1,000+ Opportunities
Find the right grant
Search federal, foundation, and corporate grants with AI — or browse by agency, topic, and state.
This listing may be outdated. Verify details at the official source before applying.
Find similar grantsNutritional Interventions and Natural Products Research—Information for Researchers is sponsored by National Center for Complementary and Integrative Health (NCCIH). NCCIH issues specific notices of funding opportunities (NOFOs) for narrow areas of high priority but also accepts nutritional and natural product applications through investigator-initiated grant mechanisms.
Get a weekly digest of new grants like this
A free weekly digest of new foundation and federal funding opportunities as they're added to Granted. Unsubscribe anytime.
Or search similar grants →Extracted from the official opportunity page/RFP to help you evaluate fit faster.
Natural Products Research—Information for Researchers | NCCIH NIH Websites Are Changing U.S. Department of Health and Human Services National Institutes of Health Nutritional Interventions and Natural Products Research—Information for Researchers The National Center for Complementary and Integrative Health (NCCIH) has a broad interest in studying the biological activities of nutritional interventions and natural products, such as probiotics (also known as microbial-based therapeutics), prebiotics, dietary supplements, botanicals, and vitamins.
A strong research emphasis is placed on products for which there is compelling preclinical evidence for potential biological activity that may lead to a health benefit or treatment intervention and/or products that are widely used by the American public. Many natural products are complex, with multiple molecular constituents that may contribute to their effects.
To fully understand their activity, it is necessary to identify the individual components responsible for a specific activity and determine how they interact with other components and biological targets. Preclinical model systems are valuable for these studies.
Clinical trials of nutritional interventions and natural products are maximally informative if they incorporate well-formulated biological hypotheses, are built on a sound foundation of basic mechanistic and pharmacologic understanding, and incorporate assessment of defined signatures of biological effects. Thus, the design of maximally informative trials of natural products requires mechanistic insight as a first step.
To move the field forward, NCCIH is emphasizing research to overcome methodological and technological hurdles that hinder advances in nutritional interventions and natural products research. This may be accomplished through technological innovation to monitor and possibly facilitate relevant underlying processes associated with these interventions.
For example, omics-based and other high-throughput technologies may help researchers evaluate the validity of hypothesized additive or synergistic effects. In addition, the use of network pharmacology—the study of the web of biologic targets for any bioactive substance—will enable researchers to investigate the complex effects of nutritional interventions and natural products on multiple targets in ways that were not possible before.
Priorities in Nutritional Interventions and Natural Products Research 1. Background and Approach Use phenotypic models (e.g., cellular, invertebrate, rodent) to study the potential of multiple components in botanical mixtures to act through multiple mechanisms and produce better outcomes than individual constituents.
Explore innovative multisystem mechanistic interactions (e.g., between the digestive system and the brain or between immune and musculoskeletal or myofascial systems) of botanicals. Investigate the theoretical framework underlying the roles of individual components in multibotanical formulae, including how they contribute to activity, bioavailability, and/or toxicity.
Investigate phytochemicals abundant in fruits and vegetables and how their diverse individual activities interact in combination and across multiple systems. Develop and test a unifying hypothesis to explain the broad activity of polyphenols. Explore spatial and temporal dynamics of biological activities of probiotics in the gastrointestinal tract.
Investigate novel mechanisms underlying multisystem effects (e.g., interlinking the gastrointestinal tract, immune system, and brain) of probiotics. Conduct systematic and mechanistic studies of how the gut microbiome influences interactive effects of probiotics with other dietary interventions.
Explore discrete combinations of plants and/or plant constituents with probiotic strains to ascertain how their combined activities differ from either individually. Develop and validate computational models to predict the presence of synergistic components in complex dietary interventions.
Develop and test advanced prognostic and diagnostic systems with a combination of biosensors and artificial intelligence to monitor and predict host physiological status improved by probiotics and complex dietary interventions. Compare and validate various traditional diagnostic and prognostic medical systems in contrast to analogous contemporary Western medical diagnostic and prognostic systems.
Develop and validate in vitro and/or in vivo models capable of simultaneously assessing multiple biological systems. Develop and validate innovative systems biology models incorporating diverse phytochemical inputs and their interaction with multiple biological systems.
Other Nutritional Interventions and Natural Products Research In addition to the topics listed above, NCCIH is interested in research on nutritional interventions and natural products related to the Center’s other top scientific priorities.
For example, within the priority on complementary and integrative management of pain , NCCIH’s interests include basic research to elucidate the biological mechanisms that underlie the analgesic properties of natural products, as well as clinical research to determine their analgesic potential.
Similarly, within the priority on supporting impactful clinical trials of complementary and integrative health approaches , NCCIH’s interests include trials of natural products to assess whether their impacts on biological signature(s) are reproducible, as well as fully powered randomized controlled efficacy or effectiveness trials when preliminary data have shown reproducible impacts on biological signature(s).
Natural Product Integrity Policy NCCIH is committed to the rigorous scientific investigation of natural products used in complementary and integrative health practices.
The Center’s Natural Product Integrity Policy establishes guidance on the information required by NCCIH for different types of products used in both mechanistic and clinical research, including complex botanical products, complex animal products, probiotics, refined products, and placebos.
Sufficient product information must be included in the application to allow the peer reviewers to evaluate the significance, feasibility, and scientific strength of the project. Investigators must demonstrate that their investigative team has the appropriate product and analytical expertise to select the test and placebo agents for study and to ensure product integrity.
For example, botanists trained in taxonomy may be required to identify voucher specimens accurately. Experts in natural products chemistry, microbiology, food science, botany, pharmacognosy, or analytical chemistry, etc., may need to be consulted to provide the analytic rigor with which to evaluate product composition. Applicants requesting funds to research natural products must review NCCIH’s guidance regarding required information.
2. Examples of High-Priority Topic Areas NCCIH is an active participant in the Helping to End Addiction Long-term ® Initiative, or NIH HEAL Initiative ® , an NIH-wide effort to accelerate scientific solutions to stem the national public health crisis related to opioids.
The Center works to identify and fund research in two priority areas outlined in the NIH HEAL Initiative scientific research plan: To improve treatments for opioid misuse and addiction through identifying new treatment options for addiction and optimizing effective existing therapies To enhance pain management via improved understanding of chronic pain and developing new, nonaddictive pain treatments Visit heal. nih.
gov/funding/awarded to see examples (which so far have been primarily studies of mind and body modalities) of NCCIH-led or co-led initiatives under the NIH HEAL Initiative. Biological Mechanisms of Natural Products Another top priority is to advance fundamental research to increase understanding of basic biological mechanisms of action of natural products.
Many of the research techniques for studying natural products, especially complex mixtures, are leveraging advances in biological and chemical methodologies. NCCIH has an interest in catalyzing advances in methods in this area.
The NIH/NCCIH Natural Product Magnetic Resonance Database (NP-MRD) is an open-access, web-enabled, FAIR-compliant database containing nuclear magnetic resonance (NMR) spectra and structure data for all known natural products allowing key information about the world’s natural products to be openly shared and used by all.
Natural Product–Drug Interactions The NIH/NCCIH Natural Product–Drug Interaction (NaPDI) Center of Excellence is addressing issues related to consistency in design, implementation, and documentation of studies to assess clinical relevance of natural product–drug interactions. Research Spotlights —Review selected summaries of published NCCIH research. Search for NCCIH-funded projects in NIH RePORTER .
NCCIH Contact Information We encourage you to discuss your proposed research with an NCCIH staff member prior to submitting a grant application. Each program staff member is responsible for coordinating research portfolios in various scientific areas. For specific questions in those areas, please review the list of NCCIH program directors and contact the most appropriate individual.
For general questions about nutritional interventions and natural product research funding, please contact: National Center for Complementary and Integrative Health National Institutes of Health National Center for Complementary and Integrative Health National Institutes of Health Natural Products Clinical Trials Resource Natural Product Libraries Natural Products and Pain: The search for novel nonopioid analgesics NIH-Supported Research on Cannabis, Cannabinoids, and Related Compounds Evaluating the Therapeutic Potential of Cannabinoids: How to conduct research within the current regulatory framework
According to the current listing, eligibility includes: Varies by specific NOFO, generally open to researchers at eligible institutions, including universities. Confirm the full requirements in the official notice before applying.
Nutritional Interventions and Natural Products Research—Information for Researchers is funded by National Center for Complementary and Integrative Health (NCCIH). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
The Gates Foundation committed at least $1 billion over two years to equitable AI alongside its 10th Goalkeepers Report — 40% education, 40% health, 10% agriculture, 10% digital infrastructure. Five days later, 60 organizations signed a five-year goal to reach 3.4 billion speakers of underrepresented languages. Here is how implementing nonprofits should read both.
Read articleThe Health and Extreme Weather highlighted topic went live September 1, 2026 with eleven awarding institutes and expires May 1, 2028. There is no set-aside, no separate deadline, and no review criteria — which makes the institute-by-institute language the only real signal, and it is not uniform.
Read articleThe NOURISH Autoimmunity Digital Health Challenge runs three phases to August 2028: 10 winners at $20,000, then 5 at $30,000, then 3 at $100,000. It is a prize competition, not a grant — no indirect costs, no cost reimbursement, and a rule that quietly disqualifies the obvious applicant.
Read article