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Find similar grantsRegulation of Capillary Blood Flow in the Choroid Vasculature is sponsored by BrightFocus Foundation. Examines how light affects choroidal blood flow in early-stage macular degeneration.
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Regulation of Capillary Blood Flow in the Choroid Vasculature Grants > Regulation of Capillary Blood Flow in the Choroid Vasculature Macular Degeneration Research Grant Regulation of Capillary Blood Flow in the Choroid Vasculature Understanding Early-Stage Macular Degeneration Macular Degeneration Research July 01, 2022 - December 30, 2025 The goal of the project is to understand the non-neuronal mechanisms regulating choroidal blood flow and identify new therapeutic targets relating to the pathogenesis of age-related macular degeneration.
Using high-speed and high-resolution spinning disk microscopy and a novel ex vivo pressurized-choroidal vasculature preparation, we will examine how the application of light affects the contractile state of the blood vessels controlling choroidal blood flow.
In addition, we will employ a combination of molecular biology, patch-clamp electrophysiology, and super-resolution imaging to identify the cellular targets and ion channels responsible for the light-dependent constriction of choroidal blood vessels.
The current proposal will use a combination of novel approaches to test the hypothesis that light stimulates light and can affect endothelial cell and mural cell calcium dynamics leading to changes in vascular tone. These approaches include a novel ex vivo pressurized-vasculature preparation; new transgenic mice expressing fluorescent calcium biosensors; and choroidal tissue from Cynomolgus monkeys.
Conceptual innovations include the concept that K+ efflux is a cellular signaling modality acting on the choriocapillaris as sensory webs responding to the metabolic needs of nearby photoreceptors.
Successful completion of the current proposal will transform our understanding of the function of capillary networks within the choroidal vasculature, establishing these networks as sensors and active contributors to the regulation of local blood flow necessary to meet the unique metabolic demand of photoreceptors of the eye.
By building a better understanding of the non-neuronal mechanisms of blood flow control, the proposed work will provide new insights into the pathogenesis of age-related macular degeneration and unearth new pathophysiological targets for therapeutic interventions.
Macular Degeneration Research Protecting Eye Blood Vessels to Slow Vision Loss in Macular Degeneration July 01, 2026 - June 30, 2028 Oklahoma Medical Research Foundation Macular Degeneration Research A Blood Test to Measure Genes Associated with Macular Degeneration July 01, 2025 - June 30, 2028 William Marsh Rice University Macular Degeneration Research Tracking Biological Responses to Lifestyle Changes in AMD Patients July 01, 2025 - June 30, 2027 Erasmus University Medical Center Rotterdam (Erasmus MC) News Featuring This Grantee Could Improving Blood Flow to the Eye Unlock Future Treatments for Macular Degeneration?
Discover research led by BrightFocus Foundation Macular Degeneration Research grant recipient, Dr. Albert Gonzales on how enhancing blood flow to the eye could lead to new treatments for macular degeneration.
According to the current listing, eligibility includes: Researchers at the University of Nevada. Confirm the full requirements in the official notice before applying.
The current listing shows $446,943. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Regulation of Capillary Blood Flow in the Choroid Vasculature is funded by BrightFocus Foundation. Verify program details on the funder's official page before applying.
This opportunity targets applicants in Nevada. If your organization operates elsewhere, check the official notice for location requirements.
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