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Open under the reissued parent STTR announcement PA-27-102. Applications are due today, September 5, 2026 (5 p.m. local time); the next standard receipt dates are January 5, 2027 and April 5, 2027.
Historical funding: Varies by NIH Institute: Phase I up to $400K-$700K; Phase II up to $2.5M-$3M
Prior eligibility: Small business concerns that partner with colleges/universities, Federally Funded Research and Development Centers (FFRDCs), or qualified non-profit research institutions.
PHS 2023 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Optional) is sponsored by National Institutes of Health (NIH). This solicitation supports cooperative research and development between small businesses and non-profit research institutions (e. g. , universities or federally funded research centers) for Small Business Technology Transfer (STTR) grant applications.
PAR-27-003 opens the NIGMS-style RM1 to 13 NIH institutes through September 2029: 3 to 6 PIs, up to $1.5M in direct costs a year but most awards $500K to $900K, at least 2.4 months of effort per PI, and a 20-page strategy with a mandatory Team Integration Plan. The NIGMS predecessor made 4 new awards in three years.
Read articleThe October 6, 2026 Director's Awards cohort is NIH's most expensive in four years at about $4.1 million per award. New Innovator rebounded from 29 to 42 while Early Independence fell from 13 to 3 after the program skipped its FY2026 competition. Here is what the composition shift means for FY2027 and FY2028 applicants.
Read articleOn October 7, 2026, Biohub, DOE, NIH, Google DeepMind, Isomorphic Labs and Meta committed $1.8 billion to build AI-ready biological data. More than $500 million of it is DOE money flowing through the Genesis Mission, and NIH's share is data rather than dollars. There is no NOFO — here is where the applyable money actually sits.
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