Proposition 64 Public Health & Safety Grant Program

The PRIMED-AI Validation Center is a single-award opportunity to build the independent evaluation infrastructure for the entire NIH Common Fund PRIMED-AI program. Its function is to serve as a dedicated hub that verifies, validates and characterizes the AI-enabled, image-based multimodal clinical decision support tools produced by other PRIMED-AI awardees, assessing reliability, reproducibility and generalizability with an eye toward clinical adoption. This is a structurally different proposition from a research grant and applicants should read it that way: the Center is a service and methods organization accountable to a consortium, not a lab pursuing its own scientific agenda. Competitive applicants will need existing capacity in AI model evaluation, access to diverse and independent clinical validation datasets spanning multiple sites and populations, expertise in regulatory science given the Software as a Medical Device framing of the tools being evaluated, and the organizational maturity to run a benchmarking operation on someone else's timeline. Because only one award is expected, this is a winner-take-all competition, and the budget structure is notably front-loaded in an unusual way - $2,000,000 in direct costs in year one rising to as much as $3,200,000 per year thereafter, making this among the largest single awards in the PRIMED-AI portfolio. Foreign organizations and foreign components are not eligible, unlike the program's tool-development announcements. Institutions that intend to submit tool-development applications under RFA-RM-27-012 or RFA-RM-27-013 should think carefully about the independence expectations before also competing for the Validation Center role. The October 2, 2026 deadline is shared with the Logistics Center announcement (RFA-RM-27-015), the program's companion coordinating infrastructure award.

Extreme Heat and Community Resilience Program Round 2 is sponsored by Governor’s Office of Land Use and Climate Innovation. The Extreme Heat and Community Resilience Program (Extreme Heat Program) is housed within the Governor’s Office of Land Use and Climate Innovation (LCI). The Program provides funding for projects to protect California communities most vulnerable to the impacts of extreme heat. Round 2 will fund infrastructure projects with funding from the 2024 Climate Bond (Proposition 4) and the Greenhouse Gas Reduction Fund. Early Infrastructure Projects fund heat-related infrastructure planning and a demonstration project that tests proposed approaches. Awards range from $750,000 to $1.2 million. Advanced Infrastructure Projects fund the implementation of heat-related infrastructure projects that have been identified through prior planning efforts and determined to be feasible. Awards range from $3 million to $4.5 million. Applications must include a Lead Applicant and at least one Co-Applicant. Eligible Lead Applicants and Co-Applicants include Local and Regional Public Entities, Community-Based Organizations (CBOs), Public Higher Academic Institutions, California Native American Tribes, and Coalitions. How do you apply? • Step 1: Submit a Pre-Application Interest Form via Submittable. Window 1 opens on June 16, 2026, and closes on July 21 at 2:00 PM PST. Technical Assistance requests are only accepted during Window 1. Window 2 opens on July 1, 2026, and closes on August 11 at 2:00 PM PST. • Step 2: Submit the Full Application Form via Submittable. The Full Application Form is only available to applicants who have completed a Pre-Application Interest Form. The Full Application Form must be submitted by October 13, 2026, at 2:00 PM PST. What are the funding priorities? The Extreme Heat Program will direct at least 40% of its funding to projects with meaningful and direct benefits for Disadvantaged Communities (DACs) or Vulnerable Populations. Of that 40%, a minimum of 10% must support Severely Disadvantaged Communities (SDACs).