
Applicants propose what to do, how to do it, and the best path toward commercialization. NIGMS will not accept applications with budget requests exceeding the statutory budget limitations defined in the specific SBIR/STTR notice of considered to fit one or more of the SBA-approved topics for awards over the statutory budget limitations listed in SBA-Approved Waiver Topics of the SBIR/STTR Program Descriptions and Topics .
Applicants who are considering a project with a budget exceeding the hard budget cap defined in the notice of funding opportunity should contact the NIGMS SBIR coordinator early in the process of application preparation and at least six weeks prior to the anticipated submission due date. In all cases, applicants should propose a budget that is reasonable and appropriate for completion of the research project.
NIGMS support of Phase 2B competing renewal grant applications is limited and should be discussed in advance with the NIGMS SBIR coordinator. NIGMS does participate in the Commercialization Readiness Pilot (CRP) program designed to facilitate the transition of previously funded SBIR and STTR Phase 2 and Phase 2B projects to the commercialization stage by providing additional support for technical assistance.
List of NIGMS funding announcements (program announcements, requests for applications and notices) for the SBIR For information about NIGMS SBIR/STTR grants administration and management, NIGMS_GAB_SBIR@nigms. nih. gov .
NIH Research Evaluation and Commercialization Hub (REACH) The NIH Research Evaluation and Commercialization Hub (REACH) program was established to facilitate and accelerate the translation of academic biomedical discoveries into products that improve patient care and public health. Through this program, NIH will provide the qualifying institutions with the funds to seed the creation of academic entrepreneurship Hubs.
Hubs will be responsible for providing innovators with both the initial investment and resources to support the proof-of-concept work and the mentorship in product development and commercialization needed to develop high priority technologies within the NIH’s mission. For more information REACH and current For information about NIGMS SBIR programs, email Eddie Billingslea, Ph. D.
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According to the current listing, eligibility includes: US-owned and operated small businesses. Specific eligibility criteria vary by program announcement, but generally require a for-profit small business with 500 or fewer employees. Confirm the full requirements in the official notice before applying.
The current listing shows up to approximately $323,090 (Phase I); Up to $2,153,927 (Phase II). Verify award ceilings, matching requirements, and allowable costs in the official notice.
NIH Small Business Innovation Research and Small Business Technology Transfer Programs is funded by National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Past winners and funding trends for this program
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward advances in AI and data science for biomedical and public health research. Projects must cross disciplinary boundaries.
NIH R25 Summer Research Education Experience Program is a grant from the National Institutes of Health (NIH) that funds universities and institutions of higher education to provide summer research experiences in environmental health sciences to high school students, college undergraduates, and science teachers. Administered through the National Institute of Environmental Health Sciences (NIEHS), the program aims to attract young people to scientific careers and help teachers communicate about the scientific process more effectively. Eligible applicants are U.S. institutions eligible for NIH grants. The application deadline was March 17, 2026.
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward advances in AI and data science for biomedical and public health research. Projects must cross disciplinary boundaries.
Innovation Grant is a grant from the Delta Dental of Arizona Foundation that funds nonprofit organizations pursuing unique, high-impact projects that improve health and wellness in Arizona communities. This two-year award supports original initiatives with measurable real-world impact, including programs serving underserved and uninsured populations through oral health education, disease prevention, and nutritional access. Projects must demonstrate the potential to make a meaningful difference in the community and stand apart from conventional approaches. Eligible applicants are Arizona-based nonprofit organizations. Awards total $100,000 per recipient over two years. The 2026 application cycle closed October 16, 2025, with recipients notified in late 2025 and funding made available shortly after.
The NIH Extramural Loan Repayment Program pays up to $50,000 a year against educational debt at roughly a 50% success rate — better odds than almost any NIH research grant. For FY2027 the six extramural subcategories collapse into three: L30, L40, and L70. Applicants who would have used L32, L50, or L60 must now pick a new lane. Here is the crosswalk, the 20% debt-to-salary rule, and why the consolidation changes how you frame the research.
Read articleNOT-OD-26-098 bars K award funds from supporting clinical trials, feasibility studies, and ancillary studies for due dates on or after October 12, 2027, and retires the Independent Clinical Trial Required K NOFOs. NIH has no replacement mechanism yet — only an RFI closing September 30, 2026. Here is what the policy actually says, who it hits, and how to sequence around it.
Read articleNIH proposed on August 14 to withhold overall impact scores and percentiles from applicants, replacing them with three bands: Most competitive, Competitive, Not discussed. Paylines already vanished in January. Here is what applicants actually lose, what survives in the summary statement, and how to rebuild a resubmission decision rule without a number.
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