NIOSH Centers for Agriculture, Forestry, and Fishing Safety and Health (U54)

NIOSH Centers for Agriculture, Forestry, and Fishing Safety and Health (U54) is sponsored by NIOSH, CDC. Establishes centers to address occupational health and safety hazards in agriculture, forestry, and fishing.

Expired RFA-OH-22-002: Centers for Agricultural Safety and Health (U54) This notice has expired. Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) Centers for Disease Control and Prevention ( CDC ) The policies, guidelines, terms, and conditions of the HHS Centers for Disease Control and Prevention (CDC) stated in this funding opportunity announcement (FOA) might differ from those used by the HHS National Institutes of Health (NIH).

If written guidance for completing this application is not available on the CDC website, then CDC will direct applicants elsewhere for that information.

of Participating Organizations National Institute for Occupational Safety and Health ( NIOSH ) Funding Opportunity Title Centers for Agricultural Safety and Specialized Center- Cooperative Agreements October 15, 2024 - Notice to close RFA-OH-22-002 Centers for Agricultural Safety and Health (U54).

See Notice NOT-OH-25-001 April 19, 2024 - Notice to Remove Risk Assessment Questionnaire Requirement for RFA-OH-22-002: Centers for Agricultural Safety and Health (U54).

See Notice NOT-OH-24-011 NOT-OD-22-190 - Adjustments to NIH and AHRQ Grant Application Due Dates Between September 22 and September 30, 2022 August 23, 2022 - Notice Regarding Changes to the Application Types Accepted under RFA-OH-22-002 "NIOSH Centers for Agricultural Safety and Health (U54)" for the October 2022 receipt date.

See Notice NOT-OH-22-008 January 21, 2022 - Notice to Add a Receipt Date for RFA-OH-22-002: Centers for Agricultural Safety and Health. See Notice NOT-OH-22-003 . Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity Only one application per institution is allowed, as defined in Section III.

3. Additional Information on Eligibility. Assistance Listing Number(s) Funding Opportunity Purpose The National Institute for Occupational Safety and Health (NIOSH) within the Centers for Disease Control and Prevention (CDC) invites applications for the Centers for Agricultural Safety and Health (Ag Centers).

These centers are expected to conduct high quality research and subsequently disseminate their findings and recommendations in audience appropriate products to contribute to improving the safety and health of agriculture, forestry, and fishing workers. Center structure should take advantage of diverse scientific resources and focus on local, regional, and/or national worker safety and health issues.

Emphasis should be placed on the creation and implementation of evidence-based solutions that address important agricultural, forestry, and fishing safety and health problems. Centers should also use innovative approaches to identifying, understanding, and developing strategies for overcoming barriers to the adoption, adaptation, integration, scale-up and sustainability of evidence-based solutions.

Collaborations with other academic institutions, nonprofit organizations, and other occupational safety and health focused groups are expected. Applicants must concisely describe the occupational safety and health burden within their service area and directly link research and outreach activities to help alleviate the burden.

Applicants should also clearly articulate the anticipated impacts of the proposed work, both during the project period and Open Date (Earliest Submission Date) Letter of Intent Due Date(s) December 17, 2021.

Thereafter, 30 days prior to the January 24, 2022; October 24, 2022; October 24, 2023; Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. Late applications will not be accepted for this announcement.

On-time submission requires that electronic applications be error-free and made available to CDC for processing from the NIH eRA system on or before the deadline date. Applications must be submitted to and validated successfully by Grants.

gov no later than 5:00 PM U.S. AIDS Application Due Date(s) 2022; March 2023; March 2024; March 2025 June 2022; April 2023; April 2024; April 2025 New Date October 15, 2024 per NOT-OH-25-001 (Prior Date December 1, 2024). Any due dates beyond the new expiration date are no longer available.

It is critical that applicants follow the Multi-Project (M) Instructions in the SF424 (R&R) Application Guide , except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Part 1. Overview Information Part 2. Full Text of the Announcement I.

Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Full Text of Announcement Section I. Funding Opportunity 1.

Background and Purpose Agriculture, forestry, and fishing (AgFF) occupations have long been recognized as some of the most dangerous in the country. The AgFF sector has a workforce over 2 million strong, and many of these laborers are at significant risk due to a combination of factors. AgFF workers encounter numerous physical, chemical, and biological hazards during their daily routines.

Physical hazards may include the dangers associated with the use of tractors and other heavy equipment, working in extreme temperatures, or coping with large livestock. Chemical hazards may include inadvertent exposure to pesticides and herbicides during their application or to potentially hazardous commodities during the production or harvesting processes (such as in green tobacco sickness).

Biological hazards may include the threat of exposure to zoonosis for those who are in nearly continuous contact with swine, poultry, or other animal vectors. Furthermore, many laborers in these industries are foreign born and therefore encounter language and cultural barriers that might exacerbate these threats. Additionally, factors such as limited access to health care and worker training resources may also intensify these hazards.

Finally, the seasonal nature of some crops might also create an economically driven, forced migration that may generate unintended second-order effects in the workforce in areas such as housing, diet, and social support systems.

The purpose of this funding opportunity is to provide support for Centers for Agricultural Safety and Health (Ag Centers) to address the significant and varied morbidity and mortality burden in U.S. AgFF occupations.

Ag Centers conduct research and outreach activities as a means of building and expanding upon existing scientific evidence and transferring evidence-based research findings to appropriate stakeholders for adoption, adaptation, integration, scale-up and sustainability. The overarching goal of the Ag Centers is to reduce adverse outcomes in AgFF worker health and safety.

The United States Public Health Service (PHS) is committed to achieving a society in which all people live long, healthy lives. The vision, mission, and goals are found in Healthy People 2030 , a PHS-led national activity to achieve better health in the United States by the year 2030.

This funding announcement is linked to the goals of Healthy People 2030, that are intended to prevent work-related diseases, injuries, and deaths while improving worker health, According to the Healthy People 2030 , more than 160 million people participate in the U.S. labor force, and their work has an intrinsic connection to their safety and health.

Decades of public health surveillance and research have demonstrated that work-related injuries adversely affect employers, workers, and communities. Workplace settings vary widely in size, sector, design, location, processes, culture, and resources. In addition, workers themselves have different ages, genders, education levels, cultural backgrounds, health practices, vulnerabilities, and levels of access to preventive health care.

This translates into great diversity and disparity in the safety and health risks for each industry sector and the need for Ag Centers are expected to have a significant and sustained impact on reducing morbidity and mortality in the AgFF workforce.

Despite safety advances in many areas of this sector, and recently documented decreases in adverse health outcomes for this workforce, AgFF workers are still disproportionately affected in comparison to workers in other industrial sectors.

Because of the diversity of activities in agriculture, forestry, and fishing jobs, Ag Centers must be sensitive to regional work practices and how these practices can be modified and improved to increase protections for the worker population.

Ag Centers should also attempt to facilitate the use and adaption of new approaches or best practices in similar segments of the workforce or regions of the country through collaboration and coordination with fellow centers, academic institutions, nonprofit entities, industry, and labor In 1990, Public Law 101-517 directed NIOSH to establish a program of improving the health and safety of agricultural workers and their families.

Details in the Senate appropriations language of PL 101-517 included the innovative call to establish centers for agricultural occupational safety and health. Beginning in 1990, NIOSH established and maintained these centers through a series of competitive FOAs, including PAR-11-022 , PAR-06-057 , RFA-OH-03-002 , and RFA-OH-01-004 .

Ag Centers conduct high quality research and subsequently disseminate their findings and recommendations to appropriate audiences and stakeholders through outreach and education activities. The centers identify practical solutions to complex problems while cultivating collaboration and partnerships. Ag Centers are distributed throughout the nation to be responsive to agricultural safety and health issues unique to different regions.

Links to the Ag Centers currently funded by NIOSH are provided at NIOSH Ag Centers . Ag Centers should address agriculture, forestry, and fishing issues in a cohesive and coordinated fashion, focusing on problems that are particularly burdensome in their region or potential solutions that are reasonably anticipated to have a high likelihood of improving the health and well-being of AgFF workers.

Although applicants are asked to define the region of the country where they will focus their efforts, NIOSH recognizes that many of the occupational safety and health concerns in this workforce are not constrained by geographic boundaries. Therefore, it is anticipated that Ag Centers will, on occasion, work on problems that go beyond their predefined region or catchment area.

In these cases, centers in the respective regions should work together to identify synergies and avoid duplicative efforts. In some cases, this may involve translation research where one center is using the evidence base developed by another center to test intervention effectiveness in a different population.

Centers inherently have different abilities, strengths, and experiences, so clear communication and coordination (with each other and with NIOSH) are strongly encouraged in trans-regional efforts. Centers are encouraged to develop a networked approach to address complex problems within the AgFF workforce which are too large and diverse for any single center to adequately address.

Applicants should clearly describe how the intended in particular, those identified in the NIOSH Priority Goals for Extramural NIOSH Ag Centers provide interdisciplinary research and outreach efforts to address AgFF-related occupational health and safety problems.

Applicants should keep in mind the required and optional components essential to Ag Center function, detailed below, in providing an overall description of the proposed Ag Center, addressing 1) the burden of occupational injuries and illnesses within their region for this work sector, 2) the regional and national need for the Ag Center’s proposed programs and projects, and 3) the Center’s impact, or potential for impact, on AgFF worker health and The following required components enable Ag Centers to cohesively address their goals and objectives for providing impact: Evaluation and Planning Core Research Projects (collectively, the "Research Core", along with the optional Pilot/Feasibility Program) and Planning Core .

The purpose of the Evaluation and Planning Core is to 1) provide oversight, leadership, and management for the Center, including establishment and maintenance of advisory committees; 2) engage in long-range planning, coordination, and implementation of work that crosses multiple cores, programs or projects; and 3) develop and assist in implementing evaluation efforts at the Center, core, program and project levels.

Any collaborative projects with other Ag Centers should include the Evaluation and Planning Core for the purposes of oversight and coordination. Core . The purpose of the Outreach Core is to ensure that evidence-based approaches, technologies, guidelines, policies, best practices, or similar activities are promoted and implemented in affected populations to benefit workers and their associated work environments.

Much of the work in the Outreach Core will be implemented through partnerships and collaborations with nonprofit organizations, community groups, industry groups, employers, or Core. The purpose of the Research Core is to develop programs and subsequently manage, monitor, and coordinate this work within the Center. Research activities include basic/etiologic, intervention, translation, and surveillance.

Activities can vary widely, from pilot or feasibility studies that are minimally resourced and may be exploratory in nature to large, R01-like projects that require preliminary data and significant investment in personnel, equipment, time, and space.

The Research Core is comprised of the required research projects and the optional Pilot/Feasibility Program Please Core" is not an actual component within the application - instead it is a construct to address budget limits across multiple and varied activities (i.e., required research projects and the optional pilot/feasibility program).

There is no limitation to the number of research projects that applicants can propose as long as they stay within the annual direct costs The primary goal of an Ag Center is to conduct high quality scientific research and outreach efforts to address local, regional, and national AgFF problems.

This will ultimately be accomplished through the goals accomplishing these goals should not be overlooked and therefore, each core, program and project should develop operational objectives to support the goals There are many affected subpopulations in AgFF professions.

The attributes of these affected subpopulations (such as demographics, size, risks/hazards encountered, and resources available to educate or assist in addressing the problem) will drive the proposed projects and their anticipated outputs and impacts. Ag Centers are distributed throughout the nation to be responsive to safety and health issues unique to different regions of the country.

The risks inherent to an AgFF job are often dependent on the work environment, local/industry work practices, and specific job tasks.

Therefore, Ag Centers should clearly describe the specific target populations they are focusing their efforts on and provide information to support the need for these Sectors, Health and Safety Cross-sectors, and Goals In the Project Description/Abstract of the application, state which industry sector(s) and health and safety cross-sector(s) the proposed work will address.

Provide a clear rationale for how the intended in particular, those identified in the NIOSH Priority Goals for Extramural Diversity, Equity and Inclusion In June 2019, NIOSH began an initiative to take substantive action in creating greater diversity, equity, and inclusion in its workforce, the workplace and in its service to the public. This initiative led to the establishment of the NIOSH Diversity and Inclusion Office.

The associated diversity, equity and inclusion (DEI) in all aspects of NIOSH's work, including NIOSH-supported extramural programs. Ag Centers should demonstrate a commitment to DEI in all aspects of their center. This commitment should be reflected in the center's core values, mission and outputs.

Asymmetrical power relationships along social axes such as age, class, gender, nativity, and race/ethnicity not only result in social, economic, and environmental disadvantages that impact the distribution of work-related benefits and risks but also result in exclusionary research practices.

Developing inclusive research practices, and the institutional capacity to effectively produce data driven solutions that reduce these avoidable inequities, is essential to ensuring the well-being of the increasingly diverse AgFF workforce. Applicants should describe how they propose to ensure inclusive governance and practice in the required center components (Evaluation and Planning, Outreach, and Research).

Discussion should include, but not be limited to, how historically underrepresented groups will be included in agenda setting for the work of the center. For example, this may include participation on advisory boards, as researchers/staff and through partnerships.

Applicants should also identify how the center will ensure that research questions, data collection methods and analysis, and dissemination of results will be inclusive of the diversity in the AgFF workforce, especially those from historically underrepresented groups. Applicants should demonstrate how the design, content, format, and dissemination of outreach efforts will be tailored to the needs of workers from diverse backgrounds.

Collaboration/Partnerships Ag Centers must demonstrate collaborative efforts by working with a diverse and broad range of organizations to enhance worker safety and health in their region. Possible collaborators include universities, labor and professional associations, nonprofit organizations, businesses, and federal, state, or local public health and regulatory agencies.

Centers should seek to address a wide range of occupational safety and health concerns in their region, as determined by the burdens posed by these problems or hazards, and their funding applications must describe how their efforts will alleviate or eliminate these All Center activities should be managed and coordinated as part of the Evaluation and Planning Core.

This core is responsible for all new and ongoing center-wide evaluation activities as well as supporting program and project level evaluation efforts. These activities should all be described in a Center evaluation plan. Ag Centers are also strongly encouraged to interact with each other on evaluation methods and best practices, to increase awareness of activities and evaluation techniques.

Similarly, centers will work with each other and NIOSH during the performance period to develop shared logic models on common AgFF health and safety outcomes. In addition to center-specific evaluation and performance measurement, Ag Centers may be asked to participate in NIOSH evaluation efforts related to the NIOSH AgFF Program and the NIOSH Evaluation Capacity Building Plan.

The transfer of evidence-based approaches to intermediaries such as unions, manufacturers, worker groups and end users (employers and blogs, websites and infographics, peer-reviewed and lay publications, etc. is an essential function of the Outreach Core.

While research strengthens our understanding of the determinants of injury, illness, and death, the potential for impact of research findings is found when paired with pragmatic approaches to move findings into practice. Information for award authorities and regulations. Section II.

Award Information Cooperative Agreement: A support mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.

2 for additional information about the substantial involvement for Application Types Allowed After the January 2022 application due date, only Revision and Resubmission applications from the funded centers will be accepted for research projects that competed and were not funded in FY2022. New and Renewal applications will not be accepted for future application due dates.

Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed Optional: Accepting applications that either propose or do not propose clinical trial(s) help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards Total Funding : $15-18 million total costs (direct and indirect costs) in FY 2022.

NIOSH intends to commit approximately $80-100 million in total costs (direct and indirect) over the entire project period (up to 5 number of awards : NIOSH anticipates funding approximately 10-12 awards through this announcement. announcement are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

Direct Costs per budget period Ceiling: $1,400,000 direct costs per budget period Floor: $800,000 direct costs per budget period It is anticipated that the maximum amount for each application/award will be $1,400,000 in direct costs for each 12-month budget period. The total project period for an application submitted in response to this funding opportunity may not exceed 5 years.

Throughout the project period, CDC's commitment to continuation of awards will depend on the availability of funds, evidence of satisfactory progress by the recipient (as documented in required reports), and CDC’s determination that continued funding is in the best interests of HHS/CDC grants policies as described in the HHS Grants Policy Statement will apply to the applications submitted and awards made from Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Nonprofits without 501(c)(3) IRS Status (Other than Institutions For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Institutions) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible Foreign components, as defined in the HHS Grants Policy Statement , are not allowed.

include collaborators or consultants from foreign institutions. All applicable federal laws and policies apply. Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Statement states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.

PLEASE NOTE: For applications due on or after January 25, 2022, applicants must have a unique entity identifier (UEI) at the time of application submission. Grant application forms and instructions will be updated to reflect and require UEI instead of DUNS. System for Award Management (SAM) Applicants must complete and maintain an active registration, which requires renewal at least annually .

The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.

must have an active DUNS number to register in eRA Commons. Organizations can register with the eRA Commons as they are working through their SAM or Grants. gov registration, but all registrations must be in place by time of submission.

eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. must have an active DUNS number and SAM registration in order to complete the Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for CDC/NIOSH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 A letter of intent is required, the information that it contains allows NIOSH staff to estimate the potential review workload and plan If an application exceeds the five-year period of performance limit or the direct cost limit of $1,400,000 per budget period (including consortium F&A costs), CDC/NIOSH will consider the application non-responsive, and it will not enter the peer review process.

CDC/NIOSH will notify the applicant that the application did not meet the submission Upon receipt, applications will be evaluated for completeness by NIH/CSR and CDC/NIOSH. CDC/NIOSH will review all applications for responsiveness. Incomplete and/or non-responsive applications This FOA does not require cost sharing as defined in the HHS Grants Policy 3.

Additional Information on Eligibility Only one application per institution (normally identified by having a unique DUNS number) is allowed. The CDC/NIOSH will not accept duplicate or highly overlapping applications under review at the same time.

This means that the CDC/NIOSH A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application. An application that has substantial overlap with another application pending appeal of initial peer review (see 2. 3.

9. 4 Similar, Essentially Identical, or Identical Applications ). CDC/NIOSH will not accept any application in response to this announcement that is essentially the same as one currently pending initial peer review, unless the applicant withdraws the pending Section IV.

Application and Submission Information The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this FOA. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions (R&R) Application Guide , except where instructed in this funding opportunity announcement to do otherwise and where instructions in the Application Guide are directly related to the Grants. gov downloadable forms currently used with most NIH opportunities.

Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review. Applicants must use FORMS-G application packages for due dates on or after January 25, 2022 and must use FORMS-F application packages for due dates on or before January 24, 2022.

Application guides for FORMS-G application packages will be posted to the How to Apply - Application Guide page no later than October 25, 17, 2021 . Thereafter, 30 days prior to the future submission A letter of intent is required , the information that it contains allows NIOSH staff to estimate the potential review workload and plan the review. By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed center Titles for each proposed research project (and pilot/feasibility Name(s), address(es), email(s), and telephone number(s) of the PD(s)/PI(s) for the center as well as for all proposed components Names of other key personnel Participating institution(s) Number and title of this funding opportunity The letter of intent should be sent to: National Institute for Occupational Safety and Health Centers for Disease Control and Prevention (CDC) In most cases, research strategy page limits are either 6 pages or 12 pages.

Unless otherwise specified in this announcement, the page limit for each component is determined by the proposed total direct cost over the entire project period, regardless of the number of years in that component's project period. When a component's total direct costs across the project period are $500K or less, the limit is 6 pages.

When a component's total direct costs across the project period are greater than $500K, the limit is 12 pages. The Overall component is allowed 15 pages. Only include proposed (prospective) work in the research strategy attachment to the PHS 398 Research Plan (i.e., "3.

*Research Strategy"). Past performance and/or prior accomplishments, whether for new or renewal applicants, is limited to 6 pages per component and should be attached to the Appendix of the PHS 398 Research Plan (i.e., "12. Appendix").

Related publications for the particular proposed component, whether for new or renewal applicants, should be attached to the progress report publication list of the PHS 398 Research Plan (i.e., "4. Progress Report Publication List").

There is no page limit for related publications Follow the page limits specified in this table: Evaluation and Planning Core Pilot/Feasibility Program Research Projects with direct costs of $500K or less during the project period Research Projects with direct costs of more than $500K during the project period Additional page limits described in the SF424 Application Page Limits must be followed.

References are not included in the page limits Instructions for the Submission of Multi-Component The following section supplements the instructions found in the SF424 (R&R) Application Guide, and should be used for preparing a multi-component application. Revision applications must include an Overall component and the components that are affected by the revision.

Therefore, the component requirements listed below may not apply to a revision application.

The application should consist of the following components: Evaluation and Planning Core: required Pilot/Feasibility Program: optional Research Projects: required Research Projects will be listed in the final application in the order in which they were entered in ASSIST as Research-Project 1, Research-Project 2, etc. There is no limit to the number of research projects, but they must conform with annual direct costs requirements for the entire research core.

The "Research Core" is not a component within the application - instead it is a construct to address budget limits across multiple and varied activities (i.e., required research projects and the optional pilot/feasibility program).

Please enter in ASSIST in the following order: When preparing your application, use Component Type All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted. SF424 (R&R) Cover (Overall) PHS 398 Cover Page Supplement (Overall) Project Information (Overall) Project Summary/Abstract: Provide a succinct summary of the proposed work for the entire Center.

Project Narrative: In 1-3 sentences, describe the relevance of the research and outreach efforts