Research Centers in Minority Institutions (RCMI) Coordinating Center (U24 - Clinical Trial Optional)

Research Centers in Minority Institutions (RCMI) Coordinating Center (U24 - Clinical Trial Optional) is sponsored by National Institute on Minority Health and Health Disparities (NIMHD), National Institutes of Health (NIH). This grant supports a coordinating center for the Research Centers in Minority Institutions (RCMI) program, which aims to enhance the research capacity of institutions that serve underrepresented minority populations.

Expired RFA-MD-24-011: Limited Competition: Research Centers in Minority Institutions (RCMI) Coordinating Center (U24 - Clinical Trial Optional) This notice has expired. For NIH, in limited situations, applications may be accepted on a case-by-case basis for a short period after expiration to accommodate NIH late or continuous submission policies . Contact the eRA Service Desk for any submission issues.

Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Institute on Minority Health and Health Disparities ( NIMHD ) Funding Opportunity Title Limited Competition: Research Centers in Minority Institutions (RCMI) Coordinating Center (U24 - Clinical Trial Optional) U24 Resource-Related Research Projects – Cooperative Agreements April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

See Notice NOT-OD-24-084 . August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198 .

August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189 . Funding Opportunity Number (FON) Companion Funding Opportunity Only one application per institution is allowed, as defined in Section III.

3. Additional Information on Eligibility . Assistance Listing Number(s) Funding Opportunity Purpose NIMHD invites applications from eligible institutions to establish a national coordinating center (CC) for NIMHD-funded Research Centers in Minority Institutions (RCMIs).

The RCMI CC will work closely with key personnel at all RCMI Specialized Centers and with NIMHD staff to help the centers collectively achieve their primary goals to: (1) enhance institutional research capacity to conduct world-class basic biomedical, behavioral, population, and/or clinical patient-centered or health services research; (2) enable all levels of investigators at recipient institutions to become more successful in obtaining competitive extramural support, especially from NIH, for research on diseases and conditions that disproportionately impact populations that experience health disparities; (3) foster institutional environments conducive to research career development and enhancement for post-doctoral fellows, junior faculty members, and other early-stage investigators; (4) enhance the tools for and conduct of research generally and specifically for improving minority health and reducing health disparities; and (5) establish sustainable partnerships with community-based organizations to promote research efforts and the dissemination of research findings that partner with RCMI centers, and (6) centralize and harmonize study operations, coordinate data management, provide biostatistical support to facilitate rapid development and implementation of minority health and health disparity studies conducted in the RCMI-CRNHE (Clinical Research Network for Health Equity) (see RFA-MD-22-006 ), and also manage a Network Steering Committee.

The RCMI CC will be responsive to requests generated by RCMI site key personnel, NIMHD, NIH, the scientific community, and the general public. Eligible applicant institutions for this NOFO are limited to recipients of RCMI awards through RFA-MD-17-003 , RFA-MD-17-006 , RFA-MD-18-012 , RFA-MD-20-006 , PAR-11-132 , RFA-MD-22-002 , RFA-MD-23-001 , or RFA-MD-24-001 .

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) The following table includes NIH standard due dates marked with an asterisk. Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. No late applications will be accepted for this Notice of Funding Opportunity (NOFO).

Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Part 1. Overview Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Information Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Part 2. Full Text of Announcement Section I.

Notice of Funding Opportunity Description The NIH established the Research Centers in Minority Institutions (RCMI) program in 1985 in response to Congressional interest in expanding the national capacity for research in the health sciences by providing support to eligible institutions that offer doctorate degrees in the health professions or health-related sciences and have a documented historical mission or historical commitment to educating underrepresented students and, for institutions that deliver health care services, have a record of providing clinical services to medically underserved communities.

NIMHD recognizes the important role such institutions play in supporting scientific research and providing health care in underserved communities. These institutions are uniquely positioned to engage minority populations and other U.S. populations that experience health disparities in research and in the translation of research advances into culturally competent, measurable and sustained improvements in health outcomes.

NIMHD Interest in the RCMI Program The NIMHD's mission is to conduct and support research, training, health information dissemination, and other programs with respect to minority health and health disparities.

This funding opportunity seeks to support an eligible institution to establish a national coordinating center that will work closely with key personnel at all RCMI Specialized Centers and with NIMHD staff to help facilitate enhancement of research capacity and faculty development in RCMI institutions to pursue basic biomedical, behavioral, and/or clinical research (patient-oriented research and health services research), particularly on diseases and/or conditions that disproportionately impact racial and ethnic minority populations and other populations that experience health disparities.

The RCMI Coordinating Center (CC) will serve as a national resource to help RCMI U54 centers achieve their primary goals to: : (1) enhance institutional research capacity to conduct world-class basic biomedical, behavioral, population and/or clinical patient-centered or health services research; (2) enable all levels of investigators at recipient institutions to become more successful in obtaining competitive extramural support, especially from NIH, for research on diseases and conditions that disproportionately impact populations that experience health disparities; (3) foster institutional environments conducive to research career development and enhancement for post-doctoral fellows, junior faculty members, and other early-stage investigators; (4) enhance the tools for and conduct of research generally and specifically for improving minority health and reducing health disparities; (5) establish sustainable partnerships with community-based organizations to promote research efforts and the dissemination of research findings; and (6) centralize and harmonize study operations, coordinate data management, provide biostatistical support to facilitate rapid development and implementation of minority health and health disparity studies conducted in the RCMI-CRNHE (Clinical Research Network for Health Equity) (see RFA-MD-22-006), and also manage a Network Steering Committee.

The RCMI CC will collectively advance the science of minority health and health disparities through intellectual exchange and collaborative interactions that enhance research capacity and competitiveness at participating institutions.

As mentioned in the Notice of Funding Opportunity focused on Research Centers in Minority Institutions (RCMI) (see RFA-MD-24-012 ), the three types of proposed research focus areas under the RCMI program are defined as follows: Basic Biomedical Research : Systematic study directed toward greater knowledge or understanding of the fundamental biological processes and mechanisms, without a specific application or product in mind, essentially focusing on the core principles underlying living organisms, laying the foundation for future advancements in disease diagnosis, treatment, and prevention.

This type of research could include cell, animal or human or secondary data-based research focused on fundamental science. Behavioral or Social Science or Population Science Research that could include epidemiological or community-engaged, or population research. Behavioral and social sciences research involves the systematic study of understanding and/or modifying behavioral or social phenomena relevant to health.

Basic behavioral research involving psychological processes (e.g., emotion, judgment, decision-making, bias) to help predict, prevent, and manage illness through observational, mechanistic or intervention studies. Research to develop and evaluate interventions delivered in community settings to improve the health of individuals, families, communities, and populations.

Population and epidemiological science research include analyses of existing databases that leverage de-identified data from populations such as the National Health Interview Survey, claims data from Medicare or other health insurance providers, or data from health-related factors such as air pollution and the built environment. Clinical Research : Research with human participants that is: Patient-oriented research.

Research conducted with human participants (or on material of human origin, such as tissues, specimens, and cognitive phenomena) for which an investigator directly interacts with the patients and includes ascertainment of clinical outcomes.

Excluded from this definition are in vitro studies that use human tissues (or other biospecimens or human pathogens) that cannot be linked to a living person, or studies in which the interaction with patients or persons is for the sole purpose of obtaining any biospecimens.

Patient-oriented research includes (i) mechanisms of human disease (for example, mechanistic trials), (ii) therapeutic interventions, (iii) clinical trials, or (iv) development of new technologies. Behavioral research in a clinical setting is included. Outcomes research and/or health services research.

Note: Studies falling under 45 CFR 46. 101(b) (4) (Exemption 4) are not considered clinical research under this definition. Therefore, studies involving deidentified human health data are not considered clinical research.

Evaluation of the RCMI Consortium The RCMI CC will conduct prospective evaluation of the overall RCMI program and coordinate establishment of common metrics to measure effectiveness of the Program, collection, analysis of data from the awarded RCMI centers and generating regular reports.

Supporting information exchange, sharing of scientific expertise and best practices, leveraging of research resources, and scientific dissemination across RCMI sites are considered essential to the success of the RCMI CC program.

The RCMI CC will monitor the extent to which investigator development activities at the RCMI U54 sites, including but not limited to pilot project programs, lead to impactful scientific publications and to extramural research grant awards from NIH and other sources to RCMI investigators.

It will also monitor the extent to which community engagement activities at RCMI U54 sites foster sustainable relationships with community-based organizations, enhance participation of minority populations as human subjects in clinical trials, and promote dissemination of research findings to communities to address their health-related concerns.

In addition, the RCMI-CC will work with RCMI U54 centers to develop common outcomes and performance metrics for project evaluation in each of the four key domains noted above that can provide information for RCMI national program evaluation.

It will also maintain a centralized database through which RCMI sites and NIMHD can track recruitment and retention of participating investigators, including investigators from underrepresented groups (see, NOT-OD-20-031) and their career trajectories, along with outcomes of RCMI-supported projects such as peer-reviewed publications and grant awards supporting RCMI investigators.

These data should be collected and maintained in standardized, structured formats that are easily analyzable and shareable to better evaluate the progress and successes of the RCMI program. The RCMI CC will use this information to prepare annual reports for NIMHD highlighting significant program developments by individual RCMI U54 centers and collectively across the RCMI program.

The RCMI CC is expected to help RCMI investigators take advantage of research and career development opportunities and address research needs as they arise in priority areas of basic biomedical, behavioral and clinical sciences.

This can include professional development and mentoring promoting submission of applications by organizations supporting RCMI investigators to relevant NIH funding opportunity announcements, as well as to ongoing NIH programs to support the development of early-career scientists, such as Research Supplements to Promote Diversity in Health-Related Research and mentored career development awards (K01, K08, K23, and K99) and research educational programs like the NIMHD Health Disparities Research Institute and other NIH-supported opportunities.

The RCMI CC will also assist efforts to build capacity in RCMI U54 centers to not only engage communities in research as partners and participants but also to effectively communicate and disseminate their research findings that advance scientific knowledge at all levels to their communities.

Specific discoveries that are useful to the community and have the potential to benefit health and well-being at the neighborhood, community and population levels can be promoted.

RCMI CC activities are expected to align with and support the objectives of the RCMI U54 centers in four key domains: (1) project administration and coordination among sites, (2) research resources to support scientific projects, (3) early-stage investigator development and mentoring, and (4) community engagement.

Toward that end, the RCMI CC must have the following essential functions: Organize and convene an annual grantees meeting bringing together RCMI U54 PDs/PIs and other senior scientists from each site, research project leaders, pilot project awardees, key community partners, and NIH staff to exchange information and discuss opportunities for collaboration and strategies for solving shared challenges in each of the four key domains noted above.

Organize and convene monthly conference video calls with the U54 principal investigators to discuss strategies, directions, and future directions of the Consortium. Support a Clinical Research Pilot Project Program that provides opportunities for post-doctoral fellows, early career faculty, or other early stage investigators as defined by NIH (see https://grants. nih.

gov/policy/early-investigators/index. htm#definition ), including outreach efforts to recruit prospective investigator participants from groups underrepresented in the biomedical research workforce (see Notice of NIH’s Interest in Diversity ) to consider applying for available opportunities. Scholars should be recruited from the RCMI institutions, from affiliated institutions, and from community-based researchers and organizations.

Pilot projects are each expected to range from $100,000 to $150,000 direct costs per year for project periods of one to two years, with two new pilot projects supported each year across the RCMI Consortium that can be in the areas of biomedical, behavioral, and/or clinical research (patient-oriented research and health services research).

Serve as a resource for connecting RCMI U54 sites and investigators to a broader spectrum of scientists and community partners to promote research collaborations and the development and adoption of best practices to improve minority health and address health disparities.

The RCMI CC will foster linkages with other NIH programs such as NIMHD Centers of Excellence on Minority Health and Health Disparities; NIMHD Multiple Chronic Disease Research Centers; NIMHD-NIEHS Environmental Disparities Centers; the NIMHD-NHLBI Community Engagement Alliance (CEAL); NCATS Clinical and Translational Science Awards (CTSA); NIGMS Institutional Development Award (IDeA) program centers and networks; NIA Resource Centers for Minority Aging Research (RCMAR), Alzheimer's Disease Research Centers, and the NIA Research Center Collaborative Network; NIAID Centers for AIDS Research (CFAR); NIDDK Network of Minority Health Research Investigators (NMRI); NHLBI minority cohort studies (e.g., Jackson Heart Study, Hispanic Community Health Study[HCHS]/Study of Latinos [SOL], Multi-Ethnic Study of Atherosclerosis [MESA], STRONG Heart Study); NCI Comprehensive Cancer Centers; NCI U54 Partnership Grants; the Adolescent Brain Cognitive Development (ABCD) Study; the NIDA Native Collective Research Effort to Enhance Wellness (N CREW) Program, the NHGRI Diversity Centers for Genome Research, the All of Us Research Program, and others.

Facilitate collaboration and resource sharing between the RCMI Centers, other academic institutions, community-based organizations, federal agencies or programs, and industry partners who are engaged in research, training and educational activities focused on reducing disparities and improving the health status of minority populations.

Establish standardized master clinical trial agreements and other agreements with the RCMI network study sites and develop and implement a plan to reduce the start-up time of each network project using these standardized agreements as well as help to resolve any issues associated with these agreements.

Develop standard operating procedures (SOPs) or best practices in the settings of research projects that are carried out across two or more RCMIs. Expand the size and scope of the annual RCMI scientific meeting that is annually organized by the RCMI CC to include all RCMI initiatives and partners.

Facilitate research collaboration across RCMI sites through periodic web-based and face-to-face meetings inclusive of the three broad RCMI program research themes of basic biomedical research, behavioral and social science, and clinical/health services research, as well as cross-cutting themes and specific scientific topics of shared interest.

Convene periodic meetings of RCMI U54 core directors and staff to discuss administrative issues, core facility management, opportunities for sharing access to specialized equipment and other technical resources, mentoring strategies and resources, best practices for community engagement, and program evaluation.

Facilitate broad access to research mentors and other resources, including the NIH-funded National Research Mentoring Network, that can enhance career development, particularly for early-stage RCMI investigators and more-established RCMI investigators seeking to expand their skill sets.

Provide methodological consultation to RCMI investigators on study design, regulatory compliance, biostatistics, bioinformatics and computational biology, data science, data management and analysis including but not limited to analysis of multi-omic datasets and other high-dimensional data, geographic information systems, health economics, or other technical areas.

Facilitate RCMI collaborations with other academic institutions, community-based organizations, federal/state/local agencies or programs, and industry partners engaged in research, training and educational activities focused on reducing health disparities and improving the health of underserved populations.

Additional activities may be proposed to promote collaboration among RCMI U54 sites, contribute to the professional development of RCMI investigators, encourage interactions between the RCMI program and other NIMHD- and NIH-supported resources, and enhance the value, visibility and scientific impact of the RCMI program.

Examples include but are not limited to: Providing visiting scientist opportunities across RCMI U54 centers for pilot project recipients to foster collaboration and career development, and for senior investigators to promote mentorship and scientific exchange.

Assist in coordinating submission of peer-reviewed manuscripts by RCMI investigators for publication in thematic special issues of scholarly journals, with the RCMI-CC organizing one special issue per year for RCMI-led research. Fostering new or existing partnerships with local, county, or state health departments and small, for-profit businesses to address community health concerns.

Assist efforts of RCMI U54 centers to assess or characterize improvements, relative to established baselines, in health-related knowledge and health outcomes at the community/neighborhood and higher levels resulting from dissemination of research advances.

Increased access to research mentors and other available resources, such as expert consultation on study design and other technical areas, that can enhance the competitiveness and career development of early-stage RCMI investigators.

Enhanced or expanded partnerships with community-based organizations and members of underserved communities to increase participation of minority populations as human subjects in clinical trials and promote effective dissemination of research findings to address community partners’ health-related concerns.

Increased dissemination and promotion of RCMI program activities, research resources, and research advances nationwide to increase the visibility and scientific impact of RCMI institutions and investigators.

In terms of coordination of the RCMI-CRNHE, the RCMI CC is expected to perform the following activities: Facilitate coordination of research activities including support for the RCMI- CRNHE Steering Committee and workgroups established for specific areas of collaborative research within the RCMI- CRNHE.

Assist the RCMI- CRNHE in the identification of network personnel and clinicians who will participate on the study teams as key contributors to study development and implementation, as needed.

Work collaboratively in the development of manual of operations and standardized protocols for data/biospecimen collection from study participants (including consent forms and IRB approvals), especially for studies performed across the RCMI- CRNHE sites. Work collaboratively with each RCMI- CRNHE to help implement the proposed projects while providing technical, design, quality control and assurance, and coordination support.

Maintain a data management system needed for study data collection, including image capture and multiple types of data relevant to individual studies, as needed and with guidance from NIMHD.

Collaborate with the RCMI- CRNHE in the development and standardization of protocols for the definition and collection of CDEs whether involving direct data/biospecimen collection from study participants and/or data extraction from electronic health records for demographics, social determinants of health (ideally aligned with those listed in the PhenX toolkit ), behavioral and clinical outcomes, and other variables of interest as agreed and recommended by the RCMI- CRNHE research teams.

Provide biostatistical support to RCMI- CRNHE research teams for study design, implementation (including but not limited to randomization) and analyses, as needed.

Provide subject matter expertise advice regarding the establishment and maintenance of the research infrastructure at every RCMI- CRNHE site, including electronic health data harmonization, creation of data dictionaries, and data science expertise, and other related expertise, as needed. Coordinate common data sharing plans among the RCMI- CRNHE sites.

Maintain a secure infrastructure for storing and providing access to study-related documents and materials, including IRB communication and data that might include identifiable for the use of such materials and for providing a secure means for approved users to access those materials. See Section VIII. Other Information for award authorities and regulations.

Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. Section II. Award Information Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement.

Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI. 2 for additional information about the substantial involvement for this NOFO.

Application Types Allowed The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO. Optional: Accepting applications that either propose or do not propose clinical trial(s).

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards NIMHD intends to commit $5 million in FY 2025 to fund one award. Application budgets cannot exceed $3,500,000 annually in direct costs.

The proposed project period cannot exceed five years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO. Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISIs) Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations To be eligible for this FOA, the applicant institution must be a domestic institution located in the United States and its territories which: Has received an average of less than $50 million per year of NIH support for the past three fiscal years; Awards doctorate degrees in the health professions or the sciences related to health; and Has a documented historical mission to educate students from any of the populations that have been identified as underrepresented in biomedical research as defined by the National Science Foundation NSF, see http://www.

nsf.

gov/statistics/wmpd/ ) (i.e., African Americans or Blacks, Hispanic or Latino Americans, American Indians, Alaska Natives, Native Hawaiians, U.S. Pacific Islanders, and persons with disabilities) or (1) has a documented historical commitment to educating and/or training underrepresented students as defined by NSF (see above) who pursue biomedical research careers and, (2) for institutions that deliver health care services, has a record of providing clinical services to medically underserved communities.

Eligible applicant institutions for this FOA are limited to recipients of RCMI awards through RFA-MD-17-003 , RFA-MD-17-006 , RFA-MD-18-012, PAR-11-132, RFA-MD-20-006 , RFA-MD-22-002 , RFA-MD-23-001 , or RFA-MD-24-001 . Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement , are not allowed. Applicant organizations must complete and maintain the following registrations as described in the How to Apply - Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted.

Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2. 3.

9. 2 Electronically Submitted Applications for additional information System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.

Individuals from diverse backgrounds, including individuals from underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support.

See, Reminder: Notice of NIH's Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities , NOT-OD-22-019 , and Notice of NIH's Interest in Diversity, NOT-OD-20-031 .

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide . This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement NIH Grants Policy Statement Section 1. 2 Definition of Terms.

3. Additional Information on Eligibility The NIH will not accept duplicate or highly overlapping applications under review at the same time, per NIH Grants Policy Statement Section 2. 3.

7. 4 Submission of Resubmission Application . This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application. An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3.

9. 4 Similar, Essentially Identical, or Identical Applications ). Only one application per institution (normally identified by having a unique UEI number or NIH IPF number) is allowed.

Section IV. Application and Submission Information 1. Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants.

gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants. gov Workspace are available in Part 1 of this NOFO.

See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2. Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise.

Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review. By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed activity Name(s), address(es), and telephone number(s) of the PD(s)/PI(s) Names of other key personnel Participating institution(s) Number and title of this funding opportunity The letter of intent should be sent to: National Institute on Minority Health and Health Disparities (NIMHD) All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO. All instructions in the How to Apply - Application Guide must be followed. SF424(R&R)