Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional)

Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional) is sponsored by National Cancer Institute (NCI). This Notice of Funding Opportunity (NOFO) solicits research projects that investigate actionable synthetic vulnerabilities that can be conditionally paired with tumor responses to radiation therapy.

The goal is to develop radiation-synthetic combination strategies and facilitate their adoption into the precision medicine toolkit.

Opportunity Listing - Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional) Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93. 395 -- Cancer Treatment Research Last Updated: May 13, 2026 View version history on Grants.

gov Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits research projects that investigate actionable synthetic vulnerabilities that can be conditionally paired with tumor responses to radiation therapy.

The goal of the Precision Approaches in Radiation Synthetic Combinations ( PAIRS) program is to develop radiation-synthetic combination strategies and facilitate their adoption into the precision medicine toolkit toward building new and effective anticancer treatments. Early synthetic lethality–based therapeutic strategies in oncology primarily focused on targeting fixed mutations or genomic abnormalities.

More recently, however, it has become clear that clinical benefit is often determined by context-dependent vulnerabilities arising from the intrinsic mutational landscape and adaptive tumor responses.

For-profit organizations other than small businesses Private institutions of higher education Public and state institutions of higher education Independent school districts Nonprofits non-higher education without 501(c)(3) Nonprofits non-higher education with 501(c)(3) Other Native American tribal organizations City or township governments Special district governments Federally recognized Native American tribal governments Public and Indian housing authorities Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Grantor contact information Email: pairsresearchgrants@nih. gov Email: pairsresearchgrants@nih. gov No documents are currently available.

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