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Find similar grantsProgram was archived June 4, 2025. Original deadline not shown on page but the opportunity is fully closed/archived.
Plant Engineering to Revolutionize Sustainable Energy Production and Heighten Opportunities for Novel Efficiency (PERSEPHONE SBIR/STTR) is sponsored by U.S. Department of Energy (DOE). This opportunity supports mission-aligned projects and measurable outcomes.
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Opportunity Listing - PLANT ENGINEERING TO REVOLUTIONIZE SUSTAINABLE ENERGY PRODUCTION AND HEIGHTEN OPPORTUNITIES FOR NOVEL EFFICIENCY SBIR/STTR (PERSEPHONE SBIR/STTR) PLANT ENGINEERING TO REVOLUTIONIZE SUSTAINABLE ENERGY PRODUCTION AND HEIGHTEN OPPORTUNITIES FOR NOVEL EFFICIENCY SBIR/STTR (PERSEPHONE SBIR/STTR) Agency: Advanced Research Projects Agency Energy Assistance Listings: 81.
135 -- Advanced Research Projects Agency - Energy Last Updated: February 10, 2025 View version history on Grants. gov This is Modification 01 to the NOFO: • Clarified the meaning of the Program Policy Factors in Section V. C.
DE-FOA-0003552 - PLANT ENGINEERING TO REVOLUTIONIZE SUSTAINABLE ENERGY PRODUCTION AND HEIGHTEN OPPORTUNITIES FOR NOVEL EFFICIENCY SBIR/STTR (PERSEPHONE SBIR/STTR) To obtain a copy of the Notice of Funding Opportunity (NOFO) please go to ARPA-E eXCHANGE at https://arpa-e-foa. energy. gov. To apply to this NOFO, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.
energy. gov/Registration. aspx).
For detailed guidance on using ARPA-E eXCHANGE,... please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa. energy.
gov/Manuals. aspx). ARPA-E will not review or consider application materials submitted through other means.
For problems with ARPA-E eXCHANGE, email ExchangeHelp@hq. doe. gov (with NOFO name and number in the subject line).
Questions about this NOFO? Check the Frequently Asked Questions available at http://arpa-e. energy.
gov/faq. For questions that have not already been answered, email ARPA-E-CO@hq. doe.
gov. The Advanced Research Projects Agency – Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P. L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.
L. 111-358), as further amended by the Energy Act of 2020 (P. L.
116-260): “(A) to enhance the economic and energy security of the United States through the development of energy technologies that— (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies.
” ARPA-E issues this Notice of Funding Opportunity (NOFO) under its authorizing statute codified at 42 U.S.C. § 16538. The NOFO and any cooperative agreements or grants made under this NOFO are subject to 2 C.
F. R. Part 200 as supplemented by 2 C.
F. R. Part 910.
ARPA-E funds research on, and the development of, transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology.
For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e. energy. gov/.
ARPA-E funds transformational research. Existing energy technologies generally progress on established “learning curves” where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive improvements to the cost/performance metric in a gradual fashion.
This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. In contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology.
Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly better than that of the incumbent technology. ARPA-E will provide support at the highest funding level only for submissions with significant technology risk, aggressive timetables, and careful management and mitigation of the associated risks.
ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive – that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets.
ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development (R&D).
The Office of Management and Budget defines “applied research” as an “original investigation undertaken in order to acquire new knowledge…directed primarily towards a specific practical aim or objective” and defines “experimental development” as “creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes.
” ARPA-E encourages submissions stemming from ideas that still require proof-of-concept R&D efforts as well as those for which some proof-of-concept demonstration already exists. Submissions can propose a project with the end deliverable being an extremely creative, but partial solution. The goal of the PERSEPHONE program is to develop disruptive new technologies for bioenergy crop genetic engineering.
Bioenergy provides about 5% of domestic energy consumption and has the potential to provide 5-10% more. Agriculture also could revolutionize the energy sector in other ways, such as providing precursors for chemicals and materials that are currently derived from petroleum. However, bioenergy crops may not maintain their current utility, much less achieve their potential, without transformative advances in tools to engineer them.
Genetic engineering is an essential strategy to realize U.S. bioenergy potential and security. The PERSEPHONE program will develop high-performance tools for bioenergy crop engineering, create novel genetic engineering modalities, and spur adoption by supporting innovative research on biocontainment.
Specifically, PERSEPHONE aims to support the development of tools that could lead to an annual impact of the production of at least 1 quad of energy or mitigation of more than 60 MT of carbon dioxide equivalents (CO2e).
The program will support projects in three areas: • Technical Category A will develop robust, high-performing tools for the genetic engineering of bioenergy crops that overcome transformation genotype dependence, increase throughput 10x, and/or reduce cost and timeline by 4x and 2x, respectively.
• Technical Category B will support the creation of radically new technologies for plant genetic engineering that have a pathway to achieve metrics well beyond the targets established in Category A. • Technical Category C will support adoption of genetically engineered bioenergy crops by developing technologies to reduce the risks of invasiveness to less than 0. 1 percent and eliminate the flow of transgenes into the environment.
The program encourages the formation of multidisciplinary teams with expertise in relevant areas such as synthetic biology, bioengineering, plant genomics and genetics, materials, robotics, and machine learning.
If PERSEPHONE is successful, the new genetic engineering tools will enable the rapid development and commercialization of bioenergy applications in areas as diverse as Sustainable Aviation Fuel (SAF), nitrogen management, and energy-efficient materials. To view the NOFO in its entirety, please visit https://arpa-e-foa. energy.
gov. Grantor contact information File name Description Last updated PERSEPHONE_SBIR_STTR_FA_NOFO. pdf NOFO_DE-FOA-0003552_PERSEPHONE SBIR STTR Jan 17, 2025 10:44 AM UTC NOFO_DE-FOA-0003552_PERSEPHONE_SBIR_STTR_Modification_01.
pdf NOFO_DE-FOA-0003552_PERSEPHONE SBIR STTR_Modification 01 Feb 10, 2025 07:26 PM UTC Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Opportunity zone benefits Science technology and other research and development
According to the current listing, eligibility includes: Small businesses. Confirm the full requirements in the official notice before applying.
Plant Engineering to Revolutionize Sustainable Energy Production and Heighten Opportunities for Novel Efficiency (PERSEPHONE SBIR/STTR) is funded by U.S. Department of Energy (DOE). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Violence Against Women Discretionary Grants for Indian Tribal Governments is sponsored by Department of Justice. To increase tribal capacity to respond to violent crimes against Indian women, and to develop and strengthen victim services in cases involving violent crimes against Indian women. This listing is currently active. Program number: 16.587. Last updated on 2024-11-26.
The NSF CISE Future Computing Research (Future CoRe) program supports research in computing and communication foundations, intelligent systems, and network systems. The program funds innovative research that advances the frontiers of computing including artificial intelligence, machine learning, computer vision, natural language processing, and robotics. This is one of NSF's largest computing research programs with $280 million in total budget. Projects can address fundamental computing challenges, novel AI architectures, scalable intelligent systems, and next-generation network infrastructure.
On September 21, 2026 DOE selected 21 projects under DE-FOA-0003472 — five EGS field tests and 16 exploration wells — for up to $99 million of a $171.5 million authorization. The solicitation is structured to reopen for up to 72 months on roughly annual cycles. Here is how to position for the next one.
Read articleDOE named 31 grid projects across 26 states for $1.9B on September 24, 2026. Recipients bring $3.35B of their own money. Here is what the selection list reveals about how to win the next GRIP round.
Read articleThe DOE Quantum Genesis Q Competition (DE-FOA-0003657) posted September 17, 2026 with an October 19 deadline. Phase I pays $250,000 then $1.25M on milestones; Phase II is a $100M pool plus two $50M bonus pools at 150 and 200 logical qubits. It is an Other Transaction Agreement, not a grant.
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