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NSF's SBIR/STTR program, branded America's Seed Fund, funds U.S. small businesses turning high-risk AI research into commercial products. It invests up to $2 million per company and takes no equity.
The Artificial Intelligence topic has eight subtopics: cognitive-science-based technologies (AI1), computer vision (AI2), conversational AI (AI3), language-based AI (AI4), novel AI hardware such as neuromorphic computing and secure edge devices (AI5), sustainable AI for low-resource environments (AI6), trustworthy AI that is safe, fair, transparent, privacy-preserving, explainable or secure (AI7), and other novel AI technologies (AI8).
Current solicitations are NSF 26-510 (deep technologies for U.S. competitiveness and security) and NSF 26-511 (scientific instrumentation pilot). Companies first submit a short Project Pitch, and only invited companies may submit a full proposal. The current full-proposal window for invited Phase I and Fast-Track proposals and eligible Phase II proposals closes November 4, 2026.
NSF has announced later windows; check the seedfund. nsf. gov solicitations page for the next date.
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Or search similar grants →According to the current listing, eligibility includes: U.S. small businesses with fewer than 500 employees, at least 50% owned by U.S. citizens or permanent residents. Companies majority-owned by multiple venture capital, private equity or hedge fund firms are not eligible. All funded work must take place in the United States. The PI must be employed by the company at least 20 hours per week and commit at least one month (173 hours) per six months of project time. An invitation from a Project Pitch is required before submitting a full proposal. Confirm the full requirements in the official notice before applying.
The current listing shows up to $2 million in non-dilutive seed funding per company with zero equity taken (Phase I up to about $305,000; Phase II up to about $1.25 million). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for NSF SBIR/STTR Artificial Intelligence Topic (NSF 26-510) for Deep-Tech AI Startups are due November 4, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
NSF SBIR/STTR Artificial Intelligence Topic (NSF 26-510) for Deep-Tech AI Startups is funded by U.S. National Science Foundation (NSF), America's Seed Fund (SBIR/STTR). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
RFA-RM-27-011 funds the development and testing of a multi-use frameworks playbook for precision medicine with AI, within the NIH Common Fund's PRIMED-AI programme. Where other PRIMED-AI awards build tools, validate them or move them toward the clinic, this one produces the shared methodology: a reusable framework that other teams can apply when integrating medical imaging with multimodal health data to build AI-based clinical decision support. The premise is that the field repeatedly re-solves the same design problems, and that codifying frameworks for data harmonisation, model development, evaluation and clinical integration is a public good worth funding separately. Funding is up to 300,000 US dollars per year for two years, which makes this the most accessible entry point into a major NIH AI health programme for groups with strong methodological credentials but without the institutional scale to host a centre. Crucially, the deliverable is to be developed and tested, not merely written, so proposals need a concrete validation plan showing the playbook works when applied by teams other than its authors. The RFA was released on 30 June 2026 with applications due 9 October 2026, the second of the five PRIMED-AI deadlines. For informatics methodologists, implementation scientists and groups working on AI reporting and reproducibility standards, this is a rare opportunity in which methodological synthesis is the funded product rather than a byproduct.
Model-to-Clinic, RFA-RM-27-013, is the translational arm of the NIH Common Fund's PRIMED-AI programme. It funds teams to take AI-enabled, image-based multimodal clinical decision support models and move them toward actual use in clinical settings, addressing the gap that has defined clinical AI for a decade: models that perform well retrospectively and then fail to change practice. The award uses a two-phase UG3/UH3 cooperative agreement, with a milestone-gated preparatory phase capped at 450,000 US dollars in direct costs per year followed, on successful transition, by a phase capped at 1,000,000 US dollars in direct costs. Clinical trials are optional, so teams can pursue prospective evaluation or focus on workflow integration, interoperability and clinician-facing deployment without being forced into a trial design. PRIMED-AI deliberately splits the pipeline across five opportunities, and M2C sits downstream of the Data-to-Model academic-industrial partnerships and alongside an independent Validation Center that will evaluate tools the programme produces, so successful applicants should expect their models to be externally scrutinised rather than self-assessed. The RFA was released on 30 June 2026 with applications due 19 October 2026. For academic medical centres with both AI development capability and real clinical implementation reach, this is one of the few federal mechanisms that pays specifically for the translation step rather than treating it as dissemination.
The NIH Common Fund launched PRIMED-AI, Precision Medicine with AI: Integrating Imaging with Multimodal Data, to combine medical imaging with other health data in order to develop AI-powered clinical decision support tools that advance personalised medicine, and announced five funding opportunities with staggered deadlines. RFA-RM-27-014 funds a Validation Center to independently verify and assess AI tools developed through the programme, due 2 October. RFA-RM-27-015 funds a Logistics Center to coordinate activities and provide administrative and outreach support, due 2 October. RFA-RM-27-011 funds a Multi-use Frameworks Playbook to develop standard processes for responsible AI use and data management, due 9 October. RFA-RM-27-012, Data-to-Model Academic-Industrial Partnerships, supports teams integrating multimodal data and developing clinical decision support tools, due 19 October 2026. RFA-RM-27-013, Model-to-Clinic, moves validated tools into real-world clinical settings with eight awards expected, due 19 October 2026. The architecture is the notable element and distinguishes PRIMED-AI from conventional AI-in-imaging funding: NIH is funding an independent Validation Center alongside the model-development awards, meaning tools built under the programme will be assessed by a separate team rather than self-reported, and a responsible-AI and data-management playbook is funded as a first-class deliverable rather than as a compliance appendix. Applicants should expect validation standards and data governance to be externally imposed rather than self-defined. All five use UG3/UH3 or similar cooperative agreement mechanisms with substantive NIH staff involvement. Eligibility is broad, including foreign organisations and international collaborations. The recorded deadline of 19 October 2026 is the latest of the five.
NSF's rebuilt SBIR/STTR program (NSF 26-510) pairs a $305,000 Phase I with a brand-new Strategic Breakthrough award worth up to $30 million for the strongest Phase II companies. The next Project Pitch deadline is July 27, 2026. Here is how the non-dilutive funding ladder now works, why the Project Pitch gate decides everything, and how a founder should sequence the next twelve months.
Read articleAfter months dark, NSF's SBIR/STTR program relaunched with $250M, a July 27, 2026 Phase I deadline, and a new $30M Strategic Breakthrough escalator. This is the deep dive on NSF 26-510, the 26-511 instrumentation pilot, the mandatory Project Pitch on-ramp, and how to sequence a non-dilutive raise that starts at $305K and can reach eight figures.
Read articleAmerica's Seed Fund powered by NSF reopened for FY2026 with two parallel solicitations: NSF 26-510 for deep technologies and a new pilot, NSF 26-511, dedicated to scientific instrumentation. Project Pitch is the mandatory first gate, the first full-proposal deadline is July 27, 2026, and Phase I runs up to $305K. Here is how the topic-agnostic NSF model differs from agency-directed SBIR — and how to use the new pilot.
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