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NSF Advancing Cell-Free Systems Toward Increased Range of Use-Inspired Applications (NSF CFIRE) is sponsored by U.S. National Science Foundation Directorate for Technology, Innovation and Partnerships (NSF TIP). This initiative aims to accelerate the adoption of cell-free systems, enable new applications of this technology, and contribute to the growth of the U.S. bioeconomy.
While not exclusively focused on mRNA, cell-free systems offer potential advantages for rapid turnaround, distributed, and highly retargetable manufacturing of biomaterials, which could be relevant for RNA therapeutics.
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Or search similar grants →According to the current listing, eligibility includes: Research teams developing new approaches to cell-free systems that benefit industries including pharmaceuticals and biomanufacturing. Confirm the full requirements in the official notice before applying.
NSF Advancing Cell-Free Systems Toward Increased Range of Use-Inspired Applications (NSF CFIRE) is funded by U.S. National Science Foundation Directorate for Technology, Innovation and Partnerships (NSF TIP). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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Tech Metal Transformation Challenge (STRIDE Ventures) is sponsored by U.S. National Science Foundation Directorate for Technology, Innovation and Partnerships (NSF TIP). This challenge seeks to strengthen the U.S. supply chain for critical and strategic metals by developing breakthrough technologies. Competing teams design and demonstrate end-to-end prototype systems that can extract, convert, and return metals from complex domestic waste streams into high-performance materials for advanced manufacturing.
Tech Metal Transformation Challenge is sponsored by U.S. National Science Foundation Directorate for Technology, Innovation and Partnerships (NSF TIP). This challenge seeks to strengthen the U.S. supply chain for critical and strategic metals by developing breakthrough technologies. Competing teams will design and demonstrate end-to-end prototype systems that can extract, convert, and return metals from complex domestic waste streams into high-performance materials for advanced manufacturing.
TCUP lists eight funding tracks and roughly $10.3M a year, but the October 14, 2026 deadline applies to only three of them — CHAI, Pre-TI, and TCUP Partnerships — and each carries a restriction that disqualifies most applicants. Here is the track-by-track math.
Read articleOn August 26, 2026, NSF named the STC class of 2026: TEMPEST at Michigan State, GENIE at Northwestern, and a human-robot co-adaptation center at UT Austin. $90 million total, $6 million a year each. The 2023 class was four centers and $120 million. The award size is intact; the shelf space shrank 25 percent — and that is the number that should reshape how you plan a center proposal.
Read articleOn July 14, 2026, NSF named 12 new Regional Innovation Engines across 20 states, each starting with $15 million over two years and eligible for up to $160 million across a decade. But the Engines program is not a research grant — it is a bet on a regional coalition's ability to convert federal seed money into private matching capital. The first cohort turned $135 million into over $2 billion in commitments. Here is how the milestone-gated structure actually works, who wins these awards, and what a region needs in place long before the next competition opens.
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