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Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Development and Testing of Multi-use Frameworks Playbook (U01 Clinical Trial Not Allowed) is sponsored by National Cancer Institute (NCI) (part of NIH Common Fund). This program supports the development and testing of standardized frameworks for multimodal AI clinical decision support tools.
It aims to integrate imaging with multimodal data for precision medicine, directly relevant to AI diagnostics, including breast cancer.
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Opportunity Listing - Development and Testing of a Multi-use Frameworks Playbook for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U01 Clinical Trial Not Allowed) Development and Testing of a Multi-use Frameworks Playbook for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U01 Clinical Trial Not Allowed) Agency: National Institutes of Health Assistance Listings: 93.
310 -- Trans-NIH Research Support Last Updated: June 30, 2026 View version history on Grants.
gov The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools.
PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools... into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.
The purpose of this NOFO is to solicit applications for the design, development, and preliminary validation of robust frameworks for the application of multimodal-artificial intelligence (AI) models for clinical use.
Frameworks developed through these awards would populate a "playbook", defined as a collection of actionable guidelines, standardized protocols, and/or standard operating procedures (SOPs) for reliable and effective development and deployment of multimodal AI tools.
It is expected that the frameworks delineated in this playbook will directly address PRIMED-AI objectives and needs, while also remaining flexible enough to enable sufficient extensibility and interoperability for use across a broad spectrum of multimodal biomedical AI applications, both internal and external to the PRIMED-AI Program.
Public and Indian housing authorities City or township governments Special district governments Federally recognized Native American tribal governments Public and state institutions of higher education Independent school districts Private institutions of higher education Nonprofits non-higher education with 501(c)(3) Other Native American tribal organizations Nonprofits non-higher education without 501(c)(3) For-profit organizations other than small businesses Refer to Section III.
Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. Grantor contact information File name Description Last updated RFA-RM-27-011-Full-Announcement. html RFA-RM-27-011-Full-Announcement.
html Jun 30, 2026 03:02 PM UTC Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: U.S.-based universities, hospitals, research centers, and small businesses (SBIR/STTR-eligible). Multidisciplinary consortia including technology developers, clinicians, and behavioral scientists are encouraged. Confirm the full requirements in the official notice before applying.
The current listing shows up to $300,000 per year for two years. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Development and Testing of Multi-use Frameworks Playbook (U01 Clinical Trial Not Allowed) are due October 8, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Development and Testing of Multi-use Frameworks Playbook (U01 Clinical Trial Not Allowed) is funded by National Cancer Institute (NCI) (part of NIH Common Fund). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward advances in AI and data science for biomedical and public health research. Projects must cross disciplinary boundaries.
Innovation Grant is a grant from the Delta Dental of Arizona Foundation that funds nonprofit organizations pursuing unique, high-impact projects that improve health and wellness in Arizona communities. This two-year award supports original initiatives with measurable real-world impact, including programs serving underserved and uninsured populations through oral health education, disease prevention, and nutritional access. Projects must demonstrate the potential to make a meaningful difference in the community and stand apart from conventional approaches. Eligible applicants are Arizona-based nonprofit organizations. Awards total $100,000 per recipient over two years. The 2026 application cycle closed October 16, 2025, with recipients notified in late 2025 and funding made available shortly after.
The NIH Common Fund launched PRIMED-AI — Precision Medicine with AI: Integrating Imaging with Multimodal Data — as five coordinated funding opportunities (RFA-RM-27-011 through -015) that build a full pipeline from standards to clinic. Here is how the Playbook, Data-to-Model partnerships, Model-to-Clinic translation, Validation Center, and Logistics Center fit together, what each pays, who is eligible, and how to position before the October 2026 deadlines.
Read articleAvoid common NIH grant proposal mistakes including vague specific aims, weak methodology, and poor budget justification that lead to rejection.
Read articleThe NIH Director's New Innovator Award (DP2, RFA-RM-27-002) closes August 17, 2026, offering roughly 30 Early Stage Investigators up to $475,000 in direct costs a year for five years — $2.375 million total — to pursue bold ideas without the preliminary data a standard R01 demands. Here is how the High-Risk, High-Reward program actually evaluates applications, who qualifies, and why the usual R01 instincts will sink you.
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