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Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Model-to-Clinic (M2C) (UG3/UH3, Clinical Trial Optional) is sponsored by U.S. Department of Health and Human Services; National Institutes of Health - Common Fund. This program funds the development and validation of multimodal AI Clinical Decision Support (CDS) tools to improve patient care, requiring existing prototypes and access to comprehensive datasets.
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Opportunity Listing - Model-to-Clinic (M2C) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (UG3/UH3, Clinical Trial Optional) Model-to-Clinic (M2C) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (UG3/UH3, Clinical Trial Optional) Agency: National Institutes of Health Assistance Listings: 93.
310 -- Trans-NIH Research Support Last Updated: June 30, 2026 View version history on Grants.
gov The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools.
PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools... into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.
The purpose of this NOFO is to catalyze the translation of Artificial Intelligence (AI)-enabled, image-centered, multimodal CDS tools, developed as Software as a Medical Device, from training and testing of prototypes towards clinical applications that address unmet health challenges in precision medicine.
These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.
Nonprofits non-higher education with 501(c)(3) Nonprofits non-higher education without 501(c)(3) Other Native American tribal organizations Public and state institutions of higher education Independent school districts Private institutions of higher education City or township governments Public and Indian housing authorities Special district governments Federally recognized Native American tribal governments For-profit organizations other than small businesses Refer to Section III.
Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed. Grantor contact information File name Description Last updated RFA-RM-27-013-Full-Announcement. html RFA-RM-27-013-Full-Announcement.
html Jun 30, 2026 03:02 PM UTC Link to additional information Closing: October 19, 2026 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Your account requires additional identity verification.
According to the current listing, eligibility includes: Organizations with existing AI CDS prototypes and access to comprehensive datasets. Confirm the full requirements in the official notice before applying.
Applications for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Model-to-Clinic (M2C) (UG3/UH3, Clinical Trial Optional) are due October 19, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Model-to-Clinic (M2C) (UG3/UH3, Clinical Trial Optional) is funded by U.S. Department of Health and Human Services; National Institutes of Health - Common Fund. Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed) is sponsored by U.S. Department of Health and Human Services; National Institutes of Health - Common Fund. This opportunity funds the creation of a Validation Center as part of the PRIMED-AI program.
Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Validation Center (U54 Clinical Trials Not Allowed) is sponsored by U.S. Department of Health and Human Services; National Institutes of Health - Common Fund. The Validation Center will serve as a hub for validating AI-enabled, multimodal CDS tools, supporting reproducibility, interoperability, and clinical translation.
Logistics Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U24 Clinical Trials Not Allowed) is sponsored by National Institutes of Health (NIH). NIH funds a Logistics Center to coordinate the PRIMED-AI program, which develops AI-based clinical decision support tools integrating medical imaging with multimodal health data. This center will manage administration, evaluation, and outreach for a consortium developing these AI tools.
Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed) is sponsored by National Institutes of Health (NIH) - Common Fund. The Validation Center will serve as a hub for validating AI-enabled, multimodal CDS tools, supporting reproducibility, interoperability, and clinical translation in precision medicine.
Logistics Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U24 Clinical Trials Not Allowed) is sponsored by National Institutes of Health (NIH) - Common Fund. This opportunity funds the creation of a Logistics Center to coordinate PRIMED-AI activities, fostering collaboration and standardization in AI-based clinical data integration.
The NIH Common Fund launched PRIMED-AI — Precision Medicine with AI: Integrating Imaging with Multimodal Data — as five coordinated funding opportunities (RFA-RM-27-011 through -015) that build a full pipeline from standards to clinic. Here is how the Playbook, Data-to-Model partnerships, Model-to-Clinic translation, Validation Center, and Logistics Center fit together, what each pays, who is eligible, and how to position before the October 2026 deadlines.
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