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Path to a Cure Research Grant is a grant from Cystic Fibrosis Foundation that funds basic science research aimed at restoring CFTR protein function or developing gene-based approaches to treat cystic fibrosis. The program specifically targets projects proposing restoration of CFTR protein function or approaches to fix or replace the defective CFTR gene.
Awards provide up to $150,000 per year (plus 12% indirect costs) for up to two years, with grants competitively renewable for additional funding. Eligible applicants are independent investigators at for-profit and nonprofit institutions. Proposals must be hypothesis-driven with sufficient preliminary data.
The fall cycle deadline is November 15, 2026.
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Research Grants | Cystic Fibrosis Foundation Intro to CFManaging CFResearch and Clinical TrialsSupportCommunity BlogNewsespañol[[separator]](https://www. cff. org/researchers/research-grants)Get involvedDonate Research grants are intended to encourage the development of new information that contributes to the understanding of the basic etiology and pathogenesis of cystic fibrosis.
Research grants are intended to support basic science research. Studies may be carried out at the subcellular, cellular, animal, or patient levels. To be considered, proposals must be hypothesis-driven and provide sufficient preliminary data to justify Cystic Fibrosis Foundation support.
For fall submissions, support is available for $150,000 per year (plus 12% for indirect costs) for up to two years, at which time a grant may be competitively renewed for additional funding. Priority will be placed on those projects that propose to better understand the mechanisms behind disease pathophysiology and to develop strategies to prevent or treat CF.
Projects proposing interventional clinical studies must not be submitted through this funding mechanism and should instead be submitted as aClinical Research AwardorClinical Pilot and Feasibility Award. Applicants seeking to submit proposals focused on topics such as the restoration of CFTR protein function or approaches to fix/replace the defective CFTR gene should apply through thePath to a Cure (PTAC) Research Grant Program.
Applicants may submit only**one**Research Grant application in 2025 (either spring or fall cycle). Please review the fall 2025Policies and Guidelinesfor complete submission information. Fall cycle applications: December 9, 2025 Applications must be submitted online atawards.
cff. orgby 5 p. m.
ET on the aforementioned deadline. Those who are interested in any funding programs offered by the CF Foundation can get further information, or discuss the potential relevance of their studies or research by contacting the Grants and Contracts Management and Administration (GCMA) office atgrants@cff. org.
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Based on current listing details, eligibility includes: Independent investigators at for-profit and nonprofit institutions Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Up to $1,000,000 per year Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is November 15, 2026. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.