Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required)

Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required) is sponsored by National Cancer Institute (NCI), National Institutes of Health (NIH). This opportunity supports mission-aligned projects and measurable outcomes.

Opportunity Listing - Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required) Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required) Agency: National Institutes of Health Assistance Listings: 93. 395 -- Cancer Treatment Research 93. 394 -- Cancer Detection and Diagnosis Research Last Updated: June 2, 2026 View version history on Grants.

gov Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to continue to support the Radiation Oncology-Biology Integration Network (ROBIN) with applications from both new and renewing investigators.

This network model will sustain an agile and effective national radiation oncology infrastructure that collectively addresses critical hypothesis-based translational research on the biological basis of responses in cancer patients who undergo radiation treatments. ROBIN supports a collaborative national research network focused on understanding how tumors and normal tissues change biologically during radiation therapy.

Because radiation can dynamically alter molecular targets over the course of treatment, the network seeks to generate foundational knowledge that can improve radiation-based cancer care and identify new opportunities for combining radiation with drugs and other therapies.

Through multidisciplinary, longitudinal studies, ROBIN centers collect and analyze biospecimens and multimodal data before, during, and after standard-of-care radiation therapy. This work is designed to reveal mechanisms of response, resistance, and toxicity; identify new therapy-induced targets; and determine whether treatment strategies based on initial tumor profiling remain optimal as therapy progresses.

The network also strengthens the radiation oncology workforce by integrating expertise in biology, clinical oncology, imaging, dosimetry, omics, biospecimen science, and data science. By sustaining this research infrastructure, NIH aims to accelerate translational discoveries that can inform future clinical trials and improve outcomes for people with cancer.

Federally recognized Native American tribal governments Special district governments Public and Indian housing authorities City or township governments Independent school districts Public and state institutions of higher education Private institutions of higher education For-profit organizations other than small businesses Nonprofits non-higher education without 501(c)(3) Other Native American tribal organizations Nonprofits non-higher education with 501(c)(3) Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

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