Pfizer – Closing Knowledge Gaps in Osteoarthritis and Osteoarthritis Pain

Pfizer – Closing Knowledge Gaps in Osteoarthritis and Osteoarthritis Pain is sponsored by Pfizer and Lilly. This grant supports virtual and potentially live programs and other innovative digital medical education for Health Care Providers.

Pfizer and Lilly Announce an Independent Medical Education Grant RFP # Closing Knowledge Gaps in Osteoarthritis and Osteoarthritis Pain # Competitive Grant Program - internal Pfizer review process Pfizer and Lilly are collaborating to provide grant support for continuing professional education in the areas of Osteoarthritis/ Osteoarthritis Pain.

We are committed to supporting innovative, independent medical education for healthcare professionals. Grants via this collaboration will be funded by Pfizer but reviewed and approved by both companies.

Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement, or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies.

Pfizer’s GMG competitive grant program involves a publicly posted general Request for Proposal (RFP) that provides detail regarding a general area of interest, sets timelines for review and approval, and uses an internal Pfizer review process to make final grant decisions.

Through this RFP we encourage organizations to submit grant requests that, if funded, will support education in a specific disease state, therapeutic area, or broader area of educational need. Educational activities should not be focused on products specific to Pfizer and/or Lilly.

For all independent medical education grants , the grant requester (and ultimately the grantee) is responsible for the design, implementation, and conduct of the independent initiative supported by the grant. Pfizer must not be involved in any aspect of project development, nor the conduct of the independent education program.

3 Applicant Eligibility Criteria • The following may apply: medical, nursing, allied health, and/or pharmacy professional schools; healthcare institutions (both large and small); professional associations and medical societies; medical education companies; and other entities with a mission related to healthcare professional education and/or healthcare improvement.

• If the project involves multiple departments within an institution and/or between different institutions / organizations / associations. all institutions must have a relevant role and the requesting organization must have a key role in the project. • For projects offering continuing education credit, the requesting organization must be accredited.

Date RFP Issued • March 3, 2021 Clinical Area • Pain - Osteoarthritis General Area of Interest for this RFP: There remains a significant unmet need in the management of osteoarthritis (OA) and chronic pain associated with OA 1.

Given the continued uncertainty regarding the status of many medical conferences worldwide, healthcare providers may have difficulty staying current with the newest recommendations for management/guidelines of OA and the emerging data for research/therapies under development to treat OA and OA pain 2.

Through this RFP, it is our intent to support virtual and potentially live programs and other innovative digital medical education for HCPs. The focus is on Osteoarthritis and Chronic Pain associated with OA and patient-centered standard of care and management including pain and function, the biopsychosocial aspects of the disease, the complexities and challenges of care, and the future of OA/OA pain management.

Programs targeted towards reviewing data at virtual or live osteoarthritis, rheumatology, pain, primary care, or other associated medical conferences, including but not limited to OARSI, EULAR, PAINWeek, AAFP, WCO, and ACR are of particular interest, as well as other meaningful education outside of congresses.

Projects that will be considered for Pfizer and Lilly support will focus on education including, but not limited to: 3 • The impact and importance of Osteoarthritis (OA) and its disease burden and the unmet medical need in OA pain management • Current standard of care for OA/OA pain, guidelines for treatment, and the challenges of management • The Biopsychosocial model of pain in OA and individualized patient experience • Biopsychosocial and comprehensive approach to care and complex multifactorial nature of disease through bio, psycho, and social domains • Setting functional goals and tools for individual pain and function assessment, goal setting, monitoring and tailored pain management for individualized patient experience (heterogeneity of disease and different patient trajectories and disease progression) • Physical and mind-body care • The impacts of COVID-19 on patients with osteoarthritis associated chronic pain • Health disparities in OA/pain + COVID-19’s effect on the gap • Optimizing care in remote environment • Comorbidities associated with chronic pain in OA (psychological disorders, cardiovascular disease etc.) • Understand decision points, patients’ motivations, key factors/drivers and disease state around knee/hip surgery due to OA • The evolution of the primary provider of Osteoarthritis - who owns OA management?

• Roles of the multidisciplinary team • Trends in OA management, the future of OA management and emerging research • Challenges with Osteoarthritis trials, including placebo effect and extrapolation of outcome measures to clinical practice • Are there best practices from other disease states -that can be extrapolated to OA?

The successful applicant will propose projects that actively engage the learner, employ innovative learning technologies, provide opportunities for learner exchange and include measurement techniques (needs assessment and outcomes data that allows for meaningful assessment of program impact). 3 It is not our intent to support clinical research projects.

Projects evaluating the efficacy of therapeutic or diagnostic agents will not be considered.

Target Audience: • Rheumatologists, Pain Specialists, Orthopedic Surgeons/Orthopedists, Primary Care Physicians/General Practitioners, as well as other healthcare providers within the multidisciplinary care team (Nurse Practitioners, Physician Assistants, Physiatrists, Physical Therapists, Pharmacists, Psychologists, Radiologists) Expected Approximate Monetary Range of Grant Applications: • The total available budget related to this RFP is approximately $1,000,000 USD.

• The typical grant maximum under this RFP will be up to $200,000 USD. However, larger proposals may be considered for funding if they include a broad geographical scope and multiple activities. • Smaller educational proposals are also encouraged.

Organizations that would like to develop activities with a more specific focus and for a more limited regional or local group of healthcare providers should also apply. Typically grant amounts for local or regional activities should not exceed $50,000 USD. • This RFP will remain open while funds last.

Once the full budget is spent the RFP will be closed and new requests will no longer be accepted.

Key Dates: • RFP release date: March 3, 2021 • Applications will be accepted and reviewed on a rolling basis within the timelines below: Note: Grant requests for innovative, live/virtual and enduring education in conjunction with the Osteoarthritis Research Society International (OARSI) 2021 World Congress and the European Alliance of Associations for Rheumatology (EULAR) 2021 Congress are encouraged to apply early.

Decision Notification Date Anticipated Project Start Date* March 19, 2021 April 2021 After May 15, 2021 June 18, 2021 July 2021 After August 15, 2021 August 20, 2021 September 2021 After October 15, 2021 3 > Please note the deadline is midnight Eastern Standard Time (e.g. New York, GMT -5). > *Start date will be individualized and dependent on decision notification date.

Processing > time may take longer for organizations outside of the U.S. o For the question “What type of request are you submitting? ” select Response to a Request for Proposal (RFP) o For the question “Are you replying to a Request for Proposal as part of the Competitive Grant Program?

” select Yes o Select the following Competitive Grant Program Name: 2021 IM G: Osteoarthritis Virtual Learning o Select the following Primary Area of Interest: Pain -Osteoarthritis • Requirements for submission: Complete all required sections of the online application and upload your project proposal (see Appendix) in the General RFP Submission field.

• If you encounter any technical difficulties with the website, please click the “Technical Questions” link at the bottom of the page. IMPORTANT: Be advised applications submitted after the due date will not be reviewed by the committee. Questions: • If you have questions regarding this RFP, please direct them in writing to the Grant Officer, Jessica Romano ( Jessica.

Romano@pfizer. com ), with the subject line “2021 Osteoarthritis Education RFP. ” Grant Agreements: • If your grant is approved, your institution will be required to enter into a written grant agreement with Pfizer.

Please click here to view the core terms of the agreement. • Pfizer has drafted the terms of these agreements to be balanced and reasonable and to further the goals of both parties.

Negotiating grant agreements requires significant resources, so please ensure that your institution (including your legal department) is able and willing to abide by these terms before proceeding with submission of your application as they will need to be accepted in their entirety. Review and Approval Process • Grant requests received in response to this RFP will be reviewed by Pfizer and Lilly to make final grant decisions.

3 Mechanism by which Applicants will be Notified: • All applicants will be notified via email by the dates noted above. • Applicants may be asked for additional clarification during the review period. 3 General RFP Submission Requirements Project Proposals should be single-spaced using Calibri 12-point font and 1-inch margins.

Note there is a 15-page limit exclusive of references. Please include the following: Goals and Objectives • Briefly state the overall goal of the project. • List the objectives you plan to meet with your project, in terms of learning and expected outcomes.

Needs Assessment for the Project • Include a description of your organization’s needs assessment for this proposed project which may include a quantitative baseline data summary, initial metrics, or a project starting point (please cite data on gap analyses or relevant patient-level data that informs the stated objectives) in your target area. Target Audience • Describe the primary audience(s) targeted for this project.

Indicate whom you believe will directly benefit from the project outcomes. Describe the overall population size as well as the size of your sample population. Project Design and Methods • Describe the planned project, the educational approach, and the way the planned methods address the established need.

Innovation • Explain what measures you have taken to assure that this project is original and does not duplicate other projects or materials already developed. Describe how this project builds upon existing work, pilot projects, or ongoing projects developed either by your institution or other institutions.

• In terms of the metrics used for the needs assessment, describe how your organization will determine if the gap was addressed for the target group. Identify the sources of data your organization anticipates using to make the determination. Describe how your organization is expected to collect and analyze the data.

Explain the method used to control for other factors outside this project (e.g., use of a control group or comparison with baseline data). Quantify the amount of change expected from this project in terms the target audience. Describe how your organization will determine if the target audience was fully engaged in the project.

Dissemination Plan • Describe how the project may have extended benefit beyond the grant. Will the teaching materials be made available to others to use? Will there be tools or resources that are made publicly available beyond the initial project.

Describe how the project outcomes might be broadly disseminated. 3 Anticipated Project Timeline • Provide an anticipated timeline for your project including project start/end dates. Additional Information • If there is any additional information you feel Pfizer should be aware of concerning the importance of this project, please summarize here.

Organization Detail • Describe the attributes of the institutions/organizations that will support and facilitate the execution of the project, the leadership of the proposed project, and the specific role of each institution in the proposed project.

Budget Narrative • Please include a budget narrative that describes in greater detail the line items specified in the budget submitted within the application • While estimating your budget please keep the following items in mind: o Independent Medical Education Grants awarded by GMG cannot be used to purchase therapeutic assets (prescription or non-prescription).

o Overhead rates of up to 28% of the total proposed project budget may be supported by Pfizer.